Protective hinge in insulin opens to enable its receptor engagement

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 33, 2014, Pages

  Menting, John G ^a   Yang, Yanwu ^b   Chan, Shu Jin ^c   Phillips, Nelson B ^b   Smith, Brian J ^d   Whittaker, Jonathan ^b   Wickramasinghe, Nalinda P ^b   Whittaker, Linda J ^b   Pandyarajan, Vijay ^b   Wan, Zhu Li ^b   Yadav, Satya P ^e   Carroll, Julie M ^f   Strokes, Natalie ^b   Roberts Jr , Charles T ^f,g   Ismail Beigi, Faramarz ^b   Milewski, Wieslawa ^c   Steiner, Donald F ^c   Chauhan, Virander S ^h   Ward, Colin W ^a   Weiss, Michael A ^b,i   Lawrence, Michael C ^a,j   more..

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d LA TROBE UNIVERSITY   (Australia)

^e LERNER RESEARCH INSTITUTE   (United States)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^h INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

ⁱ Case Western Reserve University   (United States)

^j UNIVERSITY OF MELBOURNE   (Australia)

more..

Author keywords

Diabetes mellitus; Metabolism; Protein structure; Receptor tyrosine kinase; Signal transduction

Indexed keywords

ALANINE; INSULIN; INSULIN DERIVATIVE; INSULIN RECEPTOR; ISOLEUCINE; PHENYLALANINE; SOMATOMEDIN; TYROSINE; VALINE;

ARTICLE; BETA SHEET; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; INSULIN BINDING; MUTAGENESIS; MUTATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

DIABETES MELLITUS; METABOLISM; PROTEIN STRUCTURE; RECEPTOR TYROSINE KINASE; SIGNAL TRANSDUCTION;

CRYSTALLOGRAPHY, X-RAY; INSULIN; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; RECEPTOR, INSULIN;

EID: 84906306629     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412897111     Document Type: Article

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