Solution structure of proinsulin: Connecting domain flexibility and prohormone processing

Journal of Biological Chemistry

Volumn 285, Issue 11, 2010, Pages 7847-7851

  Yang, Yanwu ^a   Hua, Qing Xin ^a   Liu, Jin ^b   Shimizu, Eri H ^b   Choquette, Meredith H ^b   Mackin, Robert B ^b   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SITE SELECTION; SULFUR COMPOUNDS;

CLASSICAL STRUCTURES; CLEAVAGE SITE SELECTION; DIABETES MELLITUS; MONOGENIC FORMS; NUCLEAR OVERHAUSER ENHANCEMENT; PANCREATIC BETA CELLS; PRO-HORMONE PROCESSING; SOLUTION STRUCTURES;

INSULIN;

HORMONE PRECURSOR; INSULIN; MONOMER; PROINSULIN; PROTEINASE; DISULFIDE; PROPROTEIN CONVERTASE 1;

ALPHA CHAIN; ALPHA HELIX; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; HORMONE STRUCTURE; HUMAN; INSULIN SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN PROCESSING; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; MUTATION; NUCLEAR MAGNETIC RESONANCE; PANCREAS ISLET BETA CELL; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

DIABETES MELLITUS, TYPE 1; DISULFIDES; HUMANS; INSULIN-SECRETING CELLS; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROINSULIN; PROPROTEIN CONVERTASE 1; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 77950915587     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C109.084921     Document Type: Article

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