Mechanism of insulin fibrillation: The structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate

Journal of Biological Chemistry

Volumn 279, Issue 20, 2004, Pages 21449-21460

  Hua, Qing Xin ^a   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; HYDROPHOBICITY; INSULIN; MONOMERS; PH EFFECTS;

FIBRILLATION; SPECTRAL ACQUISITION;

PROTEINS;

AMYLOID; INSULIN; PROINSULIN;

ALPHA HELIX; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BETA CHAIN; CONTRAST ENHANCEMENT; DIABETES MELLITUS; FIBER; HYDROPHOBICITY; INSULIN METABOLISM; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN FIBRILLATION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION;

CIRCULAR DICHROISM; HUMANS; INSULIN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS;

ANIMALIA;

EID: 2442715309     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M314141200     Document Type: Article

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