High-affinity insulin binding: Insulin interacts with two receptor ligand binding sites

Biochemistry

Volumn 47, Issue 48, 2008, Pages 12900-12909

  Whittaker, Linda ^a   Hao, Caili ^a   Fu, Wen ^a   Whittaker, Jonathan ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BINDING ENERGY; BIOCHEMISTRY; FLOW INTERACTIONS; HORMONES; INSULIN; LIGANDS; SCANNING;

293 CELLS; AFFINITY BINDINGS; AFFINITY INTERACTIONS; ALANINE MUTANTS; ALANINE MUTATIONS; BINDING PROPERTIES; COMPLEMENTATION; COOPERATIVITY; DIMERIC STRUCTURES; DO-MAINS; EQUILIBRIUM BINDINGS; INDIRECT EFFECTS; INSULIN RECEPTORS; LIGAND BINDINGS; LIGAND INTERACTIONS; NOVEL LIGANDS; RECEPTOR BINDING SITES; RECEPTOR LIGANDS;

BINDING SITES;

ALANINE; FIBRONECTIN; INSULIN; INSULIN RECEPTOR; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INSULIN BINDING; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ALANINE; BINDING SITES; CELL LINE; EXTRACELLULAR SPACE; HOLOENZYMES; HUMANS; INSULIN; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, INSULIN;

EID: 57049086436     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801693h     Document Type: Article

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