An analytical solution to the kinetics of breakable filament assembly

Science

Volumn 326, Issue 5959, 2009, Pages 1533-1537

  Knowles, Tuomas P J ^a,b   Waudby, Christopher A ^b   Devlin, Glyn L ^b   Cohen, Samuel I A ^b   Aguzzi, Adriano ^c   Vendruscolo, Michele ^b   Terentjev, Eugene M ^a   Welland, Mark E ^b   Dobson, Christopher M ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; SELF ASSEMBLED MONOLAYER;

AGGREGATION; ANALYTICAL METHOD; GROWTH RATE; MAMMAL; MOLECULAR ANALYSIS; NUCLEATION; PROTEIN; REACTION KINETICS;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; KINETICS; MACROMOLECULE; PRIORITY JOURNAL; PROTEIN AGGREGATION;

AMYLOID; BIOCHEMICAL PROCESSES; GLUTATHIONE PEROXIDASE; INSULIN; KINETICS; LACTOGLOBULINS; MATHEMATICAL CONCEPTS; MULTIPROTEIN COMPLEXES; PEPTIDE TERMINATION FACTORS; PEPTIDES; PRIONS; PROTEIN MULTIMERIZATION; SACCHAROMYCES CEREVISIAE PROTEINS;

MAMMALIAN PRION;

EID: 72149118250     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1178250     Document Type: Article

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30. T.P.J.K. acknowledges support from St John's College, Cambridge through a Research Fellowship. C.M.D. acknowledges support from the Leverhulme and Wellcome Trusts. We are grateful to A. Craig, A. Knowles, D. White, A. Buell, F. Chiti, A. Miranker, and J. Falsig for valuable discussions, and to M. Sandal for preparing a Web server, which is publicly available at www-vendruscolo. ch.cam.ac.uk/cgi-bin/nef/nefcgi.cgi, to enable the use of the equations presented in this work to fit experimental measurements and to predict aggregation kinetics.