메뉴 건너뛰기




Volumn 15, Issue 1, 2013, Pages

Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; COLLAGEN; DENDRITIC CELL LYSOSOME ASSOCIATED MEMBRANE PROTEIN; MESSENGER RNA; PHOSPHOTRANSFERASE; PKR LIKE ENDOPLASMIC RETICULUM KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ATF4 PROTEIN, HUMAN; EIF2AK3 PROTEIN, HUMAN; LAMP3 PROTEIN, HUMAN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; PROTEIN KINASE R; TUMOR PROTEIN;

EID: 84871882783     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3373     Document Type: Article
Times cited : (186)

References (50)
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • 10.1016/j.cell.2011.02.013, 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674. 10.1016/j.cell.2011.02.013, 21376230.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 84864886120 scopus 로고    scopus 로고
    • Classifying collective cancer cell invasion
    • 10.1038/ncb2548, 22854810
    • Friedl P, Locker J, Sahai E, Segall JE. Classifying collective cancer cell invasion. Nat Cell Biol 2012, 14:777-783. 10.1038/ncb2548, 22854810.
    • (2012) Nat Cell Biol , vol.14 , pp. 777-783
    • Friedl, P.1    Locker, J.2    Sahai, E.3    Segall, J.E.4
  • 4
    • 0018760476 scopus 로고
    • Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
    • 10.1259/0007-1285-52-620-650, 486895
    • Brown JM. Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br J Radiol 1979, 52:650-656. 10.1259/0007-1285-52-620-650, 486895.
    • (1979) Br J Radiol , vol.52 , pp. 650-656
    • Brown, J.M.1
  • 5
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • 10.1038/bjc.1955.55, 2073776, 13304213
    • Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 1955, 9:539-549. 10.1038/bjc.1955.55, 2073776, 13304213.
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 7
    • 0030742027 scopus 로고    scopus 로고
    • Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
    • 10.1016/S0360-3016(97)00101-6, 9226314
    • Brizel DM, Sibley GS, Prosnitz LR, Scher RL, Dewhirst MW. Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 1997, 38:285-289. 10.1016/S0360-3016(97)00101-6, 9226314.
    • (1997) Int J Radiat Oncol Biol Phys , vol.38 , pp. 285-289
    • Brizel, D.M.1    Sibley, G.S.2    Prosnitz, L.R.3    Scher, R.L.4    Dewhirst, M.W.5
  • 8
    • 0037480606 scopus 로고    scopus 로고
    • Hypoxic cervical cancers with low apoptotic index are highly aggressive
    • Hockel M, Schlenger K, Hockel S, Vaupel P. Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Res 1999, 59:4525-4528.
    • (1999) Cancer Res , vol.59 , pp. 4525-4528
    • Hockel, M.1    Schlenger, K.2    Hockel, S.3    Vaupel, P.4
  • 10
    • 0038523737 scopus 로고    scopus 로고
    • Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers
    • 10.1016/S0167-8140(03)00011-2, 12758235
    • Bussink J, Kaanders JH, Van Der Kogel AJ. Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers. Radiother Oncol 2003, 67:3-15. 10.1016/S0167-8140(03)00011-2, 12758235.
    • (2003) Radiother Oncol , vol.67 , pp. 3-15
    • Bussink, J.1    Kaanders, J.H.2    Van Der Kogel, A.J.3
  • 12
    • 0043123069 scopus 로고    scopus 로고
    • Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome
    • 10.1038/sj.bjc.6601122, 2394253, 12865916
    • Span PN, Bussink J, Manders P, Beex LV, Sweep CG. Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome. Br J Cancer 2003, 89:271-276. 10.1038/sj.bjc.6601122, 2394253, 12865916.
    • (2003) Br J Cancer , vol.89 , pp. 271-276
    • Span, P.N.1    Bussink, J.2    Manders, P.3    Beex, L.V.4    Sweep, C.G.5
  • 13
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996, 56:4509-4515.
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 14
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • Nordsmark M, Overgaard M, Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 1996, 41:31-39.
    • (1996) Radiother Oncol , vol.41 , pp. 31-39
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 15
    • 0031688165 scopus 로고    scopus 로고
    • Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
    • 10.1038/bjc.1998.586, 2062967, 9743308
    • Sundfor K, Lyng H, Rofstad EK. Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix. Br J Cancer 1998, 78:822-827. 10.1038/bjc.1998.586, 2062967, 9743308.
    • (1998) Br J Cancer , vol.78 , pp. 822-827
    • Sundfor, K.1    Lyng, H.2    Rofstad, E.K.3
  • 16
    • 34547125574 scopus 로고    scopus 로고
    • Hypoxia, gene expression, and metastasis
    • 10.1007/s10555-007-9063-1, 17458506
    • Chan DA, Giaccia AJ. Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev 2007, 26:333-339. 10.1007/s10555-007-9063-1, 17458506.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 333-339
    • Chan, D.A.1    Giaccia, A.J.2
  • 17
    • 34247528557 scopus 로고    scopus 로고
    • Hypoxia and metastasis in breast cancer
    • Chaudary N, Hill RP. Hypoxia and metastasis in breast cancer. Breast Dis 2006, 26:55-64.
    • (2006) Breast Dis , vol.26 , pp. 55-64
    • Chaudary, N.1    Hill, R.P.2
  • 18
    • 42049110099 scopus 로고    scopus 로고
    • Hypoxic regulation of metastasis via hypoxia-inducible factors
    • 10.2174/156652408783565568, 18289014
    • Gort EH, Groot AJ, Van Der Wall E, van Diest PJ, Vooijs MA. Hypoxic regulation of metastasis via hypoxia-inducible factors. Curr Mol Med 2008, 8:60-67. 10.2174/156652408783565568, 18289014.
    • (2008) Curr Mol Med , vol.8 , pp. 60-67
    • Gort, E.H.1    Groot, A.J.2    Van Der Wall, E.3    van Diest, P.J.4    Vooijs, M.A.5
  • 20
    • 58949092790 scopus 로고    scopus 로고
    • The tumor microenvironment and metastatic disease
    • 10.1007/s10585-008-9182-2, 18543068
    • Lunt SJ, Chaudary N, Hill RP. The tumor microenvironment and metastatic disease. Clin Exp Metastasis 2009, 26:19-34. 10.1007/s10585-008-9182-2, 18543068.
    • (2009) Clin Exp Metastasis , vol.26 , pp. 19-34
    • Lunt, S.J.1    Chaudary, N.2    Hill, R.P.3
  • 21
    • 0036837864 scopus 로고    scopus 로고
    • Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha
    • 10.1128/MCB.22.21.7405-7416.2002, 135664, 12370288
    • Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol Cell Biol 2002, 22:7405-7416. 10.1128/MCB.22.21.7405-7416.2002, 135664, 12370288.
    • (2002) Mol Cell Biol , vol.22 , pp. 7405-7416
    • Koumenis, C.1    Naczki, C.2    Koritzinsky, M.3    Rastani, S.4    Diehl, A.5    Sonenberg, N.6    Koromilas, A.7    Wouters, B.G.8
  • 22
    • 28844470269 scopus 로고    scopus 로고
    • The unfolded protein response: a novel component of the hypoxic stress response in tumors
    • 10.1158/1541-7786.MCR-05-0221, 16317085
    • Feldman DE, Chauhan V, Koong AC. The unfolded protein response: a novel component of the hypoxic stress response in tumors. Mol Cancer Res 2005, 3:597-605. 10.1158/1541-7786.MCR-05-0221, 16317085.
    • (2005) Mol Cancer Res , vol.3 , pp. 597-605
    • Feldman, D.E.1    Chauhan, V.2    Koong, A.C.3
  • 23
    • 33746886623 scopus 로고    scopus 로고
    • "Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways
    • 10.1158/1541-7786.MCR-06-0150, 16849518
    • Koumenis C, Wouters BG. "Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways. Mol Cancer Res 2006, 4:423-436. 10.1158/1541-7786.MCR-06-0150, 16849518.
    • (2006) Mol Cancer Res , vol.4 , pp. 423-436
    • Koumenis, C.1    Wouters, B.G.2
  • 24
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signalling through mTOR and the unfolded protein response in cancer
    • 10.1038/nrc2501, 18846101
    • Wouters BG, Koritzinsky M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer 2008, 8:851-864. 10.1038/nrc2501, 18846101.
    • (2008) Nat Rev Cancer , vol.8 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 26
    • 69949115589 scopus 로고    scopus 로고
    • Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3
    • 10.1016/j.radonc.2009.08.017, 19726095
    • Mujcic H, Rzymski T, Rouschop KM, Koritzinsky M, Milani M, Harris AL, Wouters BG. Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3. Radiother Oncol 2009, 92:450-459. 10.1016/j.radonc.2009.08.017, 19726095.
    • (2009) Radiother Oncol , vol.92 , pp. 450-459
    • Mujcic, H.1    Rzymski, T.2    Rouschop, K.M.3    Koritzinsky, M.4    Milani, M.5    Harris, A.L.6    Wouters, B.G.7
  • 27
    • 0032529242 scopus 로고    scopus 로고
    • Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2: significantly increased expression in cancers of various tissues
    • Ozaki K, Nagata M, Suzuki M, Fujiwara T, Ueda K, Miyoshi Y, Takahashi E, Nakamura Y. Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2: significantly increased expression in cancers of various tissues. Cancer Res 1998, 58:3499-3503.
    • (1998) Cancer Res , vol.58 , pp. 3499-3503
    • Ozaki, K.1    Nagata, M.2    Suzuki, M.3    Fujiwara, T.4    Ueda, K.5    Miyoshi, Y.6    Takahashi, E.7    Nakamura, Y.8
  • 28
    • 80051526098 scopus 로고    scopus 로고
    • Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer
    • 10.1002/cncr.25938, 21319150
    • Nagelkerke A, Mujcic H, Bussink J, Wouters BG, van Laarhoven HW, Sweep FC, Span PN. Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer. Cancer 2011, 117:3670-3681. 10.1002/cncr.25938, 21319150.
    • (2011) Cancer , vol.117 , pp. 3670-3681
    • Nagelkerke, A.1    Mujcic, H.2    Bussink, J.3    Wouters, B.G.4    van Laarhoven, H.W.5    Sweep, F.C.6    Span, P.N.7
  • 29
    • 0026657798 scopus 로고
    • Differential glycosylation and cell surface expression of lysosomal membrane glycoproteins in sublines of a human colon cancer exhibiting distinct metastatic potentials
    • Saitoh O, Wang WC, Lotan R, Fukuda M. Differential glycosylation and cell surface expression of lysosomal membrane glycoproteins in sublines of a human colon cancer exhibiting distinct metastatic potentials. J Biol Chem 1992, 267:5700-5711.
    • (1992) J Biol Chem , vol.267 , pp. 5700-5711
    • Saitoh, O.1    Wang, W.C.2    Lotan, R.3    Fukuda, M.4
  • 30
    • 0027180888 scopus 로고
    • E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels
    • Sawada R, Lowe JB, Fukuda M. E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels. J Biol Chem 1993, 268:12675-12681.
    • (1993) J Biol Chem , vol.268 , pp. 12675-12681
    • Sawada, R.1    Lowe, J.B.2    Fukuda, M.3
  • 32
    • 77951228508 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy: cell death or cell survival?
    • 10.1016/j.ceb.2009.11.015, 20022734
    • Mazure NM, Pouyssegur J. Hypoxia-induced autophagy: cell death or cell survival?. Curr Opin Cell Biol 2010, 22:177-180. 10.1016/j.ceb.2009.11.015, 20022734.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 177-180
    • Mazure, N.M.1    Pouyssegur, J.2
  • 33
    • 0035399174 scopus 로고    scopus 로고
    • Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells
    • 10.1006/excr.2001.5243, 11412041
    • Canning MT, Postovit LM, Clarke SH, Graham CH. Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells. Exp Cell Res 2001, 267:88-94. 10.1006/excr.2001.5243, 11412041.
    • (2001) Exp Cell Res , vol.267 , pp. 88-94
    • Canning, M.T.1    Postovit, L.M.2    Clarke, S.H.3    Graham, C.H.4
  • 35
    • 24644488689 scopus 로고    scopus 로고
    • Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia
    • 10.1096/fj.05-3699com, 16126909
    • Funasaka T, Yanagawa T, Hogan V, Raz A. Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia. FASEB J 2005, 19:1422-1430. 10.1096/fj.05-3699com, 16126909.
    • (2005) FASEB J , vol.19 , pp. 1422-1430
    • Funasaka, T.1    Yanagawa, T.2    Hogan, V.3    Raz, A.4
  • 36
    • 0033521864 scopus 로고    scopus 로고
    • Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression
    • 10.1002/(SICI)1097-0215(19990209)80:4<617::AID-IJC22>3.0.CO;2-C, 9935166
    • Graham CH, Forsdike J, Fitzgerald CJ, Macdonald-Goodfellow S. Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression. Int J Cancer 1999, 80:617-623. 10.1002/(SICI)1097-0215(19990209)80:4<617::AID-IJC22>3.0.CO;2-C, 9935166.
    • (1999) Int J Cancer , vol.80 , pp. 617-623
    • Graham, C.H.1    Forsdike, J.2    Fitzgerald, C.J.3    Macdonald-Goodfellow, S.4
  • 38
    • 0037144460 scopus 로고    scopus 로고
    • Oxygen-mediated regulation of tumor cell invasiveness. Involvement of a nitric oxide signaling pathway
    • 10.1074/jbc.M204529200, 12107174
    • Postovit LM, Adams MA, Lash GE, Heaton JP, Graham CH. Oxygen-mediated regulation of tumor cell invasiveness. Involvement of a nitric oxide signaling pathway. J Biol Chem 2002, 277:35730-35737. 10.1074/jbc.M204529200, 12107174.
    • (2002) J Biol Chem , vol.277 , pp. 35730-35737
    • Postovit, L.M.1    Adams, M.A.2    Lash, G.E.3    Heaton, J.P.4    Graham, C.H.5
  • 39
    • 33751285479 scopus 로고    scopus 로고
    • The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth
    • Fels DR, Koumenis C. The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth. Cancer Biol Ther 2006, 5:723-728.
    • (2006) Cancer Biol Ther , vol.5 , pp. 723-728
    • Fels, D.R.1    Koumenis, C.2
  • 41
    • 0034058373 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation
    • 10.1074/jbc.275.8.5361, 10681510
    • Reshkin SJ, Bellizzi A, Albarani V, Guerra L, Tommasino M, Paradiso A, Casavola V. Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation. J Biol Chem 2000, 275:5361-5369. 10.1074/jbc.275.8.5361, 10681510.
    • (2000) J Biol Chem , vol.275 , pp. 5361-5369
    • Reshkin, S.J.1    Bellizzi, A.2    Albarani, V.3    Guerra, L.4    Tommasino, M.5    Paradiso, A.6    Casavola, V.7
  • 42
    • 33646153307 scopus 로고    scopus 로고
    • Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation
    • 10.1038/sj.onc.1209273, 16369494
    • Munoz-Najar UM, Neurath KM, Vumbaca F, Claffey KP. Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation. Oncogene 2006, 25:2379-2392. 10.1038/sj.onc.1209273, 16369494.
    • (2006) Oncogene , vol.25 , pp. 2379-2392
    • Munoz-Najar, U.M.1    Neurath, K.M.2    Vumbaca, F.3    Claffey, K.P.4
  • 43
    • 0037478437 scopus 로고    scopus 로고
    • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    • 10.1016/S1535-6108(03)00085-0, 12726861
    • Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comoglio PM. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003, 3:347-361. 10.1016/S1535-6108(03)00085-0, 12726861.
    • (2003) Cancer Cell , vol.3 , pp. 347-361
    • Pennacchietti, S.1    Michieli, P.2    Galluzzo, M.3    Mazzone, M.4    Giordano, S.5    Comoglio, P.M.6
  • 44
    • 67349111975 scopus 로고    scopus 로고
    • CXCR4 receptor positive spheroid forming cells are responsible for tumor invasion in vitro
    • 10.1016/j.canlet.2009.02.005, 19286309
    • Krohn A, Song YH, Muehlberg F, Droll L, Beckmann C, Alt E. CXCR4 receptor positive spheroid forming cells are responsible for tumor invasion in vitro. Cancer Lett 2009, 280:65-71. 10.1016/j.canlet.2009.02.005, 19286309.
    • (2009) Cancer Lett , vol.280 , pp. 65-71
    • Krohn, A.1    Song, Y.H.2    Muehlberg, F.3    Droll, L.4    Beckmann, C.5    Alt, E.6
  • 46
    • 79960994652 scopus 로고    scopus 로고
    • Lysosome-associated membrane glycoprotein 3 is involved in influenza A virus replication in human lung epithelial (A549) cells
    • 10.1186/1743-422X-8-384, 3162545, 21810281
    • Zhou Z, Xue Q, Wan Y, Yang Y, Wang J, Hung T. Lysosome-associated membrane glycoprotein 3 is involved in influenza A virus replication in human lung epithelial (A549) cells. Virol J 2011, 8:384. 10.1186/1743-422X-8-384, 3162545, 21810281.
    • (2011) Virol J , vol.8 , pp. 384
    • Zhou, Z.1    Xue, Q.2    Wan, Y.3    Yang, Y.4    Wang, J.5    Hung, T.6
  • 47
    • 33749041268 scopus 로고    scopus 로고
    • Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy
    • 10.1016/j.mam.2006.08.005, 16973206
    • Eskelinen EL. Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol Aspects Med 2006, 27:495-502. 10.1016/j.mam.2006.08.005, 16973206.
    • (2006) Mol Aspects Med , vol.27 , pp. 495-502
    • Eskelinen, E.L.1
  • 48
    • 84861394761 scopus 로고    scopus 로고
    • Inhibition of autophagy impairs tumor cell invasion in an organotypic model
    • 10.4161/cc.20424, 3359125, 22580450
    • Macintosh RL, Timpson P, Thorburn J, Anderson KI, Thorburn A, Ryan KM. Inhibition of autophagy impairs tumor cell invasion in an organotypic model. Cell Cycle 2012, 11:2022-2029. 10.4161/cc.20424, 3359125, 22580450.
    • (2012) Cell Cycle , vol.11 , pp. 2022-2029
    • Macintosh, R.L.1    Timpson, P.2    Thorburn, J.3    Anderson, K.I.4    Thorburn, A.5    Ryan, K.M.6
  • 49
    • 79251578964 scopus 로고    scopus 로고
    • Hypoxia-induced autophagic response is associated with aggressive phenotype and elevated incidence of metastasis in orthotopic immunocompetent murine models of head and neck squamous cell carcinomas (HNSCC)
    • 10.1016/j.yexmp.2010.11.011, 3057178, 21236253
    • Vigneswaran N, Wu J, Song A, Annapragada A, Zacharias W. Hypoxia-induced autophagic response is associated with aggressive phenotype and elevated incidence of metastasis in orthotopic immunocompetent murine models of head and neck squamous cell carcinomas (HNSCC). Exp Mol Pathol 2011, 90:215-225. 10.1016/j.yexmp.2010.11.011, 3057178, 21236253.
    • (2011) Exp Mol Pathol , vol.90 , pp. 215-225
    • Vigneswaran, N.1    Wu, J.2    Song, A.3    Annapragada, A.4    Zacharias, W.5
  • 50
    • 84856003912 scopus 로고    scopus 로고
    • Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome
    • 10.1158/1078-0432.CCR-11-1282, 22080440
    • Lazova R, Camp RL, Klump V, Siddiqui SF, Amaravadi RK, Pawelek JM. Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome. Clin Cancer Res 2012, 18:370-379. 10.1158/1078-0432.CCR-11-1282, 22080440.
    • (2012) Clin Cancer Res , vol.18 , pp. 370-379
    • Lazova, R.1    Camp, R.L.2    Klump, V.3    Siddiqui, S.F.4    Amaravadi, R.K.5    Pawelek, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.