New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1α signaling is essential for promoting adaptation and survival to hypoxia

Radiotherapy and Oncology

Volumn 108, Issue 3, 2013, Pages 541-547

  Cojocari, Dan ^a,c   Vellanki, Ravi N ^a   Sit, Brandon ^a   Uehling, David ^b   Koritzinsky, Marianne ^a,c   Wouters, Bradly G ^a,b,c  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Hypoxia; IRE1 ; PERK; Small molecule inhibitors; UPR

Indexed keywords

4MU8C; 7 METHYL 5 [1 [[3 (TRIFLUOROMETHYL)PHENYL] 2,3 DIHYDRO 1H INDOL 5 YL] 7H PYROROLO[2,3 D]PYRIMIDIN 4 AMINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN INHIBITOR; PROTEIN IRE 1 ALPHA; PROTEIN KINASE INHIBITOR; PROTEIN KINASE R; PROTEIN KINASE R LIKE ENDOPLASMIC RETICULUM KINASE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENETIC MODEL; HYPOXIA; HYPOXIC CELL; IMMUNOBLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

HYPOXIA; IRE1Α; PERK; SMALL-MOLECULE INHIBITORS; UPR;

ADAPTATION, PHYSIOLOGICAL; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; EIF-2 KINASE; ENDORIBONUCLEASES; HUMANS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

EID: 84887019826     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2013.06.005     Document Type: Article

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