Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible Grp78 promoter resulting in eradication of sizable human tumors

Human Gene Therapy

Volumn 15, Issue 6, 2004, Pages 553-561

  Dong, Dezheng ^a   Dubeau, Louis ^a   Bading, James ^a   Nguyen, Khoi ^c   Luna, Marian ^a   Yu, Hong ^a   Gazit Bornstein, Gadi ^a   Gordon, Erlinda M ^a   Gomer, Charles ^a   Hall, Frederick L ^b   Gambhir, Sanjiv S ^d   Lee, Amy S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Epeius Biotechnologies Corporation   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; GLUCOSE REGULATED PROTEIN 78; PROTEIN P53; RETROVIRUS VECTOR; ANTIVIRUS AGENT; CHAPERONE; GANCICLOVIR; GLUCOSE; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROMOTER REGION; RETROVIRUS; SUICIDE GENE; TUMOR VOLUME; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CBA MOUSE; CELL CULTURE; DRUG EFFECT; EXPERIMENTAL NEOPLASM; FEMALE; GENE THERAPY; GENETICS; HERPES SIMPLEX VIRUS; METABOLISM; MURINE LEUKEMIA VIRUS; NUDE MOUSE; OSTEOSARCOMA; PATHOLOGY; PHOTOCHEMOTHERAPY; STRESS; SUICIDE TRANSGENE;

MURINAE; MURINE LEUKEMIA VIRUS; MUS MUSCULUS;

ANIMALS; ANTIVIRAL AGENTS; FEMALE; GANCICLOVIR; GENE EXPRESSION; GENE THERAPY; GENES, TRANSGENIC, SUICIDE; GLUCOSE; HEAT-SHOCK PROTEINS; HUMANS; LEUKEMIA VIRUS, MURINE; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, NUDE; MOLECULAR CHAPERONES; OSTEOSARCOMA; PHOTOCHEMOTHERAPY; POSITRON-EMISSION TOMOGRAPHY; PROMOTER REGIONS (GENETICS); RECEPTORS, ESTROGEN; SIMPLEXVIRUS; STRESS; THYMIDINE KINASE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 4544325038     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303404323142006     Document Type: Article

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