메뉴 건너뛰기




Volumn 5, Issue JUL, 2014, Pages

Toll-like receptors and cancer: MYD88 mutation and inflammation

Author keywords

Cancer; Drug targets; Inflammation; Lymphoma; MYD88 L265P; Pattern recognition receptors; Self nucleic acid; Toll like receptors

Indexed keywords


EID: 84905695208     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00367     Document Type: Review
Times cited : (137)

References (125)
  • 1
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology.
    • doi: 10.1101/SQB.1989.054.01.003
    • Janeway Jr C.A. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol (1989) 54(Pt 1):1-13. doi: 10.1101/SQB.1989.054.01.003
    • (1989) Cold Spring Harb Symp Quant Biol , vol.54 , Issue.PART 1 , pp. 1-13
    • Janeway Jr, C.A.1
  • 2
    • 0036212849 scopus 로고    scopus 로고
    • Innate immune recognition
    • doi:10.1146/annurev.immunol.20.083001.084359
    • Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol (2002) 20:197-216. doi:10.1146/annurev.immunol.20.083001.084359
    • (2002) Annu Rev Immunol , vol.20 , pp. 197-216
    • Janeway Jr, C.A.1    Medzhitov, R.2
  • 3
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • doi:10.1016/j.cell.2010.01.022
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell (2010) 140:805-20. doi:10.1016/j.cell.2010.01.022
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 4
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • doi:10.1038/41131
    • Medzhitov R, Preston-Hurlburt P, Janeway Jr C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature (1997) 388:394-7. doi:10.1038/41131
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr, C.A.3
  • 5
    • 0025774776 scopus 로고
    • Drosophila toll and IL-1 receptor
    • doi:10.1038/351355b0
    • Gay NJ, Keith FJ. Drosophila toll and IL-1 receptor. Nature (1991) 351:355-6. doi:10.1038/351355b0
    • (1991) Nature , vol.351 , pp. 355-356
    • Gay, N.J.1    Keith, F.J.2
  • 6
    • 0027931646 scopus 로고
    • The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor
    • doi:10.1016/0092-8674(94)90283-6
    • Whitham S, Dinesh-Kumar SP, Choi D, Hehl R, Corr C, Baker B. The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor. Cell (1994) 78:1101-15. doi:10.1016/0092-8674(94)90283-6
    • (1994) Cell , vol.78 , pp. 1101-1115
    • Whitham, S.1    Dinesh-Kumar, S.P.2    Choi, D.3    Hehl, R.4    Corr, C.5    Baker, B.6
  • 7
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • doi:10.1038/nri1391
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol (2004) 4:499-511. doi:10.1038/nri1391
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 8
    • 77249160271 scopus 로고    scopus 로고
    • Localisation and trafficking of Toll-like receptors: an important mode of regulation
    • doi:10.1016/j.coi.2009.12.002
    • McGettrick AF, O'Neill LA. Localisation and trafficking of Toll-like receptors: an important mode of regulation. Curr Opin Immunol (2010) 22:20-7. doi:10.1016/j.coi.2009.12.002
    • (2010) Curr Opin Immunol , vol.22 , pp. 20-27
    • McGettrick, A.F.1    O'Neill, L.A.2
  • 9
    • 0024299087 scopus 로고
    • The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
    • doi:10.1016/0092-8674(88)90516-8
    • Hashimoto C, Hudson KL, Anderson KV. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell (1988) 52:269-79. doi:10.1016/0092-8674(88)90516-8
    • (1988) Cell , vol.52 , pp. 269-279
    • Hashimoto, C.1    Hudson, K.L.2    Anderson, K.V.3
  • 10
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • doi:10.1016/S0092-8674(00)80172-5
    • Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell (1996) 86:973-83. doi:10.1016/S0092-8674(00)80172-5
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 11
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
    • doi:10.1126/science.282.5396.2085
    • Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 282:2085-8. doi:10.1126/science.282.5396.2085
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3    Liu, M.Y.4    Van Huffel, C.5    Du, X.6
  • 12
    • 0012929728 scopus 로고    scopus 로고
    • Toll-like receptors
    • doi:10.1146/annurev.immunol.21.120601.141126
    • Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol (2003) 21:335-76. doi:10.1146/annurev.immunol.21.120601.141126
    • (2003) Annu Rev Immunol , vol.21 , pp. 335-376
    • Takeda, K.1    Kaisho, T.2    Akira, S.3
  • 13
    • 0037290876 scopus 로고    scopus 로고
    • Mammalian Toll-like receptors
    • doi:10.1016/S0952-7915(03)00005-0
    • Akira S. Mammalian Toll-like receptors. Curr Opin Immunol (2003) 15:5-11. doi:10.1016/S0952-7915(03)00005-0
    • (2003) Curr Opin Immunol , vol.15 , pp. 5-11
    • Akira, S.1
  • 14
    • 43349087755 scopus 로고    scopus 로고
    • Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling
    • doi:10.1189/jlb.0807586
    • Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J, et al. Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. J Leukoc Biol (2008) 83:692-701. doi:10.1189/jlb.0807586
    • (2008) J Leukoc Biol , vol.83 , pp. 692-701
    • Farhat, K.1    Riekenberg, S.2    Heine, H.3    Debarry, J.4    Lang, R.5    Mages, J.6
  • 15
    • 0037189544 scopus 로고    scopus 로고
    • Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness
    • doi:10.1074/jbc.M202554200
    • Re F, Strominger JL. Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness. J Biol Chem (2002) 277:23427-32. doi:10.1074/jbc.M202554200
    • (2002) J Biol Chem , vol.277 , pp. 23427-23432
    • Re, F.1    Strominger, J.L.2
  • 16
    • 0036301797 scopus 로고    scopus 로고
    • Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    • doi:10.1038/ni809
    • Nagai Y, Akashi S, Nagafuku M, Ogata M, Iwakura Y, Akira S, et al. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol (2002) 3:667-72. doi:10.1038/ni809
    • (2002) Nat Immunol , vol.3 , pp. 667-672
    • Nagai, Y.1    Akashi, S.2    Nagafuku, M.3    Ogata, M.4    Iwakura, Y.5    Akira, S.6
  • 17
    • 77949940198 scopus 로고    scopus 로고
    • Intracellular toll-like receptors
    • doi:10.1016/j.immuni.2010.03.012
    • Blasius AL, Beutler B. Intracellular toll-like receptors. Immunity (2010) 32:305-15. doi:10.1016/j.immuni.2010.03.012
    • (2010) Immunity , vol.32 , pp. 305-315
    • Blasius, A.L.1    Beutler, B.2
  • 18
    • 3142683548 scopus 로고    scopus 로고
    • TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
    • doi:10.1016/j.immuni.2004.06.007
    • Krug A, French AR, Barchet W, Fischer JA, Dzionek A, Pingel JT, et al. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity (2004) 21:107-19. doi:10.1016/j.immuni.2004.06.007
    • (2004) Immunity , vol.21 , pp. 107-119
    • Krug, A.1    French, A.R.2    Barchet, W.3    Fischer, J.A.4    Dzionek, A.5    Pingel, J.T.6
  • 19
    • 0842328805 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
    • doi:10.1182/blood-2003-08-2674
    • Krug A, Luker GD, Barchet W, Leib DA, Akira S, Colonna M. Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood (2004) 103:1433-7. doi:10.1182/blood-2003-08-2674
    • (2004) Blood , vol.103 , pp. 1433-1437
    • Krug, A.1    Luker, G.D.2    Barchet, W.3    Leib, D.A.4    Akira, S.5    Colonna, M.6
  • 20
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • doi:10.1126/science.1093616
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 303:1529-31. doi:10.1126/science.1093616
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis e Sousa, C.5
  • 21
    • 12144286763 scopus 로고    scopus 로고
    • Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
    • doi:10.1073/pnas.0400525101
    • Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, Crozat K, et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A (2004) 101:3516-21. doi:10.1073/pnas.0400525101
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 3516-3521
    • Tabeta, K.1    Georgel, P.2    Janssen, E.3    Du, X.4    Hoebe, K.5    Crozat, K.6
  • 22
    • 31344466165 scopus 로고    scopus 로고
    • The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
    • doi:10.1038/ni1297
    • Tabeta K, Hoebe K, Janssen EM, Du X, Georgel P, Crozat K, et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol (2006) 7:156-64. doi:10.1038/ni1297
    • (2006) Nat Immunol , vol.7 , pp. 156-164
    • Tabeta, K.1    Hoebe, K.2    Janssen, E.M.3    Du, X.4    Georgel, P.5    Crozat, K.6
  • 23
    • 46449093431 scopus 로고    scopus 로고
    • Molecular mechanisms of phagocytic uptake in mammalian cells
    • doi:10.1007/s00018-008-7578-4
    • Groves E, Dart AE, Covarelli V, Caron E. Molecular mechanisms of phagocytic uptake in mammalian cells. Cell Mol Life Sci (2008) 65:1957-76. doi:10.1007/s00018-008-7578-4
    • (2008) Cell Mol Life Sci , vol.65 , pp. 1957-1976
    • Groves, E.1    Dart, A.E.2    Covarelli, V.3    Caron, E.4
  • 24
    • 0037422066 scopus 로고    scopus 로고
    • Regulated portals of entry into the cell
    • doi:10.1038/nature01451
    • Conner SD, Schmid SL. Regulated portals of entry into the cell. Nature (2003) 422:37-44. doi:10.1038/nature01451
    • (2003) Nature , vol.422 , pp. 37-44
    • Conner, S.D.1    Schmid, S.L.2
  • 25
    • 0742324860 scopus 로고    scopus 로고
    • TLR signaling pathways
    • doi:10.1016/j.smim.2003.10.003
    • Takeda K, Akira S. TLR signaling pathways. Semin Immunol (2004) 16:3-9. doi:10.1016/j.smim.2003.10.003
    • (2004) Semin Immunol , vol.16 , pp. 3-9
    • Takeda, K.1    Akira, S.2
  • 26
    • 66649127621 scopus 로고    scopus 로고
    • Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma
    • doi:10.1038/nature07968
    • Compagno M, Lim WK, Grunn A, Nandula SV, Brahmachary M, Shen Q, et al. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature (2009) 459:717-21. doi:10.1038/nature07968
    • (2009) Nature , vol.459 , pp. 717-721
    • Compagno, M.1    Lim, W.K.2    Grunn, A.3    Nandula, S.V.4    Brahmachary, M.5    Shen, Q.6
  • 27
    • 34250842580 scopus 로고    scopus 로고
    • Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88
    • doi:10.1016/j.febslet.2007.06.008
    • Nishiya T, Kajita E, Horinouchi T, Nishimoto A, Miwa S. Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88. FEBS Lett (2007) 581:3223-9. doi:10.1016/j.febslet.2007.06.008
    • (2007) FEBS Lett , vol.581 , pp. 3223-3229
    • Nishiya, T.1    Kajita, E.2    Horinouchi, T.3    Nishimoto, A.4    Miwa, S.5
  • 28
    • 0031423761 scopus 로고    scopus 로고
    • MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
    • doi:10.1016/S1074-7613(00)80402-1
    • Wesche H, Henzel WJ, Shillinglaw W, Li S, Cao Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity (1997) 7:837-47. doi:10.1016/S1074-7613(00)80402-1
    • (1997) Immunity , vol.7 , pp. 837-847
    • Wesche, H.1    Henzel, W.J.2    Shillinglaw, W.3    Li, S.4    Cao, Z.5
  • 29
    • 84886915828 scopus 로고    scopus 로고
    • Mutational analysis identifies residues crucial for homodimerization of myeloid differentiation factor 88 (MyD88) and for its function in immune cells
    • doi:10.1074/jbc.M113.490946
    • Loiarro M, Volpe E, Ruggiero V, Gallo G, Furlan R, Maiorino C, et al. Mutational analysis identifies residues crucial for homodimerization of myeloid differentiation factor 88 (MyD88) and for its function in immune cells. J Biol Chem (2013) 288:30210-22. doi:10.1074/jbc.M113.490946
    • (2013) J Biol Chem , vol.288 , pp. 30210-30222
    • Loiarro, M.1    Volpe, E.2    Ruggiero, V.3    Gallo, G.4    Furlan, R.5    Maiorino, C.6
  • 30
    • 77953714711 scopus 로고    scopus 로고
    • Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
    • doi:10.1038/nature09121
    • Lin SC, Lo YC, Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature (2010) 465:885-90. doi:10.1038/nature09121
    • (2010) Nature , vol.465 , pp. 885-890
    • Lin, S.C.1    Lo, Y.C.2    Wu, H.3
  • 31
    • 18444390259 scopus 로고    scopus 로고
    • Distinct molecular mechanism for initiating TRAF6 signalling
    • doi:10.1038/nature00888
    • Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, et al. Distinct molecular mechanism for initiating TRAF6 signalling. Nature (2002) 418:443-7. doi:10.1038/nature00888
    • (2002) Nature , vol.418 , pp. 443-447
    • Ye, H.1    Arron, J.R.2    Lamothe, B.3    Cirilli, M.4    Kobayashi, T.5    Shevde, N.K.6
  • 32
    • 69949093459 scopus 로고    scopus 로고
    • Direct activation of protein kinases by unanchored polyubiquitin chains
    • doi:10.1038/nature08247
    • Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, et al. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature (2009) 461:114-9. doi:10.1038/nature08247
    • (2009) Nature , vol.461 , pp. 114-119
    • Xia, Z.P.1    Sun, L.2    Chen, X.3    Pineda, G.4    Jiang, X.5    Adhikari, A.6
  • 33
    • 0032217264 scopus 로고    scopus 로고
    • Structure of an IkappaBalpha/NF-kappaB complex
    • doi:10.1016/S0092-8674(00)81698-0
    • Jacobs MD, Harrison SC. Structure of an IkappaBalpha/NF-kappaB complex. Cell (1998) 95:749-58. doi:10.1016/S0092-8674(00)81698-0
    • (1998) Cell , vol.95 , pp. 749-758
    • Jacobs, M.D.1    Harrison, S.C.2
  • 34
    • 24644433852 scopus 로고    scopus 로고
    • Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1)
    • doi:10.1073/pnas.0505997102
    • Li Q, Lu Q, Bottero V, Estepa G, Morrison L, Mercurio F, et al. Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1). Proc Natl Acad Sci U S A (2005) 102:12425-30. doi:10.1073/pnas.0505997102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 12425-12430
    • Li, Q.1    Lu, Q.2    Bottero, V.3    Estepa, G.4    Morrison, L.5    Mercurio, F.6
  • 35
    • 61849127839 scopus 로고    scopus 로고
    • The IkappaB kinase complex: master regulator of NF-kappaB signaling
    • doi:10.1007/s12026-008-8025-1
    • Solt LA, May MJ. The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol Res (2008) 42:3-18. doi:10.1007/s12026-008-8025-1
    • (2008) Immunol Res , vol.42 , pp. 3-18
    • Solt, L.A.1    May, M.J.2
  • 36
    • 69949185813 scopus 로고    scopus 로고
    • AP-1 activated by toll-like receptors regulates expression of IL-23 p19
    • doi:10.1074/jbc.M109.025528
    • Liu W, Ouyang X, Yang J, Liu J, Li Q, Gu Y, et al. AP-1 activated by toll-like receptors regulates expression of IL-23 p19. J Biol Chem (2009) 284:24006-16. doi:10.1074/jbc.M109.025528
    • (2009) J Biol Chem , vol.284 , pp. 24006-24016
    • Liu, W.1    Ouyang, X.2    Yang, J.3    Liu, J.4    Li, Q.5    Gu, Y.6
  • 37
    • 69949183194 scopus 로고    scopus 로고
    • MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses
    • doi:10.1074/jbc.M109.023044
    • Verstak B, Nagpal K, Bottomley SP, Golenbock DT, Hertzog PJ, Mansell A. MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses. J Biol Chem (2009) 284:24192-203. doi:10.1074/jbc.M109.023044
    • (2009) J Biol Chem , vol.284 , pp. 24192-241203
    • Verstak, B.1    Nagpal, K.2    Bottomley, S.P.3    Golenbock, D.T.4    Hertzog, P.J.5    Mansell, A.6
  • 38
    • 0037153191 scopus 로고    scopus 로고
    • Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
    • doi:10.1038/nature01182
    • Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature (2002) 420:324-9. doi:10.1038/nature01182
    • (2002) Nature , vol.420 , pp. 324-329
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3    Sanjo, H.4    Uematsu, S.5    Kaisho, T.6
  • 39
    • 67649865588 scopus 로고    scopus 로고
    • Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling
    • doi:10.1073/pnas.0812956106
    • Ohnishi H, Tochio H, Kato Z, Orii KE, Li A, Kimura T, et al. Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. Proc Natl Acad Sci U S A (2009) 106:10260-5. doi:10.1073/pnas.0812956106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 10260-10265
    • Ohnishi, H.1    Tochio, H.2    Kato, Z.3    Orii, K.E.4    Li, A.5    Kimura, T.6
  • 40
    • 80052284504 scopus 로고    scopus 로고
    • IRF7: activation, regulation, modification and function
    • doi:10.1038/gene.2011.21
    • Ning S, Pagano JS, Barber GN. IRF7: activation, regulation, modification and function. Genes Immun (2011) 12:399-414. doi:10.1038/gene.2011.21
    • (2011) Genes Immun , vol.12 , pp. 399-414
    • Ning, S.1    Pagano, J.S.2    Barber, G.N.3
  • 41
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • doi:10.1038/ni.1863
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 11:373-84. doi:10.1038/ni.1863
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 42
    • 5444274514 scopus 로고    scopus 로고
    • Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
    • doi:10.1038/ni1118
    • Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, et al. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5:1061-8. doi:10.1038/ni1118
    • (2004) Nat Immunol , vol.5 , pp. 1061-1068
    • Kawai, T.1    Sato, S.2    Ishii, K.J.3    Coban, C.4    Hemmi, H.5    Yamamoto, M.6
  • 43
    • 18644376284 scopus 로고    scopus 로고
    • IRF3 mediates a TLR3/TLR4-specific antiviral gene program
    • doi:10.1016/S1074-7613(02)00390-4
    • Doyle S, Vaidya S, O'Connell R, Dadgostar H, Dempsey P, Wu T, et al. IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity (2002) 17:251-63. doi:10.1016/S1074-7613(02)00390-4
    • (2002) Immunity , vol.17 , pp. 251-263
    • Doyle, S.1    Vaidya, S.2    O'Connell, R.3    Dadgostar, H.4    Dempsey, P.5    Wu, T.6
  • 44
    • 40949134086 scopus 로고    scopus 로고
    • TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
    • doi:10.1038/ni1569
    • Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 9:361-8. doi:10.1038/ni1569
    • (2008) Nat Immunol , vol.9 , pp. 361-368
    • Kagan, J.C.1    Su, T.2    Horng, T.3    Chow, A.4    Akira, S.5    Medzhitov, R.6
  • 45
    • 30544451546 scopus 로고    scopus 로고
    • Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
    • doi:10.1038/nature04369
    • Häcker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, et al. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature (2006) 439:204-7. doi:10.1038/nature04369
    • (2006) Nature , vol.439 , pp. 204-207
    • Häcker, H.1    Redecke, V.2    Blagoev, B.3    Kratchmarova, I.4    Hsu, L.C.5    Wang, G.G.6
  • 46
    • 30544447047 scopus 로고    scopus 로고
    • Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
    • doi:10.1038/nature04374
    • Oganesyan G, Saha SK, Guo B, He JQ, Shahangian A, Zarnegar B, et al. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature (2006) 439:208-11. doi:10.1038/nature04374
    • (2006) Nature , vol.439 , pp. 208-211
    • Oganesyan, G.1    Saha, S.K.2    Guo, B.3    He, J.Q.4    Shahangian, A.5    Zarnegar, B.6
  • 47
    • 0242624622 scopus 로고    scopus 로고
    • TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
    • doi:10.1038/ni986
    • Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol (2003) 4:1144-50. doi:10.1038/ni986
    • (2003) Nat Immunol , vol.4 , pp. 1144-1150
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3    Uematsu, S.4    Hoshino, K.5    Kaisho, T.6
  • 48
    • 0033680737 scopus 로고    scopus 로고
    • Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction
    • doi:10.1016/S1074-7613(00)00053-4
    • Sato M, Suemori H, Hata N, Asagiri M, Ogasawara K, Nakao K, et al. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity (2000) 13:539-48. doi:10.1016/S1074-7613(00)00053-4
    • (2000) Immunity , vol.13 , pp. 539-548
    • Sato, M.1    Suemori, H.2    Hata, N.3    Asagiri, M.4    Ogasawara, K.5    Nakao, K.6
  • 49
    • 74049136127 scopus 로고    scopus 로고
    • Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
    • doi:10.1038/ni.1819
    • Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DA, Karin M. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol (2010) 11:70-5. doi:10.1038/ni.1819
    • (2010) Nat Immunol , vol.11 , pp. 70-75
    • Tseng, P.H.1    Matsuzawa, A.2    Zhang, W.3    Mino, T.4    Vignali, D.A.5    Karin, M.6
  • 50
    • 79551686422 scopus 로고    scopus 로고
    • Oncogenically active MYD88 mutations in human lymphoma
    • doi:10.1038/nature09671
    • Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, et al. Oncogenically active MYD88 mutations in human lymphoma. Nature (2011) 470:115-9. doi:10.1038/nature09671
    • (2011) Nature , vol.470 , pp. 115-119
    • Ngo, V.N.1    Young, R.M.2    Schmitz, R.3    Jhavar, S.4    Xiao, W.5    Lim, K.H.6
  • 51
    • 43549097394 scopus 로고    scopus 로고
    • Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma
    • doi:10.1182/blood-2007-09-111948
    • Lam LT, Wright G, Davis RE, Lenz G, Farinha P, Dang L, et al. Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma. Blood (2008) 111:3701-13. doi:10.1182/blood-2007-09-111948
    • (2008) Blood , vol.111 , pp. 3701-3713
    • Lam, L.T.1    Wright, G.2    Davis, R.E.3    Lenz, G.4    Farinha, P.5    Dang, L.6
  • 52
    • 38949165127 scopus 로고    scopus 로고
    • Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas
    • doi:10.1182/blood-2007-04-087734
    • Ding BB, Yu JJ, Yu RY, Mendez LM, Shaknovich R, Zhang Y, et al. Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. Blood (2008) 111:1515-23. doi:10.1182/blood-2007-04-087734
    • (2008) Blood , vol.111 , pp. 1515-1523
    • Ding, B.B.1    Yu, J.J.2    Yu, R.Y.3    Mendez, L.M.4    Shaknovich, R.5    Zhang, Y.6
  • 53
    • 84961407275 scopus 로고    scopus 로고
    • Emerging targets in human lymphoma: targeting the MYD88 mutation
    • doi:10.2147/BLCTT.S35292
    • Wang JQ, Jeelall YS, Horikawa K. Emerging targets in human lymphoma: targeting the MYD88 mutation. Blood Lymphat Cancer (2013) 2013:53-61. doi:10.2147/BLCTT.S35292
    • (2013) Blood Lymphat Cancer , vol.2013 , pp. 53-61
    • Wang, J.Q.1    Jeelall, Y.S.2    Horikawa, K.3
  • 54
    • 84896814479 scopus 로고    scopus 로고
    • Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance
    • doi:10.1084/jem.20131424
    • Wang JQ, Jeelall YS, Beutler B, Horikawa K, Goodnow CC. Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. J Exp Med (2014) 211:413-26. doi:10.1084/jem.20131424
    • (2014) J Exp Med , vol.211 , pp. 413-426
    • Wang, J.Q.1    Jeelall, Y.S.2    Beutler, B.3    Horikawa, K.4    Goodnow, C.C.5
  • 55
    • 84905681094 scopus 로고    scopus 로고
    • Oncogenic MYD88 mutants require Toll-like receptors [abstract].
    • Apr 6-10; Washington, DC. Philadelphia: AACR; Cancer Res (2013) :Abst . doi:10.1158/1538-7445.AM2013-2332
    • Lim K-H, Barton GM, Staudt LM. Oncogenic MYD88 mutants require Toll-like receptors [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia: AACR; Cancer Res (2013) 73(8 Suppl):Abst 2332. doi:10.1158/1538-7445.AM2013-2332
    • (2013) Proceedings of the 104th Annual Meeting of the American Association for Cancer Research , vol.73 , Issue.8 SUPPL. , pp. 2332
    • Lim, K.-H.1    Barton, G.M.2    Staudt, L.M.3
  • 56
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • doi:10.1016/j.cell.2011.02.013
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell (2011) 144:646-74. doi:10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 57
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • doi:10.1016/j.cell.2010.01.025
    • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell (2010) 140:883-99. doi:10.1016/j.cell.2010.01.025
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 58
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • doi:10.1038/nature07201
    • Medzhitov R. Origin and physiological roles of inflammation. Nature (2008) 454:428-35. doi:10.1038/nature07201
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 59
    • 84965199448 scopus 로고
    • An address on the value of pathological experiments
    • doi:10.1136/bmj.2.1075.198
    • Virchow R. An address on the value of pathological experiments. Br Med J (1881) 2:198-203. doi:10.1136/bmj.2.1075.198
    • (1881) Br Med J , vol.2 , pp. 198-203
    • Virchow, R.1
  • 60
    • 0033831517 scopus 로고    scopus 로고
    • Infections as a major preventable cause of human cancer
    • doi:10.1046/j.1365-2796.2000.00742.x
    • Kuper H, Adami HO, Trichopoulos D. Infections as a major preventable cause of human cancer. J Intern Med (2000) 248:171-83. doi:10.1046/j.1365-2796.2000.00742.x
    • (2000) J Intern Med , vol.248 , pp. 171-183
    • Kuper, H.1    Adami, H.O.2    Trichopoulos, D.3
  • 61
    • 84892805731 scopus 로고    scopus 로고
    • Cancer statistics, 2014
    • doi:10.3322/caac.21208
    • Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin (2014) 64:9-29. doi:10.3322/caac.21208
    • (2014) CA Cancer J Clin , vol.64 , pp. 9-29
    • Siegel, R.1    Ma, J.2    Zou, Z.3    Jemal, A.4
  • 62
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • doi:10.1038/nature04870
    • Karin M. Nuclear factor-kappaB in cancer development and progression. Nature (2006) 441:431-6. doi:10.1038/nature04870
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 63
    • 69949120571 scopus 로고    scopus 로고
    • A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
    • doi:10.1038/nm.2015
    • Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med (2009) 15:1016-22. doi:10.1038/nm.2015
    • (2009) Nat Med , vol.15 , pp. 1016-1022
    • Wu, S.1    Rhee, K.J.2    Albesiano, E.3    Rabizadeh, S.4    Wu, X.5    Yen, H.R.6
  • 64
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • doi:10.1038/nature01322
    • Coussens LM, Werb Z. Inflammation and cancer. Nature (2002) 420:860-7. doi:10.1038/nature01322
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 65
    • 67649660551 scopus 로고    scopus 로고
    • Redefining chronic viral infection
    • doi:10.1016/j.cell.2009.06.036
    • Virgin HW, Wherry EJ, Ahmed R. Redefining chronic viral infection. Cell (2009) 138:30-50. doi:10.1016/j.cell.2009.06.036
    • (2009) Cell , vol.138 , pp. 30-50
    • Virgin, H.W.1    Wherry, E.J.2    Ahmed, R.3
  • 66
    • 30144443269 scopus 로고    scopus 로고
    • Paradoxical roles of the immune system during cancer development
    • doi:10.1038/nrc1782
    • de Visser KE, Eichten A, Coussens LM. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer (2006) 6:24-37. doi:10.1038/nrc1782
    • (2006) Nat Rev Cancer , vol.6 , pp. 24-37
    • De Visser, K.E.1    Eichten, A.2    Coussens, L.M.3
  • 67
    • 33847650413 scopus 로고    scopus 로고
    • Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes?
    • doi:10.1016/j.coi.2007.02.001
    • Bui JD, Schreiber RD. Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes? Curr Opin Immunol (2007) 19:203-8. doi:10.1016/j.coi.2007.02.001
    • (2007) Curr Opin Immunol , vol.19 , pp. 203-208
    • Bui, J.D.1    Schreiber, R.D.2
  • 68
    • 38649087921 scopus 로고    scopus 로고
    • Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
    • doi:10.1073/pnas.0708594105
    • Swann JB, Vesely MD, Silva A, Sharkey J, Akira S, Schreiber RD, et al. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A (2008) 105:652-6. doi:10.1073/pnas.0708594105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 652-656
    • Swann, J.B.1    Vesely, M.D.2    Silva, A.3    Sharkey, J.4    Akira, S.5    Schreiber, R.D.6
  • 69
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between innate immunity, inflammation, and cancer
    • doi:10.1172/JCI31537
    • Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest (2007) 117:1175-83. doi:10.1172/JCI31537
    • (2007) J Clin Invest , vol.117 , pp. 1175-1183
    • Lin, W.W.1    Karin, M.2
  • 70
    • 33646755569 scopus 로고    scopus 로고
    • Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity
    • doi:10.1016/S0065-2776(06)90001-7
    • Smyth MJ, Dunn GP, Schreiber RD. Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity. Adv Immunol (2006) 90:1-50. doi:10.1016/S0065-2776(06)90001-7
    • (2006) Adv Immunol , vol.90 , pp. 1-50
    • Smyth, M.J.1    Dunn, G.P.2    Schreiber, R.D.3
  • 71
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • doi:10.1016/j.immuni.2011.05.006
    • Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 34:637-50. doi:10.1016/j.immuni.2011.05.006
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 72
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
    • doi:10.1038/nri1995
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol (2007) 7:41-51. doi:10.1038/nri1995
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 73
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
    • doi:10.1093/carcin/bgp127
    • Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis (2009) 30:1073-81. doi:10.1093/carcin/bgp127
    • (2009) Carcinogenesis , vol.30 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3    Garlanda, C.4    Mantovani, A.5
  • 74
    • 34249782578 scopus 로고    scopus 로고
    • Role of AID in tumorigenesis
    • doi:10.1016/S0065-2776(06)94008-5
    • Okazaki IM, Kotani A, Honjo T. Role of AID in tumorigenesis. Adv Immunol (2007) 94:245-73. doi:10.1016/S0065-2776(06)94008-5
    • (2007) Adv Immunol , vol.94 , pp. 245-273
    • Okazaki, I.M.1    Kotani, A.2    Honjo, T.3
  • 75
    • 39149099085 scopus 로고    scopus 로고
    • Two levels of protection for the B cell genome during somatic hypermutation
    • doi:10.1038/nature06547
    • Liu M, Duke JL, Richter DJ, Vinuesa CG, Goodnow CC, Kleinstein SH, et al. Two levels of protection for the B cell genome during somatic hypermutation. Nature (2008) 451:841-5. doi:10.1038/nature06547
    • (2008) Nature , vol.451 , pp. 841-845
    • Liu, M.1    Duke, J.L.2    Richter, D.J.3    Vinuesa, C.G.4    Goodnow, C.C.5    Kleinstein, S.H.6
  • 76
    • 33644643189 scopus 로고    scopus 로고
    • Role of genomic instability and p53 in AID-induced c-myc-Igh translocations
    • doi:10.1038/nature04495
    • Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, et al. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 440:105-9. doi:10.1038/nature04495
    • (2006) Nature , vol.440 , pp. 105-109
    • Ramiro, A.R.1    Jankovic, M.2    Callen, E.3    Difilippantonio, S.4    Chen, H.T.5    McBride, K.M.6
  • 77
    • 0020621665 scopus 로고
    • Malignant lymphoma of mucosa-associated lymphoid tissue
    • doi:10.1002/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3
    • Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer (1983) 52:1410-6. doi:10.1002/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3
    • (1983) A distinctive type of B-cell lymphoma. Cancer , vol.52 , pp. 1410-1416
    • Isaacson, P.1    Wright, D.H.2
  • 78
    • 61849140711 scopus 로고    scopus 로고
    • Infectious agents and lymphoma development: molecular and clinical aspects
    • doi:10.1111/j.1365-2796.2009.02083.x
    • Ferreri AJ, Ernberg I, Copie-Bergman C. Infectious agents and lymphoma development: molecular and clinical aspects. J Intern Med (2009) 265:421-38. doi:10.1111/j.1365-2796.2009.02083.x
    • (2009) J Intern Med , vol.265 , pp. 421-438
    • Ferreri, A.J.1    Ernberg, I.2    Copie-Bergman, C.3
  • 79
    • 33846644490 scopus 로고    scopus 로고
    • Transcriptional profiling suggests that secondary and primary large B-cell lymphomas of the gastrointestinal (GI) tract are blastic variants of GI marginal zone lymphoma
    • doi:10.1002/path.2096
    • Barth TF, Barth CA, Kestler HA, Michl P, Weniger MA, Buchholz M, et al. Transcriptional profiling suggests that secondary and primary large B-cell lymphomas of the gastrointestinal (GI) tract are blastic variants of GI marginal zone lymphoma. J Pathol (2007) 211:305-13. doi:10.1002/path.2096
    • (2007) J Pathol , vol.211 , pp. 305-313
    • Barth, T.F.1    Barth, C.A.2    Kestler, H.A.3    Michl, P.4    Weniger, M.A.5    Buchholz, M.6
  • 80
    • 0034977290 scopus 로고    scopus 로고
    • Type I Helicobacter pylori lipopolysaccharide stimulates toll-like receptor 4 and activates mitogen oxidase 1 in gastric pit cells
    • doi:10.1128/IAI.69.7.4382-4389.2001
    • Kawahara T, Teshima S, Oka A, Sugiyama T, Kishi K, Rokutan K. Type I Helicobacter pylori lipopolysaccharide stimulates toll-like receptor 4 and activates mitogen oxidase 1 in gastric pit cells. Infect Immun (2001) 69:4382-9. doi:10.1128/IAI.69.7.4382-4389.2001
    • (2001) Infect Immun , vol.69 , pp. 4382-4389
    • Kawahara, T.1    Teshima, S.2    Oka, A.3    Sugiyama, T.4    Kishi, K.5    Rokutan, K.6
  • 81
    • 3242733824 scopus 로고    scopus 로고
    • Leaky catecholamine stores: undue waste or a stress response coping mechanism?
    • doi:10.1196/annals.1296.027
    • Eisenhofer G, Kopin IJ, Goldstein DS. Leaky catecholamine stores: undue waste or a stress response coping mechanism? Ann N Y Acad Sci (2004) 1018:224-30. doi:10.1196/annals.1296.027
    • (2004) Ann N Y Acad Sci , vol.1018 , pp. 224-230
    • Eisenhofer, G.1    Kopin, I.J.2    Goldstein, D.S.3
  • 82
    • 20144373185 scopus 로고    scopus 로고
    • Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori
    • doi:10.1016/j.ijmm.2005.02.009
    • Schmausser B, Andrulis M, Endrich S, Muller-Hermelink HK, Eck M. Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori. Int J Med Microbiol (2005) 295:179-85. doi:10.1016/j.ijmm.2005.02.009
    • (2005) Int J Med Microbiol , vol.295 , pp. 179-185
    • Schmausser, B.1    Andrulis, M.2    Endrich, S.3    Muller-Hermelink, H.K.4    Eck, M.5
  • 83
    • 37849033136 scopus 로고    scopus 로고
    • Role of Toll-like receptors in gastrointestinal malignancies
    • doi:10.1038/sj.onc.1210908
    • Fukata M, Abreu MT. Role of Toll-like receptors in gastrointestinal malignancies. Oncogene (2008) 27:234-43. doi:10.1038/sj.onc.1210908
    • (2008) Oncogene , vol.27 , pp. 234-243
    • Fukata, M.1    Abreu, M.T.2
  • 84
    • 27244433609 scopus 로고    scopus 로고
    • Molecular pathogenesis of mucosa-associated lymphoid tissue lymphoma
    • doi:10.1200/JCO.2005.05.011
    • Farinha P, Gascoyne RD. Molecular pathogenesis of mucosa-associated lymphoid tissue lymphoma. J Clin Oncol (2005) 23:6370-8. doi:10.1200/JCO.2005.05.011
    • (2005) J Clin Oncol , vol.23 , pp. 6370-6378
    • Farinha, P.1    Gascoyne, R.D.2
  • 85
    • 0033756964 scopus 로고    scopus 로고
    • Role of activated host T cells in the promotion of MALT lymphoma growth
    • doi:10.1006/scbi.2000.0351
    • Guindi M. Role of activated host T cells in the promotion of MALT lymphoma growth. Semin Cancer Biol (2000) 10:341-4. doi:10.1006/scbi.2000.0351
    • (2000) Semin Cancer Biol , vol.10 , pp. 341-344
    • Guindi, M.1
  • 86
    • 77953556367 scopus 로고    scopus 로고
    • Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development
    • doi:10.1038/nrgastro.2010.58
    • Sagaert X, Van Cutsem E, De Hertogh G, Geboes K, Tousseyn T. Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development. Nat Rev Gastroenterol Hepatol (2010) 7:336-46. doi:10.1038/nrgastro.2010.58
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 336-346
    • Sagaert, X.1    Van Cutsem, E.2    De Hertogh, G.3    Geboes, K.4    Tousseyn, T.5
  • 87
    • 77449108587 scopus 로고    scopus 로고
    • Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins
    • doi:10.1182/blood-2009-06-228015
    • Craig VJ, Arnold I, Gerke C, Huynh MQ, Wündisch T, Neubauer A, et al. Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins. Blood (2010) 115:581-91. doi:10.1182/blood-2009-06-228015
    • (2010) Blood , vol.115 , pp. 581-591
    • Craig, V.J.1    Arnold, I.2    Gerke, C.3    Huynh, M.Q.4    Wündisch, T.5    Neubauer, A.6
  • 88
    • 33846454674 scopus 로고    scopus 로고
    • Primary gastric lymphoma pathogenesis and treatment: what has changed over the past 10 years?
    • doi:10.1111/j.1365-2141.2006.06444.x
    • Ferrucci PF, Zucca E. Primary gastric lymphoma pathogenesis and treatment: what has changed over the past 10 years? Br J Haematol (2007) 136:521-38. doi:10.1111/j.1365-2141.2006.06444.x
    • (2007) Br J Haematol , vol.136 , pp. 521-538
    • Ferrucci, P.F.1    Zucca, E.2
  • 89
    • 68449095767 scopus 로고    scopus 로고
    • Eradication therapy for Helicobacter pylori in patients with gastric MALT lymphoma: a pooled data analysis
    • doi:10.1038/ajg.2009.314
    • Zullo A, Hassan C, Andriani A, Cristofari F, De FrancescoV, Ierardi E, et al. Eradication therapy for Helicobacter pylori in patients with gastric MALT lymphoma: a pooled data analysis. Am J Gastroenterol (2009) 104:1932-1937;quiz1938. doi:10.1038/ajg.2009.314
    • (2009) Am J Gastroenterol , vol.104
    • Zullo, A.1    Hassan, C.2    Andriani, A.3    Cristofari, F.4    De, FrancescoV.5    Ierardi, E.6
  • 90
    • 13844307760 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia
    • doi:10.1056/NEJMra041720
    • Chiorazzi N, Rai KR, Ferrarini M. Chronic lymphocytic leukemia. N Engl J Med (2005) 352:804-15. doi:10.1056/NEJMra041720
    • (2005) N Engl J Med , vol.352 , pp. 804-815
    • Chiorazzi, N.1    Rai, K.R.2    Ferrarini, M.3
  • 91
    • 73349098730 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression
    • doi:10.1182/blood-2009-06-230169
    • Enzler T, Kater AP, Zhang W, Widhopf GF2nd, Chuang HY, Lee J, et al. Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. Blood (2009) 114:4469-76. doi:10.1182/blood-2009-06-230169
    • (2009) Blood , vol.114 , pp. 4469-4476
    • Enzler, T.1    Kater, A.P.2    Zhang, W.3    Widhopf II, G.F.4    Chuang, H.Y.5    Lee, J.6
  • 92
    • 0035353212 scopus 로고    scopus 로고
    • Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia
    • doi:10.1182/blood.V97.9.2777
    • Granziero L, Ghia P, Circosta P, Gottardi D, Strola G, Geuna M, et al. Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood (2001) 97:2777-83. doi:10.1182/blood.V97.9.2777
    • (2001) Blood , vol.97 , pp. 2777-2783
    • Granziero, L.1    Ghia, P.2    Circosta, P.3    Gottardi, D.4    Strola, G.5    Geuna, M.6
  • 93
    • 0036720390 scopus 로고    scopus 로고
    • Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.
    • Pedersen IM, Kitada S, Leoni LM, Zapata JM, Karras JG, Tsukada N, et al. Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1. Blood (2002) 100:1795-801.
    • (2002) Blood , vol.100 , pp. 1795-1801
    • Pedersen, I.M.1    Kitada, S.2    Leoni, L.M.3    Zapata, J.M.4    Karras, J.G.5    Tsukada, N.6
  • 94
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.
    • Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J (1998) 334(Pt 2):297-314.
    • (1998) Biochem J , vol.334 , Issue.PART 2 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Muller-Newen, G.3    Schaper, F.4    Graeve, L.5
  • 95
    • 0027199126 scopus 로고
    • IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase
    • doi:10.1126/science.8511589
    • Murakami M, Hibi M, Nakagawa N, Nakagawa T, Yasukawa K, Yamanishi K, et al. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science (1993) 260:1808-10. doi:10.1126/science.8511589
    • (1993) Science , vol.260 , pp. 1808-1810
    • Murakami, M.1    Hibi, M.2    Nakagawa, N.3    Nakagawa, T.4    Yasukawa, K.5    Yamanishi, K.6
  • 96
    • 39649113108 scopus 로고    scopus 로고
    • Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival
    • doi:10.1002/ijc.23261
    • Wegiel B, Bjartell A, Culig Z, Persson JL. Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival. Int J Cancer (2008) 122:1521-9. doi:10.1002/ijc.23261
    • (2008) Int J Cancer , vol.122 , pp. 1521-1529
    • Wegiel, B.1    Bjartell, A.2    Culig, Z.3    Persson, J.L.4
  • 97
    • 77951018948 scopus 로고    scopus 로고
    • STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells
    • doi:10.1182/blood-2009-10-230060
    • Hazan-Halevy I, Harris D, Liu Z, Liu J, Li P, Chen X, et al. STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells. Blood (2010) 115:2852-63. doi:10.1182/blood-2009-10-230060
    • (2010) Blood , vol.115 , pp. 2852-2863
    • Hazan-Halevy, I.1    Harris, D.2    Liu, Z.3    Liu, J.4    Li, P.5    Chen, X.6
  • 98
    • 0031436969 scopus 로고    scopus 로고
    • B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues
    • doi:10.1172/JCI119869
    • Frank DA, Mahajan S, Ritz J. B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. J Clin Invest (1997) 100:3140-8. doi:10.1172/JCI119869
    • (1997) J Clin Invest , vol.100 , pp. 3140-3148
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 99
    • 64749113465 scopus 로고    scopus 로고
    • Treatment of relapsed/refractory multiple myeloma
    • doi:10.1053/j.seminhematol.2009.01.004
    • Kastritis E, Palumbo A, Dimopoulos MA. Treatment of relapsed/refractory multiple myeloma. Semin Hematol (2009) 46:143-57. doi:10.1053/j.seminhematol.2009.01.004
    • (2009) Semin Hematol , vol.46 , pp. 143-157
    • Kastritis, E.1    Palumbo, A.2    Dimopoulos, M.A.3
  • 100
    • 27544476971 scopus 로고    scopus 로고
    • The role of IL-6 and STAT3 in inflammation and cancer
    • doi:10.1016/j.ejca.2005.08.016
    • Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer (2005) 41:2502-12. doi:10.1016/j.ejca.2005.08.016
    • (2005) Eur J Cancer , vol.41 , pp. 2502-2512
    • Hodge, D.R.1    Hurt, E.M.2    Farrar, W.L.3
  • 101
    • 0035072851 scopus 로고    scopus 로고
    • Mouse plasmacytoma: an experimental model of human multiple myeloma.
    • Gadó K, Silva S, Pálóczi K, Domján G, Falus A. Mouse plasmacytoma: an experimental model of human multiple myeloma. Haematologica (2001) 86:227-36.
    • (2001) Haematologica , vol.86 , pp. 227-236
    • Gadó, K.1    Silva, S.2    Pálóczi, K.3    Domján, G.4    Falus, A.5
  • 102
    • 84879849025 scopus 로고    scopus 로고
    • A phase I, open-label study of siltuximab, an anti-IL-6 monoclonal antibody, in patients with B-cell non-Hodgkin lymphoma, multiple myeloma, or Castleman disease
    • doi:10.1158/1078-0432.CCR-12-3349
    • Kurzrock R, Voorhees PM, Casper C, Furman RR, Fayad L, Lonial S, et al. A phase I, open-label study of siltuximab, an anti-IL-6 monoclonal antibody, in patients with B-cell non-Hodgkin lymphoma, multiple myeloma, or Castleman disease. Clin Cancer Res (2013) 19:3659-70. doi:10.1158/1078-0432.CCR-12-3349
    • (2013) Clin Cancer Res , vol.19 , pp. 3659-3670
    • Kurzrock, R.1    Voorhees, P.M.2    Casper, C.3    Furman, R.R.4    Fayad, L.5    Lonial, S.6
  • 103
    • 84876196796 scopus 로고    scopus 로고
    • A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma
    • doi:10.1111/bjh.12266
    • Voorhees PM, Manges RF, Sonneveld P, Jagannath S, Somlo G, Krishnan A, et al. A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma. Br J Haematol (2013) 161:357-66. doi:10.1111/bjh.12266
    • (2013) Br J Haematol , vol.161 , pp. 357-366
    • Voorhees, P.M.1    Manges, R.F.2    Sonneveld, P.3    Jagannath, S.4    Somlo, G.5    Krishnan, A.6
  • 104
    • 0036720519 scopus 로고    scopus 로고
    • Prognostic value of plasma interleukin-6 levels in patients with chronic lymphocytic leukemia
    • doi:10.1002/cncr.10772
    • Lai R, O'Brien S, Maushouri T, Rogers A, Kantarjian H, Keating M, et al. Prognostic value of plasma interleukin-6 levels in patients with chronic lymphocytic leukemia. Cancer (2002) 95:1071-5. doi:10.1002/cncr.10772
    • (2002) Cancer , vol.95 , pp. 1071-1075
    • Lai, R.1    O'Brien, S.2    Maushouri, T.3    Rogers, A.4    Kantarjian, H.5    Keating, M.6
  • 105
    • 0032524335 scopus 로고    scopus 로고
    • MyD88, an adapter protein involved in interleukin-1 signaling
    • doi:10.1074/jbc.273.20.12203
    • Burns K, Martinon F, Esslinger C, Pahl H, Schneider P, Bodmer JL, et al. MyD88, an adapter protein involved in interleukin-1 signaling. J Biol Chem (1998) 273:12203-9. doi:10.1074/jbc.273.20.12203
    • (1998) J Biol Chem , vol.273 , pp. 12203-12209
    • Burns, K.1    Martinon, F.2    Esslinger, C.3    Pahl, H.4    Schneider, P.5    Bodmer, J.L.6
  • 106
    • 18144362027 scopus 로고    scopus 로고
    • Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B
    • doi:10.1074/jbc.C400613200
    • Loiarro M, Sette C, Gallo G, Ciacci A, Fantò N, Mastroianni D, et al. Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B. J Biol Chem (2005) 280:15809-14. doi:10.1074/jbc.C400613200
    • (2005) J Biol Chem , vol.280 , pp. 15809-15814
    • Loiarro, M.1    Sette, C.2    Gallo, G.3    Ciacci, A.4    Fantò, N.5    Mastroianni, D.6
  • 107
    • 34548415806 scopus 로고    scopus 로고
    • Pivotal advance: inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound
    • doi:10.1189/jlb.1206746
    • Loiarro M, Capolunghi F, Fantò N, Gallo G, Campo S, Arseni B, et al. Pivotal advance: inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound. J Leukoc Biol (2007) 82:801-10. doi:10.1189/jlb.1206746
    • (2007) J Leukoc Biol , vol.82 , pp. 801-810
    • Loiarro, M.1    Capolunghi, F.2    Fantò, N.3    Gallo, G.4    Campo, S.5    Arseni, B.6
  • 108
    • 0037596457 scopus 로고    scopus 로고
    • A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses
    • doi:10.1073/pnas.0932746100
    • Bartfai T, Behrens MM, Gaidarova S, Pemberton J, Shivanyuk A, Rebek JJr. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc Natl Acad Sci U S A (2003) 100:7971-6. doi:10.1073/pnas.0932746100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7971-7976
    • Bartfai, T.1    Behrens, M.M.2    Gaidarova, S.3    Pemberton, J.4    Shivanyuk, A.5    Rebek Jr., J.6
  • 109
    • 43949131788 scopus 로고    scopus 로고
    • Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells
    • doi:10.1002/ijc.23477
    • Mackenzie GG, Queisser N, Wolfson ML, Fraga CG, Adamo AM, Oteiza PI. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. Int J Cancer (2008) 123:56-65. doi:10.1002/ijc.23477
    • (2008) Int J Cancer , vol.123 , pp. 56-65
    • Mackenzie, G.G.1    Queisser, N.2    Wolfson, M.L.3    Fraga, C.G.4    Adamo, A.M.5    Oteiza, P.I.6
  • 110
    • 70349322986 scopus 로고    scopus 로고
    • STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK/T-cell lymphoma
    • doi:10.1038/leu.2009.91
    • Coppo P, Gouilleux-Gruart V, Huang Y, Bouhlal H, Bouamar H, Bouchet S, et al. STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK/T-cell lymphoma. Leukemia (2009) 23:1667-78. doi:10.1038/leu.2009.91
    • (2009) Leukemia , vol.23 , pp. 1667-1678
    • Coppo, P.1    Gouilleux-Gruart, V.2    Huang, Y.3    Bouhlal, H.4    Bouamar, H.5    Bouchet, S.6
  • 111
    • 34548225362 scopus 로고    scopus 로고
    • NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    • doi:10.1016/j.cell.2007.07.009
    • Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, et al. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell (2007) 130:918-31. doi:10.1016/j.cell.2007.07.009
    • (2007) Cell , vol.130 , pp. 918-931
    • Greten, F.R.1    Arkan, M.C.2    Bollrath, J.3    Hsu, L.C.4    Goode, J.5    Miething, C.6
  • 112
    • 78650859531 scopus 로고    scopus 로고
    • NF-kappaB and STAT3 - key players in liver inflammation and cancer
    • doi:10.1038/cr.2010.183
    • He G, Karin M. NF-kappaB and STAT3 - key players in liver inflammation and cancer. Cell Res (2011) 21:159-68. doi:10.1038/cr.2010.183
    • (2011) Cell Res , vol.21 , pp. 159-168
    • He, G.1    Karin, M.2
  • 113
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • doi:10.1038/nm1325
    • Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med (2005) 11:1314-21. doi:10.1038/nm1325
    • (2005) Nat Med , vol.11 , pp. 1314-1321
    • Kortylewski, M.1    Kujawski, M.2    Wang, T.3    Wei, S.4    Zhang, S.5    Pilon-Thomas, S.6
  • 114
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • doi:10.1038/nrc2734
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer (2009) 9:798-809. doi:10.1038/nrc2734
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 115
    • 70949094349 scopus 로고    scopus 로고
    • The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors
    • doi:10.1016/j.ccr.2009.10.015
    • Hedvat M, Huszar D, Herrmann A, Gozgit JM, Schroeder A, Sheehy A, et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell (2009) 16:487-97. doi:10.1016/j.ccr.2009.10.015
    • (2009) Cancer Cell , vol.16 , pp. 487-497
    • Hedvat, M.1    Huszar, D.2    Herrmann, A.3    Gozgit, J.M.4    Schroeder, A.5    Sheehy, A.6
  • 116
    • 60549108333 scopus 로고    scopus 로고
    • The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling
    • doi:10.1038/onc.2008.448
    • Lin L, Amin R, Gallicano GI, Glasgow E, Jogunoori W, Jessup JM, et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene (2009) 28:961-72. doi:10.1038/onc.2008.448
    • (2009) Oncogene , vol.28 , pp. 961-972
    • Lin, L.1    Amin, R.2    Gallicano, G.I.3    Glasgow, E.4    Jogunoori, W.5    Jessup, J.M.6
  • 117
    • 0036895749 scopus 로고    scopus 로고
    • TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells
    • doi:10.1053/jhep.2002.36942
    • Kim YS, Schwabe RF, Qian T, Lemasters JJ, Brenner DA. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology (2002) 36:1498-508. doi:10.1053/jhep.2002.36942
    • (2002) Hepatology , vol.36 , pp. 1498-1508
    • Kim, Y.S.1    Schwabe, R.F.2    Qian, T.3    Lemasters, J.J.4    Brenner, D.A.5
  • 118
    • 33750586523 scopus 로고    scopus 로고
    • Constitutively activated nuclear factor-kappaB, but not induced NF-kappaB, leads to TRAIL resistance by up-regulation of X-linked inhibitor of apoptosis protein in human cancer cells
    • doi:10.1158/1541-7786.MCR-05-0231
    • Braeuer SJ, Buneker C, Mohr A, Zwacka RM. Constitutively activated nuclear factor-kappaB, but not induced NF-kappaB, leads to TRAIL resistance by up-regulation of X-linked inhibitor of apoptosis protein in human cancer cells. Mol Cancer Res (2006) 4:715-28. doi:10.1158/1541-7786.MCR-05-0231
    • (2006) Mol Cancer Res , vol.4 , pp. 715-728
    • Braeuer, S.J.1    Buneker, C.2    Mohr, A.3    Zwacka, R.M.4
  • 119
    • 84862152044 scopus 로고    scopus 로고
    • Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma
    • doi:10.1016/j.ccr.2012.05.024
    • Yang Y, Shaffer AL3rd, Emre NC, Ceribelli M, Zhang M, Wright G, et al. Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma. Cancer Cell (2012) 21:723-37. doi:10.1016/j.ccr.2012.05.024
    • (2012) Cancer Cell , vol.21 , pp. 723-737
    • Yang, Y.1    Shaffer III, A.L.2    Emre, N.C.3    Ceribelli, M.4    Zhang, M.5    Wright, G.6
  • 120
    • 17144404177 scopus 로고    scopus 로고
    • IRF-7 is the master regulator of type-I interferon-dependent immune responses
    • doi:10.1038/nature03464
    • Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature (2005) 434:772-7. doi:10.1038/nature03464
    • (2005) Nature , vol.434 , pp. 772-777
    • Honda, K.1    Yanai, H.2    Negishi, H.3    Asagiri, M.4    Sato, M.5    Mizutani, T.6
  • 121
    • 77954662424 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells
    • doi:10.1182/blood-2009-03-213363
    • Liang X, Moseman EA, Farrar MA, Bachanova V, Weisdorf DJ, Blazar BR, et al. Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells. Blood (2010) 115:5041-52. doi:10.1182/blood-2009-03-213363
    • (2010) Blood , vol.115 , pp. 5041-5052
    • Liang, X.1    Moseman, E.A.2    Farrar, M.A.3    Bachanova, V.4    Weisdorf, D.J.5    Blazar, B.R.6
  • 124
    • 77953469710 scopus 로고    scopus 로고
    • Toll-like receptor agonists in cancer therapy
    • doi:10.2217/imt.09.70
    • Adams S. Toll-like receptor agonists in cancer therapy. Immunotherapy (2009) 1:949-64. doi:10.2217/imt.09.70
    • (2009) Immunotherapy , vol.1 , pp. 949-964
    • Adams, S.1
  • 125
    • 84902598355 scopus 로고    scopus 로고
    • Mutations in the Toll-like receptor/MYD88 pathway in chronic lymphocytic leukemia identify a subset of young patients with favorable outcome
    • doi:10.1182/blood-2013-12-543306
    • Martínez-Trillos A, Pinyol M, Navarro A, Aymerich M, Jares P, Juan M, et al. Mutations in the Toll-like receptor/MYD88 pathway in chronic lymphocytic leukemia identify a subset of young patients with favorable outcome. Blood (2014) 123:3790-6. doi:10.1182/blood-2013-12-543306
    • (2014) Blood , vol.123 , pp. 3790-3796
    • Martínez-Trillos, A.1    Pinyol, M.2    Navarro, A.3    Aymerich, M.4    Jares, P.5    Juan, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.