Mutational analysis identifies residues crucial for homodimerization of myeloid differentiation factor 88 (MyD88) and for its function in immune cells

Journal of Biological Chemistry

Volumn 288, Issue 42, 2013, Pages 30210-30222

  Loiarro, Maria ^a,b   Volpe, Elisabetta ^b   Ruggiero, Vito ^c   Gallo, Grazia ^c   Furlan, Roberto ^d   Maiorino, Chiara ^d   Battistini, Luca ^b   Sette, Claudio ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c Sigma Tau SpA   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEINS; AUTOIMMUNE DISEASE; HOMODIMERIZATION; IMMUNE RESPONSE; MUTATIONAL ANALYSIS; MYELOID DIFFERENTIATION FACTOR 88; SELF-ASSOCIATIONS; THERAPEUTIC STRATEGY;

ASSOCIATION REACTIONS; PROTEINS;

DIMERIZATION;

AMINO ACID; ARGININE; GLUTAMINE; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; MYELOID DIFFERENTIATION FACTOR 88; SERINE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DIMERIZATION; EMBRYO; HOMODIMERIZATION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; MONOCYTE; MUTATION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TIR DOMAIN;

CELLULAR IMMUNE RESPONSE; MUTAGENESIS; MYD88; SIGNAL TRANSDUCTION; TOLL IL-1 RECEPTOR (TIR) DOMAIN; TOLL-LIKE RECEPTOR (TLR);

AMINO ACID SUBSTITUTION; CELL LINE, TUMOR; DENDRITIC CELLS; HEK293 CELLS; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MONOCYTES; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84886915828     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.490946     Document Type: Article

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