Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-κB

Journal of Biological Chemistry

Volumn 280, Issue 16, 2005, Pages 15809-15814

  Loiarro, Maria ^a   Sette, Claudio ^a   Gallo, Grazia ^b   Ciacci, Andrea ^b   Fantó, Nicola ^b   Mastroianni, Domenico ^c   Carminati, Paolo ^b   Ruggiero, Vito ^b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b Sigma Tau SpA   (Italy)

^c Tecnogen SCpA ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; DIMERIZATION; IMMUNOLOGY; PRECIPITATION (CHEMICAL); PROTEINS; PURIFICATION; SIGNAL PROCESSING;

CO-IMMUNOPRECIPITATION; INTERLEUKIN (IL)-1; MYELOID DIFFERENTIATION FACTOR 88 (MYD88); SIGNALING PATHWAY;

AMINES;

GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 18 RECEPTOR; MYELOID DIFFERENTIATION FACTOR 88; RECEPTOR; TOLL INTERLEUKIN 1 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL FREE SYSTEM; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; STATISTICAL SIGNIFICANCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANTENNAPEDIA HOMEODOMAIN PROTEIN; ANTIGENS, DIFFERENTIATION; DIMERIZATION; HOMEODOMAIN PROTEINS; INTERLEUKIN-1; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; NUCLEAR PROTEINS; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN-1; SEQUENCE ALIGNMENT; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTORS;

EID: 18144362027     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C400613200     Document Type: Article

References (29)

1. Akira, S., and Takeda, K. (2004) Nat. Rev. Immunol. 4, 499-511
2. O'Neill, L. A. J. (2003) Biochem. Soc. Trans. 31, 643-647
3. Hardiman, G., Rock, F. L., Balasubramanian, S., Kastelein, R. A., and Bazan, J. F. (1996) Oncogene 13, 2467-2475
4. Akira, S. (2003) J. Biol. Chem. 278, 38105-38108
5. Burns, K., Martinon, F., Esslinger, C., Pahl, H., Schneider, P., Bodmer, J. L., Di Marco, F., French, L., and Tschopp, J. (1998) J. Biol. Chem. 273, 12203-12209
6. Janssens, S., and Beyaert, R. (2003) Mol. Cell. 11, 293-302
7. Janssens, S., and Beyaert, R. (2002) Trends Biochem. Sci. 27, 474-482
8. Baud, V., Liu, Z. G., Bennett, B., Suzuki, N., Xia, Y., and Karin, M. (1999) Genes Dev. 13, 1297-1308
9. Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., and Akira, S. (1998) Immunity 9, 143-150
10. Kawai, T., Adachi, O., Ogawa, T., Takeda, K., and Akira, S. (1999) Immunity 11, 115-122
11. Takeuchi, O., and Akira, S. (2002) Curr. Top. Microbiol. Immunol. 270, 155-167
12. O'Neill, L. A. J. (2004) Science 303, 1481-1482
13. Björkbacka, H., Kunjathoor, V. V., Moore, K. J., Koehn, S., Ordija, C. M., Lee, M. A., Means, T., Halmen, K., Luster, A. D., Golenbock, D. T., and Freeman, M. W. (2004) Nat. Med. 10, 416-421
14. Joosten, L. A., Koenders, M. I., Smeets, R. L., Heuvelmans-Jacobs, M., Helsen, M. M., Takeda, K., Akira, S., Lubberts, E., van de Loo, F. A., and van den Berg, W. B. (2003) J. Immunol. 171, 6145-6153
15. Choe, J. Y., Crain, B., Wu, S. R., and Corr, M. (2003) J. Exp. Med. 197, 537-542
16. Bodanszky, M. (1993) Principles of Peptide Synthesis, 2nd Ed., Springer-Verlag, Berlin
17. Guex, N., and Peitsch, M. C. (1997) Electrophoresis 18, 2714-2723
18. Schrödinger LLC (2003) MacroModel 8.5, Schrödinger LLC, Portland, OR
19. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
20. Katchalski-Katzir, E., Shariv, I., Eisenstein, M., Friesem, A. A., Aflalo, C., and Vakser, I. A. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 2195-2199
21. Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S., and Cao, Z. (1997) Immunity 7, 837-847
22. Dunne, A., Ejdeback, M., Ludidi, P. L., and O'Neill, L. A. (2003) J. Biol. Chem. 278, 41443-41451
23. Radons, J., Gabler, S., Wesche, H., Korherr, C., Hofmeister, R., and Falk, W. (2002) J. Biol. Chem. 277, 16456-16463
24. Poltorak, A., He, X. L., Smirnova, I., Liu, M. Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B., and Beutler, B. (1998) Science 282, 2085-2088
25. Xu, Y., Tao, X., Shen, B., Horng, T., Medzhitov, R., Manley, J. L., and Tong, L. (2000) Nature 408, 111-115
26. Kueltzo, L. A., and Middaugh, C. R. (2003) J. Pharm. Sci. 92, 1754-1772
27. Jiang, Z., Zamanian-Daryoush, M., Nie, H., Silva, A. M., Williams, B. R., and Li, X. (2003) J. Biol. Chem. 278, 16713-16719
28. Bartfai, T., Behrens, M. M., Gaidarova, S., Pemberton, J., Shivanyuk, A., and Rebek, J. Jr. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 7971-7976
29. Ulevitch, R. J. (2004) Nat. Rev. Immunol. 4, 512-520