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Volumn 115, Issue 14, 2010, Pages 2852-2863

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; HEMOGLOBIN; INTERLEUKIN 6; KARYOPHERIN BETA; SERINE; SHORT HAIRPIN RNA; STAT3 PROTEIN;

EID: 77951018948     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-10-230060     Document Type: Article
Times cited : (168)

References (50)
  • 1
    • 33746833990 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: Diagnosis and treatment
    • Yee KW, O'Brien SM. Chronic lymphocytic leukemia: diagnosis and treatment. Mayo Clin Proc. 2006;81(8):1105-1129. (Pubitemid 44175023)
    • (2006) Mayo Clinic Proceedings , vol.81 , Issue.8 , pp. 1105-1129
    • Yee, K.W.L.1    O'Brien, S.M.2
  • 4
    • 5444240858 scopus 로고    scopus 로고
    • Aberrant morphology, proliferation, and apoptosis of B-cell chronic lymphocytic leukemia cells
    • DOI 10.1080/10245330410001727046
    • Bueso-Ramos CE, Ferrajoli A, Medeiros LJ, Keating MJ, Estrov Z. Aberrant morphology, proliferation, and apoptosis of B-cell chronic lymphocytic leukemia cells. Hematology. 2004;9(4):279-286. (Pubitemid 39359348)
    • (2004) Hematology , vol.9 , Issue.4 , pp. 279-286
    • Bueso-Ramos, C.E.1    Ferrajoli, A.2    Medeiros, L.J.3    Keating, M.J.4    Estrov, Z.5
  • 5
    • 33645960451 scopus 로고    scopus 로고
    • Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance
    • Calin GA, Croce CM. Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance. Semin Oncol. 2006;33(2):167-173.
    • (2006) Semin Oncol , vol.33 , Issue.2 , pp. 167-173
    • Calin, G.A.1    Croce, C.M.2
  • 6
    • 34547854381 scopus 로고    scopus 로고
    • The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia
    • DOI 10.1016/j.beha.2007.02.003, PII S1521692607000199
    • Calin GA, Pekarsky Y, Croce CM. The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia. Best Pract Res Clin Haematol. 2007;20(3):425-437. (Pubitemid 47260321)
    • (2007) Best Practice and Research in Clinical Haematology , vol.20 , Issue.3 , pp. 425-437
    • Calin, G.A.1    Pekarsky, Y.2    Croce, C.M.3
  • 8
    • 0030882317 scopus 로고    scopus 로고
    • STAT3 is a serine kinase target in T lymphocytes. Interleukin 2 and T cell antigen receptor signals converge upon serine 727
    • DOI 10.1074/jbc.272.39.24542
    • Ng J, Cantrell D. STAT3 is a serine kinase target in T lymphocytes: interleukin 2 and T cell antigen receptor signals converge upon serine 727. J Biol Chem. 1997;272(39):24542-24549. (Pubitemid 27418667)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.39 , pp. 24542-24549
    • Ng, J.1    Cantrell, D.2
  • 9
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcriptional control and their impact on cellular function
    • Bromberg J, Darnell JE Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene. 2000;19(21):2468-2473. (Pubitemid 30339202)
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2468-2473
    • Bromberg, J.1    Darnell Jr., J.E.2
  • 10
    • 34547108380 scopus 로고    scopus 로고
    • JAK-STAT signaling: From interferons to cytokines
    • Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. J Biol Chem. 2007;282(28):20059-20063.
    • (2007) J Biol Chem , vol.282 , Issue.28 , pp. 20059-20063
    • Schindler, C.1    Levy, D.E.2    Decker, T.3
  • 14
    • 20944441928 scopus 로고    scopus 로고
    • Validating Stat3 in cancer therapy
    • Darnell JE. Validating Stat3 in cancer therapy. Nat Med. 2005;11(6):595-596.
    • (2005) Nat Med , vol.11 , Issue.6 , pp. 595-596
    • Darnell, J.E.1
  • 15
    • 33645067376 scopus 로고    scopus 로고
    • Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3
    • Leslie K, Lang C, Devgan G, et al. Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res. 2006;66(5):2544-2552.
    • (2006) Cancer Res , vol.66 , Issue.5 , pp. 2544-2552
    • Leslie, K.1    Lang, C.2    Devgan, G.3
  • 18
    • 0031306869 scopus 로고    scopus 로고
    • Constitutive Activation of the Janus Kinase-STAT Pathway in T Lymphoma Overexpressing the Lck Protein Tyrosine Kinase
    • Yu CL, Jove R, Burakoff SJ. Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase. J Immunol. 1997;159(11):5206-5210. (Pubitemid 127470045)
    • (1997) Journal of Immunology , vol.159 , Issue.11 , pp. 5206-5210
    • Yu, C.-L.1    Jove, R.2    Burakoff, S.J.3
  • 19
    • 0029784886 scopus 로고    scopus 로고
    • Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
    • Weber-Nordt RM, Egen C, Wehinger J, et al. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood. 1996;88(3):809-816. (Pubitemid 26333300)
    • (1996) Blood , vol.88 , Issue.3 , pp. 809-816
    • Weber-Nordt, R.M.1    Egen, C.2    Wehinger, J.3    Ludwig, W.4    Gouilleux-Gruart, V.5    Mertelsmann, R.6    Finke, J.7
  • 20
    • 0034658024 scopus 로고    scopus 로고
    • Serine phosphorylation of STATs
    • Decker T, Kovarik P. Serine phosphorylation of STATs. Oncogene. 2000;19(21):2628-2637.
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2628-2637
    • Decker, T.1    Kovarik, P.2
  • 21
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong Z, Darnell JE Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell. 1995;82(2):241-250.
    • (1995) Cell , vol.82 , Issue.2 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell Jr., J.E.3
  • 22
    • 0030744123 scopus 로고    scopus 로고
    • Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3
    • DOI 10.1093/nar/25.11.2062
    • Wen Z, Darnell JE Jr. Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res. 1997;25(11):2062-2067. (Pubitemid 27303439)
    • (1997) Nucleic Acids Research , vol.25 , Issue.11 , pp. 2062-2067
    • Wen, Z.1    Darnell Jr., J.E.2
  • 23
    • 0006603039 scopus 로고    scopus 로고
    • Serine Phosphorylation and Negative Regulation of Stat3 by JNK
    • Lim CP, Cao X. Serine phosphorylation and negative regulation of Stat3 by JNK. J Biol Chem. 1999;274(43):31055-31061. (Pubitemid 129576860)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.43 , pp. 31055-31061
    • Lim, C.P.1    Cao, X.2
  • 24
    • 0030772458 scopus 로고    scopus 로고
    • STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
    • Chung J, Uchida E, Grammer TC, Blenis J. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol. 1997;17(11):6508-6516. (Pubitemid 27451197)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.11 , pp. 6508-6516
    • Chung, J.1    Uchida, E.2    Grammer, T.C.3    Blenis, J.4
  • 25
    • 0031436969 scopus 로고    scopus 로고
    • B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues
    • Frank DA, Mahajan S, Ritz J. B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. J Clin Invest. 1997;100(12):3140-3148. (Pubitemid 28022852)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.12 , pp. 3140-3148
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 27
    • 33646909758 scopus 로고    scopus 로고
    • The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase
    • DOI 10.1074/jbc.M504977200
    • Wang S, Raven JF, Baltzis D, et al. The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell proteintyrosine phosphatase. J Biol Chem. 2006;281(14):9439-9449. (Pubitemid 43864661)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.14 , pp. 9439-9449
    • Wang, S.1    Raven, J.F.2    Baltzis, D.3    Kazemi, S.4    Brunet, D.V.5    Hatzoglou, M.6    Tremblay, M.L.7    Koromilas, A.E.8
  • 30
    • 33646410652 scopus 로고    scopus 로고
    • Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells
    • de Totero D, Meazza R, Zupo S, et al. Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells. Blood. 2006;107(9):3708-3715.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3708-3715
    • De Totero, D.1    Meazza, R.2    Zupo, S.3
  • 31
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z, Wen Z, Darnell JE Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 1994;264(5155):95-98. (Pubitemid 24144493)
    • (1994) Science , vol.264 , Issue.5155 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell Jr., J.E.3
  • 35
    • 0028942656 scopus 로고
    • Requirement of serine phosphorylation for formation of STAT-promoter complexes
    • Zhang X, Blenis J, Li HC, Schindler C, Chen-Kiang S. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science. 1995;267(5206):1990-1994.
    • (1995) Science , vol.267 , Issue.5206 , pp. 1990-1994
    • Zhang, X.1    Blenis, J.2    Li, H.C.3    Schindler, C.4    Chen-Kiang, S.5
  • 36
    • 0035852765 scopus 로고    scopus 로고
    • Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1
    • DOI 10.1073/pnas.041588198
    • Shen Y, Devgan G, Darnell JE Jr, Bromberg JF. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proc Natl Acad Sci U S A. 2001;98(4):1543-1548. (Pubitemid 32165535)
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , Issue.4 , pp. 1543-1548
    • Shen, Y.1    Devgan, G.2    Darnell Jr., J.E.3    Bromberg, J.F.4
  • 37
    • 17144383220 scopus 로고    scopus 로고
    • VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: Implication for apoptosis resistance
    • Lee YK, Shanafelt TD, Bone ND, Strege AK, Jelinek DF, Kay NE. VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance. Leukemia. 2005;19(4):513-523.
    • (2005) Leukemia , vol.19 , Issue.4 , pp. 513-523
    • Lee, Y.K.1    Shanafelt, T.D.2    Bone, N.D.3    Strege, A.K.4    Jelinek, D.F.5    Kay, N.E.6
  • 38
    • 0030875862 scopus 로고    scopus 로고
    • Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase
    • Zhu X, Wen Z, Xu LZ, Darnell JE Jr. Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase. Mol Cell Biol. 1997;17(11):6618-6623. (Pubitemid 27451208)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.11 , pp. 6618-6623
    • Zhu, X.1    Wen, Z.2    Xu, L.Z.3    Darnell Jr., J.E.4
  • 39
    • 0035917876 scopus 로고    scopus 로고
    • Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation
    • DOI 10.1016/S0014-5793(01)02354-7, PII S0014579301023547
    • Schuringa JJ, Schepers H, Vellenga E, Kruijer W. Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation. FEBS Lett. 2001;495(1):71-76. (Pubitemid 32367976)
    • (2001) FEBS Letters , vol.495 , Issue.1-2 , pp. 71-76
    • Schuringa, J.-J.1    Schepers, H.2    Vellenga, E.3    Kruijer, W.4
  • 40
    • 54249083133 scopus 로고    scopus 로고
    • Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation
    • Qin HR, Kim HJ, Kim JY, et al. Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation. Cancer Res. 2008;68(19):7736-7741.
    • (2008) Cancer Res , vol.68 , Issue.19 , pp. 7736-7741
    • Qin, H.R.1    Kim, H.J.2    Kim, J.Y.3
  • 41
    • 0032542211 scopus 로고    scopus 로고
    • Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)
    • Jain N, Zhang T, Fong SL, Lim CP, Cao X. Repression of Stat3 activity by activation of mitogenactivated protein kinase (MAPK). Oncogene. 1998;17(24):3157-3167. (Pubitemid 29020811)
    • (1998) Oncogene , vol.17 , Issue.24 , pp. 3157-3167
    • Jain, N.1    Zhang, T.2    Fong, S.L.3    Lim, C.P.4    Cao, X.5
  • 43
    • 0030946515 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, self-renewing B-1 cells but only inducibly expressed in conventional B lymphocytes
    • DOI 10.1084/jem.185.6.1035
    • Karras JG, Wang Z, Huo L, Howard RG, Frank DA, Rothstein TL. Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, self-renewing B-1 cells but only inducibly expressed in conventional B lymphocytes. J Exp Med. 1997;185(6):1035-1042. (Pubitemid 27136796)
    • (1997) Journal of Experimental Medicine , vol.185 , Issue.6 , pp. 1035-1042
    • Karras, J.G.1    Wang, Z.2    Huo, L.3    Howard, R.G.4    Frank, D.A.5    Rothstein, T.L.6
  • 44
    • 11244328888 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of STAT transcription factors
    • DOI 10.1111/j.1432-1033.2004.04423.x
    • Meyer T, Vinkemeier U. Nucleocytoplasmic shuttling of STAT transcription factors. Eur J Biochem. 2004;271(23):4606-4612. (Pubitemid 40065563)
    • (2004) European Journal of Biochemistry , vol.271 , Issue.23-24 , pp. 4606-4612
    • Meyer, T.1    Vinkemeier, U.2
  • 46
    • 0027239823 scopus 로고
    • Bcl-2 Gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
    • Hanada M, Delia D, Aiello A, Stadtmauer E, Reed JC. bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood. 1993;82(6):1820-1828. (Pubitemid 23278773)
    • (1993) Blood , vol.82 , Issue.6 , pp. 1820-1828
    • Hanada, M.1    Delia, D.2    Aiello, A.3    Stadtmauer, E.4    Reed, J.C.5
  • 48
    • 41849116690 scopus 로고    scopus 로고
    • Roles of unphosphorylated STATs in signaling
    • Yang J, Stark GR. Roles of unphosphorylated STATs in signaling. Cell Res. 2008;18(4):443-451.
    • (2008) Cell Res , vol.18 , Issue.4 , pp. 443-451
    • Yang, J.1    Stark, G.R.2
  • 49
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
    • DOI 10.1101/gad.1553707
    • Yang J, Liao X, Agarwal MK, Barnes L, Auron PE, Stark GR. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev. 2007;21(11):1396-1408. (Pubitemid 46871042)
    • (2007) Genes and Development , vol.21 , Issue.11 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 50
    • 0026684876 scopus 로고
    • B-chronic lymphocytic leukemia cells contain both endogenous kappa immunoglobulin mRNA and critical immunoglobulin gene activation transcription factors
    • Zaknoen SL, Christian SL, Suen R, Van Ness B, Kay NE. B-chronic lymphocytic leukemia cells contain both endogenous kappa immunoglobulin mRNA and critical immunoglobulin gene activation transcription factors. Leukemia. 1992;6(7):675-679.
    • (1992) Leukemia , vol.6 , Issue.7 , pp. 675-679
    • Zaknoen, S.L.1    Christian, S.L.2    Suen, R.3    Van Ness, B.4    Kay, N.E.5


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