Differential expression of the melanocortin-4 receptor in male and female C57BL/6J mice

Molecular Biology Reports

Volumn 41, Issue 5, 2014, Pages 3245-3256

  Qu, HaiE ^a   Li, JianPing ^b   Chen, Wei ^a   Li, YuMei ^a   Jiang, Qian ^a   Jiang, HuaiZhi ^b   Huo, JinLong ^c   Zhao, ZhiHui ^a   Liu, Bo ^a   Zhang, QiaoLing ^a  

^a JILIN UNIVERSITY   (China)

^b JILIN AGRICULTURAL UNIVERSITY   (China)

^c YUNNAN AGRICULTURAL UNIVERSITY   (China)

Author keywords

Brain; Kidney; Liver; Melanocortin 4 receptor; Sex; Weight regulation

Indexed keywords

MELANOCORTIN 4 RECEPTOR; MESSENGER RNA;

ANIMAL; C57BL MOUSE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; MOUSE; SEX DIFFERENCE; SEXUAL DEVELOPMENT;

ANIMALS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED C57BL; RECEPTOR, MELANOCORTIN, TYPE 4; RNA, MESSENGER; SEX CHARACTERISTICS; SEX FACTORS;

EID: 84905680368     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-014-3187-5     Document Type: Article

References (58)

1. Rediger A, Piechowski CL, Habegger K, Gruters A, Krude H, Tschop MH, Kleinau G, Biebermann H (2012) MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: Is there relevance for body weight regulation. Neuroendocrinology 95:277-288
2. Karlsson-Lindahl L, Schmidt L, Haage D, Hansson C, Taube M, Egeciouglu E, Tan YX, Admyre T, Jansson JO, Vlodavsky I, Li JP, Lindahl U, Dickson SL (2012) Heparanase affects food intake and regulates energy balance in mice. PLoS ONE 7(3):e34313
3. Wiedmer P, Chaudhary N, Rath M, Yi CX, Ananthakrishnan G, Nogueiras R, Wirth EK, Kirchner H, Schweizer U, Jonas W, Veyrat-Durebex C, Rohner-Jeanrenaud F, Schurmann A, Joost HG, Tschop MH, Perez-Tilve D (2011) The HPA axis modulates the CNs melanocortin control of livers triacylglyceride metabolism. Physiol Behav 105:791-799
4. Jing Hua, Zhangrong Xu, Chen X, Wang Y, Yi Y, Yang J, Xiao M, Jia L (2004) Relationship of lipids disorder with sex and hypertension in diabetic patients. Chin J Pract Intern Med 24(7):406-407
5. Markison S, Foster AC (2006) Nervous system disorders: targeting melanocortin receptors for the treatment of obesity. Drug Discov Today 4(3):569-5761
6. Nie R, Ba C (2008) Progress in research on melanocortin 4 receptor (MC4R) and its regulatory pathways. Acta Lab Anim Isscientia Sinica 16(4):317-320
7. Cannon WB (1962) Physiological regulation of normal states: Some tentative postulates concerning biological homeostasis. Editions Medicales, Jubilee volume to Charles Richet, pp 91-93
8. Trevaskis JL, Meyer EA, Galgani JE, Butler AA (2008) Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in C57BL/6J mice. Endocrinology 149(1):174-184
9. Chen AS, Metzger JM, Trumbauer ME, Guan XM, Yu H, Frazier EG, Marsh DJ, Forrest MJ, Gopal-Truter S, Fisher J, Camacho RE, Strack AM, Mellin TN, MacIntyre DE, Chen HY, Van der Ploeg LH (2000) Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res 9:145-154 (Pubitemid 30610232)
10. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Eedlstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Untioy K, Kishi T, Elmquist JK, Lowell BB (2005) Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123(3):493-505 (Pubitemid 41546678)
11. Marsh DJ, Hollopeter G, Huszar D, Laufer R, Yagaloff KA, Fisher SL, Burn P, Palmiter RD (1999) Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 21:119-122 (Pubitemid 29036297)
12. Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T (2003) Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 348:1085-1109
13. Decherf S, Seugnet I, Kouidhi S, Lopez-Juarez A, Clerget-Froidevaux MS (2010) Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression. Proc Natl Acad Sci USA 107(9):4471-4476
14. Lezoualc'h F, Hassan AH, Giraud P, Loeffler JP, Lee SL, Demeneix BA (1992) Assignment of the beta-thyroid hormone receptor to 3,5,3′ triiodothyronine-dependent inhibition of transcription from the thyrotropin-releasing hormone promoter in chick hypothalamic neurons. Mol Endocrinol 6:1797-1804
15. Lechan RM, Fekete C (2006) Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis. Peptides 27:310-325 (Pubitemid 43168170)
16. Malik IA, Triebel J, Posselt J, Khan S, Ramadori P, Raddatz D, Ramadori G (2012) Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase response. Histochem Cell Biol 137:279-291
17. Hainerova I, Larsen LH, Holst B, Finkova M, Hainer V, Lebl J, Hansen T, Pederson O (2007) Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis. J Clin Endocrinol Metab 92(9):3689-3696 (Pubitemid 47435357)
18. Trevaskis JL, Butler AA (2005) Double leptin (Lepob) and melanocortin-4 receptor (MC4R) gene mutations have an additive effect on fat mass, and are associated with reduced effects of leptin on weight loss and food intake. Endocrinology 146:4257-4265 (Pubitemid 41324021)
19. Smith ML, Kiechler AR, Goodin SZ (2007) The hyperphagic effect of the selective melanocortin-4 receptor antagonist HS014 is gender specific. Appetit 49(1):3311
20. Hadley Mac E (2005) Discovery that a melanocortin regulates sexual functions in male and female humans. Peptides 26:1687-1689
21. Wikberg JE, Mutulis F (2008) Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction. Nat Rev Drug Discov. 7:307-323
22. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-delta delta C(T)) method. Methods 25:402-408 (Pubitemid 34164012)
23. Benz V, Bloch M, Wardat S, Bohm C, Maurer L, Mahmoodzadeh S, Wiedmer P, Spranger J, Foryst-Ludwing A, Kintscher U (2012) Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis. PLoS ONE 7(5):e37794
24. Li J (2011) Progress in the effect of melanocortin system on bone metabolism. J Med Postgra 24(4):441-444
25. Caruso C, Camiglia L, Durand D, Gonzalez PV, Scimonelli TN (2012) Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP-protein kinase A pathway. Mol Cell Endocrinol 348:47-54
26. Butler AA (2006) The melanocortin system and energy balance. Peptides 27:281-290
27. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD (1992) The cloning of a family of genes that encode the melanocortin receptors. Science 257:1248-1251
28. Gantz I, Fong TM (2003) The melanocortin system. Am J Physiol Endocrinol Metab 284:E468-E474 (Pubitemid 36237533)
29. Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH, Reichardt LF (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6:736-742 (Pubitemid 36792889)
30. Tao YX (2010) The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr Rev 31:506-543
31. Breit A, Buch TRH, Boekhoff I, Solinski HJ, Damm E (2010) Alternative G protein coupling and biased agonism: new insights into melanocortin-4 receptor signalling. Mol Cell Endocrinol 331:232-240
32. Kumar KG, Sutton GM, Dong JZ (2009) Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R and MCAR deficient C57BL/6J mice. Peptides 30(10):1892-1900
33. Bertolini A, Tacchi R, Vergon AV (2009) Brain effects of melanocortins. Pharmacol Res 59:13-47
34. Catania A, Lonati C, Sordi A, Carlin A, Leonardi P, Gatti S (2010) The melanocortin system in control of inflammation. Sci World 10:1840-1853
35. Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosenblum CI, Vongs A, Feng Y, Cao L, Metzger JM, Strack AM, Camacho RE, Mellin TN, Nunes CN, Min W, Fisher J, Gopal-Truter S, MacIntyre DE, Chen HY, Van der Ploeg LH (2000) Activation of melanocortin type 3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26:97-102
36. Weide K, Christ N, Moar KM, Arens J, Hinney A, Mercer JG, Eiden S, Schmidt I (2003) Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice. Physiol Genom 13:47-56 (Pubitemid 37129168)
37. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berke-meier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-141 (Pubitemid 27180337)
38. Agranat-Meged A, Ghanadri Y, Eisenberg I, Neriah ZB, Kieselstein-Gross E (2008) Attention deficit hyperactivity disorder in obese melanocortin-4-receptor (MC4R) deficient subjects: a newly described expression of MC4R deficiency. Neuropsychiatr Genet 147B:1547-1553
39. Benoit SC, Air EL, Coolen LM, Strauss R, Jackman A, Clegg DJ (2002) The catabolic action of insulin in the brain is mediated by melanocortins. J Neurosci 22:9048-9052 (Pubitemid 35379074)
40. Schwartz MW, Seeley RJ, Woods SC, Weigle DS, Campfield LA, Burn P (1997) Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46:2119-2123 (Pubitemid 27512108)
41. Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-661 (Pubitemid 36262986)
42. Buettner C, Muse ED, Cheng A, Chen L, Scherer T, Pocai A (2008) Leptin controls adipose tissue lipogenes is via central, STAT3-independent mechanisms. Nat Med 14:667-675 (Pubitemid 351809549)
43. Gallardo N, Bonzon-Kulichenko E, Fernandez-Agullo T, Molto E, Gomez-Alonso S, Blanco P (2007) Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Endocrinology 148:5604-5610 (Pubitemid 350146140)
44. Theander-Carrillo C, Wiedmer P, Cettour-Rose P, Nogueiras R, Perez-Tilve D, Pflu-ger P (2006) Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest 116:1983-1993 (Pubitemid 44033322)
45. Lu XY, Barsh GS, Akil H, Watson SJ (2003) Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J Neurosci 23:7863-7872 (Pubitemid 37052354)
46. Legradi G, Lechan RM (1999) Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 140:3643-3652 (Pubitemid 30645419)
47. Mihaly E, Fekete C, Tatro JB, Liposits Z, Stopa EG, Lechan RM (2000) Hypophysiotropic-thyrotropin-releasing hormone-synthesizing neurons in the human hypothalamus are innervated by neuropeptide Y, agouti-related protein, and alpha-melanocyte-stimulating hormone. J Clin Endocrinol Metab 85:2596-2603 (Pubitemid 32269220)
48. Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjorbaek C, Elmquist JK, Flier JS, Hollenberg AN (2001) Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest 107:111-120 (Pubitemid 32047420)
49. Smith MA, Hisadome K, Al-Qassab H, Heffron H, Withers DJ, Ashford ML (2007) Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances. J Physiol 578:425-438 (Pubitemid 46092207)
50. Kong WM, Martin NM, Smith KL, Gardiner JV, Connoley IP, Stephens DA, Dhillo WS, Ghatei MA, Small CJ, Bloom SR (2004) Triiodothyronine stimulates food intake via the hypothalamic entromedial nucleus independent of changes in energy expenditure. Endocrinology 145:5252-5258 (Pubitemid 39551147)
51. Coppola A, Liu ZW, Andrews ZB, Paradis E, Roy MC, Friedman JM, Ricquier D, Richard D, Horvath TL, Gao XB, Diano S (2007) A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metab 5:21-33 (Pubitemid 44939398)
52. Mario P, Theodore F, Veronica PE, Xiaoxiong S, Stuart RC, Nillni Eduardo A (2006) Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus. Endocrinology 147:2705-2716 (Pubitemid 43764607)
53. Ishii S, Kamegal J, Tamura H, Shimizu T, Sugihara H, Oikawa S (2003) Hypothalamic neuropeptide Y/Y1 receptor pathway activated by a reduction in circulating leptin, but not by an increase in circulating ghrelin, contributes to hyperphagia associated with triiodothyronine-induced thyrotoxicosis. Neuroendocrinology 78:321-330 (Pubitemid 38037048)
54. Garza JC, Kim CS, Liu J, Zhang W, Lu XY (2008) Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity. J Endocrinol 197:471-482 (Pubitemid 351803952)
55. Lasaga M, Debeljuk L, Durand D, Scimonelli TN, Caruso C (2008) Role of alpha-melanocyte stimulating hormone and melanocortin 4 receptor in brain inflammation. Peptides 29:1825-1835
56. Haus-Seuffert P, Meisterernst M (2000) Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB. Mol Cell Biochem 212:5-9
57. Van Straten EM, Bloks VW, Van Dijk TH, Baller JF, Huijkman NC, Kuipers I, Verkade HJ, Plosch T (2012) Sex-dependent programming of glucose and fatty acid metabolism in mouse offspring by maternal protein restriction. Gend Med 9(3):166-179
58. Manole MD, Tehranian-DePasquale R, Du L, Bayir H, Kochanek PM, Ckark RS (2011) Unmasking sex-based disparity in neuronal metabolism. Curr Pharm Des 17(35):3854-3860