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Volumn 348, Issue 1, 2012, Pages 47-54

Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP - Protein kinase A pathway

Author keywords

Astrocytes; BDNF; CAMP; CREB; MC4R; PKA

Indexed keywords

ADENYLATE CYCLASE; ALPHA INTERMEDIN; ALPHA INTERMEDIN DERIVATIVE; BACTERIUM LIPOPOLYSACCHARIDE; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATING AGENT; MELANOCORTIN 4 RECEPTOR; MESSENGER RNA;

EID: 80755187744     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2011.07.036     Document Type: Article
Times cited : (62)

References (57)
  • 1
    • 0032505723 scopus 로고    scopus 로고
    • Activation of cAMP-dependent protein kinase is required for optimal alpha-melanocyte-stimulating hormone-induced pigmentation
    • Ao Y., Park H.Y., Olaizola-Horn S., Gilchrest B.A. Activation of cAMP-dependent protein kinase is required for optimal alpha-melanocyte-stimulating hormone-induced pigmentation. Exp. Cell Res. 1998, 244:117-124.
    • (1998) Exp. Cell Res. , vol.244 , pp. 117-124
    • Ao, Y.1    Park, H.Y.2    Olaizola-Horn, S.3    Gilchrest, B.A.4
  • 2
    • 77950613775 scopus 로고    scopus 로고
    • Role of CREB in modulation of TNF-α and IL-10 expression in LPS-stimulated RAW264.7 macrophages
    • Avni D., Ernst O., Philosoph A., Zor T. Role of CREB in modulation of TNF-α and IL-10 expression in LPS-stimulated RAW264.7 macrophages. Mol. Immunol 2010, 47:1396-1403.
    • (2010) Mol. Immunol , vol.47 , pp. 1396-1403
    • Avni, D.1    Ernst, O.2    Philosoph, A.3    Zor, T.4
  • 5
    • 5744233877 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor
    • Binder E., Scharfman H. Brain-derived neurotrophic factor. Growth Factors 2004, 22:123-131.
    • (2004) Growth Factors , vol.22 , pp. 123-131
    • Binder, E.1    Scharfman, H.2
  • 6
    • 78650273555 scopus 로고    scopus 로고
    • Alternative G protein coupling and biased agonism: new insights into melanocortin-4 receptor signalling
    • Breit A., Büch T.R., Boekhoff I., Solinski H.J., Damm E., Gudermann T. Alternative G protein coupling and biased agonism: new insights into melanocortin-4 receptor signalling. Mol. Cell. Endocrinol. 2011, 331:232-240.
    • (2011) Mol. Cell. Endocrinol. , vol.331 , pp. 232-240
    • Breit, A.1    Büch, T.R.2    Boekhoff, I.3    Solinski, H.J.4    Damm, E.5    Gudermann, T.6
  • 7
    • 0036740702 scopus 로고    scopus 로고
    • Inflammatory mediators increase the expression of nociciptin/orphanin FQ in rat astrocytes in culture
    • Buzas B., Rosenberger J., Kim K.W., Cox B.M. Inflammatory mediators increase the expression of nociciptin/orphanin FQ in rat astrocytes in culture. Glia 2002, 39:237-246.
    • (2002) Glia , vol.39 , pp. 237-246
    • Buzas, B.1    Rosenberger, J.2    Kim, K.W.3    Cox, B.M.4
  • 8
    • 3242756910 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats
    • Caruso C., Mohn C., Karara A.L., Rettori V., Watanobe H., Schiöth H.B., Seilicovich A., Lasaga M. Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats. Neuroendocrinology 2004, 79:278-286.
    • (2004) Neuroendocrinology , vol.79 , pp. 278-286
    • Caruso, C.1    Mohn, C.2    Karara, A.L.3    Rettori, V.4    Watanobe, H.5    Schiöth, H.B.6    Seilicovich, A.7    Lasaga, M.8
  • 9
    • 34748907751 scopus 로고    scopus 로고
    • Activation of melanocortin 4 receptors reduces the inflammatory response and prevents apoptosis induced by lipopolysaccharide and interferon-gamma in astrocytes
    • Caruso C., Durand D., Schiöth H.B., Rey R., Seilicovich A., Lasaga M. Activation of melanocortin 4 receptors reduces the inflammatory response and prevents apoptosis induced by lipopolysaccharide and interferon-gamma in astrocytes. Endocrinology 2007, 148:4918-4926.
    • (2007) Endocrinology , vol.148 , pp. 4918-4926
    • Caruso, C.1    Durand, D.2    Schiöth, H.B.3    Rey, R.4    Seilicovich, A.5    Lasaga, M.6
  • 10
    • 77956647428 scopus 로고    scopus 로고
    • α-Melanocyte-stimulating hormone modulates lipopolysaccharide plus interferon-γ-induced tumor necrosis factor-α expression but not tumor necrosis factor-α receptor expression in cultured hypothalamic neurons
    • Caruso C., Sánchez M., Durand D., Pérez M.C., Lasaga M., Scimonelli T. α-Melanocyte-stimulating hormone modulates lipopolysaccharide plus interferon-γ-induced tumor necrosis factor-α expression but not tumor necrosis factor-α receptor expression in cultured hypothalamic neurons. J. Neuroimmunol. 2010, 227:52-59.
    • (2010) J. Neuroimmunol. , vol.227 , pp. 52-59
    • Caruso, C.1    Sánchez, M.2    Durand, D.3    Pérez, M.C.4    Lasaga, M.5    Scimonelli, T.6
  • 12
    • 33750042605 scopus 로고    scopus 로고
    • Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase
    • Chai B., Li J.Y., Zhang W., Newman E., Ammori J., Mulholland M.W. Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase. Peptides 2006, 27:2846-2857.
    • (2006) Peptides , vol.27 , pp. 2846-2857
    • Chai, B.1    Li, J.Y.2    Zhang, W.3    Newman, E.4    Ammori, J.5    Mulholland, M.W.6
  • 14
    • 0034617476 scopus 로고    scopus 로고
    • Astrocytes in culture express the full-length Trk-B receptor and respond to brain derived neurotrophic factor by changing intracellular calcium levels: effect of ethanol exposure in rats
    • Climent E., Sancho-Tello M., Miñana R., Barettino D., Guerri C. Astrocytes in culture express the full-length Trk-B receptor and respond to brain derived neurotrophic factor by changing intracellular calcium levels: effect of ethanol exposure in rats. Neurosci. Lett. 2000, 288:53-56.
    • (2000) Neurosci. Lett. , vol.288 , pp. 53-56
    • Climent, E.1    Sancho-Tello, M.2    Miñana, R.3    Barettino, D.4    Guerri, C.5
  • 15
    • 79952805074 scopus 로고    scopus 로고
    • Astroglial inhibition of NF-κB does not ameliorate disease onset and progression in a mouse model for amyotrophic lateral sclerosis
    • Crosio C., Valle C., Casciati A., Iaccarino C., Carri M.T. Astroglial inhibition of NF-κB does not ameliorate disease onset and progression in a mouse model for amyotrophic lateral sclerosis. PLOS one 2011, 6:e1787.
    • (2011) PLOS one , vol.6
    • Crosio, C.1    Valle, C.2    Casciati, A.3    Iaccarino, C.4    Carri, M.T.5
  • 16
    • 38349105880 scopus 로고    scopus 로고
    • Disruption of the RII β subunit of PKA reverses the obesity syndrome of agouti lethal yellow mice
    • Czyzyk T.A., Sikorski M.A., Yang L., McKnight S. Disruption of the RII β subunit of PKA reverses the obesity syndrome of agouti lethal yellow mice. P.N.A.S. 2008, 105:276-281.
    • (2008) P.N.A.S. , vol.105 , pp. 276-281
    • Czyzyk, T.A.1    Sikorski, M.A.2    Yang, L.3    McKnight, S.4
  • 17
    • 79955684278 scopus 로고    scopus 로고
    • Neuroinflammation and neuroprotection: an update on (future) neurotrophin-related strategies in multiple sclerosis treatment
    • De Santi L., Polimeni G., Cuzzocrea S., Esposito E., Sessa E., Annunziata P., Bramanti P. Neuroinflammation and neuroprotection: an update on (future) neurotrophin-related strategies in multiple sclerosis treatment. Curr. Med. Chem. 2011, 18:1775-1784.
    • (2011) Curr. Med. Chem. , vol.18 , pp. 1775-1784
    • De Santi, L.1    Polimeni, G.2    Cuzzocrea, S.3    Esposito, E.4    Sessa, E.5    Annunziata, P.6    Bramanti, P.7
  • 20
    • 67650077092 scopus 로고    scopus 로고
    • Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
    • Gonzalez P.V., Schiöth H.B., Lasaga M., Scimonelli T. Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors. Brain Behav. Immun. 2009, 6:817-822.
    • (2009) Brain Behav. Immun. , vol.6 , pp. 817-822
    • Gonzalez, P.V.1    Schiöth, H.B.2    Lasaga, M.3    Scimonelli, T.4
  • 21
    • 0035810771 scopus 로고    scopus 로고
    • Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortins-4 receptor
    • Haskell-Luevano C., Monck E.K. Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortins-4 receptor. Regul. Pept. 2001, 99:1-7.
    • (2001) Regul. Pept. , vol.99 , pp. 1-7
    • Haskell-Luevano, C.1    Monck, E.K.2
  • 22
    • 0033773179 scopus 로고    scopus 로고
    • Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB
    • Haus-Seuffert P., Meisterernst M. Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB. Mol. Cell. Biochem. 2000, 212:5-9.
    • (2000) Mol. Cell. Biochem. , vol.212 , pp. 5-9
    • Haus-Seuffert, P.1    Meisterernst, M.2
  • 24
    • 0033050644 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation
    • Ichiyama T., Zhao H., Catania A., Furukawa S., Lipton J.M. Alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation. Exp. Neurol. 1999, 157:359-365.
    • (1999) Exp. Neurol. , vol.157 , pp. 359-365
    • Ichiyama, T.1    Zhao, H.2    Catania, A.3    Furukawa, S.4    Lipton, J.M.5
  • 25
    • 78650748359 scopus 로고    scopus 로고
    • Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats
    • Jiang Y., Jiang Y., Wei N., Lu T., Zhu J., Xu G., Liu X. Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience 2011, 172:398-405.
    • (2011) Neuroscience , vol.172 , pp. 398-405
    • Jiang, Y.1    Jiang, Y.2    Wei, N.3    Lu, T.4    Zhu, J.5    Xu, G.6    Liu, X.7
  • 26
    • 36849051420 scopus 로고    scopus 로고
    • Noradrenergic stimulation of BDNF synthesis in astrocytes: mediation via alpha1- and beta1/beta2-adrenergic receptors
    • Juric D.M., Loncar D., Carman-Krzan M. Noradrenergic stimulation of BDNF synthesis in astrocytes: mediation via alpha1- and beta1/beta2-adrenergic receptors. Neurochem. Int. 2008, 52:297-306.
    • (2008) Neurochem. Int. , vol.52 , pp. 297-306
    • Juric, D.M.1    Loncar, D.2    Carman-Krzan, M.3
  • 29
    • 52049094806 scopus 로고    scopus 로고
    • Role of alpha-melanocyte stimulating hormone and melanocortin 4 receptor in brain inflammation
    • Lasaga M., Debeljuk L., Durand D., Scimonelli T.N., Caruso C. Role of alpha-melanocyte stimulating hormone and melanocortin 4 receptor in brain inflammation. Peptides 2008, 29:1825-1835.
    • (2008) Peptides , vol.29 , pp. 1825-1835
    • Lasaga, M.1    Debeljuk, L.2    Durand, D.3    Scimonelli, T.N.4    Caruso, C.5
  • 30
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • Li Q., Verma I.M. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2002, 2:725-734.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 31
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 32
    • 0037101970 scopus 로고    scopus 로고
    • Function and regulation of CREB family transcription factors in the nervous system
    • Lonze B.E., Ginty D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 2002, 35:605-623.
    • (2002) Neuron , vol.35 , pp. 605-623
    • Lonze, B.E.1    Ginty, D.D.2
  • 33
    • 0032531035 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents
    • Manna S.K., Aggarwal B.B. Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents. J. Immunol. 1998, 161:2873-2880.
    • (1998) J. Immunol. , vol.161 , pp. 2873-2880
    • Manna, S.K.1    Aggarwal, B.B.2
  • 34
    • 0035845567 scopus 로고    scopus 로고
    • Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB
    • Mayr B.M., Canettieri G., Montminy M.R. Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB. Proc. Natl. Acad. Sci. USA 2001, 98:10936-10941.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10936-10941
    • Mayr, B.M.1    Canettieri, G.2    Montminy, M.R.3
  • 35
    • 0032528159 scopus 로고    scopus 로고
    • Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord
    • McTigue D.M., Horner P.J., Stokes B.T., Gage F.H. Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J. Neurosci. 1998, 18:5354-5365.
    • (1998) J. Neurosci. , vol.18 , pp. 5354-5365
    • McTigue, D.M.1    Horner, P.J.2    Stokes, B.T.3    Gage, F.H.4
  • 36
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • Mountjoy K., Mortrud M., Low M.J., Simerly R.B., Cone R.D. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol. Endocrinol. 1994, 8:1298-1308.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1298-1308
    • Mountjoy, K.1    Mortrud, M.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 37
    • 36248944567 scopus 로고    scopus 로고
    • Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function
    • Nicholson J.R., Peter J.C., Lecourt A.C., Barde Y.A., Hofbauer K.G. Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function. J. Neuroendocrinol. 2007, 19:974-982.
    • (2007) J. Neuroendocrinol. , vol.19 , pp. 974-982
    • Nicholson, J.R.1    Peter, J.C.2    Lecourt, A.C.3    Barde, Y.A.4    Hofbauer, K.G.5
  • 38
    • 0025923645 scopus 로고
    • Inhibition of prostaglandin E2-stimulated cAMP accumulation by lipopolysaccharide in murine peritoneal macrophages
    • Okonogi K., Gettys T.W., Uhing R.J., Tarry W.C., Adams D.O., Prpic V. Inhibition of prostaglandin E2-stimulated cAMP accumulation by lipopolysaccharide in murine peritoneal macrophages. J. Biol. Chem. 1991, 266:10305-10312.
    • (1991) J. Biol. Chem. , vol.266 , pp. 10305-10312
    • Okonogi, K.1    Gettys, T.W.2    Uhing, R.J.3    Tarry, W.C.4    Adams, D.O.5    Prpic, V.6
  • 40
    • 62949102680 scopus 로고    scopus 로고
    • Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signalling mechanism
    • Rodrigues A.R., Pignatelli D., Almeida H., Gouveia A.M. Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signalling mechanism. Mol. Cell. Endocrinol. 2009, 303:74-81.
    • (2009) Mol. Cell. Endocrinol. , vol.303 , pp. 74-81
    • Rodrigues, A.R.1    Pignatelli, D.2    Almeida, H.3    Gouveia, A.M.4
  • 41
    • 79952068392 scopus 로고    scopus 로고
    • Adrenocorticotropin hormone (ACTH) effects on MAPK phosphorylation in human fasciculata cells and in embryonic kidney 293 cells expressing human melanocortin 2 receptor (MC2R) and MC2R accessory protein (MRAP) β
    • Roy S., Pinard S., Chouinard L., Gallo-Payet N. Adrenocorticotropin hormone (ACTH) effects on MAPK phosphorylation in human fasciculata cells and in embryonic kidney 293 cells expressing human melanocortin 2 receptor (MC2R) and MC2R accessory protein (MRAP) β. Mol. Cell. Endocrinol. 2011, 336:31-40.
    • (2011) Mol. Cell. Endocrinol. , vol.336 , pp. 31-40
    • Roy, S.1    Pinard, S.2    Chouinard, L.3    Gallo-Payet, N.4
  • 42
    • 0142231439 scopus 로고    scopus 로고
    • Alpha-melanocyte stimulating hormone inhibits lipopolysaccharide-induced biological responses by downregulating CD14 from macrophages
    • Sarkar A., Sreenivasan Y., Manna S.K. Alpha-melanocyte stimulating hormone inhibits lipopolysaccharide-induced biological responses by downregulating CD14 from macrophages. FEBS Lett. 2003, 553:286-294.
    • (2003) FEBS Lett. , vol.553 , pp. 286-294
    • Sarkar, A.1    Sreenivasan, Y.2    Manna, S.K.3
  • 43
    • 0037178647 scopus 로고    scopus 로고
    • Intracerebroventricular of alpha-melanocyte stimulating hormone increases phosphorylation of CREB in TRH- and CRH- neurons of the hypothalamic paraventricular nucleus
    • Sarkar S., Légradi G., Lechan R.M. Intracerebroventricular of alpha-melanocyte stimulating hormone increases phosphorylation of CREB in TRH- and CRH- neurons of the hypothalamic paraventricular nucleus. Brain Res. 2002, 945:50-59.
    • (2002) Brain Res. , vol.945 , pp. 50-59
    • Sarkar, S.1    Légradi, G.2    Lechan, R.M.3
  • 45
    • 33846311331 scopus 로고    scopus 로고
    • Identification of differential melanocortin 4 receptor agonist profiles at natively expressed receptors in rat cortical astrocytes and recombinantly expressed receptors in human embryonic kidney cells
    • Selkirk J.V., Nottebaum L.M., Lee J., Yang W., Foster A.C., Lechner S.M. Identification of differential melanocortin 4 receptor agonist profiles at natively expressed receptors in rat cortical astrocytes and recombinantly expressed receptors in human embryonic kidney cells. Neuropharmacology 2007, 52:459-466.
    • (2007) Neuropharmacology , vol.52 , pp. 459-466
    • Selkirk, J.V.1    Nottebaum, L.M.2    Lee, J.3    Yang, W.4    Foster, A.C.5    Lechner, S.M.6
  • 47
    • 1242269968 scopus 로고    scopus 로고
    • Roles of the melanocortin-4 receptor in antipyretic and hyperthermic actions of centrally administered alpha-MSH
    • Sinha P., Schiöth H.B., Tatro J. Roles of the melanocortin-4 receptor in antipyretic and hyperthermic actions of centrally administered alpha-MSH. Brain Res. 2004, 1001:150-158.
    • (2004) Brain Res. , vol.1001 , pp. 150-158
    • Sinha, P.1    Schiöth, H.B.2    Tatro, J.3
  • 48
    • 67649850260 scopus 로고    scopus 로고
    • Regulation of pigmentation in human epidermal melanocytes by functional high-affinity beta-melanocyte-stimulating hormone/melanocortin-4 receptor signaling
    • Spencer J.D., Schallreuter K.U. Regulation of pigmentation in human epidermal melanocytes by functional high-affinity beta-melanocyte-stimulating hormone/melanocortin-4 receptor signaling. Endocrinology 2009, 150:1250-1258.
    • (2009) Endocrinology , vol.150 , pp. 1250-1258
    • Spencer, J.D.1    Schallreuter, K.U.2
  • 49
    • 23844542825 scopus 로고    scopus 로고
    • Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signalling in rat solitary nucleus
    • Sutton G.M., Duos B., Patterson L.M., Berthoud H.-R. Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signalling in rat solitary nucleus. Endocrinology 2005, 146:3739-3747.
    • (2005) Endocrinology , vol.146 , pp. 3739-3747
    • Sutton, G.M.1    Duos, B.2    Patterson, L.M.3    Berthoud, H.-R.4
  • 50
    • 0032034262 scopus 로고    scopus 로고
    • Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism
    • Tao X., Finkbeiner S., Arnold D.B., Shaywitz A.J., Greenberg M.E. Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 1998, 20:709-726.
    • (1998) Neuron , vol.20 , pp. 709-726
    • Tao, X.1    Finkbeiner, S.2    Arnold, D.B.3    Shaywitz, A.J.4    Greenberg, M.E.5
  • 51
    • 77955409173 scopus 로고    scopus 로고
    • The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology
    • Tao Y.X. The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr. Rev. 2010, 31:506-543.
    • (2010) Endocr. Rev. , vol.31 , pp. 506-543
    • Tao, Y.X.1
  • 52
    • 2642517794 scopus 로고    scopus 로고
    • Activation of MAP kinase by MC4-R through PI3 kinase
    • Vongs A., Lynn N.M., Rosenblum C.I. Activation of MAP kinase by MC4-R through PI3 kinase. Regul. Pept. 2004, 120:113-118.
    • (2004) Regul. Pept. , vol.120 , pp. 113-118
    • Vongs, A.1    Lynn, N.M.2    Rosenblum, C.I.3
  • 54
    • 0041856376 scopus 로고    scopus 로고
    • Alpha-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in leukocytes by modulating protein kinase A, p38 kinase, and nuclear factor kappa B signaling pathways
    • Yoon S.W., Goh S.H., Chun J.S., Cho E.W., Lee M.K., Kim K.L., Kim J.J., Kim C.J., Poo H. Alpha-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in leukocytes by modulating protein kinase A, p38 kinase, and nuclear factor kappa B signaling pathways. J. Biol. Chem. 2003, 278:32914-32920.
    • (2003) J. Biol. Chem. , vol.278 , pp. 32914-32920
    • Yoon, S.W.1    Goh, S.H.2    Chun, J.S.3    Cho, E.W.4    Lee, M.K.5    Kim, K.L.6    Kim, J.J.7    Kim, C.J.8    Poo, H.9
  • 55
    • 43549095680 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by kainic acid mediates brain-derived neurotrophic factor expression through a NF-kappaB dependent mechanism in C6 glioma cells
    • Yoon H., Oh Y.T., Lee J.Y., Choi J.H., Lee J.H., Baik H.H., Kim S.S., Choe W., Yoon K.S., Ha J., Kang I. Activation of AMP-activated protein kinase by kainic acid mediates brain-derived neurotrophic factor expression through a NF-kappaB dependent mechanism in C6 glioma cells. Biochem. Biophys. Res. Commun. 2008, 371:495-500.
    • (2008) Biochem. Biophys. Res. Commun. , vol.371 , pp. 495-500
    • Yoon, H.1    Oh, Y.T.2    Lee, J.Y.3    Choi, J.H.4    Lee, J.H.5    Baik, H.H.6    Kim, S.S.7    Choe, W.8    Yoon, K.S.9    Ha, J.10    Kang, I.11
  • 56
    • 2342452712 scopus 로고    scopus 로고
    • Cytokines increase CRE binding but decrease CRE-mediated reporter activity in rat hepatocytes by increasing c-Jun
    • Zhang B., Liu S., Perpetua M.D., Walker W.H., Harbrecht B.G. Cytokines increase CRE binding but decrease CRE-mediated reporter activity in rat hepatocytes by increasing c-Jun. Hepatology 2004, 39:1343-1352.
    • (2004) Hepatology , vol.39 , pp. 1343-1352
    • Zhang, B.1    Liu, S.2    Perpetua, M.D.3    Walker, W.H.4    Harbrecht, B.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.