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Volumn 149, Issue 1, 2008, Pages 174-184

Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in C57BL/6J mice

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; MELANOCORTIN 4 RECEPTOR;

EID: 37549003312     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0868     Document Type: Article
Times cited : (24)

References (61)
  • 1
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • Cone RD 2005 Anatomy and regulation of the central melanocortin system. Nat Neurosci 8:571-578
    • (2005) Nat Neurosci , vol.8 , pp. 571-578
    • Cone, R.D.1
  • 2
    • 0028606308 scopus 로고
    • Differential effects of melanocortin peptides on neural melanocortin receptors
    • Adan RA, Cone RD, Burbach JP, Gispen WH 1994 Differential effects of melanocortin peptides on neural melanocortin receptors. Mol Pharmacol 46:1182-1190
    • (1994) Mol Pharmacol , vol.46 , pp. 1182-1190
    • Adan, R.A.1    Cone, R.D.2    Burbach, J.P.3    Gispen, W.H.4
  • 4
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS 1997 Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135-138
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 5
    • 31544465224 scopus 로고    scopus 로고
    • The melanocortin system and energy balance
    • Butler AA 2006 The melanocortin system and energy balance. Peptides 27:301-309
    • (2006) Peptides , vol.27 , pp. 301-309
    • Butler, A.A.1
  • 10
    • 0032400808 scopus 로고    scopus 로고
    • Brainstem application of melanocortin receptor ligands produces long- lasting effects on feeding and body weight
    • Grill HJ, Ginsberg AB, Seeley RJ, Kaplan JM 1998 Brainstem application of melanocortin receptor ligands produces long- lasting effects on feeding and body weight. J Neurosci 18:10128-10135
    • (1998) J Neurosci , vol.18 , pp. 10128-10135
    • Grill, H.J.1    Ginsberg, A.B.2    Seeley, R.J.3    Kaplan, J.M.4
  • 11
    • 0033200153 scopus 로고    scopus 로고
    • Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
    • Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD 1999 Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24:155-163
    • (1999) Neuron , vol.24 , pp. 155-163
    • Cowley, M.A.1    Pronchuk, N.2    Fan, W.3    Dinulescu, D.M.4    Colmers, W.F.5    Cone, R.D.6
  • 12
    • 0034981271 scopus 로고    scopus 로고
    • Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat
    • Butler AA, Marks DL, Fan W, Kuhn CM, Bartolome M, Cone RD 2001 Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci 4:605-611
    • (2001) Nat Neurosci , vol.4 , pp. 605-611
    • Butler, A.A.1    Marks, D.L.2    Fan, W.3    Kuhn, C.M.4    Bartolome, M.5    Cone, R.D.6
  • 16
    • 33645839593 scopus 로고    scopus 로고
    • Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors
    • Sutton GM, Trevaskis JL, Hulver MW, McMillan RP, Markward NJ, Babin MJ, Meyer EA, Butler AA 2006 Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Endocrinology 147:2183-2196
    • (2006) Endocrinology , vol.147 , pp. 2183-2196
    • Sutton, G.M.1    Trevaskis, J.L.2    Hulver, M.W.3    McMillan, R.P.4    Markward, N.J.5    Babin, M.J.6    Meyer, E.A.7    Butler, A.A.8
  • 19
    • 33845567553 scopus 로고    scopus 로고
    • Genetics of obesity in humans
    • Farooqi S, O'Rahilly S 2006 Genetics of obesity in humans. Endocr Rev 27:710-718
    • (2006) Endocr Rev , vol.27 , pp. 710-718
    • Farooqi, S.1    O'Rahilly, S.2
  • 21
    • 33845572889 scopus 로고    scopus 로고
    • Studies on the physiological functions of the melanocortin system
    • Cone RD 2006 Studies on the physiological functions of the melanocortin system. Endocr Rev 27:736-749
    • (2006) Endocr Rev , vol.27 , pp. 736-749
    • Cone, R.D.1
  • 24
    • 0030729210 scopus 로고    scopus 로고
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
    • Thornton JE, Cheung CC, Clifton DK, Steiner RA 1997 Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 138:5063-5066
    • (1997) Endocrinology , vol.138 , pp. 5063-5066
    • Thornton, J.E.1    Cheung, C.C.2    Clifton, D.K.3    Steiner, R.A.4
  • 25
    • 0030893647 scopus 로고    scopus 로고
    • Hypothalamic expression of ART, a novel gene related to agouti, is up- regulated in obese and diabetic mutant mice
    • Shutter JR, Graham M, Kinsey AC, Scully S, Luthy R, Stark KL 1997 Hypothalamic expression of ART, a novel gene related to agouti, is up- regulated in obese and diabetic mutant mice. Genes Dev 11:593-602
    • (1997) Genes Dev , vol.11 , pp. 593-602
    • Shutter, J.R.1    Graham, M.2    Kinsey, A.C.3    Scully, S.4    Luthy, R.5    Stark, K.L.6
  • 27
    • 24944495425 scopus 로고    scopus 로고
    • Double leptin (Lepob) and melanocortin-4 receptor (Mc4r) gene mutations have an additive effect on fat mass, and are associated with reduced effects of leptin on weight loss and food intake
    • Trevaskis JL, Butler AA 2005 Double leptin (Lepob) and melanocortin-4 receptor (Mc4r) gene mutations have an additive effect on fat mass, and are associated with reduced effects of leptin on weight loss and food intake. Endocrinology 146:4257-4265
    • (2005) Endocrinology , vol.146 , pp. 4257-4265
    • Trevaskis, J.L.1    Butler, A.A.2
  • 28
    • 33845911799 scopus 로고    scopus 로고
    • Grill HJ 2006 Distributed neural control of energy balance: contributions from hindbrain and hypothalamus. Obesity (Silver Spring) 14(Suppl 5):216S-221S
    • Grill HJ 2006 Distributed neural control of energy balance: contributions from hindbrain and hypothalamus. Obesity (Silver Spring) 14(Suppl 5):216S-221S
  • 30
    • 0018139377 scopus 로고
    • Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
    • Coleman DL 1978 Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14:141-148
    • (1978) Diabetologia , vol.14 , pp. 141-148
    • Coleman, D.L.1
  • 34
    • 0019471997 scopus 로고
    • Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice
    • Flatt PR, Bailey CJ 1981 Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice. Diabetologia 20:573-577
    • (1981) Diabetologia , vol.20 , pp. 573-577
    • Flatt, P.R.1    Bailey, C.J.2
  • 35
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG 2000 Obesity as a medical problem. Nature 404:635-643
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 36
    • 33749073279 scopus 로고    scopus 로고
    • Genetics of food intake and eating behavior phenotypes in humans
    • Rankinen T, Bouchard C 2006 Genetics of food intake and eating behavior phenotypes in humans. Annu Rev Nutr 26:413-434
    • (2006) Annu Rev Nutr , vol.26 , pp. 413-434
    • Rankinen, T.1    Bouchard, C.2
  • 37
    • 33749017409 scopus 로고    scopus 로고
    • Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, Perusse L, Bouchard C 2006 The human obesity gene map: the 2005 update. Obesity (Silver Spring) 14:529-644
    • Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, Perusse L, Bouchard C 2006 The human obesity gene map: the 2005 update. Obesity (Silver Spring) 14:529-644
  • 39
    • 0030678119 scopus 로고    scopus 로고
    • Independent and additive effects of central POMC and leptin pathways on murine obesity
    • Boston BA, Blaydon KM, Varnerin J, Cone RD 1997 Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 278:1641-1644
    • (1997) Science , vol.278 , pp. 1641-1644
    • Boston, B.A.1    Blaydon, K.M.2    Varnerin, J.3    Cone, R.D.4
  • 40
    • 2342625391 scopus 로고    scopus 로고
    • Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis
    • Tinsley FC, Taicher GZ, Heiman ML 2004 Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis. Obes Res 12:150-160
    • (2004) Obes Res , vol.12 , pp. 150-160
    • Tinsley, F.C.1    Taicher, G.Z.2    Heiman, M.L.3
  • 42
    • 2442710044 scopus 로고    scopus 로고
    • Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: Physiological and molecular characteristics
    • Collins S, Martin TL, Surwit RS, Robidoux J 2004 Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics. Physiol Behav 81:243-248
    • (2004) Physiol Behav , vol.81 , pp. 243-248
    • Collins, S.1    Martin, T.L.2    Surwit, R.S.3    Robidoux, J.4
  • 46
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS 2006 Inflammation and metabolic disorders. Nature 444:860-867
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 47
    • 3142782772 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
    • Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjorbaek C, Flier JS 2004 Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 10:734-738
    • (2004) Nat Med , vol.10 , pp. 734-738
    • Howard, J.K.1    Cave, B.J.2    Oksanen, L.J.3    Tzameli, I.4    Bjorbaek, C.5    Flier, J.S.6
  • 50
    • 33748073120 scopus 로고    scopus 로고
    • Leptin as a proinflammatory cytokine
    • Lord GM 2006 Leptin as a proinflammatory cytokine. Contrib Nephrol 151:151-164
    • (2006) Contrib Nephrol , vol.151 , pp. 151-164
    • Lord, G.M.1
  • 56
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • Munzberg H, Flier JS, Bjorbaek C 2004 Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145:4880-4889
    • (2004) Endocrinology , vol.145 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 58
    • 33745298324 scopus 로고    scopus 로고
    • Gonadal hormones determine sensitivity to central leptin and insulin
    • Clegg DJ, Brown LM, Woods SC, Benoit SC 2006 Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes 55:978-987
    • (2006) Diabetes , vol.55 , pp. 978-987
    • Clegg, D.J.1    Brown, L.M.2    Woods, S.C.3    Benoit, S.C.4
  • 60
    • 1442348151 scopus 로고    scopus 로고
    • Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice
    • Tortoriello DV, McMinn J, Chua SC 2004 Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice. Endocrinology 145:1238-1247
    • (2004) Endocrinology , vol.145 , pp. 1238-1247
    • Tortoriello, D.V.1    McMinn, J.2    Chua, S.C.3
  • 61
    • 34247382073 scopus 로고    scopus 로고
    • Johnston SL, Souter DM, Tolkamp BJ, Gordon IJ, Illius AW, Kyriazakis I, Speakman JR 2007 Intake compensates for resting metabolic rate variation in female C57BL/6J mice fed high-fat diets. Obesity (Silver Spring) 15:600-606
    • Johnston SL, Souter DM, Tolkamp BJ, Gordon IJ, Illius AW, Kyriazakis I, Speakman JR 2007 Intake compensates for resting metabolic rate variation in female C57BL/6J mice fed high-fat diets. Obesity (Silver Spring) 15:600-606


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