Discovery that a melanocortin regulates sexual functions in male and female humans

Peptides

Volumn 26, Issue 10, 2005, Pages 1687-1689

  Hadley, Mac E ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Melanocortins; MSH; MTI and MTII

Indexed keywords

ALPHA INTERMEDIN; AMINO ACID DERIVATIVE; ERECTIDE; HORMONE DERIVATIVE; MELANOCORTIN; MELANOTAN I; MELANOTAN II; N ACETYLNORLEUCYLASPARTYLHISTIDYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLLYSINE 2,7 CYCLIC AMIDE; PEPTIDE HORMONE; SILDENAFIL; UNCLASSIFIED DRUG;

BRAIN LEVEL; CENTRAL NERVOUS SYSTEM; DOSE TIME EFFECT RELATION; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; ERECTILE DYSFUNCTION; FEMALE SEXUAL DYSFUNCTION; HORMONAL REGULATION; HORMONE DETERMINATION; HUMAN; HYPOTENSION; IMPOTENCE; LICENSING; MOLECULAR WEIGHT; NAUSEA; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; REVIEW; SEXUAL BEHAVIOR; SEXUAL FUNCTION; SKIN PIGMENTATION;

ALPHA-MSH; ANIMALS; FEMALE; GENITALIA, FEMALE; HUMANS; MALE; PENILE ERECTION; PEPTIDES, CYCLIC; SEXUAL BEHAVIOR;

ANIMALIA;

EID: 25144523361     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2005.01.023     Document Type: Review

References (13)

1. F. Al-Obeidi, A.M. Castrucci, M.E. Hadley, and V.J. Hruby Potent and prolonged acting cyclic lactam analogues of α-melanotropin: design based on molecular dynamics J Med Chem 32 1989 2555 2561
2. F. Al-Obeidi, M.E. Hadley, B.M. Pettitt, and V.J. Hruby Design of a new class of superpotent cyclic α-melanotropins based on quenched dynamic stimulations J Am Chem Soc 111 1989 3413 3416
3. A. Argiolis, M.R. Meles, and G.L. Gessa Yawning and penile erection: central dopamine-oxytocin-adrenocorticotropin connection Ann N Y Acad Sci 525 1988 330 337
4. R.T. Dorr, G. Ertl, N. Levine, C. Brooks, J.L. Bangert, and M. Broome Powell Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers Arch Dermatol 140 2004 827 835
5. M.E. Hadley The melanotropic hormones D. Brake Endocrinology 4th ed. 1982 Simon & Schuster New York, NY 153 176
6. H. Krude, H. Biebermann, and A. Grüters Mutations in the human proopiomelanocortin gene Ann N Y Acad Sci 2003 233 239
7. P.D. Johnson, B.V. Dawson, R.T. Dorr, M.E. Hadley, N. Levine, and V.J. Hruby Coat color darkening in a canine in response to a potent melanotropic peptide Am J Vet Res 55 1994 1593 1596
8. P.B. Molinoff, A.M. Shadiack, D. Earle, L.E. Diamond, and C.Y. Quon PT-141: a melanocortin agonist for the treatment of sexual dysfunction Ann N Y Acad Sci 994 2003 96 102
9. T.K. Sawyer, P.J. Sanfillippo, V.J. Hruby, M.H. Engel, C.B. Heward, and J.B. Burnett [Nle4, DPhe7]α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultra long biological activity Proc Natl Acad Sci USA 77 1980 4754 4758
10. A.J. Thody, C.A. Wilson, and D. Everard Facilitation and inhibition of sexual receptivity in the female rat by α-MSH Physiol Behav 22 1979 147 150
11. H. Wessells, K. Fuciarelli, J. Hansen, M.E. Hadley, V. Hruby, and R.T. Dorr Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind crossover placebo-controlled study J Urol 160 1998 389 393
12. H. Wessells, N. Levine, M.E. Hadley, R.T. Dorr, and V.J. Hruby Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II Int J Impotence Res 12 4 2000 574 579
13. H. Wessells, D. Gralnek, R.T. Dorr, V.J. Hruby, M.E. Hadley, and N. Levine Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction Urology 56 2000 641 646