The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism

Physiology and Behavior

Volumn 105, Issue 3, 2012, Pages 791-799

  Wiedmer, Petra ^a   Chaudhary, Nilika ^b   Rath, Michaela ^a   Yi, Chun Xia ^b   Ananthakrishnan, Gayathri ^b   Nogueiras, Rubén ^c,d   Wirth, Eva K ^e   Kirchner, Henriette ^f   Schweizer, Ulrich ^e   Jonas, Wenke ^a   Veyrat Durebex, Christelle ^g   Rohner Jeanrenaud, Francoise ^g   Schürmann, Annette ^a   Joost, Hans Georg ^a   Tschöp, Matthias H ^a,b   Perez Tilve, Diego ^b  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^d Instituto de Salud Carlos III   (Spain)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f KAROLINSKA INSTITUTE   (Sweden)

^g UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Adrenalectomy; Melanocortin receptor; MTII; Obesity; SHU9119; Thyroidectomy

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; LEVOTHYROXINE; LIVER ENZYME; MELANOCORTIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MESSENGER RNA; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; PROTIRELIN; SODIUM CHLORIDE; TRIACYLGLYCEROL;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY MASS; CONTROLLED STUDY; EPIDIDYMIS; FOOD INTAKE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LIPID METABOLISM; LIPOGENESIS; LIVER METABOLISM; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHAM PROCEDURE; THYROIDECTOMY; WHITE ADIPOSE TISSUE;

ADIPOCYTES, WHITE; ADRENALECTOMY; ADRENOCORTICOTROPIC HORMONE; ALPHA-MSH; ANIMALS; BODY WEIGHT; CORTICOSTERONE; DRUG DELIVERY SYSTEMS; EATING; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INJECTIONS, INTRAVENTRICULAR; LIVER; MALE; MELANOCORTINS; MELANOCYTE-STIMULATING HORMONES; NEUROPEPTIDES; PITUITARY-ADRENAL SYSTEM; RATS; RATS, WISTAR; RECEPTORS, CORTICOTROPIN; THYROIDECTOMY; THYROXINE; TRIGLYCERIDES;

EID: 81155124473     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2011.10.019     Document Type: Article

References (35)

1. Flegal K.M., Graubard B.I., Williamson D.F., Gail M.H. Excess deaths associated with underweight, overweight, and obesity. JAMA 2005, 293:1861-1867.
2. Pischon T., Boeing H., Hoffmann K., Bergmann M., Schulze M.B., Overvad K., et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med 2008, 359:2105-2120.
3. Nogueiras R., Wiedmer P., Perez-Tilve D., Veyrat-Durebex C., Keogh J.M., Sutton G.M., et al. The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest 2007, 117:3475-3488.
4. Buettner C., Muse E.D., Cheng A., Chen L., Scherer T., Pocai A., et al. Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat Med 2008, 14:667-675.
5. Koch L., Wunderlich F.T., Seibler J., Konner A.C., Hampel B., Irlenbusch S., et al. Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Invest 2008, 118:2132-2147.
6. Nogueiras R., Perez-Tilve D., Veyrat-Durebex C., Morgan D.A., Varela L., Haynes W.G., et al. Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci 2009, 29:5916-5925.
7. Benoit S.C., Air E.L., Coolen L.M., Strauss R., Jackman A., Clegg D.J., et al. The catabolic action of insulin in the brain is mediated by melanocortins. J Neurosci 2002, 22:9048-9052.
8. Schwartz M.W., Seeley R.J., Woods S.C., Weigle D.S., Campfield L.A., Burn P., et al. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 1997, 46:2119-2123.
9. Cowley M.A., Smith R.G., Diano S., Tschop M., Pronchuk N., Grove K.L., et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003, 37:649-661.
10. Gallardo N., Bonzon-Kulichenko E., Fernandez-Agullo T., Molto E., Gomez-Alonso S., Blanco P., et al. Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Endocrinology 2007, 148:5604-5610.
11. Theander-Carrillo C., Wiedmer P., Cettour-Rose P., Nogueiras R., Perez-Tilve D., Pfluger P., et al. Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest 2006, 116:1983-1993.
12. Nogueiras R., Wilson H., Rohner-Jeanrenaud F., Tschop M.H. Central nervous system regulation of adipocyte metabolism. Regul Pept 2008, 149:26-31.
13. Bartness T.J., Song C.K. Thematic review series: adipocyte biology. Sympathetic and sensory innervation of white adipose tissue. J Lipid Res 2007, 48:1655-1672.
14. Brito M.N., Brito N.A., Baro D.J., Song C.K., Bartness T.J. Differential activation of the sympathetic innervation of adipose tissues by melanocortin receptor stimulation. Endocrinology 2007, 148:5339-5347.
15. Lu X.Y., Barsh G.S., Akil H., Watson S.J. Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J Neurosci 2003, 23:7863-7872.
16. Legradi G., Lechan R.M. Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 1999, 140:3643-3652.
17. Mihaly E., Fekete C., Tatro J.B., Liposits Z., Stopa E.G., Lechan R.M. Hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in the human hypothalamus are innervated by neuropeptide Y, agouti-related protein, and alpha-melanocyte-stimulating hormone. J Clin Endocrinol Metab 2000, 85:2596-2603.
18. Lechan R.M., Fekete C. Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis. Peptides 2006, 27:310-325.
19. Wortley K.E., Anderson K.D., Yasenchak J., Murphy A., Valenzuela D., Diano S., et al. Agouti-related protein-deficient mice display an age-related lean phenotype. Cell Metab 2005, 2:421-427.
20. Liu H., Kishi T., Roseberry A.G., Cai X., Lee C.E., Montez J.M., et al. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci 2003, 23:7143-7154.
21. Edwardson J.A., Hough C.A.M. The pituitary-adrenal system of the genetically obese (ob/ob) mouse. J Endocrinol 1975, 65:99-107.
22. Smart J.L., Tolle V., Low M.J. Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice. J Clin Invest 2006, 116:495-505.
23. Fekete C., Legradi G., Mihaly E., Huang Q.-H., Tatro J.B., Rand W.M., et al. Alpha-melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J Neurosci 2000, 20:1550-1558.
24. Harris M., Aschkenasi C., Elias C.F., Chandrankunnel A., Nillni E.A., BjÃ̧rbÃk C., et al. Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest 2001, 107:111-120.
25. Kim M.S., Small C.J., Stanley S.A., Morgan D.G., Seal L.J., Kong W.M., et al. The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J Clin Invest 2000, 105:1005-1011.
26. Fekete C., Sarkar S., Rand W.M., Harney J.W., Emerson C.H., Bianco A.C., et al. Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. Endocrinology 2002, 143:3846-3853.
27. Decherf S., Seugnet I., Kouidhi S., Lopez-Juarez A., Clerget-Froidevaux M.S., Demeneix B.A. Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression. Proc Natl Acad Sci U S A 2010, 107:4471-4476.
28. Kalsbeek A., Buijs R.M., van Schaik R., Kaptein E., Visser T.J., Doulabi B.Z., et al. Daily variations in type II iodothyronine deiodinase activity in the rat brain as controlled by the biological clock. Endocrinology 2005, 146:1418-1427.
29. Atkinson H.C., Waddell B.J. Circadian variation in basal plasma corticosterone and adrenocorticotropin in the rat: sexual dimorphism and changes across the estrous cycle. Endocrinology 1997, 138:3842-3848.
30. Leitch M.M., Ingram C.D., Young A.H., McQuade R., Gartside S.E. Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression. Neuropsychopharmacology 2002, 28:119-125.
31. Drazen D.L., Wortman M.D., Schwartz M.W., Clegg D.J., van Dijk G., Woods S.C., et al. Adrenalectomy alters the sensitivity of the central nervous system melanocortin system. Diabetes 2003, 52:2928-2934.
32. Pierroz D.D., Ziotopoulou M., Ungsunan L., Moschos S., Flier J.S., Mantzoros C.S. Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes 2002, 51:1337-1345.
33. Spinedi E., Gaillard R.C. A regulatory loop between the hypothalamo-pituitary-adrenal (HPA) axis and circulating leptin: a physiological role of ACTH. Endocrinology 1998, 139:4016-4020.
34. Mantha L., Palacios E., Deshaies Y. Modulation of triglyceride metabolism by glucocorticoids in diet-induced obesity. Am J Physiol 1999, 277:R455-R464.
35. De Boer S.F., Van Der Gugten J. Daily variations in plasma noradrenaline, adrenaline and corticosterone concentrations in rats. Physiol Behav 1987, 40:323-328.