Attention deficit hyperactivity disorder in obese melanocortin-4-receptor (MC4R) deficient subjects: A newly described expression of MC4R deficiency

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 147, Issue 8, 2008, Pages 1547-1553

  Agranat Meged, Anat ^a,b   Ghanadri, Yoad ^a   Eisenberg, Iris ^a   Ben Neriah, Ziva ^a   Kieselstein Gross, Eva ^a   Mitrani Rosenbaum, Stella ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b NONE   (Israel)

Author keywords

Attention deficit hyperactivity disorder; Genetics behavioral; Melanocortin 4 receptor; Obesity

Indexed keywords

MELANOCORTIN 4 RECEPTOR;

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; BODY MASS; CHILD; CLINICAL ARTICLE; COMORBIDITY; CONSANGUINEOUS MARRIAGE; CONTROLLED STUDY; EATING DISORDER; FEMALE; GENE MUTATION; GENETICS; GENOTYPE; HUMAN; HUNGER; MALE; OBESITY; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; SATIETY;

EID: 57349125835     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30842     Document Type: Article

References (43)

1. Agranat-Meged AN, Deitcher C, Goldzweig G, Leibenson L, Stein M, Galili-Weisstub E. 2005. Childhood obesity and attention deficit/hyperactivity disorder: A newly described comorbidity in obese hospitalized children. Int J Eat Disord 37: 357-359.
2. Albayrak O, Friedel S, Schimmelmann BG, Hinney A, Heberbrand J. 2008. Genetic aspects in attention-deficit/hyperactivity disorder. J Neural Transm 115(2):305-315.
3. Alfas JR. 2002. Prevalence of attention deficit/hyperactivity disorder among adults in obesity treatment. BMC Psychiatry 2:9.
4. Ambrosini P. 2000. Historical development and present status of the schedule for affective disorders and schizophrenia for school-age children (K-SADS). J Am Acad Child Adolesc Psychiatry 39:49-58.
5. American Psychiatric Association. 1994. Diagnostic and statistical manual of mental disorders, 4th edition. Washington DC: Author.
6. Biederman J, Faraone SV. 2005. Attention deficit hyperactivity disorder. Lancet 366:237-248.
7. Branson R, Potoczna N, Kral JG, Lentes KU, Hoehe MR, Horber FF. 2003. Binge eating as a Major phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 348(12):1096-1103.
8. Conners CK. 1997. The Conners rating scales (revised), technical manual, Toronto, Canada.
9. Cortese S, Isnard P, Frelut ML, Michel G, Quantin L, Guedeney A, Falissard B, Ecquaviva E, Dalla Bernardina B, Mouren MC. 2007. Association between symptoms of attention-deficit/hyperactivity disorder and bulimic behaviors in a clinical sample of severely obese adolescents. Int J Obes 31: 341-346.
10. Faraone SV, Khan SA. 2006. Candidate gene studies of attention-deficit/ hyperactivity disorder. J Clin Psychiatry 67 (Suppl 8):13-20.
11. Farooqi SI, O'Rahilly S. 2006. Genetics of obesity in humans. Endocr Rev 27(7):710-718.
12. Farooqi IS, Yeo GS, Keogh JM, Aminian S, Jebb SA, Butler G, Cheetham T, O'Rahilly S. 2000. Dominant and recessive inheritance ofmorbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 106(2):271-279.
13. Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S. 2003. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 348:1085-1095.
14. Fleming JP, Levy LD, Levitan RD. 2005. Symptoms of attention deficit hyperactivity disorder in severely obese woman. Eat Weight Disord 10(1):e10-e13.
15. Hainerova I, Larsen LH, Holst B, Finkova M, Hainer V, Lebl J, Hansen T, Pederson O. 2007. Melanocortin 4 receptor mutations in obese Czech children: Studies of prevalence, phenotype development, weight reduction response, and functional analysis. J Clin Endocrinol Metab 92(9):3689-3696.
16. Hebebrand J, Geller F, Dempfle A, Heinzel-Gutenbrunner M, Raab M, Gerber G, Wermter A-K, Horro FF, Blundell J, Schafer H, Remschmidt H, Herpertz S, Hinney A. 2004. Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations. Mol Psychiatry 9:796-800.
17. Hinney A, Bettecken T, Tarnow P, Brumm H, Reichwald K, Lichtner P, Scherag A, Nguyen TT, Schlumberger P, Rief W, Vollmert C, Illig T, Wichmann HE, Schafer H, Platzer M, Bieberman H, Meitinger T, Hebebrand J. 2006. Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany. J Clin Endocrinol Metab 91(5):1761-1769.
18. Holtkamp K, Konrad K, Muller B, Heussen N, Herpertz S, Herpertz-Dahlmann B, Hebebrand J. 2004. Overweight and obesity in children with attention-deficit/hyperactivity disorder. Int J Obes 28:685-689.
19. Hubel R, Jass J, Marcus A, Laessle RG. 2006. Overweight and basal metabolic rate in boys with attention-deficit/hyperactivity disorder. Eat Weight Disord 11(3): 139-146.
20. Jacobson P, Ukkola O, Rankinen T, Snyder EE, Leon AS, Rao DC, Skinner JS, Wilmore JH, Lonn L, Cowan GS Jr, Sjostrom L, Bouchard C. 2002. Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: The Swedish Obese Subjects, the HERITAGE Family Study and the Memphis cohort. J Clin Endocrinol Metab 87(10):4442-4446.
21. Kaplan A, Ciliska D. 1999. The relationship between eating disorders and obesity: Psychopathologic and treatment considerations. Psychiatr Ann 29(4):197-202.
22. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N. 1997. Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36: 980-988.
23. Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O, Faraone SV, Greenhill LL, Howes MJ, Secnik K, Spencer T, Ustun TB, Walters EE, Zaslavsky AM. 2006. The prevalence and correlates of adult ADHD in the United States: Results from the National Comorbidity Survey Replication. Am J Psychiatry 163(4):716-723.
24. Lam LT, Yang L. 2007. Overweight/obesity and attention deficit and hyperactivity disorder tendency among adolescents in China. Int J Obes 31:584-590.
25. Larsen LH, Echwald SM, Sorensen TI, Andersen T, Wulff BS, Pedersen O. 2005. Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity. J Clin Endocrinol Metab 90(1):219-224.
26. Levitan RD, Masellis M, Lam RW, Muglia P, Basile VS, Jain U, Kaplan AS, Tharmalingam S, Kennedy SH, Kennedy JL. 2004. Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder. Neuropsychopharmacology 29:179-186.
27. Lubrano-Berthelier C, Dubern B, Lacorte JM, Picard F, Shapiro A, Zhang S, Bertrais S, Hercberg S, Basdevant A, Clement K, Vaisse C. 2006. Melanocortin 4 receptor mutations in a large cohort of severely obese adults: Prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating. J Clin Endocrinol Metab 91(5):1181-1818.
28. MacKenzie RG. 2006. Obesity-associated mutations in the human melanocortin-4 receptor gene. Peptides 27:395-403.
29. Matarazzo J. 1972. Basic data and test results. In: Wechsler's measurement and appraisal of adult intelligence 5th and enlarged edition. Baltimore: Williams and Wilkins Company. pp 228-258.
30. Miraglia Del Giudice E, Cirrilo G, Nigro V, Santoro N, D'Urso L, Raimondo P, Cozzolino D, Scafato D, Perrone L. 2002. Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with early-onset obesity. Int J Obes Relat Metab Disord 26:647-651.
31. Mustillo S, Worthman C, Erkanli A, Keeler G, Angold A, Costello EJ. 2003. Obesity and psychiatric disorder: Developmental trajectories. Pediatrics 111(4):851-859.
32. O'rahilly S, Farooqi IS, Yeo GS, Challis BG. 2003. Minireview: Human obesity-lessons from monogenic disorders. Endocrinology 144(9):3757-3764.
33. Ryan J. 1981. Clinical utility of a WISC-R short form. J Clin Psychol 37:389-391.
34. SAS Institute. 2004. Proc Freq, SAS version 9.1 statistical software. Cary, NC: SAS Institute Inc.
35. Scahill L, Schwab-Stone M. 2000. Epidemiology of attention-deficit/ hyperactivity disorder in school aged children. Child Adolesc Psychiatr Clin N Am 9:541-555.
36. Sina A, Hinney A, Ziegler A, Neupert T, Mayer H, Siegfried W, Blum WF, Remschmidt H, Hebebrand J. 1999. Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene. Am J Med Genet 65(6):1501-1507.
37. Stunkard AJ, Wadden TA. 1992. Psychological aspects of severe obesity. Am J Clin Nutr 55(2):s524-s532.
38. Vaisse C, Clement K, Guy-Grand B, Froguel P. 1998. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 20:113-114.
39. Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P. 2000. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 106:253-262.
40. Wang CL, Liang L, Wang HJ, Fu JF, Hebebrand J, Hinney A. 2006. Several mutations in the melanocortin 4 receptor gene are associated with obesity in Chinese children and adolescents. J Endocrinol Invest 29(10):894-898.
41. Wechsler D. 1974. Manual for the Wechsler intelligence scale for children-revised. New York: Psychological Corporation.
42. WHO Press. 2000. Obesity: Preventing and managing the global epidemic: Report of a WHO consultation. WHO Tech Rep Ser 894:1-253.
43. Yeo GS, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG, O'Rahilly S. 1998. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 20:111-112.