-
1
-
-
0032539702
-
Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids
-
Adams J, Behnke M, Chen S et al (1998) Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids. Bioorg Med Chem Lett 8:333–338
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 333-338
-
-
Adams, J.1
Behnke, M.2
Chen, S.3
-
2
-
-
0033152760
-
Proteasome inhibitors: A novel class of potent and effective antitumor agents
-
Adams J, Palombella VJ, Sausville EA et al (1999) Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 59:2615–2622
-
(1999)
Cancer Res
, vol.59
, pp. 2615-2622
-
-
Adams, J.1
Palombella, V.J.2
Sausville, E.A.3
-
3
-
-
0036023407
-
A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies
-
Aghajanian C, Soignet S, Dizon DS et al (2002) A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res 8:2505–2511
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2505-2511
-
-
Aghajanian, C.1
Soignet, S.2
Dizon, D.S.3
-
4
-
-
24944526723
-
Phase I trial of bortezomib and carboplatin in recurrent ovarian or primary peritoneal cancer
-
Aghajanian C, Dizon DS, Sabbatini P et al (2005) Phase I trial of bortezomib and carboplatin in recurrent ovarian or primary peritoneal cancer. J Clin Oncol 23:5943–5949
-
(2005)
J Clin Oncol
, vol.23
, pp. 5943-5949
-
-
Aghajanian, C.1
Dizon, D.S.2
Sabbatini, P.3
-
5
-
-
0025064260
-
VAD-based regimens as primary treatment for multiple myeloma
-
Alexanian R, Barlogie B, Tucker S (1990) VAD-based regimens as primary treatment for multiple myeloma. Am J Hematol 33:86–89
-
(1990)
Am J Hematol
, vol.33
, pp. 86-89
-
-
Alexanian, R.1
Barlogie, B.2
Tucker, S.3
-
6
-
-
0026656725
-
Primary dexamethasone treatment of multiple myeloma
-
Alexanian R, Dimopoulos MA, Delasalle K et al (1992) Primary dexamethasone treatment of multiple myeloma. Blood 80(4):887–890
-
(1992)
Blood
, vol.80
, Issue.4
, pp. 887-890
-
-
Alexanian, R.1
Dimopoulos, M.A.2
Delasalle, K.3
-
7
-
-
50249150555
-
Phase I single agent antitumor activity of twice weekly-consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies
-
Alsina M, Trudel S, Vallone M et al (2007) Phase I single agent antitumor activity of twice weekly-consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies. Blood 110:128a (abstract 411)
-
(2007)
Blood
, vol.110
, pp. 128
-
-
Alsina, M.1
Trudel, S.2
Vallone, M.3
-
8
-
-
84887476028
-
Therapeutic advances in relapsed or refractory multiple myeloma
-
Anderson KC (2013) Therapeutic advances in relapsed or refractory multiple myeloma. J Natl Compr Canc Netw 11(5 Suppl):676–679
-
(2013)
J Natl Compr Canc Netw
, vol.11
, pp. 676-679
-
-
Anderson, K.C.1
-
9
-
-
8944220233
-
A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe francais du myelome
-
Attal M, Harousseau JL, Stoppa AM et al (1996) A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe francais du myelome. New Engl J Med 335:91–97
-
(1996)
New Engl J Med
, vol.335
, pp. 91-97
-
-
Attal, M.1
Harousseau, J.L.2
Stoppa, A.M.3
-
11
-
-
33846530661
-
A phase II study of bortezomib in mantle cell lymphoma: The National Cancer Institute of Canada Clinical Trials Group trial IND.150
-
Belch A, Kouroukis CT, Crump M et al (2007) A phase II study of bortezomib in mantle cell lymphoma: the National Cancer Institute of Canada Clinical Trials Group trial IND.150. Ann Oncol 18:116–121
-
(2007)
Ann Oncol
, vol.18
, pp. 116-121
-
-
Belch, A.1
Kouroukis, C.T.2
Crump, M.3
-
13
-
-
33644916110
-
Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma
-
Berenson JR, Yang HH, Sadler K et al (2006) Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma. J Clin Oncol 24:937–944
-
(2006)
J Clin Oncol
, vol.24
, pp. 937-944
-
-
Berenson, J.R.1
Yang, H.H.2
Sadler, K.3
-
14
-
-
33846691618
-
Extended follow-up of outcome measures in multiple myeloma patients treated on a phase I study with bortezomib and pegylated liposomal doxorubicin
-
Biehn SE, Moore DT, Voorhees PM et al (2007) Extended follow-up of outcome measures in multiple myeloma patients treated on a phase I study with bortezomib and pegylated liposomal doxorubicin. Ann Hematol 86:211–216
-
(2007)
Ann Hematol
, vol.86
, pp. 211-216
-
-
Biehn, S.E.1
Moore, D.T.2
Voorhees, P.M.3
-
15
-
-
17944381821
-
Increased conventional chemotherapy does not improve survival in multiple myeloma: Longterm results of two PETHEMA trials including 914 patients
-
Bladé J, San Miguel JF, Fontanillas M et al (2001) Increased conventional chemotherapy does not improve survival in multiple myeloma: longterm results of two PETHEMA trials including 914 patients. Hematol J 2:272–278
-
(2001)
Hematol J
, vol.2
, pp. 272-278
-
-
Bladé, J.1
San Miguel, J.F.2
Fontanillas, M.3
-
16
-
-
16544389047
-
Phase I study of the proteasome inhibitor bortezomib in pediatric patients with refractory solid tumors: A Children’s Oncology Group study (ADVL0015)
-
Blaney SM, Bernstein M, Neville K et al (2004) Phase I study of the proteasome inhibitor bortezomib in pediatric patients with refractory solid tumors: A Children’s Oncology Group study (ADVL0015). J Clin Oncol 22:4804–4809
-
(2004)
J Clin Oncol
, vol.22
, pp. 4804-4809
-
-
Blaney, S.M.1
Bernstein, M.2
Neville, K.3
-
17
-
-
33645541393
-
Degrade to create: Developmental requirements for ubiquitinmediated proteolysis during early C. Elegans embryogenesis
-
Bowerman B, Kurz T (2006) Degrade to create: developmental requirements for ubiquitinmediated proteolysis during early C. elegans embryogenesis. Development 133:773–784
-
(2006)
Development
, vol.133
, pp. 773-784
-
-
Bowerman, B.1
Kurz, T.2
-
18
-
-
0033176770
-
The base of the proteasome regulatory particle exhibits chaperone-like activity
-
Braun BC, Glickman M, Kraft R, Dahlmann B, Kloetzel PM, Finley D, Schmidt M (1999) The base of the proteasome regulatory particle exhibits chaperone-like activity. Nat Cell Biol 1:221–226
-
(1999)
Nat Cell Biol
, vol.1
, pp. 221-226
-
-
Braun, B.C.1
Glickman, M.2
Kraft, R.3
Dahlmann, B.4
Kloetzel, P.M.5
Finley, D.6
Schmidt, M.7
-
19
-
-
0034652143
-
Subcellular localization of proteasomes and their regulatory complexes in mammalian cells
-
Brooks P, Fuertes G, Murray RZ, Bose S, Knecht E, Rechsteiner MC, Hendil KB, Tanaka K, Dyson J, Rivett J (2000) Subcellular localization of proteasomes and their regulatory complexes in mammalian cells. Biochem J 346(Pt 1):155–161
-
(2000)
Biochem J
, vol.346
, Issue.1
, pp. 155-161
-
-
Brooks, P.1
Fuertes, G.2
Murray, R.Z.3
Bose, S.4
Knecht, E.5
Rechsteiner, M.C.6
Hendil, K.B.7
Tanaka, K.8
Dyson, J.9
Rivett, J.10
-
20
-
-
6444244370
-
Melphalan-prednisone versus alternating combination VAD/MP or VND/MP as primary therapy for multiple myeloma: Final analysis of a randomized clinical study
-
Cavo M, Benni M, Ronconi S et al (2002) Melphalan-prednisone versus alternating combination VAD/MP or VND/MP as primary therapy for multiple myeloma: final analysis of a randomized clinical study. Haematologica 87:934–942
-
(2002)
Haematologica
, vol.87
, pp. 934-942
-
-
Cavo, M.1
Benni, M.2
Ronconi, S.3
-
21
-
-
34248195600
-
Final results of a phase II study of bortezomib (Velcade) in combination with liposomal doxorubicin (Doxil) and thalidomide (VDT) demonstrate a sustained high response rate in patients (pts) with relapsed (rel) or refractory (ref) multiple myeloma
-
Chanan-Khan AA, Padmanabhan S, Miller KC et al (2006) Final results of a phase II study of bortezomib (Velcade) in combination with liposomal doxorubicin (Doxil) and thalidomide (VDT) demonstrate a sustained high response rate in patients (pts) with relapsed (rel) or refractory (ref) multiple myeloma. In: Updated data presented at the 2006 annual meeting of the American Society of Hematology. Blood vol 108, p 1010a
-
(2006)
Updated Data Presented at the 2006 Annual Meeting of the American Society of Hematology. Blood
, vol.108
, pp. 1010
-
-
Chanan-Khan, A.A.1
Padmanabhan, S.2
Miller, K.C.3
-
22
-
-
33947201310
-
Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: A multicenter retrospective study
-
Chanan-Khan AA, Kaufman JL, Mehta J et al (2007) Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: a multicenter retrospective study. Blood 109:2604–2606
-
(2007)
Blood
, vol.109
, pp. 2604-2606
-
-
Chanan-Khan, A.A.1
Kaufman, J.L.2
Mehta, J.3
-
23
-
-
0030041147
-
Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kB
-
Chauhan D, Uchiyama H, Akbarali Y et al (1996) Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kB. Blood 87:1104–1112
-
(1996)
Blood
, vol.87
, pp. 1104-1112
-
-
Chauhan, D.1
Uchiyama, H.2
Akbarali, Y.3
-
24
-
-
27644562277
-
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib
-
Chauhan D, Catley L, Li G et al (2005) A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib. Cancer Cell 8:407–419
-
(2005)
Cancer Cell
, vol.8
, pp. 407-419
-
-
Chauhan, D.1
Catley, L.2
Li, G.3
-
25
-
-
34248159391
-
Bortezomib is active in patients with untreated or relapsed Waldenstrom’s macroglobulinemia: A phase II study of the National Cancer Institute of Canada Clinical Trials Group
-
Chen CI, Kouroukis CT, White D et al (2007) Bortezomib is active in patients with untreated or relapsed Waldenstrom’s macroglobulinemia: a phase II study of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25:1570–1575
-
(2007)
J Clin Oncol
, vol.25
, pp. 1570-1575
-
-
Chen, C.I.1
Kouroukis, C.T.2
White, D.3
-
26
-
-
41549164880
-
Current status and future prospect for satraplatin: An oral platinum analogue
-
Choy H, Park C, Yao M (2008) Current status and future prospect for satraplatin: an oral platinum analogue. Clin Cancer Res 14:1618–1623
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1618-1623
-
-
Choy, H.1
Park, C.2
Yao, M.3
-
27
-
-
23944474593
-
Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
-
Ciechanover A (2005) Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Cell Death Differ 12:1178–1190
-
(2005)
Cell Death Differ
, vol.12
, pp. 1178-1190
-
-
Ciechanover, A.1
-
28
-
-
0034065822
-
Ubiquitin-mediated proteolysis: Biological regulation via destruction
-
Ciechanover A, Orian A, Schwartz AL (2000) Ubiquitin-mediated proteolysis: biological regulation via destruction. BioEssays 22:442–451
-
(2000)
Bioessays
, vol.22
, pp. 442-451
-
-
Ciechanover, A.1
Orian, A.2
Schwartz, A.L.3
-
29
-
-
2542481724
-
Phase I study of bortezomib in refractory or relapsed acute leukemias
-
Cortes J, Thomas D, Koller C et al (2004) Phase I study of bortezomib in refractory or relapsed acute leukemias. Clin Cancer Res 10:3371–3376
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3371-3376
-
-
Cortes, J.1
Thomas, D.2
Koller, C.3
-
30
-
-
0035328584
-
Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kB inhibition
-
Cusack JC Jr, Liu R, Houston M et al (2001) Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kB inhibition. Cancer Res 61:3535–3540
-
(2001)
Cancer Res
, vol.61
, pp. 3535-3540
-
-
Cusack, J.C.1
Liu, R.2
Houston, M.3
-
31
-
-
34249915205
-
The combination of cyclophosphamide, velcade and dexamethasone (CVD) induces high response rates with minimal toxicity compared to velcade alone (V) and velcade plus dexamethasone (VD)
-
Davies FE, Wu P, Srikanth M et al (2006) The combination of cyclophosphamide, velcade and dexamethasone (CVD) induces high response rates with minimal toxicity compared to velcade alone (V) and velcade plus dexamethasone (VD). In: Updated data presented at the 2006 annual meeting of the American Society of Hematology. Blood vol 108, p 1009a
-
(2006)
Updated Data Presented at the 2006 Annual Meeting of the American Society of Hematology. Blood
, vol.108
, pp. 1009
-
-
Davies, F.E.1
Wu, P.2
Srikanth, M.3
-
32
-
-
0031906567
-
The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-a-initiated apoptosis
-
Delic J, Masdehors P, Omura S et al (1998) The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-a-initiated apoptosis. Br J Cancer 77:1103–1107
-
(1998)
Br J Cancer
, vol.77
, pp. 1103-1107
-
-
Delic, J.1
Masdehors, P.2
Omura, S.3
-
33
-
-
34249085552
-
Proteasomes: Machines for all reasons
-
Demartino GN, Gillette TG (2007) Proteasomes: machines for all reasons. Cell 129:659–662
-
(2007)
Cell
, vol.129
, pp. 659-662
-
-
Demartino, G.N.1
Gillette, T.G.2
-
34
-
-
34447116376
-
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
-
Demo SD, Kirk CJ, Aujay MA et al (2007) Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res 67:6383–6391
-
(2007)
Cancer Res
, vol.67
, pp. 6383-6391
-
-
Demo, S.D.1
Kirk, C.J.2
Aujay, M.A.3
-
35
-
-
0043203040
-
Prospective randomized comparison of vincristine, doxorubicin and dexamethasone (VAD) administered as intravenous bolus injection and VAD with liposomal doxorubicin as first-line treatment in multiple myeloma
-
Dimopoulos MA, Pouli A, Zervas K et al (2003) Prospective randomized comparison of vincristine, doxorubicin and dexamethasone (VAD) administered as intravenous bolus injection and VAD with liposomal doxorubicin as first-line treatment in multiple myeloma. Ann Oncol 14:1039–1044
-
(2003)
Ann Oncol
, vol.14
, pp. 1039-1044
-
-
Dimopoulos, M.A.1
Pouli, A.2
Zervas, K.3
-
36
-
-
29144514707
-
Treatment of relapsed or refractory Waldenstrom’s macroglobulinemia with bortezomib
-
Dimopoulos MA, Anagnostopoulos A, Kyrtsonis MC et al (2005) Treatment of relapsed or refractory Waldenstrom’s macroglobulinemia with bortezomib. Haematologica 90:1655–1658
-
(2005)
Haematologica
, vol.90
, pp. 1655-1658
-
-
Dimopoulos, M.A.1
Anagnostopoulos, A.2
Kyrtsonis, M.C.3
-
37
-
-
20944450476
-
A phase and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (Bortezomib, velcade), in patients with advanced cancer
-
Dy GK, Thomas JP, Wilding G et al (2005) A phase and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (bortezomib, velcade), in patients with advanced cancer. Clin Cancer Res 11:3410–3416
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3410-3416
-
-
Dy, G.K.1
Thomas, J.P.2
Wilding, G.3
-
38
-
-
0037569481
-
Proteasome inhibition: A new anti-inflammatory strategy
-
Elliott PJ, Zollner TM, Boehncke WH (2003) Proteasome inhibition: a new anti-inflammatory strategy. J Mol Med 81:235–245
-
(2003)
J Mol Med
, vol.81
, pp. 235-245
-
-
Elliott, P.J.1
Zollner, T.M.2
Boehncke, W.H.3
-
39
-
-
32644438680
-
Dexamethasone-based regimens versus melphalanprednisone for elderly multiple myeloma patients ineligible for high-dose therapy
-
Facon T, Mary JY, Pegourie B et al (2006) Dexamethasone-based regimens versus melphalanprednisone for elderly multiple myeloma patients ineligible for high-dose therapy. Blood 107:1292–1298
-
(2006)
Blood
, vol.107
, pp. 1292-1298
-
-
Facon, T.1
Mary, J.Y.2
Pegourie, B.3
-
40
-
-
0037455147
-
Salinosporamide A: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora
-
Feling RH, Buchanan GO, Mincer TJ et al (2003) Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora. Angew Chem Int Ed Engl 42:355–357
-
(2003)
Angew Chem Int Ed Engl
, vol.42
, pp. 355-357
-
-
Feling, R.H.1
Buchanan, G.O.2
Mincer, T.J.3
-
41
-
-
0032502719
-
Lactacystin, proteasome function, and cell fate
-
Fenteany G, Schreiber SL (1998) Lactacystin, proteasome function, and cell fate. J Biol Chem 273:8545–8548
-
(1998)
J Biol Chem
, vol.273
, pp. 8545-8548
-
-
Fenteany, G.1
Schreiber, S.L.2
-
42
-
-
33750625445
-
Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma
-
Fisher RI, Bernstein SH, Kahl BS et al (2006) Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma. J Clin Oncol 24:4867–4874
-
(2006)
J Clin Oncol
, vol.24
, pp. 4867-4874
-
-
Fisher, R.I.1
Bernstein, S.H.2
Kahl, B.S.3
-
44
-
-
0242344011
-
The role of ubiquitin-proteasome pathway in oncogenic signaling
-
Fuchs SY (2002) The role of ubiquitin-proteasome pathway in oncogenic signaling. Cancer Biol Ther 1:337–341
-
(2002)
Cancer Biol Ther
, vol.1
, pp. 337-341
-
-
Fuchs, S.Y.1
-
46
-
-
33644890183
-
High-dose chemotherapy with autologous hematopoietic stem cell transplantation in patients with multiple myeloma
-
Gertz MA, Lacy MQ, Dispenzieri A et al (2006) High-dose chemotherapy with autologous hematopoietic stem cell transplantation in patients with multiple myeloma. Expet Rev Anticancer Ther 6:343–360
-
(2006)
Expet Rev Anticancer Ther
, vol.6
, pp. 343-360
-
-
Gertz, M.A.1
Lacy, M.Q.2
Dispenzieri, A.3
-
47
-
-
0346727127
-
Protein degradation and protection against misfolded or damaged proteins
-
Goldberg AL (2003) Protein degradation and protection against misfolded or damaged proteins. Nature 426:895–899
-
(2003)
Nature
, vol.426
, pp. 895-899
-
-
Goldberg, A.L.1
-
48
-
-
20044396543
-
Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin’s lymphoma
-
Goy A, Younes A, McLaughlin P et al (2005) Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin’s lymphoma. J Clin Oncol 23:667–675
-
(2005)
J Clin Oncol
, vol.23
, pp. 667-675
-
-
Goy, A.1
Younes, A.2
McLaughlin, P.3
-
49
-
-
0033766480
-
A gated channel into the proteasome core particle
-
Groll M, Bajorek M, Kohler A, Moroder L, Rubin DM, Huber R, Glickman MH, Finley D (2000) A gated channel into the proteasome core particle. Nat Struct Biol 7:1062–1067
-
(2000)
Nat Struct Biol
, vol.7
, pp. 1062-1067
-
-
Groll, M.1
Bajorek, M.2
Kohler, A.3
Moroder, L.4
Rubin, D.M.5
Huber, R.6
Glickman, M.H.7
Finley, D.8
-
50
-
-
44649149612
-
VELCADE/dexamethasone (Vel/D) versus VAD as induction treatment prior to autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma (MM): Updated results of the IFM 2005/01 trial
-
Harousseau JL, Mathiot C, Attal M et al (2007) VELCADE/dexamethasone (Vel/D) versus VAD as induction treatment prior to autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma (MM): updated results of the IFM 2005/01 trial. Blood 110:139a
-
(2007)
Blood
, vol.110
, pp. 139
-
-
Harousseau, J.L.1
Mathiot, C.2
Attal, M.3
-
51
-
-
62649159169
-
Bortezomib/dexamethasone versus VAD as induction prior to autologous stem cell transplantation (ASCT) in previously untreated multiple myeloma (MM): Updated data from IFM 2005/01 trial
-
Harousseau JL, Mathiot C, Attal M et al (2008) Bortezomib/dexamethasone versus VAD as induction prior to autologous stem cell transplantation (ASCT) in previously untreated multiple myeloma (MM): updated data from IFM 2005/01 trial. J Clin Oncol 26:455s
-
(2008)
J Clin Oncol
, vol.26
, pp. 455
-
-
Harousseau, J.L.1
Mathiot, C.2
Attal, M.3
-
52
-
-
5644267858
-
Randomized comparison of dexamethasone combined with melphalan versus melphalan with prednisone in the treatment of elderly patients with multiple myeloma
-
Hernandez JM, Garcia-Sanz R, Golvano E et al (2004) Randomized comparison of dexamethasone combined with melphalan versus melphalan with prednisone in the treatment of elderly patients with multiple myeloma. Br J Haematol 127:159–164
-
(2004)
Br J Haematol
, vol.127
, pp. 159-164
-
-
Hernandez, J.M.1
Garcia-Sanz, R.2
Golvano, E.3
-
54
-
-
0035211881
-
Novel therapies targeting the myeloma cell and its bone marrow micro environment
-
(Review)
-
Hideshima T, Chauhan D, Podar K et al (2001) Novel therapies targeting the myeloma cell and its bone marrow micro environment. Semin Oncol (6):607–612 (Review)
-
(2001)
Semin Oncol
, Issue.6
, pp. 607-612
-
-
Hideshima, T.1
Chauhan, D.2
Podar, K.3
-
55
-
-
18544367201
-
NF-jB as a therapeutic target in multiple myeloma
-
Hideshima T, Chauhan D, Richardson P et al (2002) NF-jB as a therapeutic target in multiple myeloma. J Biol Chem 277:16639–16647
-
(2002)
J Biol Chem
, vol.277
, pp. 16639-16647
-
-
Hideshima, T.1
Chauhan, D.2
Richardson, P.3
-
56
-
-
9944242716
-
Chauhan D et al (2004) p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells
-
Hideshima T, Podar K, Chauhan D et al (2004) p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells. Oncogene 23:8766–8776
-
Oncogene
, vol.23
, pp. 8766-8776
-
-
Hideshima, T.1
Podar, K.2
-
57
-
-
20844435806
-
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
-
Hideshima T, Bradner JE, Wong J et al (2005) Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci USA 102:8567–8572
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8567-8572
-
-
Hideshima, T.1
Bradner, J.E.2
Wong, J.3
-
58
-
-
33646577479
-
Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
-
Hideshima T, Catley L, Yasui H et al (2006) Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood 107:4053–4062
-
(2006)
Blood
, vol.107
, pp. 4053-4062
-
-
Hideshima, T.1
Catley, L.2
Yasui, H.3
-
59
-
-
34247190754
-
LMP2-specific inhibitors: Chemical genetic tools for proteasome biology
-
Ho YK, Bargagna-Mohan P, Wehenkel M, Mohan R, Kim KB (2007) LMP2-specific inhibitors: chemical genetic tools for proteasome biology. Chem Biol 14:419–430
-
(2007)
Chem Biol
, vol.14
, pp. 419-430
-
-
Ho, Y.K.1
Bargagna-Mohan, P.2
Wehenkel, M.3
Mohan, R.4
Kim, K.B.5
-
60
-
-
33846873224
-
Bortezomib (VelcadeTM) + AdriamycinTM + thalidomide + dexamethasone (VATD) as an effective regimen in patients with refractory or relapsed multiple myeloma (MM)
-
Hollmig K, Stover J, Talamo G et al (2004) Bortezomib (VelcadeTM) + AdriamycinTM + thalidomide + dexamethasone (VATD) as an effective regimen in patients with refractory or relapsed multiple myeloma (MM). In: Updated data presented at the 2004 annual meeting of the American Society of Hematology. Blood, vol 104, p 659a
-
(2004)
Updated Data Presented at the 2004 Annual Meeting of the American Society of Hematology. Blood
, vol.104
, pp. 659
-
-
Hollmig, K.1
Stover, J.2
Talamo, G.3
-
61
-
-
0029564960
-
Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells
-
Imajoh-Ohmi KT, Sugiyama S, Tanaka K, Omura S, Kikuchi H (1995) Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells. Biochem Biophys Res Commun 217:1070–1077
-
(1995)
Biochem Biophys Res Commun
, vol.217
, pp. 1070-1077
-
-
Imajoh-Ohmi, K.T.1
Sugiyama, S.2
Tanaka, K.3
Omura, S.4
Kikuchi, H.5
-
62
-
-
5644250621
-
A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma
-
Jagannath S, Barlogie B, Berenson J et al (2004) A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol 127:165–172
-
(2004)
Br J Haematol
, vol.127
, pp. 165-172
-
-
Jagannath, S.1
Barlogie, B.2
Berenson, J.3
-
63
-
-
20044381304
-
Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impaired renal function
-
Jagannath S, Barlogie B, Berenson JR et al (2005) Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impaired renal function. Cancer 103:1195–1200
-
(2005)
Cancer
, vol.103
, pp. 1195-1200
-
-
Jagannath, S.1
Barlogie, B.2
Berenson, J.R.3
-
64
-
-
33845518467
-
Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials
-
Jagannath S, Richardson PG, Sonneveld P et al (2007) Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials. Leukemia 21:151–157
-
(2007)
Leukemia
, vol.21
, pp. 151-157
-
-
Jagannath, S.1
Richardson, P.G.2
Sonneveld, P.3
-
65
-
-
0036483901
-
Deadly encounter: Ubiquitin meets apoptosis
-
Jesenberger V, Jentsch S (2002) Deadly encounter: ubiquitin meets apoptosis. Nat Rev Mol Cell Biol 3:112–1121
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 112-1121
-
-
Jesenberger, V.1
Jentsch, S.2
-
66
-
-
1042278905
-
Proteasome and peptidase function in MHC-class-I-mediated antigen presentation
-
Kloetzel PM, Ossendorp F (2004) Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr Opin Immunol 16:76–81
-
(2004)
Curr Opin Immunol
, vol.16
, pp. 76-81
-
-
Kloetzel, P.M.1
Ossendorp, F.2
-
67
-
-
38849144480
-
Adjusted dose lenalidomide is safe and effective in patients with deletion (5q) myelodysplastic syndrome and severe renal impairment
-
Knop S, Einsele H, Bargou R et al (2008) Adjusted dose lenalidomide is safe and effective in patients with deletion (5q) myelodysplastic syndrome and severe renal impairment. Leuk Lymphoma 49(2):346–349
-
(2008)
Leuk Lymphoma
, vol.49
, Issue.2
, pp. 346-349
-
-
Knop, S.1
Einsele, H.2
Bargou, R.3
-
68
-
-
0033525589
-
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
-
Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (1999) A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell 96:635–644
-
(1999)
Cell
, vol.96
, pp. 635-644
-
-
Koegl, M.1
Hoppe, T.2
Schlenker, S.3
Ulrich, H.D.4
Mayer, T.U.5
Jentsch, S.6
-
69
-
-
0034964524
-
The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release
-
Kohler A, Cascio P, Leggett DS, Woo KM, Goldberg AL, Finley D (2001) The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release. Mol Cell 7:1143–1152
-
(2001)
Mol Cell
, vol.7
, pp. 1143-1152
-
-
Kohler, A.1
Cascio, P.2
Leggett, D.S.3
Woo, K.M.4
Goldberg, A.L.5
Finley, D.6
-
71
-
-
14744278225
-
Bortezomib in combination with dexamethasone for relapsed multiple myeloma
-
Kropff MH, Bisping G, Wenning D et al (2005a) Bortezomib in combination with dexamethasone for relapsed multiple myeloma. Leuk Res 29:587–590
-
(2005)
Leuk Res
, vol.29
, pp. 587-590
-
-
Kropff, M.H.1
Bisping, G.2
Wenning, D.3
-
73
-
-
36148944490
-
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against pre-clinical models of multiple myeloma
-
Kuhn DJ, Chen Q, Voorhees PM et al (2007) Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against pre-clinical models of multiple myeloma. Blood 110:3281–3290
-
(2007)
Blood
, vol.110
, pp. 3281-3290
-
-
Kuhn, D.J.1
Chen, Q.2
Voorhees, P.M.3
-
75
-
-
41549164459
-
The epothilones: Translating from the laboratory to the clinic
-
Lee JL, Swain SM (2008) The epothilones: translating from the laboratory to the clinic. Clin Cancer Res 14:1643–1649
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1643-1649
-
-
Lee, J.L.1
Swain, S.M.2
-
76
-
-
34247330985
-
Health-related quality of life (HRQL) associated with bortezomib compared with high-dose dexamethasone in relapsed multiple myeloma (MM): Results from APEX study
-
Lee SJ, Richardson PG, Sonneveld P et al (2005) Health-related quality of life (HRQL) associated with bortezomib compared with high-dose dexamethasone in relapsed multiple myeloma (MM): results from APEX study. J Clin Oncol 23:568s
-
(2005)
J Clin Oncol
, vol.23
, pp. 568
-
-
Lee, S.J.1
Richardson, P.G.2
Sonneveld, P.3
-
77
-
-
33947258767
-
Low dose bortezomib, dexamethasone, thalidomide plus liposomal doxorubicin in relapsed and refractory myeloma
-
Leoni F, Casini C, Breschi C et al (2006) Low dose bortezomib, dexamethasone, thalidomide plus liposomal doxorubicin in relapsed and refractory myeloma. In: Updated data presented at the 2006 annual meeting of the European Hematology Association. Haematologica, vol 91, p 281
-
(2006)
Updated Data Presented at the 2006 Annual Meeting of the European Hematology Association. Haematologica
, vol.91
, pp. 281
-
-
Leoni, F.1
Casini, C.2
Breschi, C.3
-
78
-
-
0036690648
-
PS-341, a novel proteasome inhibitor, induces Bcl-2 phosphorylation and cleavage in association with G2-M phase arrest and apoptosis
-
Ling YH, Liebes L, Ng B et al (2002) PS-341, a novel proteasome inhibitor, induces Bcl-2 phosphorylation and cleavage in association with G2-M phase arrest and apoptosis. Mol Cancer Ther 1:841–849
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 841-849
-
-
Ling, Y.H.1
Liebes, L.2
Ng, B.3
-
79
-
-
28444436266
-
Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma
-
Lonial S, Waller EK, Richardson PG et al (2005) Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma. Blood 106:3777–3784
-
(2005)
Blood
, vol.106
, pp. 3777-3784
-
-
Lonial, S.1
Waller, E.K.2
Richardson, P.G.3
-
80
-
-
0032510958
-
Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrateinduced transmembrane domain interactions
-
Loo TW, Clarke DM (1998) Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrateinduced transmembrane domain interactions. J Biol Chem 273:14671–14674
-
(1998)
J Biol Chem
, vol.273
, pp. 14671-14674
-
-
Loo, T.W.1
Clarke, D.M.2
-
81
-
-
0032862993
-
The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: Potential for a role in cancer chemotherapy
-
Loo TW, Clarke DM (1999) The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: potential for a role in cancer chemotherapy. FASEB J 7:1724–1732
-
(1999)
FASEB J
, vol.7
, pp. 1724-1732
-
-
Loo, T.W.1
Clarke, D.M.2
-
82
-
-
0037342894
-
The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents
-
Ma MH, Yang HH, Parker K et al (2003) The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res 3:1136–1144
-
(2003)
Clin Cancer Res
, vol.3
, pp. 1136-1144
-
-
Ma, M.H.1
Yang, H.H.2
Parker, K.3
-
83
-
-
33845363835
-
A phase I and pharmacologic study of sequences of the proteasome inhibitor, bortezomib (PS-341, velcade), in combination with paclitaxel and carboplatin in patients with advanced malignancies
-
Ma C, Mandrekar SJ, Alberts SR et al (2007) A phase I and pharmacologic study of sequences of the proteasome inhibitor, bortezomib (PS-341, velcade), in combination with paclitaxel and carboplatin in patients with advanced malignancies. Cancer Chemother Pharmacol 59:207–215
-
(2007)
Cancer Chemother Pharmacol
, vol.59
, pp. 207-215
-
-
Ma, C.1
Mandrekar, S.J.2
Alberts, S.R.3
-
84
-
-
33748287079
-
Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: Results of a multicenter phase 1/2 study
-
Mateos MV, Hernandez JM, Hernandez MT et al (2006) Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study. Blood 108:2165–2172
-
(2006)
Blood
, vol.108
, pp. 2165-2172
-
-
Mateos, M.V.1
Hernandez, J.M.2
Hernandez, M.T.3
-
86
-
-
33644785935
-
Phase I trial of bortezomib in combination with docetaxel in patients with advanced solid tumors
-
Messersmith WA, Baker SD, Lassiter L et al (2006) Phase I trial of bortezomib in combination with docetaxel in patients with advanced solid tumors. Clin Cancer Res 12:1270–1275
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1270-1275
-
-
Messersmith, W.A.1
Baker, S.D.2
Lassiter, L.3
-
87
-
-
0036624741
-
Biologic sequelae of nuclear factor-jB blockade in multiple myeloma: Therapeutic applications
-
Mitsiades N, Mitsiades CS, Poulaki V et al (2002) Biologic sequelae of nuclear factor-jB blockade in multiple myeloma: therapeutic applications. Blood 99:4079–4086
-
(2002)
Blood
, vol.99
, pp. 4079-4086
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
-
88
-
-
0037443551
-
The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications
-
Mitsiades N, Mitsiades CS, Richardson PG et al (2003) The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood 101:2377–2380
-
(2003)
Blood
, vol.101
, pp. 2377-2380
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Richardson, P.G.3
-
89
-
-
31544436323
-
Antimyeloma activity of heat shock protein-90 inhibition
-
Mitsiades CS, Mitsiades NS, McMullan CJ et al (2006) Antimyeloma activity of heat shock protein-90 inhibition. Blood 107:1092–1100
-
(2006)
Blood
, vol.107
, pp. 1092-1100
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
-
90
-
-
32844455809
-
Reversal of advanced renal dysfunction on bortezomib treatment in multiple myeloma patients
-
Mohrbacher A, Levine AM (2005) Reversal of advanced renal dysfunction on bortezomib treatment in multiple myeloma patients. J Clin Oncol 23:612s
-
(2005)
J Clin Oncol
, vol.23
, pp. 612
-
-
Mohrbacher, A.1
Levine, A.M.2
-
91
-
-
84872806944
-
Pharmacokinetic, pharmacodynamic and covariate analysis of subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma
-
Moreau P, Karamanesht II, Domnikova N, Kyselyova MY, Vilchevska KV, Doronin VA, Schmidt A, Hulin C, Leleu X, Esseltine DL, Venkatakrishnan K, Skee D, Feng H, Girgis S, Cakana A, van de Velde H, Deraedt W, Facon T (2012) Pharmacokinetic, pharmacodynamic and covariate analysis of subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma. Clin Pharmacokinet 51(12):823–829
-
(2012)
Clin Pharmacokinet
, vol.51
, Issue.12
, pp. 823-829
-
-
Moreau, P.1
Karamanesht, I.I.2
Domnikova, N.3
Kyselyova, M.Y.4
Vilchevska, K.V.5
Doronin, V.A.6
Schmidt, A.7
Hulin, C.8
Leleu, X.9
Esseltine, D.L.10
Venkatakrishnan, K.11
Skee, D.12
Feng, H.13
Girgis, S.14
Cakana, A.15
Van De Velde, H.16
Deraedt, W.17
Facon, T.18
-
92
-
-
0037335034
-
How the ubiquitin-proteasome system controls transcription
-
Muratani M, Tansey WP (2003) How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol 4:192–201
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 192-201
-
-
Muratani, M.1
Tansey, W.P.2
-
93
-
-
0344076348
-
Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: An overview of 6, 633 patients from 27 randomized trials
-
Myeloma Trialists’ Collaborative Group
-
Myeloma Trialists’ Collaborative Group (1998) Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: an overview of 6, 633 patients from 27 randomized trials. J Clin Oncol 16:3832–3842
-
(1998)
J Clin Oncol
, vol.16
, pp. 3832-3842
-
-
-
94
-
-
0036678959
-
Role and function of the 26 S proteasome in proliferation and apoptosis
-
Naujokat C, Hoffmann S (2002) Role and function of the 26 S proteasome in proliferation and apoptosis. Lab Invest 82:965–980
-
(2002)
Lab Invest
, vol.82
, pp. 965-980
-
-
Naujokat, C.1
Hoffmann, S.2
-
95
-
-
29244470510
-
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells
-
Nawrocki ST, Carew JS, Dunner K Jr et al (2005a) Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. Cancer Res 65:11510–11519
-
(2005)
Cancer Res
, vol.65
, pp. 11510-11519
-
-
Nawrocki, S.T.1
Carew, J.S.2
Dunner, K.3
-
96
-
-
29244454269
-
Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis
-
Nawrocki ST, Carew JS, Pino MS et al (2005b) Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. Cancer Res 65:11658–11666
-
(2005)
Cancer Res
, vol.65
, pp. 11658-11666
-
-
Nawrocki, S.T.1
Carew, J.S.2
Pino, M.S.3
-
97
-
-
33845520806
-
Proteasome inhibitors: Antitumor effects and beyond
-
Nencioni A, Grunebach F, Patrone F, Ballestrero A, Brossart P (2007) Proteasome inhibitors: antitumor effects and beyond. Leukemia 21:30–36
-
(2007)
Leukemia
, vol.21
, pp. 30-36
-
-
Nencioni, A.1
Grunebach, F.2
Patrone, F.3
Ballestrero, A.4
Brossart, P.5
-
98
-
-
20044376092
-
Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non–Hodgkin’s lymphoma and mantle cell lymphoma
-
O’Connor OA, Wright J, Moskowitz C et al (2005) Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non–Hodgkin’s lymphoma and mantle cell lymphoma. J Clin Oncol 23:676–684
-
(2005)
J Clin Oncol
, vol.23
, pp. 676-684
-
-
O’Connor, O.A.1
Wright, J.2
Moskowitz, C.3
-
99
-
-
33744539521
-
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
-
Obeng EA, Carlson LM, Gutman DM et al (2006) Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 107:4907–4916
-
(2006)
Blood
, vol.107
, pp. 4907-4916
-
-
Obeng, E.A.1
Carlson, L.M.2
Gutman, D.M.3
-
100
-
-
0036020941
-
NF-jB as a therapeutic target in cancer
-
Orlowski RZ, Baldwin AS (2002) NF-jB as a therapeutic target in cancer. Trends Mol Med 8:385–389
-
(2002)
Trends Mol Med
, vol.8
, pp. 385-389
-
-
Orlowski, R.Z.1
Baldwin, A.S.2
-
101
-
-
0032189685
-
Tumor growth inhibition induced in a murine model of human Burkitt’s lymphoma by a proteasome inhibitor
-
Orlowski RZ, Eswara JR, Lafond-Walker A et al (1998) Tumor growth inhibition induced in a murine model of human Burkitt’s lymphoma by a proteasome inhibitor. Cancer Res 58:4342–4348
-
(1998)
Cancer Res
, vol.58
, pp. 4342-4348
-
-
Orlowski, R.Z.1
Eswara, J.R.2
Lafond-Walker, A.3
-
102
-
-
0037008780
-
Evidence that inhibition of p44/42 mitogen-activated protein kinase signaling is a factor in proteasome inhibitor-mediated apoptosis
-
Orlowski RZ, Small GW, Shi YY (2002a) Evidence that inhibition of p44/42 mitogen-activated protein kinase signaling is a factor in proteasome inhibitor-mediated apoptosis. J Biol Chem 277:27864–27871
-
(2002)
J Biol Chem
, vol.277
, pp. 27864-27871
-
-
Orlowski, R.Z.1
Small, G.W.2
Shi, Y.Y.3
-
103
-
-
0037111832
-
Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
-
Orlowski RZ, Stinchcombe TE, Mitchell BS et al (2002b) Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 20:4420–4427
-
(2002)
J Clin Oncol
, vol.20
, pp. 4420-4427
-
-
Orlowski, R.Z.1
Stinchcombe, T.E.2
Mitchell, B.S.3
-
104
-
-
33646538333
-
Identification of novel inhibitors that specifically target the immunoproteasome, and selectively induce apoptosis in multiple myeloma and other immunoproteasome-expressing model systems
-
abstract 248
-
Orlowski RZ, Kuhn DJ, Small GW, Michaud C, Orlowski M (2005a) Identification of novel inhibitors that specifically target the immunoproteasome, and selectively induce apoptosis in multiple myeloma and other immunoproteasome-expressing model systems. Blood 106:76a (abstract 248)
-
(2005)
Blood
, vol.106
, pp. 76
-
-
Orlowski, R.Z.1
Kuhn, D.J.2
Small, G.W.3
Michaud, C.4
Orlowski, M.5
-
105
-
-
20144387627
-
Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies
-
Orlowski RZ, Voorhees PM, Garcia RA et al (2005b) Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. Blood 105:3058–3065
-
(2005)
Blood
, vol.105
, pp. 3058-3065
-
-
Orlowski, R.Z.1
Voorhees, P.M.2
Garcia, R.A.3
-
106
-
-
34249792782
-
DOXIL-MMY-3001 Study Investigators. The combination of pegylated liposomal doxorubicin and bortezomib significantly improves time to progression of patients with relapsed/refractory multiple myeloma compared with bortezomib alone: Results from a planned interim analysis of a randomized phase III study
-
Orlowski RZ, Zhuang SH, Parekh T et al (2006) DOXIL-MMY-3001 Study Investigators. The combination of pegylated liposomal doxorubicin and bortezomib significantly improves time to progression of patients with relapsed/refractory multiple myeloma compared with bortezomib alone: results from a planned interim analysis of a randomized phase III study. In: Updated data presented at the 2006 annual meeting of the American Society of Hematology. Blood, vol 108, p 124a
-
(2006)
Updated Data Presented at the 2006 Annual Meeting of the American Society of Hematology. Blood
, vol.108
, pp. 124
-
-
Orlowski, R.Z.1
Zhuang, S.H.2
Parekh, T.3
-
107
-
-
50249138003
-
Safety and antitumor efficacy of the proteasome inhibitor carfilzomib (PR-171) dosed for five consecutive days in hematologic malignancies: Phase I results
-
abstract 409
-
Orlowski RZ, Stewart K, Vallone M et al (2007) Safety and antitumor efficacy of the proteasome inhibitor carfilzomib (PR-171) dosed for five consecutive days in hematologic malignancies: phase I results. Blood 110:127a (abstract 409)
-
(2007)
Blood
, vol.110
, pp. 127
-
-
Orlowski, R.Z.1
Stewart, K.2
Vallone, M.3
-
108
-
-
33644843725
-
Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: Randomised controlled trial
-
Palumbo A, Bringhen S, Caravita T et al (2006) Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial. Lancet 367:825–831
-
(2006)
Lancet
, vol.367
, pp. 825-831
-
-
Palumbo, A.1
Bringhen, S.2
Caravita, T.3
-
109
-
-
33947575994
-
Bortezomib, melphalan, prednisone, and thalidomide for relapsed multiple myeloma
-
Palumbo A, Ambrosini MT, Benevolo G et al (2007) Bortezomib, melphalan, prednisone, and thalidomide for relapsed multiple myeloma. Blood 109:2767–2772
-
(2007)
Blood
, vol.109
, pp. 2767-2772
-
-
Palumbo, A.1
Ambrosini, M.T.2
Benevolo, G.3
-
110
-
-
66849142577
-
Prolonged therapy with bortezomib plus melphalan–prednisone (VMP) results in improved quality and duration of response in the phase III VISTA study in previously untreated multiple myeloma (MM)
-
Palumbo A, Schlag R, Khuageva N et al (2008) Prolonged therapy with bortezomib plus melphalan–prednisone (VMP) results in improved quality and duration of response in the phase III VISTA study in previously untreated multiple myeloma (MM). Haematologica 93:83
-
(2008)
Haematologica
, vol.93
, pp. 83
-
-
Palumbo, A.1
Schlag, R.2
Khuageva, N.3
-
111
-
-
2942692143
-
Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer
-
Papandreou CN, Daliani DD, Nix D et al (2004) Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer. J Clin Oncol 22:2108–2121
-
(2004)
J Clin Oncol
, vol.22
, pp. 2108-2121
-
-
Papandreou, C.N.1
Daliani, D.D.2
Nix, D.3
-
112
-
-
84884268262
-
The mechanism of action, pharmacokinetics, and clinical efficacy of carfilzomib for the treatment of multiple myeloma
-
Jul, (Epub ahead of print)
-
Pautasso C, Bringhen S, Cerrato C, Magarotto V, Palumbo A (2013) The mechanism of action, pharmacokinetics, and clinical efficacy of carfilzomib for the treatment of multiple myeloma. Expert Opin Drug Metab Toxicol, 9 Jul 2013 (Epub ahead of print)
-
(2013)
Expert Opin Drug Metab Toxicol
, vol.9
-
-
Pautasso, C.1
Bringhen, S.2
Cerrato, C.3
Magarotto, V.4
Palumbo, A.5
-
113
-
-
33748905522
-
Changes in Mcl-1 and Bim expression with bortezomib and melphalan therapy for multiple myeloma
-
Popat R, Goff L, Oakervee HE et al (2005) Changes in Mcl-1 and Bim expression with bortezomib and melphalan therapy for multiple myeloma. Blood 106:697a
-
(2005)
Blood
, vol.106
-
-
Popat, R.1
Goff, L.2
Oakervee, H.E.3
-
114
-
-
34548148380
-
A phase I/ II trial of bortezomib, low dose intravenous melphalan and dexamethasone for patients with relapsed multiple myeloma
-
Popat R, Williams C, Cook M et al (2006) A phase I/ II trial of bortezomib, low dose intravenous melphalan and dexamethasone for patients with relapsed multiple myeloma. In: Updated data presented at the 2006 annual meeting of the American Society of Hematology. Blood, vol 108, p 1011a
-
(2006)
Updated Data Presented at the 2006 Annual Meeting of the American Society of Hematology. Blood
, vol.108
, pp. 1011
-
-
Popat, R.1
Williams, C.2
Cook, M.3
-
117
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
Richardson PG, Barlogie B, Berenson J et al (2003) A phase 2 study of bortezomib in relapsed, refractory myeloma. New Engl J Med 348:2609–2617
-
(2003)
New Engl J Med
, vol.348
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
-
119
-
-
20444433230
-
Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
-
Richardson PG, Sonneveld P, Schuster MW et al (2005b) Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. New Engl J Med 352:2487–2498
-
(2005)
New Engl J Med
, vol.352
, pp. 2487-2498
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.W.3
-
120
-
-
33644844108
-
Extended follow-up of a phase II trial in relapsed, refractory multiple myeloma: Final time-to-event results from the SUMMIT trial
-
Richardson PG, Barlogie B, Berenson J et al (2006a) Extended follow-up of a phase II trial in relapsed, refractory multiple myeloma: final time-to-event results from the SUMMIT trial. Cancer 106:1316–1319
-
(2006)
Cancer
, vol.106
, pp. 1316-1319
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
-
121
-
-
33746010219
-
Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib
-
Richardson PG, Briemberg H, Jagannath S et al (2006b) Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib. J Clin Oncol 24:3113–3120
-
(2006)
J Clin Oncol
, vol.24
, pp. 3113-3120
-
-
Richardson, P.G.1
Briemberg, H.2
Jagannath, S.3
-
123
-
-
33748913900
-
Beyond single-agent bortezomib: Combination regimens in relapsed multiple myeloma
-
Richardson PG, Mitsiades C, Ghobrial I et al (2006d) Beyond single-agent bortezomib: combination regimens in relapsed multiple myeloma. Curr Opin Oncol 18:598–608
-
(2006)
Curr Opin Oncol
, vol.18
, pp. 598-608
-
-
Richardson, P.G.1
Mitsiades, C.2
Ghobrial, I.3
-
125
-
-
35148825003
-
Extended follow-up of a phase 3 trial in relapsed multiple myeloma: Final time-to-event results of the APEX trial
-
Richardson PG, Sonneveld P, Schuster M et al (2007a) Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial. Blood 110:3557–3560
-
(2007)
Blood
, vol.110
, pp. 3557-3560
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.3
-
126
-
-
34247846013
-
Safety and efficacy of bortezomib in high-risk and elderly patients with relapsed multiple myeloma
-
Richardson PG, Sonneveld P, Schuster MW et al (2007b) Safety and efficacy of bortezomib in high-risk and elderly patients with relapsed multiple myeloma. Br J Haematol 137:429–435
-
(2007)
Br J Haematol
, vol.137
, pp. 429-435
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.W.3
-
127
-
-
84877605245
-
Phase 1 study of pomalidomide MTD, safety, and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib
-
Richardson PG, Siegel D, Baz R, Kelley SL, Munshi NC, Laubach J, Sullivan D, Alsina M, Schlossman R, Ghobrial IM, Doss D, Loughney N, McBride L, Bilotti E, Anand P, Nardelli L, Wear S, Larkins G, Chen M, Zaki MH, Jacques C, Anderson KC (2013) Phase 1 study of pomalidomide MTD, safety, and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib. Blood 121(11):1961–1967
-
(2013)
Blood
, vol.121
, Issue.11
, pp. 1961-1967
-
-
Richardson, P.G.1
Siegel, D.2
Baz, R.3
Kelley, S.L.4
Munshi, N.C.5
Laubach, J.6
Sullivan, D.7
Alsina, M.8
Schlossman, R.9
Ghobrial, I.M.10
Doss, D.11
Loughney, N.12
McBride, L.13
Bilotti, E.14
Anand, P.15
Nardelli, L.16
Wear, S.17
Larkins, G.18
Chen, M.19
Zaki, M.H.20
Jacques, C.21
Erson, K.C.22
more..
-
128
-
-
32544446935
-
Pegylated liposomal doxorubicin, vincristine, and dexamethasone provide significant reduction in toxicity compared with doxorubicin, vincristine, and dexamethasone in patients with newly diagnosed multiple myeloma: A phase III multicenter randomized trial
-
Rifkin RM, Gregory SA, Mohrbacher A et al (2006) Pegylated liposomal doxorubicin, vincristine, and dexamethasone provide significant reduction in toxicity compared with doxorubicin, vincristine, and dexamethasone in patients with newly diagnosed multiple myeloma: a phase III multicenter randomized trial. Cancer 106:848–858
-
(2006)
Cancer
, vol.106
, pp. 848-858
-
-
Rifkin, R.M.1
Gregory, S.A.2
Mohrbacher, A.3
-
129
-
-
2442515965
-
Proteasome function in antigen presentation: Immunoproteasome complexes, peptide production, and interactions with viral proteins
-
Rivett AJ, Hearn AR (2004) Proteasome function in antigen presentation: immunoproteasome complexes, peptide production, and interactions with viral proteins. Curr Protein Pept Sci 5:153–161
-
(2004)
Curr Protein Pept Sci
, vol.5
, pp. 153-161
-
-
Rivett, A.J.1
Hearn, A.R.2
-
130
-
-
0033408418
-
Heat-shock protein 70 antisense oligomers enhance proteasome inhibitor-induced apoptosis
-
Robertson JD, Datta K, Biswal SS, Kehrer JP (1999) Heat-shock protein 70 antisense oligomers enhance proteasome inhibitor-induced apoptosis. Biochem J 344:477–485
-
(1999)
Biochem J
, vol.344
, pp. 477-485
-
-
Robertson, J.D.1
Datta, K.2
Biswal, S.S.3
Kehrer, J.P.4
-
131
-
-
33748300908
-
The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia
-
Ruiz S, Krupnik Y, Keating M et al (2006) The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia. Mol Cancer Ther 5:1836–1843
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1836-1843
-
-
Ruiz, S.1
Krupnik, Y.2
Keating, M.3
-
132
-
-
33751563004
-
A phase I study of bortezomib plus irinotecan in patients with advanced solid tumors
-
Ryan DP, O’Neil BH, Supko JG et al (2006) A phase I study of bortezomib plus irinotecan in patients with advanced solid tumors. Cancer 107:2688–2697
-
(2006)
Cancer
, vol.107
, pp. 2688-2697
-
-
Ryan, D.P.1
O’Neil, B.H.2
Supko, J.G.3
-
133
-
-
33845524012
-
Bortezomib in relapsed multiple myeloma: Response rates and duration of response are independent of a chromosome 13q-deletion
-
Sagaster V, Ludwig H, Kaufmann H et al (2007) Bortezomib in relapsed multiple myeloma: response rates and duration of response are independent of a chromosome 13q-deletion. Leukemia 21:164–168
-
(2007)
Leukemia
, vol.21
, pp. 164-168
-
-
Sagaster, V.1
Ludwig, H.2
Kaufmann, H.3
-
134
-
-
50449086728
-
Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
-
San Miguel JF, Schlag R, Khuageva NK et al (2008) Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. New Eng J Med 359:906–917
-
(2008)
New Eng J Med
, vol.359
, pp. 906-917
-
-
San Miguel, J.F.1
Schlag, R.2
Khuageva, N.K.3
-
135
-
-
84874768399
-
Persistent overall survival benefit and no increased risk of second malignancies with bortezomib-melphalan-prednisone versus melphalan-prednisone in patients with previously untreated multiple myeloma
-
San Miguel JF, Schlag R, Khuageva NK, Dimopoulos MA, Shpilberg O, Kropff M, Spicka I, Petrucci MT, Palumbo A, Samoilova OS, Dmoszynska A, Abdulkadyrov KM, Delforge M, Jiang B, Mateos MV, Anderson KC, Esseltine DL, Liu K, Deraedt W, Cakana A, van de Velde H, Richardson PG (2013) Persistent overall survival benefit and no increased risk of second malignancies with bortezomib-melphalan-prednisone versus melphalan-prednisone in patients with previously untreated multiple myeloma. J Clin Oncol 31(4):448–455
-
(2013)
J Clin Oncol
, vol.31
, Issue.4
, pp. 448-455
-
-
San Miguel, J.F.1
Schlag, R.2
Khuageva, N.K.3
Dimopoulos, M.A.4
Shpilberg, O.5
Kropff, M.6
Spicka, I.7
Petrucci, M.T.8
Palumbo, A.9
Samoilova, O.S.10
Dmoszynska, A.11
Abdulkadyrov, K.M.12
Delforge, M.13
Jiang, B.14
Mateos, M.V.15
Erson, K.C.16
Esseltine, D.L.17
Liu, K.18
Deraedt, W.19
Cakana, A.20
Van De Velde, H.21
Richardson, P.G.22
more..
-
136
-
-
26844433577
-
Proteasome-associated proteins: Regulation of a proteolytic machine
-
Schmidt M, Hanna J, Elsasser S, Finley D (2005) Proteasome-associated proteins: regulation of a proteolytic machine. Biol Chem 386:725–737
-
(2005)
Biol Chem
, vol.386
, pp. 725-737
-
-
Schmidt, M.1
Hanna, J.2
Elsasser, S.3
Finley, D.4
-
137
-
-
34249062137
-
Proteasome inhibitors induce a p38 mitogen-activated protein kinase (MAPK)-dependent anti-apoptotic program involving MAPK phosphatase-1 and Akt in models of breast cancer
-
Shi YY, Small GW, Orlowski RZ (2006) Proteasome inhibitors induce a p38 mitogen-activated protein kinase (MAPK)-dependent anti-apoptotic program involving MAPK phosphatase-1 and Akt in models of breast cancer. Breast Cancer Res Treat 100:33–47
-
(2006)
Breast Cancer Res Treat
, vol.100
, pp. 33-47
-
-
Shi, Y.Y.1
Small, G.W.2
Orlowski, R.Z.3
-
138
-
-
0030016329
-
Apoptosis induction resulting from proteasome inhibition
-
Shinohara K, Tomioka M, Nakano H et al (1996) Apoptosis induction resulting from proteasome inhibition. Biochem J 317:385–388
-
(1996)
Biochem J
, vol.317
, pp. 385-388
-
-
Shinohara, K.1
Tomioka, M.2
Nakano, H.3
-
139
-
-
0033517032
-
Total synthesis of the potent proteasome inhibitor epoxomicin: A useful tool for understanding proteasome biology
-
Sin N, Kim KB, Elofsson M et al (1999) Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology. Bioorg Med Chem Lett 9:2283–2288
-
(1999)
Bioorg Med Chem Lett
, vol.9
, pp. 2283-2288
-
-
Sin, N.1
Kim, K.B.2
Elofsson, M.3
-
140
-
-
9444249941
-
Evidence that mitogen-activated protein kinase phosphatase-1 induction by proteasome inhibitors plays an antiapoptotic role
-
Small GW, Shi YY, Edmund NA et al (2004) Evidence that mitogen-activated protein kinase phosphatase-1 induction by proteasome inhibitors plays an antiapoptotic role. Mol Pharmacol 66:1478–1490
-
(2004)
Mol Pharmacol
, vol.66
, pp. 1478-1490
-
-
Small, G.W.1
Shi, Y.Y.2
Edmund, N.A.3
-
141
-
-
33644823732
-
Bortezomib at first relapse is superior to high-dose dexamethasone and more effective than when given later in relapsed multiple myeloma
-
Sonneveld P, Richardson PG, Schuster MW et al (2005) Bortezomib at first relapse is superior to high-dose dexamethasone and more effective than when given later in relapsed multiple myeloma. Haematologica 90:146–147
-
(2005)
Haematologica
, vol.90
, pp. 146-147
-
-
Sonneveld, P.1
Richardson, P.G.2
Schuster, M.W.3
-
142
-
-
84865171981
-
Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma: Results of the randomized phase III HOVON-65/ GMMG-HD4 trial
-
Sonneveld P, Schmidt-Wolf IG, van der Holt B, El Jarari L, Bertsch U, Salwender H, Zweegman S, Vellenga E, Broyl A, Blau IW, Weisel KC, Wittebol S, Bos GM, Stevens-Kroef M, Scheid C, Pfreundschuh M, Hose D, Jauch A, van der Velde H, Raymakers R, Schaafsma MR, Kersten MJ, van Marwijk-Kooy M, Duehrsen U, Lindemann W, Wijermans PW, Lokhorst HM, Goldschmidt HM (2012) Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma: results of the randomized phase III HOVON-65/ GMMG-HD4 trial. J Clin Oncol 30(24):2946–2955
-
(2012)
J Clin Oncol
, vol.30
, Issue.24
, pp. 2946-2955
-
-
Sonneveld, P.1
Schmidt-Wolf, I.G.2
Van Der Holt, B.3
El Jarari, L.4
Bertsch, U.5
Salwender, H.6
Zweegman, S.7
Vellenga, E.8
Broyl, A.9
Blau, I.W.10
Weisel, K.C.11
Wittebol, S.12
Bos, G.M.13
Stevens-Kroef, M.14
Scheid, C.15
Pfreundschuh, M.16
Hose, D.17
Jauch, A.18
Van Der Velde, H.19
Raymakers, R.20
Schaafsma, M.R.21
Kersten, M.J.22
Van Marwijk-Kooy, M.23
Duehrsen, U.24
Lindemann, W.25
Wijermans, P.W.26
Lokhorst, H.M.27
Goldschmidt, H.M.28
more..
-
143
-
-
33847410207
-
The proteasome inhibitors bortezomib and PR- 171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells
-
Stapnes C, Doskeland AP, Hatfield K et al (2007) The proteasome inhibitors bortezomib and PR- 171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells. Br J Haematol 136:814–828
-
(2007)
Br J Haematol
, vol.136
, pp. 814-828
-
-
Stapnes, C.1
Doskeland, A.P.2
Hatfield, K.3
-
144
-
-
33646462752
-
Bortezomib therapy in patients with relapsed or refractory lymphoma: Potential correlation of in vitro sensitivity and tumor necrosis factor a response with clinical activity
-
Strauss SJ, Maharaj L, Hoare S et al (2006) Bortezomib therapy in patients with relapsed or refractory lymphoma: potential correlation of in vitro sensitivity and tumor necrosis factor a response with clinical activity. J Clin Oncol 24:2105–2212
-
(2006)
J Clin Oncol
, vol.24
, pp. 2105-2212
-
-
Strauss, S.J.1
Maharaj, L.2
Hoare, S.3
-
145
-
-
0034090632
-
Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome
-
Strickland E, Hakala K, Thomas PJ, DeMartino GN (2000) Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome. J Biol Chem 275:5565–5572
-
(2000)
J Biol Chem
, vol.275
, pp. 5565-5572
-
-
Strickland, E.1
Hakala, K.2
Thomas, P.J.3
Demartino, G.N.4
-
146
-
-
33750144933
-
Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma
-
Suvannasankha A, Smith GG, Juliar BE et al (2006) Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma. Clin Lymphoma Myeloma 7:131–134
-
(2006)
Clin Lymphoma Myeloma
, vol.7
, pp. 131-134
-
-
Suvannasankha, A.1
Smith, G.G.2
Juliar, B.E.3
-
147
-
-
41549130929
-
Newer cytotoxic agents: Attacking cancer broadly
-
Teicher BA (2008) Newer cytotoxic agents: attacking cancer broadly. Clin Cancer Res 14:1650–1657
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1650-1657
-
-
Teicher, B.A.1
-
148
-
-
33748892264
-
Addition of bortezomib to thalidomide, dexamethasone and zoledronic acid (VTD-Z regimen) significantly improves complete remission rates in patients with relapsed/refractory multiple myeloma
-
Teoh G, Tan D, Hwang W et al (2006) Addition of bortezomib to thalidomide, dexamethasone and zoledronic acid (VTD-Z regimen) significantly improves complete remission rates in patients with relapsed/refractory multiple myeloma. In: Updated data presented at the 2006 annual meeting of the American Society of Clinical Oncology. J Clin Oncol, vol 24, p 683s
-
(2006)
Updated Data Presented at the 2006 Annual Meeting of the American Society of Clinical Oncology. J Clin Oncol
, vol.24
, pp. 683
-
-
Teoh, G.1
Tan, D.2
Hwang, W.3
-
149
-
-
34548044067
-
The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide (VMDT) is an effective regimen for relapsed/refractory myeloma and reduces serum levels of Dickkopf-1, RANKL, MIP-1-alpha and angiogenic cytokines
-
Terpos E, Anagnostopoulos A, Heath D et al (2006) The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide (VMDT) is an effective regimen for relapsed/refractory myeloma and reduces serum levels of Dickkopf-1, RANKL, MIP-1-alpha and angiogenic cytokines. In: Updated data presented at the 2006 annual meeting of the American Society of Hematology. Blood, vol 108, pp 1010a–1011a
-
(2006)
Updated Data Presented at the 2006 Annual Meeting of the American Society of Hematology. Blood
, vol.108
, pp. 1010-1011
-
-
Terpos, E.1
Anagnostopoulos, A.2
Heath, D.3
-
150
-
-
34250630491
-
Multicenter clinical trial of bortezomib in relapsed/refractory Waldenstrom’s macroglobulinemia: Results of WMCTG Trial 03–248
-
Treon SP, Hunter ZR, Matous J et al (2007) Multicenter clinical trial of bortezomib in relapsed/refractory Waldenstrom’s macroglobulinemia: results of WMCTG Trial 03–248. Clin Cancer Res 13:3320–3325
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3320-3325
-
-
Treon, S.P.1
Hunter, Z.R.2
Matous, J.3
-
151
-
-
84880271428
-
New developments in the management and treatment of newly diagnosed and relapsed/refractory multiple myeloma patients
-
van de Donk NW, Lokhorst HM (2013) New developments in the management and treatment of newly diagnosed and relapsed/refractory multiple myeloma patients. Expert Opin Pharmacother 14(12):1569–1573
-
(2013)
Expert Opin Pharmacother
, vol.14
, Issue.12
, pp. 1569-1573
-
-
Van De Donk, N.W.1
Lokhorst, H.M.2
-
152
-
-
0026786503
-
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex
-
Vinitsky A, Michaud C, Powers JC, Orlowski M (1992) Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex. Biochemistry 31:9421–9428
-
(1992)
Biochemistry
, vol.31
, pp. 9421-9428
-
-
Vinitsky, A.1
Michaud, C.2
Powers, J.C.3
Orlowski, M.4
-
153
-
-
0028150688
-
Inhibition of the proteolytic activity of the multicatalytic proteinase complex (Proteasome) by substrate-related peptidyl aldehydes
-
Vinitsky A, Cardozo C, Sepp-Lorenzino L, Michaud C, Orlowski M (1994) Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes. J Biol Chem 269:29860–29866
-
(1994)
J Biol Chem
, vol.269
, pp. 29860-29866
-
-
Vinitsky, A.1
Cardozo, C.2
Sepp-Lorenzino, L.3
Michaud, C.4
Orlowski, M.5
-
155
-
-
35948943113
-
Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma
-
Voorhees PM, Chen Q, Kuhn DJ et al (2007) Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma. Clin Cancer Res 13:6469–6478
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6469-6478
-
-
Voorhees, P.M.1
Chen, Q.2
Kuhn, D.J.3
-
156
-
-
34250770091
-
A parallel dose-escalation study of weekly and twice-weekly bortezomib in combination with gemcitabine and cisplatin in the first-line treatment of patients with advanced solid tumors
-
Voortman J, Smit EF, Honeywell R et al (2007) A parallel dose-escalation study of weekly and twice-weekly bortezomib in combination with gemcitabine and cisplatin in the first-line treatment of patients with advanced solid tumors. Clin Cancer Res 13:3642–3651
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3642-3651
-
-
Voortman, J.1
Smit, E.F.2
Honeywell, R.3
-
157
-
-
3242687326
-
The 26S proteasome system in the signaling pathways of TGF-beta superfamily
-
Wang T (2003) The 26S proteasome system in the signaling pathways of TGF-beta superfamily. Front Biosci 8:d1109–d1127
-
(2003)
Front Biosci
, vol.8
, pp. 1109-1127
-
-
Wang, T.1
-
158
-
-
0029858387
-
TNF-and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kB
-
Wang CY, Mayo MW, Baldwin AS Jr (1996) TNF-and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kB. Science 274:784–787
-
(1996)
Science
, vol.274
, pp. 784-787
-
-
Wang, C.Y.1
Mayo, M.W.2
Baldwin, A.S.3
-
159
-
-
0032905030
-
Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kB
-
Wang CY, Cusack JC Jr, Liu R, Baldwin AS Jr (1999) Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kB. Nat Med 5:412–417
-
(1999)
Nat Med
, vol.5
, pp. 412-417
-
-
Wang, C.Y.1
Cusack, J.C.2
Liu, R.3
Baldwin, A.S.4
-
160
-
-
84940987181
-
Efficacy and safety of bortezomib in systemic AL amyloidosis-a preliminary report. Blood 108:42a (abstract 129) Wojcikiewicz RJ (2004) Regulated ubiquitination of proteins in GPCR-initiated signaling pathways
-
Wechalekar A, Gillmore J, Lachmann H, Offer M, Hawkins P (2006) Efficacy and safety of bortezomib in systemic AL amyloidosis-a preliminary report. Blood 108:42a (abstract 129) Wojcikiewicz RJ (2004) Regulated ubiquitination of proteins in GPCR-initiated signaling pathways. Trends Pharmacol Sci 25:35–41
-
(2006)
Trends Pharmacol Sci
, vol.25
, pp. 35-41
-
-
Wechalekar, A.1
Gillmore, J.2
Lachmann, H.3
Offer, M.4
Hawkins, P.5
-
161
-
-
33746340326
-
Velcade (V)-thalidomide (T)-dexamethasone (D) for advanced and refractory multiple myeloma (MM): Long-term follow-up of phase I-II trial UARK 2001–37: Superior outcome in patients with normal cytogenetics and no prior T
-
Zangari M, Barlogie B, Burns MJ et al (2005) Velcade (V)-thalidomide (T)-dexamethasone (D) for advanced and refractory multiple myeloma (MM): long-term follow-up of phase I-II trial UARK 2001–37: superior outcome in patients with normal cytogenetics and no prior T. In: Updated data presented at the 2005 Annual Meeting of the American Society of Hematology. Blood, vol 106, p 717.
-
(2005)
Updated Data Presented at the 2005 Annual Meeting of the American Society of Hematology. Blood
, vol.106
, pp. 717
-
-
Zangari, M.1
Barlogie, B.2
Burns, M.J.3
|