-
1
-
-
0035290730
-
Antigen processing by the proteasome
-
Kloetzel P.M. Antigen processing by the proteasome. Nat. Rev. Mol. Cell. Biol. 2:2001;179-187.
-
(2001)
Nat. Rev. Mol. Cell. Biol.
, vol.2
, pp. 179-187
-
-
Kloetzel, P.M.1
-
2
-
-
0033451923
-
Proteolysis and class I major histocompatibility complex antigen presentation
-
York L.A., Goldberg A.L., Mo X.Y., Rock K.L. Proteolysis and class I major histocompatibility complex antigen presentation. Immunol. Rev. 172:1999;29-48.
-
(1999)
Immunol. Rev.
, vol.172
, pp. 29-48
-
-
York, L.A.1
Goldberg, A.L.2
Mo, X.Y.3
Rock, K.L.4
-
3
-
-
0034643336
-
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
-
Schubert U., Anton L.C., Gibbs J., Norbury C.C., Yewdell J.W., Bennink J.R. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature. 404:2000;770-774.
-
(2000)
Nature
, vol.404
, pp. 770-774
-
-
Schubert, U.1
Anton, L.C.2
Gibbs, J.3
Norbury, C.C.4
Yewdell, J.W.5
Bennink, J.R.6
-
4
-
-
0034643348
-
The major substrates for TAP in vivo are derived from newly synthesized proteins
-
Reits E.A., Vos J.C., Gromme M., Neefjes J. The major substrates for TAP in vivo are derived from newly synthesized proteins. Nature. 404:2000;774-778.
-
(2000)
Nature
, vol.404
, pp. 774-778
-
-
Reits, E.A.1
Vos, J.C.2
Gromme, M.3
Neefjes, J.4
-
5
-
-
0037342270
-
Quantitating protein synthesis, degradation, and endogenous antigen processing
-
The authors of this paper present an excellent quantitative analysis on the efficiency of MHC class I surface expression, they demonstrate the relative inefficiency of the system and present data to support the importance of DRiPs for antigen presentation.
-
Princiotta M.F., Finzi D., Qian S.B., Gibbs J., Schuchmann S., Buttgereit F., Bennink J.R., Yewdell J.W. Quantitating protein synthesis, degradation, and endogenous antigen processing. Immunity. 18:2003;343-354 The authors of this paper present an excellent quantitative analysis on the efficiency of MHC class I surface expression, they demonstrate the relative inefficiency of the system and present data to support the importance of DRiPs for antigen presentation.
-
(2003)
Immunity
, vol.18
, pp. 343-354
-
-
Princiotta, M.F.1
Finzi, D.2
Qian, S.B.3
Gibbs, J.4
Schuchmann, S.5
Buttgereit, F.6
Bennink, J.R.7
Yewdell, J.W.8
-
6
-
-
0035873704
-
26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide
-
Cascio P., Hilton C., Kisselev A.F., Rock K.L., Goldberg A.L. 26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide. EMBO J. 20:2001;2357-2366.
-
(2001)
EMBO J.
, vol.20
, pp. 2357-2366
-
-
Cascio, P.1
Hilton, C.2
Kisselev, A.F.3
Rock, K.L.4
Goldberg, A.L.5
-
7
-
-
0037443409
-
Quantifying recruitment of cytosolic peptides for HLA class I presentation: Impact of TAP transport
-
Fruci and co-workers present an excellent and very detailed analysis of the usage of proteasome-generated peptide pools for antigen presentation, and demonstrate that these pools are used rather inefficiently.
-
Fruci D., Lauvau G., Saveanu L., Amicosante M., Butler R.H., Polack A., Ginhoux F., Lemonnier F., Firat H., van Endert P.M. Quantifying recruitment of cytosolic peptides for HLA class I presentation: impact of TAP transport. J. Immunol. 170:2003;2977-2984 Fruci and co-workers present an excellent and very detailed analysis of the usage of proteasome-generated peptide pools for antigen presentation, and demonstrate that these pools are used rather inefficiently.
-
(2003)
J. Immunol.
, vol.170
, pp. 2977-2984
-
-
Fruci, D.1
Lauvau, G.2
Saveanu, L.3
Amicosante, M.4
Butler, R.H.5
Polack, A.6
Ginhoux, F.7
Lemonnier, F.8
Firat, H.9
Van Endert, P.M.10
-
8
-
-
0028907938
-
Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport
-
Cerundolo V., Kelly A., Elliott T., Trowsdale J., Townsend A. Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport. Eur. J. Immunol. 25:1995;554-562.
-
(1995)
Eur. J. Immunol.
, vol.25
, pp. 554-562
-
-
Cerundolo, V.1
Kelly, A.2
Elliott, T.3
Trowsdale, J.4
Townsend, A.5
-
9
-
-
0035806246
-
Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens
-
Chen W., Norbury C.C., Cho Y., Yewdell J.W., Bennink J.R. Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens. J. Exp. Med. 193:2001;1319-1326.
-
(2001)
J. Exp. Med.
, vol.193
, pp. 1319-1326
-
-
Chen, W.1
Norbury, C.C.2
Cho, Y.3
Yewdell, J.W.4
Bennink, J.R.5
-
10
-
-
0035796461
-
Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products
-
Toes R.E., Nussbaum A.K., Degermann S., Schirle M., Emmerich N.P., Kraft M., Laplace C., Zwinderman A., Dick T.P., Muller J.et al. Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products. J. Exp. Med. 194:2001;1-12.
-
(2001)
J. Exp. Med.
, vol.194
, pp. 1-12
-
-
Toes, R.E.1
Nussbaum, A.K.2
Degermann, S.3
Schirle, M.4
Emmerich, N.P.5
Kraft, M.6
Laplace, C.7
Zwinderman, A.8
Dick, T.P.9
Muller, J.10
-
11
-
-
0034698738
-
Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28
-
van Hall T., Sijts A., Camps M., Offringa R., Melief C., Kloetzel P.M., Ossendorp F. Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28. J. Exp. Med. 192:2000;483-494.
-
(2000)
J. Exp. Med.
, vol.192
, pp. 483-494
-
-
Van Hall, T.1
Sijts, A.2
Camps, M.3
Offringa, R.4
Melief, C.5
Kloetzel, P.M.6
Ossendorp, F.7
-
12
-
-
0033980648
-
Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells
-
Morel S., Levy F., Burlet-Schiltz O., Brasseur V., Probst-Kepper F., Peitrequin A.L., Monsarrat B., Van Velthoven R., Cerottini J.C., Boon T.et al. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells. Immunity. 12:2000;107-117.
-
(2000)
Immunity
, vol.12
, pp. 107-117
-
-
Morel, S.1
Levy, F.2
Burlet-Schiltz, O.3
Brasseur, V.4
Probst-Kepper, F.5
Peitrequin, A.L.6
Monsarrat, B.7
Van Velthoven, R.8
Cerottini, J.C.9
Boon, T.10
-
13
-
-
0037089678
-
Link between organ-specific antigen processing by 20S proteasomes and CD8(+) T cell-mediated autoimmunity
-
This report shows that different organs have a different subunit composition of 20S proteasomes with other cleavage qualities, suggesting that processing mechanisms have a role in tissue-specific immunity and tolerance.
-
Kuckelkorn U., Ruppert T., Strehl B., Jungblut P.R., Zimny-Arndt U., Lamer S., Prinz I., Drung I., Kloetzel P.M., Kaufmann S.H., Steinhoff U. Link between organ-specific antigen processing by 20S proteasomes and CD8(+) T cell-mediated autoimmunity. J. Exp. Med. 195:2002;983-990 This report shows that different organs have a different subunit composition of 20S proteasomes with other cleavage qualities, suggesting that processing mechanisms have a role in tissue-specific immunity and tolerance.
-
(2002)
J. Exp. Med.
, vol.195
, pp. 983-990
-
-
Kuckelkorn, U.1
Ruppert, T.2
Strehl, B.3
Jungblut, P.R.4
Zimny-Arndt, U.5
Lamer, S.6
Prinz, I.7
Drung, I.8
Kloetzel, P.M.9
Kaufmann, S.H.10
Steinhoff, U.11
-
14
-
-
0034597824
-
Structural basis for the activation of 20S proteasomes by 11S regulators
-
Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C., Hill C.P. Structural basis for the activation of 20S proteasomes by 11S regulators. Nature. 408:2000;115-120.
-
(2000)
Nature
, vol.408
, pp. 115-120
-
-
Whitby, F.G.1
Masters, E.I.2
Kramer, L.3
Knowlton, J.R.4
Yao, Y.5
Wang, C.C.6
Hill, C.P.7
-
15
-
-
0030602834
-
Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands
-
Dick T.P., Ruppert T., Groettrup M., Kloetzel P.M., Kuehn L., Koszinowski U.H., Stevanovic S., Schild H., Rammensee H.G. Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands. Cell. 86:1996;253-262.
-
(1996)
Cell
, vol.86
, pp. 253-262
-
-
Dick, T.P.1
Ruppert, T.2
Groettrup, M.3
Kloetzel, P.M.4
Kuehn, L.5
Koszinowski, U.H.6
Stevanovic, S.7
Schild, H.8
Rammensee, H.G.9
-
16
-
-
0029918289
-
A role for the proteasome regulator PA28α in antigen presentation
-
Groettrup M., Soza A., Eggers M., Kuehn L., Dick T.P., Schild H., Rammensee H.G., Koszinowski U.H., Kloetzel P.M. A role for the proteasome regulator PA28α in antigen presentation. Nature. 381:1996;166-168.
-
(1996)
Nature
, vol.381
, pp. 166-168
-
-
Groettrup, M.1
Soza, A.2
Eggers, M.3
Kuehn, L.4
Dick, T.P.5
Schild, H.6
Rammensee, H.G.7
Koszinowski, U.H.8
Kloetzel, P.M.9
-
17
-
-
17944369433
-
Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta
-
Murata S., Udono H., Tanahashi N., Hamada N., Watanabe K., Adachi K., Yamano T., Yui K., Kobayashi N., Kasahara M.et al. Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta. EMBO J. 20:2001;5898-5907.
-
(2001)
EMBO J.
, vol.20
, pp. 5898-5907
-
-
Murata, S.1
Udono, H.2
Tanahashi, N.3
Hamada, N.4
Watanabe, K.5
Adachi, K.6
Yamano, T.7
Yui, K.8
Kobayashi, N.9
Kasahara, M.10
-
18
-
-
0037093234
-
Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells
-
Sun Y., Sijts A.J., Song M., Janek K., Nussbaum A.K., Kral S., Schirle M., Stevanovic S., Paschen A., Schild H.et al. Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells. Cancer Res. 62:2002;2875-2882.
-
(2002)
Cancer Res.
, vol.62
, pp. 2875-2882
-
-
Sun, Y.1
Sijts, A.J.2
Song, M.3
Janek, K.4
Nussbaum, A.K.5
Kral, S.6
Schirle, M.7
Stevanovic, S.8
Paschen, A.9
Schild, H.10
-
19
-
-
0037099735
-
Two distinct pathways mediated by PA28 and Hsp90 in major histocompatibility complex class I antigen processing
-
Using PA28-deficient mice, these authors report that Hsp90 can also regulate proteasome function for MHC class I peptide generation.
-
Yamano T., Murata S., Shimbara N., Tanaka N., Chiba T., Tanaka K., Yui K., Udono H. Two distinct pathways mediated by PA28 and Hsp90 in major histocompatibility complex class I antigen processing. J. Exp. Med. 196:2002;185-196 Using PA28-deficient mice, these authors report that Hsp90 can also regulate proteasome function for MHC class I peptide generation.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 185-196
-
-
Yamano, T.1
Murata, S.2
Shimbara, N.3
Tanaka, N.4
Chiba, T.5
Tanaka, K.6
Yui, K.7
Udono, H.8
-
20
-
-
0042313977
-
The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome
-
The authors report a novel function for Hsp90 in the ATP-dependent assembly of the 26S proteasome in yeast.
-
Imai J., Maruya M., Yashiroda H., Yahara I., Tanaka K. The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome. EMBO J. 22:2003;3557-3567 The authors report a novel function for Hsp90 in the ATP-dependent assembly of the 26S proteasome in yeast.
-
(2003)
EMBO J.
, vol.22
, pp. 3557-3567
-
-
Imai, J.1
Maruya, M.2
Yashiroda, H.3
Yahara, I.4
Tanaka, K.5
-
21
-
-
0032563221
-
Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase
-
Beninga J., Rock K.L., Goldberg A.L. Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase. J. Biol. Chem. 273:1998;18734-18742.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18734-18742
-
-
Beninga, J.1
Rock, K.L.2
Goldberg, A.L.3
-
22
-
-
0035424145
-
The murine cytomegalovirus pp89 immunodominant H-2Ld epitope is generated and translocated into the endoplasmic reticulum as an 11-mer precursor peptide
-
Knuehl C., Spee P., Ruppert T., Kuckelkorn U., Henklein P., Neefjes J., Kloetzel P.M. The murine cytomegalovirus pp89 immunodominant H-2Ld epitope is generated and translocated into the endoplasmic reticulum as an 11-mer precursor peptide. J. Immunol. 167:2001;1515-1521.
-
(2001)
J. Immunol.
, vol.167
, pp. 1515-1521
-
-
Knuehl, C.1
Spee, P.2
Ruppert, T.3
Kuckelkorn, U.4
Henklein, P.5
Neefjes, J.6
Kloetzel, P.M.7
-
23
-
-
0034802622
-
Efficient MHC class I-independent amino-terminal trimming of epitope precursor peptides in the endoplasmic reticulum
-
Fruci D., Niedermann G., Butler R.H., vanEndert P.M. Efficient MHC class I-independent amino-terminal trimming of epitope precursor peptides in the endoplasmic reticulum. Immunity. 15:2001;467-476.
-
(2001)
Immunity
, vol.15
, pp. 467-476
-
-
Fruci, D.1
Niedermann, G.2
Butler, R.H.3
Vanendert, P.M.4
-
24
-
-
5944236047
-
Two new proteases in the MHC class I processing pathway
-
Stoltze L., Schirle M., Schwarz G., Schroter C., Thompson M.W., Hersh L.B., Kalbacher H.S., Rammensee H.G., Schild H. Two new proteases in the MHC class I processing pathway. Nat. Immunol. 1:2000;413-418.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 413-418
-
-
Stoltze, L.1
Schirle, M.2
Schwarz, G.3
Schroter, C.4
Thompson, M.W.5
Hersh, L.B.6
Kalbacher, H.S.7
Rammensee, H.G.8
Schild, H.9
-
25
-
-
0035965357
-
Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase
-
Saric T., Beninga J., Graef C.I., Akopian T.N., Rock K.L., Goldberg A.L. Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase. J. Biol. Chem. 276:2001;36474-36481.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 36474-36481
-
-
Saric, T.1
Beninga, J.2
Graef, C.I.3
Akopian, T.N.4
Rock, K.L.5
Goldberg, A.L.6
-
26
-
-
0037341473
-
The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation
-
It is shown that the upregulation of TOP results in the downregulation of class I surface expression.
-
York I.A., Mo A.X., Lemerise K., Zeng W., Shen Y., Abraham C.R., Saric T., Goldberg A.L., Rock K.L. The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity. 18:2003;429-440 It is shown that the upregulation of TOP results in the downregulation of class I surface expression.
-
(2003)
Immunity
, vol.18
, pp. 429-440
-
-
York, I.A.1
Mo, A.X.2
Lemerise, K.3
Zeng, W.4
Shen, Y.5
Abraham, C.R.6
Saric, T.7
Goldberg, A.L.8
Rock, K.L.9
-
27
-
-
0033230777
-
Human transporters associated with antigen processing (TAP) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells
-
Lauveau G., Kakimi K., Niedermann G., Ostankovitch M., Yotnda P., Firat H., Chisari F.V., vanEndert P.M. Human transporters associated with antigen processing (TAP) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells. J. Exp. Med. 190:1999;1227-1240.
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1227-1240
-
-
Lauveau, G.1
Kakimi, K.2
Niedermann, G.3
Ostankovitch, M.4
Yotnda, P.5
Firat, H.6
Chisari, F.V.7
Vanendert, P.M.8
-
28
-
-
0034907526
-
MHC class I molecules can direct proteolytic cleavage of antigenic precursors in the endoplasmic reticulum
-
Brouwenstijn N., Serwold T., Shastri N. MHC class I molecules can direct proteolytic cleavage of antigenic precursors in the endoplasmic reticulum. Immunity. 15:2001;95-104.
-
(2001)
Immunity
, vol.15
, pp. 95-104
-
-
Brouwenstijn, N.1
Serwold, T.2
Shastri, N.3
-
29
-
-
0034913229
-
ER aminopeptidases generate a unique pool of peptides for MHC class I molecules
-
Serwold T., Gaw S., Shastri N. ER aminopeptidases generate a unique pool of peptides for MHC class I molecules. Nat. Immunol. 2:2001;644-651.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 644-651
-
-
Serwold, T.1
Gaw, S.2
Shastri, N.3
-
30
-
-
0035839492
-
A role for a novel luminal endoplasmic reticulum aminopeptidase in final trimming of 26 S proteasome-generated major histocompatability complex class I antigenic peptides
-
Komlosh A., Momburg F., Weinschenk T., Emmerich N., Schild H., Nadav E., Shaked I., Reiss Y. A role for a novel luminal endoplasmic reticulum aminopeptidase in final trimming of 26 S proteasome-generated major histocompatability complex class I antigenic peptides. J. Biol. Chem. 276:2001;30050-30056.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 30050-30056
-
-
Komlosh, A.1
Momburg, F.2
Weinschenk, T.3
Emmerich, N.4
Schild, H.5
Nadav, E.6
Shaked, I.7
Reiss, Y.8
-
31
-
-
0037015624
-
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
-
The paper reports the first molecular characterisation of an ER-resident IFN-γ-inducible aminopeptidase.
-
Serwold T., Gonzalez F., Kim J., Jacob R., Shastri N. ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum. Nature. 419:2002;480-483 The paper reports the first molecular characterisation of an ER-resident IFN-γ-inducible aminopeptidase.
-
(2002)
Nature
, vol.419
, pp. 480-483
-
-
Serwold, T.1
Gonzalez, F.2
Kim, J.3
Jacob, R.4
Shastri, N.5
-
32
-
-
0036902105
-
An IFN-gamma induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
-
The authors of this paper describe the isolation of, as well as the biochemical and molecular characterisation of, ERAP1 and demonstrate its functional importance for the trimming of amino-terminal-elongated epitopes.
-
Saric T., Chang S.C., Hattori A., York I.A., Markant S., Rock K.L., Tsujimoto M., Goldberg A.L. An IFN-gamma induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat. Immunol. 3:2002;1169-1176 The authors of this paper describe the isolation of, as well as the biochemical and molecular characterisation of, ERAP1 and demonstrate its functional importance for the trimming of amino-terminal-elongated epitopes.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 1169-1176
-
-
Saric, T.1
Chang, S.C.2
Hattori, A.3
York, I.A.4
Markant, S.5
Rock, K.L.6
Tsujimoto, M.7
Goldberg, A.L.8
-
33
-
-
0036884090
-
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues
-
In this paper, the authors show that ERAP1 can exert differential effects on MHC class I epitope presentation.
-
York I.A., Chang S.C., Saric T., Keys J.A., Favreau J.M., Goldberg A.L., Rock K.L. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat. Immunol. 3:2002;1177-1184 In this paper, the authors show that ERAP1 can exert differential effects on MHC class I epitope presentation.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 1177-1184
-
-
York, I.A.1
Chang, S.C.2
Saric, T.3
Keys, J.A.4
Favreau, J.M.5
Goldberg, A.L.6
Rock, K.L.7
-
34
-
-
0031858602
-
Allelic differences in the relationship between proteasome activity and MHC class I peptide loading
-
Benham A.M., Gromme M., Neefjes J. Allelic differences in the relationship between proteasome activity and MHC class I peptide loading. J. Immunol. 161:1998;83-89.
-
(1998)
J. Immunol.
, vol.161
, pp. 83-89
-
-
Benham, A.M.1
Gromme, M.2
Neefjes, J.3
-
35
-
-
0033198680
-
Tripeptidyl peptidases: Enzymes that count
-
Tomkinson B. Tripeptidyl peptidases: enzymes that count. Trends Biochem. Sci. 24:1999;355-359.
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 355-359
-
-
Tomkinson, B.1
-
36
-
-
0033548055
-
A giant protease with potential to substitute for some functions of the proteasome
-
Geier E., Pfeifer G., Wilm M., Lucchiari-Hartz M., Baumeister W., Eichmann K., Niedermann G. A giant protease with potential to substitute for some functions of the proteasome. Science. 283:1999;978-981.
-
(1999)
Science
, vol.283
, pp. 978-981
-
-
Geier, E.1
Pfeifer, G.2
Wilm, M.3
Lucchiari-Hartz, M.4
Baumeister, W.5
Eichmann, K.6
Niedermann, G.7
-
37
-
-
0037386260
-
An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope
-
It is shown for the first time that TPPII is able to generate both the correct carboxyl and amino termini of a MHC class I epitope by endoproteolytic cleavages, and that TPPII can act independently of the proteasome.
-
Seifert U., Maranon C., Shmueli A., Desoutter J.F., Wesoloski L., Janek K., Henklein P., Diescher S., Andrieu M., de la Salle H.et al. An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope. Nat. Immunol. 4:2003;375-379 It is shown for the first time that TPPII is able to generate both the correct carboxyl and amino termini of a MHC class I epitope by endoproteolytic cleavages, and that TPPII can act independently of the proteasome.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 375-379
-
-
Seifert, U.1
Maranon, C.2
Shmueli, A.3
Desoutter, J.F.4
Wesoloski, L.5
Janek, K.6
Henklein, P.7
Diescher, S.8
Andrieu, M.9
De La Salle, H.10
-
38
-
-
0037108488
-
The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases
-
Levy F., Burri L., Morel S., Peitrequin A.L., Levy N., Bachi A., Hellman U., Van den Eynde B.J., Servis C. The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases. J. Immunol. 169:2002;4161-4171.
-
(2002)
J. Immunol.
, vol.169
, pp. 4161-4171
-
-
Levy, F.1
Burri, L.2
Morel, S.3
Peitrequin, A.L.4
Levy, N.5
Bachi, A.6
Hellman, U.7
Van Den Eynde, B.J.8
Servis, C.9
|