메뉴 건너뛰기




Volumn 108, Issue 7, 2006, Pages 2165-2172

Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: Results of a multicenter phase 1/2 study

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; BORTEZOMIB PLUS MELPHALAN; MELPHALAN; PREDNISONE; UNCLASSIFIED DRUG;

EID: 33748287079     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-04-019778     Document Type: Article
Times cited : (367)

References (60)
  • 1
    • 0344076348 scopus 로고    scopus 로고
    • Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: An overview of 6,633 patients from 27 randomized trials
    • Myeloma Trialists' Collaborative Group
    • Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: an overview of 6,633 patients from 27 randomized trials. Myeloma Trialists' Collaborative Group. J Clin Oncol. 1998;16:3832-3842.
    • (1998) J Clin Oncol , vol.16 , pp. 3832-3842
  • 2
    • 0014661330 scopus 로고
    • Treatment for multiple myeloma. Combination chemotherapy with different melphalan dose regimens
    • Alexanian R, Haut A, Khan AU, et al. Treatment for multiple myeloma. Combination chemotherapy with different melphalan dose regimens. JAMA. 1969;208:1680-1685.
    • (1969) JAMA , vol.208 , pp. 1680-1685
    • Alexanian, R.1    Haut, A.2    Khan, A.U.3
  • 3
    • 6444244370 scopus 로고    scopus 로고
    • Melphalan-prednisone versus alternating combination VAD/MP or VND/MP as primary therapy for multiple myeloma: Final analysis of a randomized clinical study
    • Cavo M, Benni M, Ronconi S, et al. Melphalan-prednisone versus alternating combination VAD/MP or VND/MP as primary therapy for multiple myeloma: final analysis of a randomized clinical study. Haematologica. 2002;87:934-942.
    • (2002) Haematologica , vol.87 , pp. 934-942
    • Cavo, M.1    Benni, M.2    Ronconi, S.3
  • 4
    • 0026099489 scopus 로고
    • Multiple myeloma: VMCP/VBAP alternating combination chemotherapy is not superior to melphalan and prednisone even in high-risk patients
    • Boccadoro M, Marmont F, Tribalto M, et al. Multiple myeloma: VMCP/VBAP alternating combination chemotherapy is not superior to melphalan and prednisone even in high-risk patients. J Clin Oncol. 1991;9:444-448.
    • (1991) J Clin Oncol , vol.9 , pp. 444-448
    • Boccadoro, M.1    Marmont, F.2    Tribalto, M.3
  • 5
    • 32644438680 scopus 로고    scopus 로고
    • Dexamethasone-based regimens versus melphalan-prednisone for elderly multiple myeloma patients ineligible for high-dose therapy
    • Facon T, Mary JY, Pegourie B, et al. Dexamethasone-based regimens versus melphalan-prednisone for elderly multiple myeloma patients ineligible for high-dose therapy. Blood. 2006;107:1292-1298.
    • (2006) Blood , vol.107 , pp. 1292-1298
    • Facon, T.1    Mary, J.Y.2    Pegourie, B.3
  • 6
    • 17944381821 scopus 로고    scopus 로고
    • Increased conventional chemotherapy does not improve survival in multiple myeloma: Long-term results of two PETHEMA trials including 914 patients
    • Blade J, San Miguel JF, Fontanillas M, et al. Increased conventional chemotherapy does not improve survival in multiple myeloma: long-term results of two PETHEMA trials including 914 patients. Hematol J. 2001;2:272-278.
    • (2001) Hematol J , vol.2 , pp. 272-278
    • Blade, J.1    San Miguel, J.F.2    Fontanillas, M.3
  • 7
    • 8944220233 scopus 로고    scopus 로고
    • A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma
    • Intergroupe Francais du Myelome
    • Attal M, Harousseau JL, Stoppa AM, et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Francais du Myelome. N Engl J Med. 1996;335:91-97.
    • (1996) N Engl J Med , vol.335 , pp. 91-97
    • Attal, M.1    Harousseau, J.L.2    Stoppa, A.M.3
  • 8
    • 0037739753 scopus 로고    scopus 로고
    • High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma
    • Child JA, Morgan GJ, Davies FE, et al. High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med. 2003;348:1875-1883.
    • (2003) N Engl J Med , vol.348 , pp. 1875-1883
    • Child, J.A.1    Morgan, G.J.2    Davies, F.E.3
  • 9
    • 28444494386 scopus 로고    scopus 로고
    • High-dose therapy intensification compared with continued standard chemotherapy in multiple myeloma patients responding to the initial chemotherapy: Long-term results from a prospective randomized trial from the Spanish cooperative group PET-HEMA
    • Blade J, Rosinol L, Sureda A, et al. High-dose therapy intensification compared with continued standard chemotherapy in multiple myeloma patients responding to the initial chemotherapy: long-term results from a prospective randomized trial from the Spanish cooperative group PET-HEMA. Blood. 2005;106:3755-3759.
    • (2005) Blood , vol.106 , pp. 3755-3759
    • Blade, J.1    Rosinol, L.2    Sureda, A.3
  • 10
    • 33644920953 scopus 로고    scopus 로고
    • Standard chemotherapy compared with high-dose chemoradiotherapy for multiple myeloma: Final results of phase III US Intergroup Trial S9321
    • Barlogie B, Kyle RA, Anderson KC, et al. Standard chemotherapy compared with high-dose chemoradiotherapy for multiple myeloma: final results of phase III US Intergroup Trial S9321. J Clin Oncol. 2006;24:929-936.
    • (2006) J Clin Oncol , vol.24 , pp. 929-936
    • Barlogie, B.1    Kyle, R.A.2    Anderson, K.C.3
  • 11
    • 0037326714 scopus 로고    scopus 로고
    • Mobilization of CD34+ cells in elderly patients (>/= 70 years) with multiple myeloma: Influence of age, prior therapy, platelet count and mobilization regimen
    • Morris CL, Siegel E, Barlogie B, et al. Mobilization of CD34+ cells in elderly patients (>/= 70 years) with multiple myeloma: influence of age, prior therapy, platelet count and mobilization regimen. Br J Haematol. 2003;120:413-423.
    • (2003) Br J Haematol , vol.120 , pp. 413-423
    • Morris, C.L.1    Siegel, E.2    Barlogie, B.3
  • 12
    • 28244477516 scopus 로고    scopus 로고
    • Cardiovascular toxicity is increased, but manageable, during high-dose chemotherapy and autologous peripheral blood stem cell transplantation for patients aged 60 years and older
    • Mileshkin LR, Seymour JF, Wolf MM, et al. Cardiovascular toxicity is increased, but manageable, during high-dose chemotherapy and autologous peripheral blood stem cell transplantation for patients aged 60 years and older. Leuk Lymphoma. 2005;46:1575-1579.
    • (2005) Leuk Lymphoma , vol.46 , pp. 1575-1579
    • Mileshkin, L.R.1    Seymour, J.F.2    Wolf, M.M.3
  • 13
    • 0033656056 scopus 로고    scopus 로고
    • Autologous blood and marrow transplantation in patients 60 years and older
    • Leger CS, Bredeson C, Kearns B, et al. Autologous blood and marrow transplantation in patients 60 years and older. Biol Blood Marrow Transplant. 2000;6:204-210.
    • (2000) Biol Blood Marrow Transplant , vol.6 , pp. 204-210
    • Leger, C.S.1    Bredeson, C.2    Kearns, B.3
  • 14
  • 15
    • 20444502596 scopus 로고    scopus 로고
    • Longterm outcomes of previously untreated myeloma patients: Responses to induction chemotherapy and high-dose melphalan incorporated within a risk stratification model can help to direct the use of novel treatments
    • Alvares CL, Davies FE, Horton C, et al. Longterm outcomes of previously untreated myeloma patients: responses to induction chemotherapy and high-dose melphalan incorporated within a risk stratification model can help to direct the use of novel treatments. Br J Haematol. 2005;129:607-614.
    • (2005) Br J Haematol , vol.129 , pp. 607-614
    • Alvares, C.L.1    Davies, F.E.2    Horton, C.3
  • 16
    • 13244271387 scopus 로고    scopus 로고
    • Prognostic factors for survival after autologous transplantation: A single centre experience in 133 multiple myeloma patients
    • Krejci M, Buchler T, Hajek R, et al. Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients. Bone Marrow Transplant. 2005;35:159-164.
    • (2005) Bone Marrow Transplant , vol.35 , pp. 159-164
    • Krejci, M.1    Buchler, T.2    Hajek, R.3
  • 17
    • 0742324364 scopus 로고    scopus 로고
    • High-dose therapy/autologous stem cell transplantation in patients with chemosensitive multiple myeloma: Predictors of complete remission
    • Nadal E, Gine E, Blade J, et al. High-dose therapy/autologous stem cell transplantation in patients with chemosensitive multiple myeloma: predictors of complete remission. Bone Marrow Transplant. 2004;33:61-64.
    • (2004) Bone Marrow Transplant , vol.33 , pp. 61-64
    • Nadal, E.1    Gine, E.2    Blade, J.3
  • 18
    • 33646339149 scopus 로고    scopus 로고
    • Complete response in multiple myeloma: Clinical trial E9486, an Eastern Cooperative Oncology Group study not involving stem cell transplantation
    • Kyle RA, Leong T, Li S, et al. Complete response in multiple myeloma: clinical trial E9486, an Eastern Cooperative Oncology Group study not involving stem cell transplantation. Cancer. 2006;106:1958-1966.
    • (2006) Cancer , vol.106 , pp. 1958-1966
    • Kyle, R.A.1    Leong, T.2    Li, S.3
  • 19
    • 33645706760 scopus 로고    scopus 로고
    • Predictive factors for survival in myeloma patients who undergo autologous stem cell transplantation: A single-centre experience in 211 patients
    • O'Shea D, Giles C, Terpos E, et al. Predictive factors for survival in myeloma patients who undergo autologous stem cell transplantation: a single-centre experience in 211 patients. Bone Marrow Transplant. 2006;37:731-737.
    • (2006) Bone Marrow Transplant , vol.37 , pp. 731-737
    • O'Shea, D.1    Giles, C.2    Terpos, E.3
  • 20
    • 33645504594 scopus 로고    scopus 로고
    • Total therapy 2 without thalidomide in comparison with total therapy 1: Role of intensified induction and posttransplantation consolidation therapies
    • Barlogie B, Tricot G, Rasmussen E, et al. Total therapy 2 without thalidomide in comparison with total therapy 1: role of intensified induction and posttransplantation consolidation therapies. Blood. 2006;107:2633-2638.
    • (2006) Blood , vol.107 , pp. 2633-2638
    • Barlogie, B.1    Tricot, G.2    Rasmussen, E.3
  • 21
    • 0033962755 scopus 로고    scopus 로고
    • Autologous peripheral blood stem cell transplantation as first line treatment of multiple myeloma: An Italian Multicenter Study
    • Tribalto M, Amadori S, Cudillo L, et al. Autologous peripheral blood stem cell transplantation as first line treatment of multiple myeloma: an Italian Multicenter Study. Haematologica. 2000;85:52-58.
    • (2000) Haematologica , vol.85 , pp. 52-58
    • Tribalto, M.1    Amadori, S.2    Cudillo, L.3
  • 22
    • 33644843725 scopus 로고    scopus 로고
    • Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: Randomised controlled trial
    • Palumbo A, Bringhen S, Caravita T, et al. Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial. Lancet. 2006;367:825-831.
    • (2006) Lancet , vol.367 , pp. 825-831
    • Palumbo, A.1    Bringhen, S.2    Caravita, T.3
  • 23
    • 33646901123 scopus 로고    scopus 로고
    • Major superiority of melphalan - Prednisone (MP) - thalidomide (THAL) over MP and autologous stem cell transplantation in the treatment of newly diagnosed elderly patients with multiple myeloma
    • [abstract] Abstract 780
    • Facon T, Mary JY, Hulin C, et al. Major superiority of melphalan - prednisone (MP) - thalidomide (THAL) over MP and autologous stem cell transplantation in the treatment of newly diagnosed elderly patients with multiple myeloma [abstract]. Blood. 2005;106. Abstract 780.
    • (2005) Blood , vol.106
    • Facon, T.1    Mary, J.Y.2    Hulin, C.3
  • 25
    • 0028607435 scopus 로고
    • Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53
    • Scheffner M, Huibregtse JM, Howley PM. Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. Proc Natl Acad Sci U S A. 1994;91:8797-8801.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8797-8801
    • Scheffner, M.1    Huibregtse, J.M.2    Howley, P.M.3
  • 26
    • 0036181371 scopus 로고    scopus 로고
    • Development of the proteasome inhibitor PS-341
    • Adams J. Development of the proteasome inhibitor PS-341. Oncologist. 2002;7:9-16.
    • (2002) Oncologist , vol.7 , pp. 9-16
    • Adams, J.1
  • 27
    • 26844452967 scopus 로고    scopus 로고
    • Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy
    • Boccadoro M, Morgan G, Cavenagh J. Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. Cancer Cell Int. 2005;5:1-9.
    • (2005) Cancer Cell Int , vol.5 , pp. 1-9
    • Boccadoro, M.1    Morgan, G.2    Cavenagh, J.3
  • 28
    • 1942467844 scopus 로고    scopus 로고
    • Update on the proteasome inhibitor bortezomib in hematologic malignancies
    • Goy A, Gilles F. Update on the proteasome inhibitor bortezomib in hematologic malignancies. Clin Lymphoma. 2004;4:230-237.
    • (2004) Clin Lymphoma , vol.4 , pp. 230-237
    • Goy, A.1    Gilles, F.2
  • 29
    • 0037973279 scopus 로고    scopus 로고
    • A phase 2 study of bortezomib in relapsed, refractory myeloma
    • Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med. 2003;348:2609-2617.
    • (2003) N Engl J Med , vol.348 , pp. 2609-2617
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3
  • 30
    • 5644250621 scopus 로고    scopus 로고
    • A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma
    • Jagannath S, Barlogie B, Berenson J, et al. A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol. 2004;127:165-172.
    • (2004) Br J Haematol , vol.127 , pp. 165-172
    • Jagannath, S.1    Barlogie, B.2    Berenson, J.3
  • 31
    • 20444433230 scopus 로고    scopus 로고
    • Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
    • Richardson PG, Sonneveld P, Schuster MW, et al. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med. 2005;352:2487-2498.
    • (2005) N Engl J Med , vol.352 , pp. 2487-2498
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.W.3
  • 32
    • 0037443551 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications
    • Mitsiades N, Mitsiades CS, Richardson PG, et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood. 2003;101:2377-2380.
    • (2003) Blood , vol.101 , pp. 2377-2380
    • Mitsiades, N.1    Mitsiades, C.S.2    Richardson, P.G.3
  • 33
    • 0037342894 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents
    • Ma MH, Yang HH, Parker K, et al. The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res. 2003;9:1136-1144.
    • (2003) Clin Cancer Res , vol.9 , pp. 1136-1144
    • Ma, M.H.1    Yang, H.H.2    Parker, K.3
  • 34
    • 0142186217 scopus 로고    scopus 로고
    • A prospective, open-label safety and efficacy study of combination treatment with bortezomib (PS-341, Velcade) and melphalan in patients with relapsed or refractory multiple myeloma
    • Yang HH, Vescio R, Schenkein D, Berenson JR. A prospective, open-label safety and efficacy study of combination treatment with bortezomib (PS-341, Velcade) and melphalan in patients with relapsed or refractory multiple myeloma. Clin Lymphoma. 2003;4:119-122.
    • (2003) Clin Lymphoma , vol.4 , pp. 119-122
    • Yang, H.H.1    Vescio, R.2    Schenkein, D.3    Berenson, J.R.4
  • 35
    • 33644916110 scopus 로고    scopus 로고
    • Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma
    • Berenson JR, Yang HH, Sadler K, et al. Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma. J Clin Oncol. 2006;24:937-944.
    • (2006) J Clin Oncol , vol.24 , pp. 937-944
    • Berenson, J.R.1    Yang, H.H.2    Sadler, K.3
  • 36
    • 21344469223 scopus 로고    scopus 로고
    • Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma
    • Jagannath S, Durie BG, Wolf J, et al. Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma. Br J Haematol. 2005;129:776-783.
    • (2005) Br J Haematol , vol.129 , pp. 776-783
    • Jagannath, S.1    Durie, B.G.2    Wolf, J.3
  • 37
    • 21344435052 scopus 로고    scopus 로고
    • PAD combination therapy (PS-341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma
    • Oakervee HE, Popat R, Curry N, et al. PAD combination therapy (PS-341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma. Br J Haematol. 2005;129:755-762.
    • (2005) Br J Haematol , vol.129 , pp. 755-762
    • Oakervee, H.E.1    Popat, R.2    Curry, N.3
  • 38
    • 27944439118 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: Preliminary results of an IFM phase II study [abstract]
    • Abstract 6653
    • Harousseau J, Attal M, Coiteux V, et al. Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: preliminary results of an IFM phase II study [abstract]. J Clin Oncol. 2005;23(pt I):598s. Abstract 6653.
    • (2005) J Clin Oncol , vol.23 , Issue.1 PART
    • Harousseau, J.1    Attal, M.2    Coiteux, V.3
  • 39
    • 33744826216 scopus 로고    scopus 로고
    • Bortezomib therapy alone and in combination with dexamethasone for patients with previously untreated multiple myeloma
    • [abstract] Abstract 783
    • Jagannath S, Durie B, Wolf J, et al. Bortezomib therapy alone and in combination with dexamethasone for patients with previously untreated multiple myeloma [abstract]. Blood. 2005;106. Abstract 783.
    • (2005) Blood , vol.106
    • Jagannath, S.1    Durie, B.2    Wolf, J.3
  • 40
    • 33645341982 scopus 로고    scopus 로고
    • Safety and efficacy of bortezomib in high-risk and elderly patients with relapsed myeloma
    • [abstract] Abstract 6533
    • Richardson PG, Sonneveld P, Schuster MW, et al. Safety and efficacy of bortezomib in high-risk and elderly patients with relapsed myeloma [abstract]. J Clin Oncol. 2005;23. Abstract 6533.
    • (2005) J Clin Oncol , vol.23
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.W.3
  • 41
    • 5644267858 scopus 로고    scopus 로고
    • Randomized comparison of dexamethasone combined with melphalan versus melphalan with prednisone in the treatment of elderly patients with multiple myeloma
    • Hernandez JM, Garcia-Sanz R, Golvano E, et al. Randomized comparison of dexamethasone combined with melphalan versus melphalan with prednisone in the treatment of elderly patients with multiple myeloma. Br J Haematol. 2004;127:159-164.
    • (2004) Br J Haematol , vol.127 , pp. 159-164
    • Hernandez, J.M.1    Garcia-Sanz, R.2    Golvano, E.3
  • 42
    • 18244428600 scopus 로고    scopus 로고
    • Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation
    • Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant
    • Blade J, Samson D, Reece D, et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. Br J Haematol. 1998;102:1115-1123.
    • (1998) Br J Haematol , vol.102 , pp. 1115-1123
    • Blade, J.1    Samson, D.2    Reece, D.3
  • 43
    • 0036493775 scopus 로고    scopus 로고
    • Immunophenotypic evaluation of the plasma cell compartment in multiple myeloma: A tool for comparing the efficacy of different treatment strategies and predicting outcome
    • San Miguel JF, Almeida J, Mateo G, et al. Immunophenotypic evaluation of the plasma cell compartment in multiple myeloma: a tool for comparing the efficacy of different treatment strategies and predicting outcome. Blood. 2002;99:1853-1856.
    • (2002) Blood , vol.99 , pp. 1853-1856
    • San Miguel, J.F.1    Almeida, J.2    Mateo, G.3
  • 45
    • 7244234267 scopus 로고    scopus 로고
    • Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma
    • Gutierrez NC, Garcia JL, Hernandez JM, et al. Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma. Blood. 2004;104:2661-2666.
    • (2004) Blood , vol.104 , pp. 2661-2666
    • Gutierrez, N.C.1    Garcia, J.L.2    Hernandez, J.M.3
  • 46
    • 0034039018 scopus 로고    scopus 로고
    • Remission status defined by immunofixation vs. electrophoresis after autologous transplantation has a major impact on the outcome of multiple myeloma patients
    • Lahuerta JJ, Martinez-Lopez J, Serna JD, et al. Remission status defined by immunofixation vs. electrophoresis after autologous transplantation has a major impact on the outcome of multiple myeloma patients. Br J Haematol. 2000;109:438-446.
    • (2000) Br J Haematol , vol.109 , pp. 438-446
    • Lahuerta, J.J.1    Martinez-Lopez, J.2    Serna, J.D.3
  • 47
    • 0035103579 scopus 로고    scopus 로고
    • The impact of attaining a minimal disease state after high-dose melphalan and autologous transplantation for multiple myeloma
    • Davies FE, Forsyth PD, Rawstron AC, et al. The impact of attaining a minimal disease state after high-dose melphalan and autologous transplantation for multiple myeloma. Br J Haematol. 2001;112:814-819.
    • (2001) Br J Haematol , vol.112 , pp. 814-819
    • Davies, F.E.1    Forsyth, P.D.2    Rawstron, A.C.3
  • 48
    • 8644260170 scopus 로고    scopus 로고
    • Intermediate-dose melphalan improves survival of myeloma patients aged 50 to 70: Results of a randomized controlled trial
    • Palumbo A, Bringhen S, Petrucci MT, et al. Intermediate-dose melphalan improves survival of myeloma patients aged 50 to 70: results of a randomized controlled trial. Blood. 2004;104:3052-3057.
    • (2004) Blood , vol.104 , pp. 3052-3057
    • Palumbo, A.1    Bringhen, S.2    Petrucci, M.T.3
  • 49
    • 0041438792 scopus 로고    scopus 로고
    • Molecular remission after myeloablative allogeneic stem cell transplantation predicts a better relapse-free survival in patients with multiple myeloma
    • Corradini P, Cavo M, Lokhorst H, et al. Molecular remission after myeloablative allogeneic stem cell transplantation predicts a better relapse-free survival in patients with multiple myeloma. Blood. 2003;102:1927-1929.
    • (2003) Blood , vol.102 , pp. 1927-1929
    • Corradini, P.1    Cavo, M.2    Lokhorst, H.3
  • 50
    • 27144546033 scopus 로고    scopus 로고
    • Minimal residual disease monitoring in multiple myeloma: A comparison between allelic-specific oligonucleotide real-time quantitative polymerase chain reaction and flow cytometry
    • Sarasquete ME, Garcia-Sanz R, Gonzalez D, et al. Minimal residual disease monitoring in multiple myeloma: a comparison between allelic-specific oligonucleotide real-time quantitative polymerase chain reaction and flow cytometry. Haematologica. 2005;90:1365-1372.
    • (2005) Haematologica , vol.90 , pp. 1365-1372
    • Sarasquete, M.E.1    Garcia-Sanz, R.2    Gonzalez, D.3
  • 51
    • 27144487753 scopus 로고    scopus 로고
    • Evaluation and monitoring of response to therapy in multiple myeloma
    • Rajkumar SV, Dispenzieri A. Evaluation and monitoring of response to therapy in multiple myeloma. Haematologica. 2005;90:1305-1308.
    • (2005) Haematologica , vol.90 , pp. 1305-1308
    • Rajkumar, S.V.1    Dispenzieri, A.2
  • 52
    • 25144435821 scopus 로고    scopus 로고
    • Oral melphalan, prednisone, and thalidomide for newly diagnosed patients with myeloma
    • Palumbo A, Bertola A, Musto P, et al. Oral melphalan, prednisone, and thalidomide for newly diagnosed patients with myeloma. Cancer. 2005;104:1428-1433.
    • (2005) Cancer , vol.104 , pp. 1428-1433
    • Palumbo, A.1    Bertola, A.2    Musto, P.3
  • 53
    • 33746332717 scopus 로고    scopus 로고
    • Bortezomib continues to demonstrate superior efficacy compared with high-dose dexamethasone in relapsed multiple myeloma: Updated results of the APEX trial
    • [abstract] Abstract 2547
    • Richardson P, Sonneveld P, Schuster M, et al. Bortezomib continues to demonstrate superior efficacy compared with high-dose dexamethasone in relapsed multiple myeloma: updated results of the APEX trial [abstract]. Blood. 2005;106(pt 1):568s. Abstract 2547.
    • (2005) Blood , vol.106 , Issue.1 PART
    • Richardson, P.1    Sonneveld, P.2    Schuster, M.3
  • 54
    • 17344395438 scopus 로고    scopus 로고
    • Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization
    • Zojer N, Konigsberg R, Ackermann J, et al. Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization. Blood. 2000;95:1925-1930.
    • (2000) Blood , vol.95 , pp. 1925-1930
    • Zojer, N.1    Konigsberg, R.2    Ackermann, J.3
  • 55
    • 2642617778 scopus 로고    scopus 로고
    • Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes
    • Perez-Simon JA, Garcia-Sanz R, Tabernero MD, et al. Prognostic value of numerical chromosome aberrations in multiple myeloma: a FISH analysis of 15 different chromosomes. Blood. 1998;91:3366-3371.
    • (1998) Blood , vol.91 , pp. 3366-3371
    • Perez-Simon, J.A.1    Garcia-Sanz, R.2    Tabernero, M.D.3
  • 56
    • 0032929769 scopus 로고    scopus 로고
    • Total therapy with tandem transplants for newly diagnosed multiple myeloma
    • Barlogie B, Jagannath S, Desikan KR, et al. Total therapy with tandem transplants for newly diagnosed multiple myeloma. Blood. 1999;93:55-65.
    • (1999) Blood , vol.93 , pp. 55-65
    • Barlogie, B.1    Jagannath, S.2    Desikan, K.R.3
  • 57
    • 27244439379 scopus 로고    scopus 로고
    • Prognostic and therapeutic significance of myeloma genetics and gene expression profiling
    • Stewart AK, Fonseca R. Prognostic and therapeutic significance of myeloma genetics and gene expression profiling. J Clin Oncol. 2005;23:6339-6344.
    • (2005) J Clin Oncol , vol.23 , pp. 6339-6344
    • Stewart, A.K.1    Fonseca, R.2
  • 58
    • 30944436753 scopus 로고    scopus 로고
    • Bortezomib appears to overcome poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials
    • [abstract] Abstract 6501
    • Jagannath S, Richardson PG, Sonneveld P, et al. Bortezomib appears to overcome poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials [abstract]. J Clin Oncol. 2005;23(pt 1):561s. Abstract 6501.
    • (2005) J Clin Oncol , vol.23 , Issue.1 PART
    • Jagannath, S.1    Richardson, P.G.2    Sonneveld, P.3
  • 59
    • 33746356913 scopus 로고    scopus 로고
    • A multicenter phase II trial of bortezomib in patients with previously untreated multiple myeloma: Efficacy with manageable toxicity in patients with unexpectedly high rates of baseline peripheral neuropathy
    • [abstract] Abstract 2548
    • Richardson P, Chanan-Khan A, Schlossman R, et al. A multicenter phase II trial of bortezomib in patients with previously untreated multiple myeloma: efficacy with manageable toxicity in patients with unexpectedly high rates of baseline peripheral neuropathy [abstract]. Blood. 2005;106. Abstract 2548.
    • (2005) Blood , vol.106
    • Richardson, P.1    Chanan-Khan, A.2    Schlossman, R.3
  • 60
    • 33644829447 scopus 로고    scopus 로고
    • Early mortality after diagnosis of multiple myeloma: Analysis of patients entered onto the United Kingdom Medical Research Council trials between 1980 and 2002-Medical Research Council Adult Leukaemia Working Party
    • Augustson BM, Begum G, Dunn JA, et al. Early mortality after diagnosis of multiple myeloma: analysis of patients entered onto the United Kingdom Medical Research Council trials between 1980 and 2002-Medical Research Council Adult Leukaemia Working Party. J Clin Oncol. 2005;23:9219-9226.
    • (2005) J Clin Oncol , vol.23 , pp. 9219-9226
    • Augustson, B.M.1    Begum, G.2    Dunn, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.