β-Site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged2 (Jag2) proteins

Journal of Biological Chemistry

Volumn 289, Issue 30, 2014, Pages 20630-20637

  He, Wanxia ^a   Hu, Jinxuan ^a   Xia, Yuxing ^a   Yan, Riqiang ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; MOLECULES;

AMYLOID PEPTIDES; AMYLOID PRECURSOR PROTEINS; ASPARTYL PROTEASE; CELLULAR FUNCTION; MEMBRANE-BOUND; NOTCH SIGNALING; SIGNALING MOLECULES; TRANSMEMBRANES;

PROTEINS;

ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; ADAM10 PROTEIN, MOUSE; ADAM10 PROTEIN, RAT; ASPARTIC PROTEINASE; BACE PROTEIN, RAT; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; CALCIUM BINDING PROTEIN; JAG2 PROTEIN, HUMAN; JAG2 PROTEIN, MOUSE; JAG2 PROTEIN, RAT; MEMBRANE PROTEIN; NOTCH RECEPTOR; SECRETASE; SERRATE PROTEINS; SIGNAL PEPTIDE; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

ANIMAL; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOUSE; MUTANT MOUSE STRAIN; PHYSIOLOGY; PROTEIN DEGRADATION; RAT; SIGNAL TRANSDUCTION;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CALCIUM-BINDING PROTEINS; HEK293 CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, MUTANT STRAINS; PROTEOLYSIS; RATS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 84905409164     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.579862     Document Type: Article

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