Employing a superior BACE1 cleavage sequence to probe cellular APP processing

Journal of Neurochemistry

Volumn 84, Issue 5, 2003, Pages 1006-1017

  Tomasselli, Alfredo G ^a   Qahwash, Isam ^a   Emmons, Thomas L ^a   Lu, Yifeng ^a   Leonem, Joseph W ^a   Lull, June M ^a   Fok, Kam F ^a   Bannow, Carol A ^a   Smith, Clark W ^a   Bienkowski, Michael J ^a   Heinrikson, Robert L ^a   Yan, Riqiang ^a  

^a PFIZER INC   (United States)

Author keywords

Alzheimer's secretase; Amyloid peptide; APP processing; BACE1; BACE2; Mutant amyloid precursor protein

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; INSULIN; MUTANT PROTEIN; SYNTHETIC PEPTIDE; UBIQUITIN;

ALZHEIMER DISEASE; AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL ASSAY; CHO CELL; CONTROLLED STUDY; ENZYME ASSAY; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; KIDNEY CELL; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CHO CELLS; CRICETINAE; ENDOPEPTIDASES; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN PROCESSING, POST-TRANSLATIONAL; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0037343153     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01597.x     Document Type: Article

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