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Volumn 588, Issue 16, 2014, Pages 2558-2570

Deregulation of cell signaling in cancer

Author keywords

Cancer cell biology; Cell signaling; Targeted therapies; Tumorigenesis

Indexed keywords

CADHERIN; FOCAL ADHESION KINASE; INTEGRIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; NOTCH RECEPTOR; PROTEIN P53; PROTEIN TYROSINE KINASE; RETINOBLASTOMA PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RECEPTOR; WNT PROTEIN;

EID: 84905096063     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.02.005     Document Type: Review
Times cited : (103)

References (139)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 2009 1029 1033
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 4
    • 79954533158 scopus 로고    scopus 로고
    • Shifting the equilibrium in cancer immunoediting: From tumor tolerance to eradication
    • S.A. Quezada, K.S. Peggs, T.R. Simpson, and J.P. Allison Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication Immunol. Rev. 241 2011 104 118
    • (2011) Immunol. Rev. , vol.241 , pp. 104-118
    • Quezada, S.A.1    Peggs, K.S.2    Simpson, T.R.3    Allison, J.P.4
  • 5
    • 77955928161 scopus 로고    scopus 로고
    • Tumors as organs: Complex tissues that interface with the entire organism
    • M. Egeblad, E.S. Nakasone, and Z. Werb Tumors as organs: complex tissues that interface with the entire organism Dev. Cell 18 2010 884 901
    • (2010) Dev. Cell , vol.18 , pp. 884-901
    • Egeblad, M.1    Nakasone, E.S.2    Werb, Z.3
  • 7
    • 0034614490 scopus 로고    scopus 로고
    • Signaling-2000 and beyond
    • T. Hunter Signaling-2000 and beyond Cell 100 2000 113 127
    • (2000) Cell , vol.100 , pp. 113-127
    • Hunter, T.1
  • 8
    • 0842346438 scopus 로고    scopus 로고
    • Specificity in signal transduction: From phosphotyrosine-SH2 domain interactions to complex cellular systems
    • T. Pawson Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems Cell 116 2004 191 203
    • (2004) Cell , vol.116 , pp. 191-203
    • Pawson, T.1
  • 9
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • B. Vogelstein, and K.W. Kinzler Cancer genes and the pathways they control Nat. Med. 10 2004 789 799
    • (2004) Nat. Med. , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 10
    • 77952917698 scopus 로고    scopus 로고
    • Spatial organization of intracellular communication: Insights from imaging
    • L. Dehmelt, and P.I. Bastiaens Spatial organization of intracellular communication: insights from imaging Nat. Rev. Mol. Cell Biol. 11 2010 440 452
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 440-452
    • Dehmelt, L.1    Bastiaens, P.I.2
  • 12
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • M.A. Lemmon, and J. Schlessinger Cell signaling by receptor tyrosine kinases Cell 141 2010 1117 1134
    • (2010) Cell , vol.141 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 13
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • J. Downward Targeting RAS signalling pathways in cancer therapy Nat. Rev. Cancer 3 2003 11 22
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 14
    • 78649487698 scopus 로고    scopus 로고
    • Ras superfamily GEFs and GAPs: Validated and tractable targets for cancer therapy?
    • D. Vigil, J. Cherfils, K.L. Rossman, and C.J. Der Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat. Rev. Cancer 10 2010 842 857
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 842-857
    • Vigil, D.1    Cherfils, J.2    Rossman, K.L.3    Der, C.J.4
  • 15
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
    • J. Luo, B.D. Manning, and L.C. Cantley Targeting the PI3K-Akt pathway in human cancer: rationale and promise Cancer Cell 4 2003 257 262
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 16
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • B.D. Manning, and L.C. Cantley AKT/PKB signaling: navigating downstream Cell 129 2007 1261 1274
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 17
    • 0034681264 scopus 로고    scopus 로고
    • The multiple roles of PTEN in tumor suppression
    • A. Di Cristofano, and P.P. Pandolfi The multiple roles of PTEN in tumor suppression Cell 100 2000 387 390
    • (2000) Cell , vol.100 , pp. 387-390
    • Di Cristofano, A.1    Pandolfi, P.P.2
  • 18
    • 79952395270 scopus 로고    scopus 로고
    • Cancer genomics: From discovery science to personalized medicine
    • L. Chin, J.N. Andersen, and P.A. Futreal Cancer genomics: from discovery science to personalized medicine Nat. Med. 17 2011 297 303
    • (2011) Nat. Med. , vol.17 , pp. 297-303
    • Chin, L.1    Andersen, J.N.2    Futreal, P.A.3
  • 19
    • 34249018869 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumour
    • B.P. Rubin, M.C. Heinrich, and C.L. Corless Gastrointestinal stromal tumour Lancet 369 2007 1731 1741
    • (2007) Lancet , vol.369 , pp. 1731-1741
    • Rubin, B.P.1    Heinrich, M.C.2    Corless, C.L.3
  • 20
    • 5444227865 scopus 로고    scopus 로고
    • Guilty as charged: B-RAF is a human oncogene
    • M.J. Garnett, and R. Marais Guilty as charged: B-RAF is a human oncogene Cancer Cell 6 2004 313 319
    • (2004) Cancer Cell , vol.6 , pp. 313-319
    • Garnett, M.J.1    Marais, R.2
  • 22
    • 84866709500 scopus 로고    scopus 로고
    • Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
    • P.S. Hammerman et al. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer Cancer Discov. 1 2011 78 89
    • (2011) Cancer Discov. , vol.1 , pp. 78-89
    • Hammerman, P.S.1
  • 23
    • 0030056968 scopus 로고    scopus 로고
    • Cell adhesion: The molecular basis of tissue architecture and morphogenesis
    • B.M. Gumbiner Cell adhesion: the molecular basis of tissue architecture and morphogenesis Cell 84 1996 345 357
    • (1996) Cell , vol.84 , pp. 345-357
    • Gumbiner, B.M.1
  • 24
  • 25
    • 0345687500 scopus 로고    scopus 로고
    • Positional control of cell fate through joint integrin/receptor protein kinase signaling
    • F.G. Giancotti, and G. Tarone Positional control of cell fate through joint integrin/receptor protein kinase signaling Annu. Rev. Cell Dev. Biol. 19 2003 173 206
    • (2003) Annu. Rev. Cell Dev. Biol. , vol.19 , pp. 173-206
    • Giancotti, F.G.1    Tarone, G.2
  • 26
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • R.O. Hynes Integrins: bidirectional, allosteric signaling machines Cell 110 2002 673 687
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 27
    • 61749094852 scopus 로고    scopus 로고
    • Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling
    • Y. Pylayeva, K.M. Gillen, W. Gerald, H.E. Beggs, L.F. Reichardt, and F.G. Giancotti Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling J. Clin. Invest. 119 2009 252 266
    • (2009) J. Clin. Invest. , vol.119 , pp. 252-266
    • Pylayeva, Y.1    Gillen, K.M.2    Gerald, W.3    Beggs, H.E.4    Reichardt, L.F.5    Giancotti, F.G.6
  • 29
    • 44849097747 scopus 로고    scopus 로고
    • DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma
    • W. Xue et al. DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma Genes Dev. 22 2008 1439 1444
    • (2008) Genes Dev. , vol.22 , pp. 1439-1444
    • Xue, W.1
  • 30
    • 76749108011 scopus 로고    scopus 로고
    • Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus
    • W. Li et al. Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus Cell 140 2010 477 490
    • (2010) Cell , vol.140 , pp. 477-490
    • Li, W.1
  • 31
    • 79961087833 scopus 로고    scopus 로고
    • E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
    • N.G. Kim, E. Koh, X. Chen, and B.M. Gumbiner E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components Proc. Natl. Acad. Sci. U.S.A. 108 2011 11930 11935
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 11930-11935
    • Kim, N.G.1    Koh, E.2    Chen, X.3    Gumbiner, B.M.4
  • 32
    • 33847206401 scopus 로고    scopus 로고
    • The Salvador-Warts-Hippo pathway - An emerging tumour-suppressor network
    • K. Harvey, and N. Tapon The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network Nat. Rev. Cancer 7 2007 182 191
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 182-191
    • Harvey, K.1    Tapon, N.2
  • 33
    • 77957883342 scopus 로고    scopus 로고
    • The hippo signaling pathway in development and cancer
    • D. Pan The hippo signaling pathway in development and cancer Dev. Cell 19 2010 491 505
    • (2010) Dev. Cell , vol.19 , pp. 491-505
    • Pan, D.1
  • 34
    • 78650724753 scopus 로고    scopus 로고
    • Hippo signaling: Growth control and beyond
    • G. Halder, and R.L. Johnson Hippo signaling: growth control and beyond Development 138 2011 9 22
    • (2011) Development , vol.138 , pp. 9-22
    • Halder, G.1    Johnson, R.L.2
  • 35
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • H. Clevers Wnt/beta-catenin signaling in development and disease Cell 127 2006 469 480
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 37
    • 1042267263 scopus 로고    scopus 로고
    • Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
    • U. Cavallaro, and G. Christofori Cell adhesion and signalling by cadherins and Ig-CAMs in cancer Nat. Rev. Cancer 4 2004 118 132
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 118-132
    • Cavallaro, U.1    Christofori, G.2
  • 38
    • 79959694149 scopus 로고    scopus 로고
    • The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma
    • M. Bott et al. The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma Nat. Genet. 43 2011 668 672
    • (2011) Nat. Genet. , vol.43 , pp. 668-672
    • Bott, M.1
  • 39
    • 33745253109 scopus 로고    scopus 로고
    • Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    • L. Zender et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach Cell 125 2006 1253 1267
    • (2006) Cell , vol.125 , pp. 1253-1267
    • Zender, L.1
  • 40
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • S. Wullschleger, R. Loewith, and M.N. Hall TOR signaling in growth and metabolism Cell 124 2006 471 484
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 41
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • R. Zoncu, A. Efeyan, and D.M. Sabatini MTOR: from growth signal integration to cancer, diabetes and ageing Nat. Rev. Mol. Cell Biol. 12 2011 21 35
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 42
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • X.M. Ma, and J. Blenis Molecular mechanisms of mTOR-mediated translational control Nat. Rev. Mol. Cell Biol. 10 2009 307 318
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 43
    • 79958696694 scopus 로고    scopus 로고
    • The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
    • P.P. Hsu et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling Science 332 2011 1317 1322
    • (2011) Science , vol.332 , pp. 1317-1322
    • Hsu, P.P.1
  • 44
    • 79958696336 scopus 로고    scopus 로고
    • Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
    • Y. Yu et al. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling Science 332 2011 1322 1326
    • (2011) Science , vol.332 , pp. 1322-1326
    • Yu, Y.1
  • 45
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • O. Warburg On respiratory impairment in cancer cells Science 124 1956 269 270
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 47
    • 34547580590 scopus 로고    scopus 로고
    • HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation
    • J.D. Gordan, C.B. Thompson, and M.C. Simon HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation Cancer Cell 12 2007 108 113
    • (2007) Cancer Cell , vol.12 , pp. 108-113
    • Gordan, J.D.1    Thompson, C.B.2    Simon, M.C.3
  • 48
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • E.R. Mardis et al. Recurring mutations found by sequencing an acute myeloid leukemia genome N. Engl. J. Med. 361 2009 1058 1066
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1058-1066
    • Mardis, E.R.1
  • 49
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • H. Yan et al. IDH1 and IDH2 mutations in gliomas N. Engl. J. Med. 360 2009 765 773
    • (2009) N. Engl. J. Med. , vol.360 , pp. 765-773
    • Yan, H.1
  • 50
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • R.G. Verhaak et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 Cancer Cell 17 2010 98 110
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1
  • 51
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • L. Dang et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature 462 2009 739 744
    • (2009) Nature , vol.462 , pp. 739-744
    • Dang, L.1
  • 52
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • P.S. Ward et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate Cancer Cell 17 2010 225 234
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1
  • 53
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • M.E. Figueroa et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation Cancer Cell 18 2010 553 567
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1
  • 54
    • 79960064353 scopus 로고    scopus 로고
    • Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
    • K. Moran-Crusio et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation Cancer Cell 20 2011 11 24
    • (2011) Cancer Cell , vol.20 , pp. 11-24
    • Moran-Crusio, K.1
  • 55
    • 79960062301 scopus 로고    scopus 로고
    • TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
    • C. Quivoron et al. TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis Cancer Cell 20 2011 25 38
    • (2011) Cancer Cell , vol.20 , pp. 25-38
    • Quivoron, C.1
  • 56
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • B. Levine, and G. Kroemer Autophagy in the pathogenesis of disease Cell 132 2008 27 42
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 57
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • N. Mizushima, B. Levine, A.M. Cuervo, and D.J. Klionsky Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 58
    • 79952228407 scopus 로고    scopus 로고
    • Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
    • J.Y. Guo et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis Genes Dev. 25 2011 460 470
    • (2011) Genes Dev. , vol.25 , pp. 460-470
    • Guo, J.Y.1
  • 59
    • 79952229430 scopus 로고    scopus 로고
    • Pancreatic cancers require autophagy for tumor growth
    • S. Yang et al. Pancreatic cancers require autophagy for tumor growth Genes Dev. 25 2011 717 729
    • (2011) Genes Dev. , vol.25 , pp. 717-729
    • Yang, S.1
  • 60
    • 79551634458 scopus 로고    scopus 로고
    • Autophagy in tumorigenesis and energy metabolism: Friend by day, foe by night
    • R. Mathew, and E. White Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night Curr. Opin. Genet. Dev. 21 2011 113 119
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 113-119
    • Mathew, R.1    White, E.2
  • 61
    • 0034614334 scopus 로고    scopus 로고
    • A long twentieth century of the cell cycle and beyond
    • P. Nurse A long twentieth century of the cell cycle and beyond Cell 100 2000 71 78
    • (2000) Cell , vol.100 , pp. 71-78
    • Nurse, P.1
  • 62
    • 0842324788 scopus 로고    scopus 로고
    • Recycling the cell cycle: Cyclins revisited
    • A.W. Murray Recycling the cell cycle: cyclins revisited Cell 116 2004 221 234
    • (2004) Cell , vol.116 , pp. 221-234
    • Murray, A.W.1
  • 63
    • 33645960654 scopus 로고    scopus 로고
    • Stabilizers and destabilizers controlling cell cycle oscillators
    • D. Guardavaccaro, and M. Pagano Stabilizers and destabilizers controlling cell cycle oscillators Mol. Cell 22 2006 1 4
    • (2006) Mol. Cell , vol.22 , pp. 1-4
    • Guardavaccaro, D.1    Pagano, M.2
  • 64
    • 0842346437 scopus 로고    scopus 로고
    • Principles of tumor suppression
    • C.J. Sherr Principles of tumor suppression Cell 116 2004 235 246
    • (2004) Cell , vol.116 , pp. 235-246
    • Sherr, C.J.1
  • 66
    • 0037023755 scopus 로고    scopus 로고
    • Signaling networks that link cell proliferation and cell fate
    • R.C. Sears, and J.R. Nevins Signaling networks that link cell proliferation and cell fate J. Biol. Chem. 277 2002 11617 11620
    • (2002) J. Biol. Chem. , vol.277 , pp. 11617-11620
    • Sears, R.C.1    Nevins, J.R.2
  • 68
    • 9244239811 scopus 로고    scopus 로고
    • G1 cell-cycle control and cancer
    • J. Massague G1 cell-cycle control and cancer Nature 432 2004 298 306
    • (2004) Nature , vol.432 , pp. 298-306
    • Massague, J.1
  • 69
    • 44349122993 scopus 로고    scopus 로고
    • Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: Tipping the scales of cancer
    • D. Frescas, and M. Pagano Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer Nat. Rev. Cancer 8 2008 438 449
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 438-449
    • Frescas, D.1    Pagano, M.2
  • 72
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • J. Massague TGFbeta in cancer Cell 134 2008 215 230
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 73
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Y. Shi, and J. Massague Mechanisms of TGF-beta signaling from cell membrane to the nucleus Cell 113 2003 685 700
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 74
    • 9244224723 scopus 로고    scopus 로고
    • Intrinsic tumour suppression
    • S.W. Lowe, E. Cepero, and G. Evan Intrinsic tumour suppression Nature 432 2004 307 315
    • (2004) Nature , vol.432 , pp. 307-315
    • Lowe, S.W.1    Cepero, E.2    Evan, G.3
  • 75
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: The growing complexity of p53
    • K.H. Vousden, and C. Prives Blinded by the light: the growing complexity of p53 Cell 137 2009 413 431
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 77
    • 67649595826 scopus 로고    scopus 로고
    • Apoptosis and cancer: The genesis of a research field
    • T.G. Cotter Apoptosis and cancer: the genesis of a research field Nat. Rev. Cancer 9 2009 501 507
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 501-507
    • Cotter, T.G.1
  • 78
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • N.N. Danial, and S.J. Korsmeyer Cell death: critical control points Cell 116 2004 205 219
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 79
    • 54949132875 scopus 로고    scopus 로고
    • Bcl-2 family proteins and cancer
    • K.W. Yip, and J.C. Reed Bcl-2 family proteins and cancer Oncogene 27 2008 6398 6406
    • (2008) Oncogene , vol.27 , pp. 6398-6406
    • Yip, K.W.1    Reed, J.C.2
  • 80
    • 79551620159 scopus 로고    scopus 로고
    • Apoptosis and oncogenesis: Give and take in the BCL-2 family
    • F. Llambi, and D.R. Green Apoptosis and oncogenesis: give and take in the BCL-2 family Curr. Opin. Genet. Dev. 21 2011 12 20
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 12-20
    • Llambi, F.1    Green, D.R.2
  • 81
    • 41149152733 scopus 로고    scopus 로고
    • How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
    • J.E. Chipuk, and D.R. Green How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol. 18 2008 157 164
    • (2008) Trends Cell Biol. , vol.18 , pp. 157-164
    • Chipuk, J.E.1    Green, D.R.2
  • 82
    • 3943071150 scopus 로고    scopus 로고
    • Cytochrome C-mediated apoptosis
    • X. Jiang, and X. Wang Cytochrome C-mediated apoptosis Annu. Rev. Biochem. 73 2004 87 106
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 87-106
    • Jiang, X.1    Wang, X.2
  • 83
    • 69449095860 scopus 로고    scopus 로고
    • Caspases and kinases in a death grip
    • M. Kurokawa, and S. Kornbluth Caspases and kinases in a death grip Cell 138 2009 838 854
    • (2009) Cell , vol.138 , pp. 838-854
    • Kurokawa, M.1    Kornbluth, S.2
  • 86
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • M.B. Kastan, and J. Bartek Cell-cycle checkpoints and cancer Nature 432 2004 316 323
    • (2004) Nature , vol.432 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 87
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: Making it safe to play with knives
    • A. Ciccia, and S.J. Elledge The DNA damage response: making it safe to play with knives Mol. Cell 40 2010 179 204
    • (2010) Mol. Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 88
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: Building a framework
    • G.P. Gupta, and J. Massague Cancer metastasis: building a framework Cell 127 2006 679 695
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 89
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • C.L. Chaffer, and R.A. Weinberg A perspective on cancer cell metastasis Science 331 2011 1559 1564
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 90
    • 35549001736 scopus 로고    scopus 로고
    • The PAR proteins: Fundamental players in animal cell polarization
    • B. Goldstein, and I.G. Macara The PAR proteins: fundamental players in animal cell polarization Dev. Cell 13 2007 609 622
    • (2007) Dev. Cell , vol.13 , pp. 609-622
    • Goldstein, B.1    Macara, I.G.2
  • 91
    • 25444443688 scopus 로고    scopus 로고
    • Modelling glandular epithelial cancers in three-dimensional cultures
    • J. Debnath, and J.S. Brugge Modelling glandular epithelial cancers in three-dimensional cultures Nat. Rev. Cancer 5 2005 675 688
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 675-688
    • Debnath, J.1    Brugge, J.S.2
  • 92
    • 33748967069 scopus 로고    scopus 로고
    • Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer
    • C.M. Nelson, and M.J. Bissell Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer Annu. Rev. Cell Dev. Biol. 22 2006 287 309
    • (2006) Annu. Rev. Cell Dev. Biol. , vol.22 , pp. 287-309
    • Nelson, C.M.1    Bissell, M.J.2
  • 93
    • 34548295877 scopus 로고    scopus 로고
    • Cell polarity in development and cancer
    • A. Wodarz, and I. Nathke Cell polarity in development and cancer Nat. Cell Biol. 9 2007 1016 1024
    • (2007) Nat. Cell Biol. , vol.9 , pp. 1016-1024
    • Wodarz, A.1    Nathke, I.2
  • 95
    • 76049106434 scopus 로고    scopus 로고
    • Polarity protein alterations in carcinoma: A focus on emerging roles for polarity regulators
    • L. Huang, and S.K. Muthuswamy Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators Curr. Opin. Genet. Dev. 20 2010 41 50
    • (2010) Curr. Opin. Genet. Dev. , vol.20 , pp. 41-50
    • Huang, L.1    Muthuswamy, S.K.2
  • 96
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • J. Yang, and R.A. Weinberg Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis Dev. Cell 14 2008 818 829
    • (2008) Dev. Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 97
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • J.P. Thiery, H. Acloque, R.Y. Huang, and M.A. Nieto Epithelial- mesenchymal transitions in development and disease Cell 139 2009 871 890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 98
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • H. Peinado, D. Olmeda, and A. Cano Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 7 2007 415 428
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 99
    • 60149084560 scopus 로고    scopus 로고
    • MicroRNAs and cancer: Short RNAs go a long way
    • A. Ventura, and T. Jacks MicroRNAs and cancer: short RNAs go a long way Cell 136 2009 586 591
    • (2009) Cell , vol.136 , pp. 586-591
    • Ventura, A.1    Jacks, T.2
  • 100
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • K. Polyak, and R.A. Weinberg Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits Nat. Rev. Cancer 9 2009 265 273
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 101
    • 75749146306 scopus 로고    scopus 로고
    • Plasticity of cell migration: A multiscale tuning model
    • P. Friedl, and K. Wolf Plasticity of cell migration: a multiscale tuning model J. Cell Biol. 188 2010 11 19
    • (2010) J. Cell Biol. , vol.188 , pp. 11-19
    • Friedl, P.1    Wolf, K.2
  • 103
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: Biochemistry and biology
    • A.B. Jaffe, and A. Hall Rho GTPases: biochemistry and biology Annu. Rev. Cell Dev. Biol. 21 2005 247 269
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 104
    • 77957243835 scopus 로고    scopus 로고
    • The plasticity of cytoskeletal dynamics underlying neoplastic cell migration
    • V. Sanz-Moreno, and C.J. Marshall The plasticity of cytoskeletal dynamics underlying neoplastic cell migration Curr. Opin. Cell Biol. 22 2010 690 696
    • (2010) Curr. Opin. Cell Biol. , vol.22 , pp. 690-696
    • Sanz-Moreno, V.1    Marshall, C.J.2
  • 106
    • 69949129056 scopus 로고    scopus 로고
    • Cancer stem cells: Mirage or reality?
    • P.B. Gupta, C.L. Chaffer, and R.A. Weinberg Cancer stem cells: mirage or reality? Nat. Med. 15 2009 1010 1012
    • (2009) Nat. Med. , vol.15 , pp. 1010-1012
    • Gupta, P.B.1    Chaffer, C.L.2    Weinberg, R.A.3
  • 107
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • H. Clevers The cancer stem cell: premises, promises and challenges Nat. Med. 17 2011 313 319
    • (2011) Nat. Med. , vol.17 , pp. 313-319
    • Clevers, H.1
  • 108
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • P.A. Beachy, S.S. Karhadkar, and D.M. Berman Tissue repair and stem cell renewal in carcinogenesis Nature 432 2004 324 331
    • (2004) Nature , vol.432 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 111
    • 77951101203 scopus 로고    scopus 로고
    • The primary cilium: A signalling centre during vertebrate development
    • S.C. Goetz, and K.V. Anderson The primary cilium: a signalling centre during vertebrate development Nat. Rev. Genet. 11 2010 331 344
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 331-344
    • Goetz, S.C.1    Anderson, K.V.2
  • 112
    • 26444585020 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling in stem cells and cancer
    • L. Mishra, R. Derynck, and B. Mishra Transforming growth factor-beta signaling in stem cells and cancer Science 310 2005 68 71
    • (2005) Science , vol.310 , pp. 68-71
    • Mishra, L.1    Derynck, R.2    Mishra, B.3
  • 113
  • 114
    • 33750266831 scopus 로고    scopus 로고
    • Trafficking and signaling by fatty-acylated and prenylated proteins
    • M.D. Resh Trafficking and signaling by fatty-acylated and prenylated proteins Nat. Chem. Biol. 2 2006 584 590
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 584-590
    • Resh, M.D.1
  • 115
    • 0033590110 scopus 로고    scopus 로고
    • The hedgehog signalling pathway in tumorigenesis and development
    • C. Wicking, I. Smyth, and A. Bale The hedgehog signalling pathway in tumorigenesis and development Oncogene 18 1999 7844 7851
    • (1999) Oncogene , vol.18 , pp. 7844-7851
    • Wicking, C.1    Smyth, I.2    Bale, A.3
  • 116
    • 9244222261 scopus 로고    scopus 로고
    • Targeted cancer therapy
    • C. Sawyers Targeted cancer therapy Nature 432 2004 294 297
    • (2004) Nature , vol.432 , pp. 294-297
    • Sawyers, C.1
  • 117
    • 10944228766 scopus 로고    scopus 로고
    • Oncogene addiction: Sometimes a temporary slavery
    • J. Jonkers, and A. Berns Oncogene addiction: sometimes a temporary slavery Cancer Cell 6 2004 535 538
    • (2004) Cancer Cell , vol.6 , pp. 535-538
    • Jonkers, J.1    Berns, A.2
  • 118
    • 37249003928 scopus 로고    scopus 로고
    • Oncogene addiction: Setting the stage for molecularly targeted cancer therapy
    • S.V. Sharma, and J. Settleman Oncogene addiction: setting the stage for molecularly targeted cancer therapy Genes Dev. 21 2007 3214 3231
    • (2007) Genes Dev. , vol.21 , pp. 3214-3231
    • Sharma, S.V.1    Settleman, J.2
  • 119
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes - The Achilles heal of cancer
    • I.B. Weinstein Cancer. Addiction to oncogenes - the Achilles heal of cancer Science 297 2002 63 64
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 121
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab-mechanism of action and use in clinical practice
    • C.A. Hudis Trastuzumab-mechanism of action and use in clinical practice N. Engl. J. Med. 357 2007 39 51
    • (2007) N. Engl. J. Med. , vol.357 , pp. 39-51
    • Hudis, C.A.1
  • 122
    • 77956513286 scopus 로고    scopus 로고
    • Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
    • G. Bollag et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma Nature 467 2010 596 599
    • (2010) Nature , vol.467 , pp. 596-599
    • Bollag, G.1
  • 123
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • P.B. Chapman et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation N. Engl. J. Med. 364 2011 2507 2516
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2507-2516
    • Chapman, P.B.1
  • 124
    • 34547673400 scopus 로고    scopus 로고
    • Applying the discovery of the Philadelphia chromosome
    • D.W. Sherbenou, and B.J. Druker Applying the discovery of the Philadelphia chromosome J. Clin. Invest. 117 2007 2067 2074
    • (2007) J. Clin. Invest. , vol.117 , pp. 2067-2074
    • Sherbenou, D.W.1    Druker, B.J.2
  • 125
    • 78651418282 scopus 로고    scopus 로고
    • Mutant BRAF melanomas-dependence and resistance
    • P.I. Poulikakos, and N. Rosen Mutant BRAF melanomas-dependence and resistance Cancer Cell 19 2011 11 15
    • (2011) Cancer Cell , vol.19 , pp. 11-15
    • Poulikakos, P.I.1    Rosen, N.2
  • 126
    • 33745325007 scopus 로고    scopus 로고
    • Mechanisms of drug inhibition of signalling molecules
    • J.S. Sebolt-Leopold, and J.M. English Mechanisms of drug inhibition of signalling molecules Nature 441 2006 457 462
    • (2006) Nature , vol.441 , pp. 457-462
    • Sebolt-Leopold, J.S.1    English, J.M.2
  • 127
    • 57749188299 scopus 로고    scopus 로고
    • Targeting cancer with small molecule kinase inhibitors
    • J. Zhang, P.L. Yang, and N.S. Gray Targeting cancer with small molecule kinase inhibitors Nat. Rev. Cancer 9 2009 28 39
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 28-39
    • Zhang, J.1    Yang, P.L.2    Gray, N.S.3
  • 128
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: Cancer stem cells versus clonal evolution
    • M. Shackleton, E. Quintana, E.R. Fearon, and S.J. Morrison Heterogeneity in cancer: cancer stem cells versus clonal evolution Cell 138 2009 822 829
    • (2009) Cell , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 129
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • M. Dean, T. Fojo, and S. Bates Tumour stem cells and drug resistance Nat. Rev. Cancer 5 2005 275 284
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 130
    • 42549142280 scopus 로고    scopus 로고
    • Getting to the stem of chronic myeloid leukaemia
    • M. Savona, and M. Talpaz Getting to the stem of chronic myeloid leukaemia Nat. Rev. Cancer 8 2008 341 350
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 341-350
    • Savona, M.1    Talpaz, M.2
  • 131
    • 43749120045 scopus 로고    scopus 로고
    • DNA repair deficiency as a therapeutic target in cancer
    • S.A. Martin, C.J. Lord, and A. Ashworth DNA repair deficiency as a therapeutic target in cancer Curr. Opin. Genet. Dev. 18 2008 80 86
    • (2008) Curr. Opin. Genet. Dev. , vol.18 , pp. 80-86
    • Martin, S.A.1    Lord, C.J.2    Ashworth, A.3
  • 132
    • 79551643707 scopus 로고    scopus 로고
    • Framework models of tumor dormancy from patient-derived observations
    • C.A. Klein Framework models of tumor dormancy from patient-derived observations Curr. Opin. Genet. Dev. 21 2011 42 49
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 42-49
    • Klein, C.A.1
  • 133
    • 84887981252 scopus 로고    scopus 로고
    • Mechanisms governing metastatic dormancy and reactivation
    • F.G. Giancotti Mechanisms governing metastatic dormancy and reactivation Cell 155 2013 750 764
    • (2013) Cell , vol.155 , pp. 750-764
    • Giancotti, F.G.1
  • 134
    • 77953998205 scopus 로고    scopus 로고
    • Non-germline genetically engineered mouse models for translational cancer research
    • J. Heyer, L.N. Kwong, S.W. Lowe, and L. Chin Non-germline genetically engineered mouse models for translational cancer research Nat. Rev. Cancer 10 2010 470 480
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 470-480
    • Heyer, J.1    Kwong, L.N.2    Lowe, S.W.3    Chin, L.4
  • 135
    • 79953158399 scopus 로고    scopus 로고
    • Exploring the genomes of cancer cells: Progress and promise
    • M.R. Stratton Exploring the genomes of cancer cells: progress and promise Science 331 2011 1553 1558
    • (2011) Science , vol.331 , pp. 1553-1558
    • Stratton, M.R.1
  • 136
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • J.A. Joyce, and J.W. Pollard Microenvironmental regulation of metastasis Nat. Rev. Cancer 9 2009 239 252
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 137
    • 34047175559 scopus 로고    scopus 로고
    • Targeting VEGF-A to treat cancer and age-related macular degeneration
    • N. Ferrara, R.D. Mass, C. Campa, and R. Kim Targeting VEGF-A to treat cancer and age-related macular degeneration Annu. Rev. Med. 58 2007 491 504
    • (2007) Annu. Rev. Med. , vol.58 , pp. 491-504
    • Ferrara, N.1    Mass, R.D.2    Campa, C.3    Kim, R.4
  • 138
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • S.I. Grivennikov, F.R. Greten, and M. Karin Immunity, inflammation, and cancer Cell 140 2010 883 899
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 139
    • 33744493093 scopus 로고    scopus 로고
    • The new era in cancer research
    • H. Varmus The new era in cancer research Science 312 2006 1162 1165
    • (2006) Science , vol.312 , pp. 1162-1165
    • Varmus, H.1


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