메뉴 건너뛰기




Volumn 34, Issue , 2014, Pages 77-94

Bone morphogenetic proteins as regulators of iron metabolism

Author keywords

Bone morphogenic proteins; Hepcidin; Hereditary hemochromatosis; Iron homeostasis

Indexed keywords

BONE MORPHOGENETIC PROTEIN; HEMOJUVELIN; HEPCIDIN; IRON; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; IRON INTAKE;

EID: 84904666636     PISSN: 01999885     EISSN: 15454312     Source Type: Book Series    
DOI: 10.1146/annurev-nutr-071813-105646     Document Type: Article
Times cited : (84)

References (76)
  • 1
    • 70450046739 scopus 로고    scopus 로고
    • Things that go BMP in the liver: Bone morphogenetic protein 6 and the control of body iron homeostasis
    • Anderson GJ 2009. Things that go BMP in the liver: bone morphogenetic protein 6 and the control of body iron homeostasis. Hepatology 50:316-19
    • (2009) Hepatology , vol.50 , pp. 316-319
    • Anderson, G.J.1
  • 4
    • 63449103712 scopus 로고    scopus 로고
    • BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
    • Andriopoulos B, Corradini E, Xia Y, Faasse SA, Chen SZ, et al. 2009. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat. Genet. 41:482-87
    • (2009) Nat. Genet. , vol.41 , pp. 482-487
    • Andriopoulos, B.1    Corradini, E.2    Xia, Y.3    Faasse, S.A.4    Chen, S.Z.5
  • 5
    • 72249109128 scopus 로고    scopus 로고
    • Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo
    • Arndt S,Maegdefrau U, Dorn C, SchardtK,Hellerbrand C, BosserhoffAK. 2010. Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo. Gastroenterology 138:372-82
    • (2010) Gastroenterology , vol.138 , pp. 372-382
    • Arndt, S.1    Maegdefrau, U.2    Dorn, C.3    Schardt, K.4    Hellerbrand, C.5    Bosserhoff, A.K.6
  • 6
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt JL, Huang FW,Wrighting DM, Xia Y, Sidis Y, et al. 2006. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38:531-39
    • (2006) Nat. Genet. , vol.38 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3    Xia, Y.4    Sidis, Y.5
  • 7
    • 34447137331 scopus 로고    scopus 로고
    • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    • Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY. 2007. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J. Clin. Invest. 117:1933-39
    • (2007) J. Clin. Invest. , vol.117 , pp. 1933-1939
    • Babitt, J.L.1    Huang, F.W.2    Xia, Y.3    Sidis, Y.4    Andrews, N.C.5    Lin, H.Y.6
  • 8
    • 80052655782 scopus 로고    scopus 로고
    • The molecular pathogenesis of hereditary hemochromatosis
    • Babitt JL, Lin HY. 2011. The molecular pathogenesis of hereditary hemochromatosis. Semin. Liver Dis. 31:280-92
    • (2011) Semin. Liver Dis. , vol.31 , pp. 280-292
    • Babitt, J.L.1    Lin, H.Y.2
  • 9
    • 0036399170 scopus 로고    scopus 로고
    • Extracellular regulation of BMP signaling in vertebrates: A cocktail of modulators
    • Balemans W, Vanhul W. 2002. Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. Dev. Biol. 250:231-50
    • (2002) Dev. Biol. , vol.250 , pp. 231-250
    • Balemans, W.1    Vanhul, W.2
  • 10
    • 78751558997 scopus 로고    scopus 로고
    • Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice
    • BartnikasTB, AndrewsNC, FlemingMD. 2011. Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Blood 117:630-37
    • (2011) Blood , vol.117 , pp. 630-637
    • Bartnikas, T.B.1    Andrews, N.C.2    Fleming, M.D.3
  • 11
    • 70349083390 scopus 로고    scopus 로고
    • Genetic variation in hepcidin expression and its implications for phenotypic differences in iron metabolism
    • Bayele HK, Srai SK. 2009. Genetic variation in hepcidin expression and its implications for phenotypic differences in iron metabolism. Haematologica 94:1185-88
    • (2009) Haematologica , vol.94 , pp. 1185-1188
    • Bayele, H.K.1    Srai, S.K.2
  • 12
    • 84984775346 scopus 로고    scopus 로고
    • BMP6 orchestrates iron metabolism
    • Camaschella C. 2009. BMP6 orchestrates iron metabolism. Nat. Genet. 41:386-88
    • (2009) Nat. Genet. , vol.41 , pp. 386-388
    • Camaschella, C.1
  • 14
    • 79953316619 scopus 로고    scopus 로고
    • The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
    • Castoldi M, Vujic Spasic M, Altamura S, Elmen J, Lindow M, et al. 2011. The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J. Clin. Invest. 121:1386-96
    • (2011) J. Clin. Invest. , vol.121 , pp. 1386-1396
    • Castoldi, M.1    Vujic Spasic, M.2    Altamura, S.3    Elmen, J.4    Lindow, M.5
  • 16
    • 79959544190 scopus 로고    scopus 로고
    • Liver and serum iron: Discrete regulators of hepatic hepcidin expression
    • Chua AC, Trinder D, Olynyk JK. 2011. Liver and serum iron: discrete regulators of hepatic hepcidin expression. Hepatology 54:16-19
    • (2011) Hepatology , vol.54 , pp. 16-19
    • Chua, A.C.1    Trinder, D.2    Olynyk, J.K.3
  • 17
  • 18
    • 70349494083 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling is impaired in an Hfe knockout mouse model of hemochromatosis
    • Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B, et al. 2009. Bone morphogenetic protein signaling is impaired in an Hfe knockout mouse model of hemochromatosis. Gastroenterology 137:1489-97
    • (2009) Gastroenterology , vol.137 , pp. 1489-1497
    • Corradini, E.1    Garuti, C.2    Montosi, G.3    Ventura, P.4    Andriopoulos, B.5
  • 19
    • 79959562083 scopus 로고    scopus 로고
    • Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice
    • Corradini E, Meynard D,WuQ, Chen S, Ventura P, et al. 2011. Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice. Hepatology 54:273-84
    • (2011) Hepatology , vol.54 , pp. 273-284
    • Corradini, E.1    Dwuq, M.2    Chen, S.3    Ventura, P.4
  • 20
    • 80052666748 scopus 로고    scopus 로고
    • Iron regulation of hepcidin despite attenuated Smad1, 5,8 signaling in mice without transferrin receptor 2 or Hfe
    • Corradini E, Rozier M, Meynard D, Odhiambo A, Lin HY, et al. 2011. Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe. Gastroenterology 141:1907-14
    • (2011) Gastroenterology , vol.141 , pp. 1907-1914
    • Corradini, E.1    Rozier, M.2    Meynard, D.3    Odhiambo, A.4    Lin, H.Y.5
  • 21
    • 78049463632 scopus 로고    scopus 로고
    • BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice
    • Corradini E, Schmidt PJ, MeynardD,GarutiC,Montosi G, et al. 2010. BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice. Gastroenterology 139:1721-29
    • (2010) Gastroenterology , vol.139 , pp. 1721-1729
    • Corradini, E.1    Schmidt, P.J.2    Meynard, D.3    Garuti, C.4    Montosi, G.5
  • 22
    • 37549059612 scopus 로고    scopus 로고
    • Regulation of iron acquisition and storage: Consequences for iron-linked disorders
    • De Domenico I, McVeyWardD,Kaplan J. 2008. Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat. Rev. Mol. Cell Biol. 9:72-81
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 72-81
    • De Domenico, I.1    McVeyward, D.2    Kaplan, J.3
  • 23
    • 84875649042 scopus 로고    scopus 로고
    • Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway
    • Enns CA, Ahmed R, Wang J, Ueno A, Worthen C, et al. 2013. Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway. PLoS ONE 8:e60534
    • (2013) PLoS ONE , vol.8
    • Enns, C.A.1    Ahmed, R.2    Wang, J.3    Ueno, A.4    Worthen, C.5
  • 24
    • 84867411483 scopus 로고    scopus 로고
    • Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage
    • Enns CA, Ahmed R, Zhang AS. 2012. Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage. J. Biol. Chem. 287:35104-17
    • (2012) J. Biol. Chem. , vol.287 , pp. 35104-35117
    • Enns, C.A.1    Ahmed, R.2    Zhang, A.S.3
  • 26
    • 70349309740 scopus 로고    scopus 로고
    • Iron-refractory iron deficiency anemia
    • Finberg KE. 2009. Iron-refractory iron deficiency anemia. Semin. Hematol. 46:378-86
    • (2009) Semin. Hematol. , vol.46 , pp. 378-386
    • Finberg, K.E.1
  • 28
    • 54349096688 scopus 로고    scopus 로고
    • Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis
    • Folgueras AR, de Lara FM, Pendas AM, Garabaya C, Rodriguez F, et al. 2008. Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood 112:2539-45
    • (2008) Blood , vol.112 , pp. 2539-2545
    • Folgueras, A.R.1    De Lara, F.M.2    Pendas, A.M.3    Garabaya, C.4    Rodriguez, F.5
  • 29
    • 24144438593 scopus 로고    scopus 로고
    • BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos
    • Gamer LW, Nove J, Levin M, Rosen V. 2005. BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos. Dev. Biol. 285:156-68
    • (2005) Dev. Biol. , vol.285 , pp. 156-168
    • Gamer, L.W.1    Nove, J.2    Levin, M.3    Rosen, V.4
  • 30
    • 79955958017 scopus 로고    scopus 로고
    • Hepcidin and iron regulation, 10 years later
    • Ganz T. 2011. Hepcidin and iron regulation, 10 years later. Blood 117:4425-33
    • (2011) Blood , vol.117 , pp. 4425-4433
    • Ganz, T.1
  • 31
    • 79551583056 scopus 로고    scopus 로고
    • Hepcidin and disorders of iron metabolism
    • Ganz T, Nemeth E. 2011. Hepcidin and disorders of iron metabolism. Annu. Rev. Med. 62:347-60
    • (2011) Annu. Rev. Med. , vol.62 , pp. 347-360
    • Ganz, T.1    Nemeth, E.2
  • 33
    • 34547905022 scopus 로고    scopus 로고
    • Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis
    • Huang XX, McCaughan GW, Shackel NA, Gorrell MD. 2007. Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis. Liver Int. 27:960-68
    • (2007) Liver Int. , vol.27 , pp. 960-968
    • Huang, X.X.1    McCaughan, G.W.2    Shackel, N.A.3    Gorrell, M.D.4
  • 34
    • 66049158678 scopus 로고    scopus 로고
    • A new mutation in the hepcidin promoter impairs its BMP response and contributes to a severe phenotype in HFE related hemochromatosis
    • Island ML, Jouanolle AM, Mosser A, Deugnier Y, David V, et al. 2009. A new mutation in the hepcidin promoter impairs its BMP response and contributes to a severe phenotype in HFE related hemochromatosis. Haematologica 94:720-24
    • (2009) Haematologica , vol.94 , pp. 720-724
    • Island, M.L.1    Jouanolle, A.M.2    Mosser, A.3    Deugnier, Y.4    David, V.5
  • 35
    • 70350494274 scopus 로고    scopus 로고
    • BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression
    • Kautz L, Meynard D, Besson-Fournier C, Darnaud V, Al Saati T, et al. 2009. BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression. Blood 114:2515-20
    • (2009) Blood , vol.114 , pp. 2515-2520
    • Kautz, L.1    Meynard, D.2    Besson-Fournier, C.3    Darnaud, V.4    Al Saati, T.5
  • 36
    • 51649096725 scopus 로고    scopus 로고
    • Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
    • Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, et al. 2008. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112:1503-9
    • (2008) Blood , vol.112 , pp. 1503-1509
    • Kautz, L.1    Meynard, D.2    Monnier, A.3    Darnaud, V.4    Bouvet, R.5
  • 37
    • 70350567326 scopus 로고    scopus 로고
    • Hepatic iron overload and hepatocellular carcinoma
    • Kew MC. 2009. Hepatic iron overload and hepatocellular carcinoma. Cancer Lett. 286:38-43
    • (2009) Cancer Lett. , vol.286 , pp. 38-43
    • Kew, M.C.1
  • 38
    • 0031149802 scopus 로고    scopus 로고
    • Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1
    • Knittel T, Fellmer P, Muller L, Ramadori G. 1997. Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1. Exp. Cell Res. 232:263-69
    • (1997) Exp. Cell Res. , vol.232 , pp. 263-269
    • Knittel, T.1    Fellmer, P.2    Muller, L.3    Ramadori, G.4
  • 39
    • 1842556785 scopus 로고    scopus 로고
    • Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system
    • Knuesel M,Wan Y, Xiao Z, Holinger E, Lowe N, et al. 2003. Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system. Mol. Cell Proteomics 2:1225-33
    • (2003) Mol. Cell Proteomics , vol.2 , pp. 1225-1233
    • Knuesel Mwan, Y.1    Xiao, Z.2    Holinger, E.3    Lowe, N.4
  • 40
    • 70450212843 scopus 로고    scopus 로고
    • Role of matriptase-2 (TMPRSS6) in iron metabolism
    • Lee P. 2009. Role of matriptase-2 (TMPRSS6) in iron metabolism. Acta Haematol. 122:87-96
    • (2009) Acta Haematol. , vol.122 , pp. 87-96
    • Lee, P.1
  • 41
    • 67650169908 scopus 로고    scopus 로고
    • Biological functions ofmiR-29b contribute to positive regulation of osteoblast differentiation
    • Li Z, HassanMQ, Jafferji M, Aqeilan RI,GarzonR, et al. 2009. Biological functions ofmiR-29b contribute to positive regulation of osteoblast differentiation. J. Biol. Chem. 284:15676-84
    • (2009) J. Biol. Chem. , vol.284 , pp. 15676-15684
    • Li, Z.1    Hassan, M.Q.2    Jafferji, M.3    Aqeilan, R.I.4    Garzon, R.5
  • 42
    • 27144459908 scopus 로고    scopus 로고
    • Competitive regulation of hepcidin mRNA by soluble and cellassociated hemojuvelin
    • Lin L, Goldberg YP, Ganz T. 2005. Competitive regulation of hepcidin mRNA by soluble and cellassociated hemojuvelin. Blood 106:2884-89
    • (2005) Blood , vol.106 , pp. 2884-2889
    • Lin, L.1    Goldberg, Y.P.2    Ganz, T.3
  • 43
    • 34548825938 scopus 로고    scopus 로고
    • Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
    • Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. 2007. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood 110:2182-89
    • (2007) Blood , vol.110 , pp. 2182-2189
    • Lin, L.1    Valore, E.V.2    Nemeth, E.3    Goodnough, J.B.4    Gabayan, V.5    Ganz, T.6
  • 44
    • 33646562542 scopus 로고    scopus 로고
    • The logic of TGF signaling
    • Massague J, Gomis RR. 2006. The logic of TGF?signaling. FEBS Lett. 580:2811-20
    • (2006) FEBS Lett. , vol.580 , pp. 2811-2820
    • Massague, J.1    Gomis, R.R.2
  • 46
    • 78649839347 scopus 로고    scopus 로고
    • Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression
    • Maxson JE, Chen J, Enns CA, Zhang AS. 2010. Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression. J. Biol. Chem. 285:39021-28
    • (2010) J. Biol. Chem. , vol.285 , pp. 39021-39028
    • Maxson, J.E.1    Chen, J.2    Enns, C.A.3    Zhang, A.S.4
  • 48
    • 79960674973 scopus 로고    scopus 로고
    • Regulation of TMPRSS6 by BMP6 and iron in human cells and mice
    • Meynard D, Vaja V, Sun CC, Corradini E, Chen S, et al. 2011. Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood 118:747-56
    • (2011) Blood , vol.118 , pp. 747-756
    • Meynard, D.1    Vaja, V.2    Sun, C.C.3    Corradini, E.4    Chen, S.5
  • 49
    • 77950979752 scopus 로고    scopus 로고
    • SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
    • Mleczko-Sanecka K, Casanovas G, Ragab A, Breitkopf K, Muller A, et al. 2010. SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood 115:2657-65
    • (2010) Blood , vol.115 , pp. 2657-2665
    • Mleczko-Sanecka, K.1    Casanovas, G.2    Ragab, A.3    Breitkopf, K.4    Muller, A.5
  • 50
    • 84861525631 scopus 로고    scopus 로고
    • Deletion of Tmprss6 attenuates the phenotype in a mouse model of thalassemia
    • Nai A, Pagani A, Mandelli G, Lidonnici MR, Silvestri L, et al. 2012. Deletion of Tmprss6 attenuates the phenotype in a mouse model of ?-thalassemia. Blood 119:5021-29
    • (2012) Blood , vol.119 , pp. 5021-5029
    • Nai, A.1    Pagani, A.2    Mandelli, G.3    Lidonnici, M.R.4    Silvestri, L.5
  • 51
    • 41949133287 scopus 로고    scopus 로고
    • Iron regulation and erythropoiesis
    • Nemeth E. 2008. Iron regulation and erythropoiesis. Curr. Opin. Hematol. 15:169-75
    • (2008) Curr. Opin. Hematol. , vol.15 , pp. 169-175
    • Nemeth, E.1
  • 52
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, TuttleMS, Powelson J, VaughnMB, Donovan A, et al. 2004. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090-93
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttlems Powelson, J.2    Vaughnmb Donovan, A.3
  • 53
    • 77955298048 scopus 로고    scopus 로고
    • Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression
    • Nili M, Shinde U, Rotwein P. 2010. Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression. J. Biol. Chem. 285:24783-92
    • (2010) J. Biol. Chem. , vol.285 , pp. 24783-24792
    • Nili, M.1    Shinde, U.2    Rotwein, P.3
  • 54
    • 84859336675 scopus 로고    scopus 로고
    • Decreased hepcidin expression in murine-thalassemia is associated with suppression of Bmp/Smad signaling
    • Parrow NL, Gardenghi S, Ramos P, Casu C, Grady RW, et al. 2012. Decreased hepcidin expression in murine ?-thalassemia is associated with suppression of Bmp/Smad signaling. Blood 119:3187-89
    • (2012) Blood , vol.119 , pp. 3187-3189
    • Parrow, N.L.1    Gardenghi, S.2    Ramos, P.3    Casu, C.4    Grady, R.W.5
  • 55
    • 84856700549 scopus 로고    scopus 로고
    • BMPER protein is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice
    • Patel N, Masaratana P, Diaz-Castro J, Latunde-Dada GO, Qureshi A, et al. 2012. BMPER protein is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice. J. Biol. Chem. 287:4099-106
    • (2012) J. Biol. Chem. , vol.287 , pp. 4099-4106
    • Patel, N.1    Masaratana, P.2    Diaz-Castro, J.3    Latunde-Dada, G.O.4    Qureshi, A.5
  • 56
    • 79953757053 scopus 로고    scopus 로고
    • Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
    • Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, et al. 2011. Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology 53:1333-41
    • (2011) Hepatology , vol.53 , pp. 1333-1341
    • Ramos, E.1    Kautz, L.2    Rodriguez, R.3    Hansen, M.4    Gabayan, V.5
  • 57
    • 79251571756 scopus 로고    scopus 로고
    • Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis
    • Ramos P, Guy E, Chen N, Proenca CC, Gardenghi S, et al. 2011. Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis. Blood 117:1379-89
    • (2011) Blood , vol.117 , pp. 1379-1389
    • Ramos, P.1    Guy, E.2    Chen, N.3    Proenca, C.C.4    Gardenghi, S.5
  • 59
    • 77957964766 scopus 로고    scopus 로고
    • Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis
    • Ryan JD, Ryan E, Fabre A, Lawless MW, Crowe J. 2010. Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis. Hepatology 52:1266-73
    • (2010) Hepatology , vol.52 , pp. 1266-1273
    • Ryan, J.D.1    Ryan, E.2    Fabre, A.3    Lawless, M.W.4    Crowe, J.5
  • 60
    • 36448936383 scopus 로고    scopus 로고
    • TGF?-SMAD signal transduction: Molecular specificity and functional flexibility
    • Schmierer B, Hill CS. 2007. TGF?-SMAD signal transduction: molecular specificity and functional flexibility. Nat. Rev. Mol. Cell Biol. 8:970-82
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 970-982
    • Schmierer, B.1    Hill, C.S.2
  • 61
    • 84857374333 scopus 로고    scopus 로고
    • The long history of iron in theUniverse and in health and disease
    • Sheftel AD, Mason AB, Ponka P. 2011. The long history of iron in theUniverse and in health and disease. Biochim. Biophys. Acta 1820:161-87
    • (2011) Biochim. Biophys. Acta , pp. 161-187
    • Sheftel, A.D.1    Mason, A.B.2    Ponka, P.3
  • 62
    • 56449096622 scopus 로고    scopus 로고
    • The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin
    • Silvestri L, Pagani A, Nai A, De Domenico I, Kaplan J, Camaschella C. 2008. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab. 8:502-11
    • (2008) Cell Metab. , vol.8 , pp. 502-511
    • Silvestri, L.1    Pagani, A.2    Nai, A.3    De Domenico, I.4    Kaplan, J.5    Camaschella, C.6
  • 63
    • 79955980950 scopus 로고    scopus 로고
    • Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation
    • Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, et al. 2011. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood 117:4915-23
    • (2011) Blood , vol.117 , pp. 4915-4923
    • Steinbicker, A.U.1    Sachidanandan, C.2    Vonner, A.J.3    Yusuf, R.Z.4    Deng, D.Y.5
  • 65
    • 67651043722 scopus 로고    scopus 로고
    • Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells
    • Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, et al. 2009. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood 114:181-86
    • (2009) Blood , vol.114 , pp. 181-186
    • Tanno, T.1    Porayette, P.2    Sripichai, O.3    Noh, S.J.4    Byrnes, C.5
  • 66
    • 60249095353 scopus 로고    scopus 로고
    • Two BMPresponsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness
    • Truksa J, Lee P, Beutler E. 2009. Two BMPresponsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness. Blood 113:688-95
    • (2009) Blood , vol.113 , pp. 688-695
    • Truksa, J.1    Lee, P.2    Beutler, E.3
  • 67
    • 36148955432 scopus 로고    scopus 로고
    • The distal location of the iron responsive region of the hepcidin promoter
    • Truksa J, Lee P, Peng H, Flanagan J, Beutler E. 2007. The distal location of the iron responsive region of the hepcidin promoter. Blood 110:3436-37
    • (2007) Blood , vol.110 , pp. 3436-3437
    • Truksa, J.1    Lee, P.2    Peng, H.3    Flanagan, J.4    Beutler, E.5
  • 68
    • 5644257032 scopus 로고    scopus 로고
    • New insights into the pathophysiology and management of osteoporosis in patients with beta thalassaemia
    • Voskaridou E, Terpos E. 2004. New insights into the pathophysiology and management of osteoporosis in patients with beta thalassaemia. Br. J. Haematol. 127:127-39
    • (2004) Br. J. Haematol. , vol.127 , pp. 127-139
    • Voskaridou, E.1    Terpos, E.2
  • 69
    • 73149083742 scopus 로고    scopus 로고
    • Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
    • Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, Subramaniam VN. 2009. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology 50:1992-2000
    • (2009) Hepatology , vol.50 , pp. 1992-2000
    • Wallace, D.F.1    Summerville, L.2    Crampton, E.M.3    Frazer, D.M.4    Anderson, G.J.5    Subramaniam, V.N.6
  • 70
    • 33644876815 scopus 로고    scopus 로고
    • A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
    • Wang RH, Li C, Xu X, Zheng Y, Xiao C, et al. 2005. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2:399-409
    • (2005) Cell Metab. , vol.2 , pp. 399-409
    • Wang, R.H.1    Li, C.2    Xu, X.3    Zheng, Y.4    Xiao, C.5
  • 71
    • 46749158788 scopus 로고    scopus 로고
    • Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
    • Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY. 2008. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111:5195-204
    • (2008) Blood , vol.111 , pp. 5195-5204
    • Xia, Y.1    Babitt, J.L.2    Sidis, Y.3    Chung, R.T.4    Lin, H.Y.5
  • 73
    • 84876938545 scopus 로고    scopus 로고
    • Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis
    • Zhang AS. 2010. Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis. Adv. Nutr. 1:38-45
    • (2010) Adv. Nutr. , vol.1 , pp. 38-45
    • Zhang, A.S.1
  • 74
    • 77952747961 scopus 로고    scopus 로고
    • The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo
    • Zhang AS, Gao J, Koeberl DD, Enns CA. 2010. The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo. J. Biol. Chem. 285:16416-23
    • (2010) J. Biol. Chem. , vol.285 , pp. 16416-16423
    • Zhang, A.S.1    Gao, J.2    Koeberl, D.D.3    Enns, C.A.4
  • 75
    • 84897994449 scopus 로고    scopus 로고
    • Bmp6 expression can be regulated independently of liver iron in mice
    • Zhang Z, Guo X, Herrera C, Tao Y,Wu Q, et al. 2014. Bmp6 expression can be regulated independently of liver iron in mice. PLoS ONE 9:e84906
    • (2014) PLoS ONE , vol.9
    • Zhang, Z.1    Guo, X.2    Herrera, C.3    Tao Ywu, Q.4
  • 76
    • 84857467602 scopus 로고    scopus 로고
    • The transcription factor osterix (SP7) regulates BMP6-induced human osteoblast differentiation
    • Zhu F, Friedman MS, Luo W, Woolf P, Hankenson KD. 2012. The transcription factor osterix (SP7) regulates BMP6-induced human osteoblast differentiation. J. Cell Physiol. 227:2677-85
    • (2012) J. Cell Physiol. , vol.227 , pp. 2677-2685
    • Zhu, F.1    Friedman, M.S.2    Luo, W.3    Woolf, P.4    Hankenson, K.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.