Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling

Blood

Volumn 119, Issue 13, 2012, Pages 3187-3189

  Parrow, Nermi L ^a   Gardenghi, Sara ^a   Ramos, Pedro ^a   Casu, Carla ^a   Grady, Robert W ^a   Anderson, Erik R ^b   Shah, Yatrik M ^b   Li, Huihui ^c   Ginzburg, Yelena Z ^c   Fleming, Robert E ^d   Rivella, Stefano ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c NEW YORK BLOOD CENTER   (United States)

^d SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; HEPCIDIN; IRON; MESSENGER RNA; SMAD PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; BETA THALASSEMIA; DISEASE ASSOCIATION; IRON OVERLOAD; LETTER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84859336675     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-01-405563     Document Type: Letter

References (9)

1. Ginzburg Y, Rivella S. Beta-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood. 2011;118(16):4321-4330.
2. Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090-2093. (Pubitemid 40007660)
3. Babitt JL, Huang FW, Wrighting DM, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006;38(5):531-539.
4. Kautz L, Meynard D, Monnier A, et al. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood. 2008;112(4):1503-1509.
5. Rivella S, May C, Chadburn A, et al. A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer. Blood. 2003;101(8):2932-2939. (Pubitemid 36857977)
6. Pak M, Lopez MA, Gabayan V, et al. Suppression of hepcidin during anemia requires erythropoietic activity. Blood. 2006;108(12):3730-3735. (Pubitemid 44864551)
7. Gardenghi S, Marongiu MF, Ramos P, et al. Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by downregulation of hepcidin and up-regulation of ferroportin. Blood. 2007;109(11):5027-5035. (Pubitemid 46827803)
8. Tanno T, Noel P, and Miller JL. Growth differentiation factor 15 in erythroid health and disease. Curr Opin Hematol. 2010;17(3):184-190.
9. Krijt J, Jonásová A, Neuwirtová R, Necas E. Effect of erythropoietin on hepcidin expression in hemojuvelin-mutant mice. Blood Cells Mol Dis. 2010;44(4): 257-261.