Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression

Journal of Biological Chemistry

Volumn 285, Issue 50, 2010, Pages 39021-39028

  Maxson, Julia E ^a   Chen, Juxing ^a   Enns, Caroline A ^a   Zhang, An Sheng ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENIC PROTEIN; CLEAVAGE PRODUCTS; CONVERTASES; DOWN-REGULATION; HEPCIDIN; IN-CELL; IRON METABOLISM; SIGNALING PATHWAYS;

CELL MEMBRANES;

SIGNALING;

ARGININE; BONE MORPHOGENETIC PROTEIN 6; HEMOJUVELIN; HEPCIDIN; MATRIPTASE; MATRIPTASE 2; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; ARGININE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GPI-LINKED PROTEINS; HEMOCHROMATOSIS; HUMANS; IRON; MEMBRANE PROTEINS; MUTATION; PROPROTEIN CONVERTASES; PROTEIN BINDING; RATS; RNA, SMALL INTERFERING; SERINE ENDOPEPTIDASES; TISSUE DISTRIBUTION;

EID: 78649839347     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.183160     Document Type: Article

References (31)

1. De Domenico, I., McVey Ward, D., and Kaplan, J. (2008) Nat. Rev. Mol. Cell. Biol. 9, 72-81
2. Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., and Kaplan, J. (2004) Science 306, 2090-2093
3. Camaschella, C. (1998) Baillieres Clin. Gastroenterol. 12, 227-235
4. Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L., Franchini, P. L., Dubé, M. P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., Nemeth, E., Thompson, J., Risler, J. K., Zaborowska, C., Babakaiff, R., Radomski, C. C., Pape, T. D., Davidas, O., Christakis, J., Brissot, P., Lockitch, G., Ganz, T., Hayden, M. R., and Goldberg, Y. P. (2004) Nat. Genet. 36, 77-82
5. Huang, F. W., Pinkus, J. L., Pinkus, G. S., Fleming, M. D., and Andrews, N. C. (2005) J. Clin. Invest. 115, 2187-2191
6. Niederkofler, V., Salie, R., and Arber, S. (2005) J. Clin. Invest. 115, 2180-2186
7. Babitt, J. L., Huang, F. W., Wrighting, D. M., Xia, Y., Sidis, Y., Samad, T. A., Campagna, J. A., Chung, R. T., Schneyer, A. L., Woolf, C. J., Andrews, N. C., and Lin, H. Y. (2006) Nat. Genet. 38, 531-539
8. Wang, R. H., Li, C., Xu, X., Zheng, Y., Xiao, C., Zerfas, P., Cooperman, S., Eckhaus, M., Rouault, T., Mishra, L., and Deng, C. X. (2005) Cell. Metab. 2, 399-409
9. Babitt, J. L., Huang, F. W., Xia, Y., Sidis, Y., Andrews, N. C., and Lin, H. Y. (2007) J. Clin. Invest. 117, 1933-1939
10. Andriopoulos, B., Jr., Corradini, E., Xia, Y., Faasse, S. A., Chen, S., Grgurevic, L., Knutson, M. D., Pietrangelo, A., Vukicevic, S., Lin, H. Y., and Babitt, J. L. (2009) Nat. Genet. 41, 482-487
11. Meynard, D., Kautz, L., Darnaud, V., Canonne-Hergaux, F., Coppin, H., and Roth, M. P. (2009) Nat. Genet. 41, 478-481
12. Kautz, L., Meynard, D., Monnier, A., Darnaud, V., Bouvet, R., Wang, R. H., Deng, C., Vaulont, S., Mosser, J., Coppin, H., and Roth, M. P. (2008) Blood 112, 1503-1509
13. Zhang, A. S., Anderson, S. A., Meyers, K. R., Hernandez, C., Eisenstein, R. S., and Enns, C. A. (2007) J. Biol. Chem. 282, 12547-12556
14. Kuninger, D., Kuns-Hashimoto, R., Kuzmickas, R., and Rotwein, P. (2006) J. Cell. Sci. 119, 3273-3283
15. Lin, L., Goldberg, Y. P., and Ganz, T. (2005) Blood 106, 2884-2889
16. Niederkofler, V., Salie, R., Sigrist, M., and Arber, S. (2004) J. Neurosci. 24, 808-818
17. Silvestri, L., Pagani, A., and Camaschella, C. (2008) Blood 111, 924-931
18. Folgueras, A. R., de Lara, F. M., Pendás, A. M., Garabaya, C., Rodríguez, F., Astudillo, A., Bernal, T., Cabanillas, R., López-Otín, C., and Velasco, G. (2008) Blood 112, 2539-2545
19. Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M., Beutler, E., and Beutler, B. (2008) Science 320, 1088-1092
20. Silvestri, L., Pagani, A., Nai, A., De Domenico, I., Kaplan, J., and Camaschella, C. (2008) Cell Metab. 8, 502-511
21. Zhang, A. S., West, A. P., Jr., Wyman, A. E., Bjorkman, P. J., and Enns, C. A. (2005) J. Biol. Chem. 280, 33885-33894
22. Maxson, J. E., Enns, C. A., and Zhang, A. S. (2009) Blood 113, 1786-1793
23. Zhang, A. S., Xiong, S., Tsukamoto, H., and Enns, C. A. (2004) Blood 103, 1509-1514
24. Kuninger, D., Kuns-Hashimoto, R., Nili, M., and Rotwein, P. (2008) BMC Biochem. 9, 9
25. Lin, L., Nemeth, E., Goodnough, J. B., Thapa, D. R., Gabayan, V., and Ganz, T. (2008) Blood Cells Mol. Dis. 40, 122-131
26. Velasco, G., Cal, S., Quesada, V., Sánchez, L. M., and López-Otín, C. (2002) J. Biol. Chem. 277, 37637-37646
27. Thomas, G. (2002) Nat. Rev. Mol. Cell Biol. 3, 753-766
28. Zhang, A. S., Yang, F., Meyer, K., Hernandez, C., Chapman-Arvedson, T., Bjorkman, P. J., and Enns, C. A. (2008) J. Biol. Chem. 283, 17494-17502
29. Seidah, N. G., Mayer, G., Zaid, A., Rousselet, E., Nassoury, N., Poirier, S., Essalmani, R., and Prat, A. (2008) Int. J. Biochem. Cell. Biol. 40, 1111-1125
30. Lin, L., Valore, E. V., Nemeth, E., Goodnough, J. B., Gabayan, V., and Ganz, T. (2007) Blood 110, 2182-2189
31. Yang, F., West, A. P., Jr., Allendorph, G. P., Choe, S., and Bjorkman, P. J. (2008) Biochemistry 47, 4237-4245