The distal location of the iron responsive region of the hepcidin promoter

Blood

Volumn 110, Issue 9, 2007, Pages 3436-3437

  Truksa, Jaroslav ^a   Lee, Pauline ^a   Peng, Hongfan ^a   Flanagan, Jonathan ^b   Beutler, Ernest ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; HEPCIDIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LUCIFERASE;

ANIMAL EXPERIMENT; ARTICLE; GENE CONSTRUCT; GENE FUSION; GENE MAPPING; HUMAN; HUMAN CELL; HYDRODYNAMICS BASED TRANSFECTION; IRON INTAKE; IRON RESPONSIVE ELEMENT; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; RNA TRANSLATION;

EID: 36148955432     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-05-091108     Document Type: Article

References (7)

1. Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr. 2006;26:323-342.
2. Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. Iron-transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. Pre-published May 31, 2007, as DOI 10.1182/blood-2007-04-087593.
3. Flanagan JM, Truksa J, Peng H, Lee P, Beutler E. In vivo imaging of hepcidin promoter stimulation by iron and inflammation. Blood Cells Mol Dis. 2007;38:253-257.
4. Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood. 2005;106:2196-2199.
5. Truksa J, Peng H, Lee P, Beutler E. Different regulatory elements are required for response of hepcidin to IL-6 and bone morphogenetic proteins BMP 4 and 9. Br J Haematol. 2007; 139:138-147.
6. Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006;108:3204-3209.
7. Verga Falzacappa MV, Vujic SM, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood. 2007;109:353-358.