A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology

Cellular Signalling

Volumn 26, Issue 10, 2014, Pages 2147-2160

  Balakumar, Pitchai ^a   Jagadeesh, Gowraganahalli ^b  

^a AIMST UNIVERSITY   (Malaysia)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Alamandine; G protein dependent and independent signals; RAS components; Transactivation cascades

Indexed keywords

ALDOSTERONE; ALLAMANDIN; ANGIOPROTECTIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN A; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; ANGIOTENSIN[1-7]; BETA ARRESTIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR; PRORENIN; PRORENIN RECEPTOR; PROTEIN TYROSINE KINASE; RAF PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RENIN; RENIN INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; VASOPRESSIN; ANGIOTENSIN 2 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; RETINA S ANTIGEN; STAT PROTEIN;

ALDOSTERONE RELEASE; BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; CALCIUM CELL LEVEL; CARDIOVASCULAR DISEASE; ELECTROLYTE BALANCE; FLUID INTAKE; HEART FAILURE; HEART INFARCTION; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; INTRACELLULAR SIGNALING; KIDNEY DISEASE; NONHUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SIGNAL TRANSDUCTION; SODIUM ABSORPTION; SYMPATHETIC TONE; TRANSACTIVATION; VASOCONSTRICTION; VASODILATATION; VASOPRESSIN RELEASE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANGIOTENSIN II; ARRESTINS; CARDIOVASCULAR DISEASES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RENIN-ANGIOTENSIN SYSTEM; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS;

EID: 84904513966     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2014.06.011     Document Type: Review

References (192)

1. de Gasparo M., Catt K.J., Inagami T., Wright J.W., Unger T. Pharmacol. Rev. 2000, 52:415-472.
2. Sever P.S., Gradman A.H., Azizi M. J. Renin Angiotensin Aldosterone Syst. 2009, 10:65-76.
3. Sata M., Fukuda D. J. Med. Investig. 2010, 57:12-25.
4. Wang C.H., Li F., Takahashi N. Open Hypertens. J. 2010, 3:1-13.
5. Abadir P.M. Clin. Geriatr. Med. 2011, 27:53-65.
6. Tigerstedt R., Bergman P.G. Skand. Arch. Physiol. 1898, 8:223-271.
7. Goldblatt H., Lynch J., Hanzal R.F., Summerville W.W. J. Exp. Med. 1934, 59:347-379.
8. Basso N., Terragno N.A. Hypertension 2001, 38:1246-1249.
9. Skrbic R., Igic R. Peptides 2009, 30:1945-1950.
10. Jagadeesh G. Indian J. Exp. Biol. 1998, 36:1171-1194.
11. Mehta P.K., Griendling K.K. Am. J. Physiol. Cell Physiol. 2007, 292:C82-C97.
12. Balakumar P., Mahadevan N. Biomed. Aging Pathol. 2011, 1:197-202.
13. Dell'Italia L.J., Ferrario C.M. Circ. Res. 2013, 112:1086-1087.
14. Donoghue M., Hsieh F., Baronas E., Godbout K., Gosselin M., Stagliano N., et al. Circ. Res. 2000, 87:E1-E9.
15. Ferreira A.J., Santos R.A. Braz. J. Med. Biol. Res. 2005, 38:499-507.
16. Keidar S., Kaplan M., Gamliel-Lazarovich A. Cardiovasc. Res. 2007, 73:463-469.
17. Liu Q., Huang Y., Lu L.M. Sheng Li Ke Xue Jin Zhan 2007, 38:43-48.
18. Santos R.A., Simoes e Silva A.C., Maric C., Silva D.M., Machado R.P., de Buhr I., et al. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:8258-8263.
19. Santos R.A. Hypertension 2014, 10.1161/HYPERTENSIONAHA.113.01274/-/DC1.
20. Morrell N.W., Upton P.D., Higham M.A., Yacoub M.H., Polak J.M., Wharton J. Chest 1998, 114:90S-91S.
21. Doyon P., Servant M.J. J. Biol. Chem. 2010, 285:30708-30718.
22. Silva-Filho J.L., Souza M.C., Md Henriques, Morrot A., Savino W., Nunes M.P., Caruso-Neves C., Pinheiro A.A. Mol. Immunol. 2011, 48:1835-1843.
23. DelliPizzi A.M., Hilchey S.D., Bell-Quilley C.P. Br. J. Pharmacol. 1994, 111:1-3.
24. Collister J.P., Hendel M.D. J. Renin Angiotensin Aldosterone Syst. 2003, 4:176-179.
25. Ferreira A.J., Jacoby B.A., Araújo C.A., Macedo F.A., Silva G.A., Almeida A.P., Caliari M.V., Santos R.A. Am. J. Physiol. Heart Circ. Physiol. 2007, 292:H1113-H1119.
26. Sampaio W.O., Henrique de Castro C., Santos R.A., Schiffrin E.L., Touyz R.M. Hypertension 2007, 50:1093-1098.
27. Ebermann L., Spillmann F., Sidiropoulos M., Escher F., Heringer-Walther S., Schultheiss H.P., Tschöpe C., Walther T. Eur. J. Pharmacol. 2008, 590:276-280.
28. Zhang F., Hu Y., Xu Q., Ye S. PLoS One 2010, 5:e12323.
29. Silva D.M., Gomes-Filho A., Olivon V.C., Santos T.M., Becker L.K., Santos R.A., Lemos V.S. J. Appl. Physiol. 2011, 111:1272-1277.
30. Iwai M., Horiuchi M. Hypertens. Res. 2009, 32:533-536.
31. Collister J.P., Nahey D.B. J. Renin Angiotensin Aldosterone Syst. 2010, 11:99-102.
32. Zhou L.M., Shi Z., Gao J., Han Y., Yuan N., Gao X.Y., Zhu G.Q. Pflugers Arch. 2010, 459:681-688.
33. Shao Y., He M., Zhou L., Yao T., Huang Y., Lu L.M. Acta Pharmacol. Sin. 2008, 29:829-837.
34. Velkoska E., Dean R.G., Griggs K., Burchill L., Burrell L.M. Clin. Sci. (Lond.) 2011, 120:335-345.
35. Silveira K.D., Barroso L.C., Vieira A.T., Cisalpino D., Lima C.X., Bader M., Arantes R.M., Dos Santos R.A., Simões-E-Silva A.C., Teixeira M.M. PLoS One 2013, 8:e66082. 10.1371/journal.pone.0066082.
36. Souza Á.P., Sobrinho D.B., Almeida J.F., Alves G.M., Macedo L.M., Porto J.E., Vêncio E.F., Colugnati D.B., Santos R.A., Ferreira A.J., Mendes E.P., Castro C.H. Clin. Sci. (Lond.) 2013, 125:449-459.
37. Jankowski V., Vanholder R., van der Giet M., Tölle M., Karadogan S., Gobom J., Furkert J., Oksche A., Krause E., Tran T.N., Tepel M., Schuchardt M., Schlüter H., Wiedon A., Beyermann M., Bader M., Todiras M., Zidek W., Jankowski J. Arterioscler. Thromb. Vasc. Biol. 2007, 27:297-302.
38. Yang R., Smolders I., Vanderheyden P., Demaegdt H., Van Eeckhaut A., Vauquelin G., Lukaszuk A., Tourwé D., Chai S.Y., Albiston A.L., Nahmias C., Walther T., Dupont A.G. Hypertension 2011, 57:956-964.
39. Coutinho D.C., Foureaux G., Rodrigues K.D., Salles R.L., Moraes P.L., Murça T.M., De Maria M.L., Gomes E.R., Santos R.A., Guatimosim S., Ferreira A.J. J. Renin Angiotensin Aldosterone Syst. 2013, 10.1177/1470320312474856.
40. Jankowski V., Tölle M., Santos R.A., Günthner T., Krause E., Beyermann M., Welker P., Bader M., Pinheiro S.V., Sampaio W.O., Lautner R., Kretschmer A., van der Giet M., Zidek W., Jankowski J. FASEB J. 2011, 25:2987-2995.
41. Lautner R.Q., Villela D.C., Fraga-Silva R.A., Silva N., Verano-Braga T., Costa-Fraga F., et al. Circ. Res. 2013, 12(112):1104-1111.
42. Wood J.M., Stanton J.L., Hofbauer K.G. J. Enzym. Inhib. 1987, 1:169-185.
43. Danser J.A.H., Saris J.J. J. Mol. Cell. Cardiol. 2002, 34:1463-1472.
44. Krop M.K., Danser A.H.J. Curr. Hypertens. Rep. 2008, 10:112-118.
45. Reudelhuber T.L., Ramla D., Chiu L., et al. Kidney Int. 1994, 46:1522-1524.
46. Neves F.A., Duncan K.G., Baxter J.D. Hypertension 1996, 27:514-517.
47. Danser A.H., Batenburg W.W., van Esch J.H., et al. J. Mol. Med. 2008, 86:655-658.
48. Franken A.A., Derkx F.H., Man in't Veld A.J., et al. J. Hypertens. 1988, 6:S461-S463.
49. Deinum J., Ronn B., Mathiesen E., et al. Diabetologia 1999, 42:1006-1010.
50. Susic D., Zhou X., Frohlich E.D., et al. Am. J. Physiol. Heart Circ. Physiol. 2008, 295:H1117-H1121.
51. Nguyen G., Delarue F., Burcklé C., Bouzhir L., Giller T., Sraer J.D. J. Clin. Invest. 2002, 109:1417-1427.
52. Nguyen G., Danser A.H. Exp. Physiol. 2008, 93:557-563.
53. Saris J.J., van den Eijnden M.M., Lamers J.M., et al. Hypertension 2002, 39:573-577.
54. Danser A.H. Hypertension 2006, 47:824-826.
55. Nguyen G. Kidney Int. 2006, 69:1503-1506.
56. Huang Y., Wongamorntham S., Kasting J., et al. Kidney Int. 2006, 69:105-113.
57. Nguyen G., Muller D.N. J. Am. Soc. Nephrol. 2010, 21:18-23.
58. Balakumar P., Jagadeesh G. J. Cardiovasc. Pharmacol. 2010, 56:570-579.
59. Balakumar P., Jagadeesh G. Hypertens. Res. 2011, 34:1161-1170.
60. Ille F., Sommer L. Cell. Mol. Life Sci. 2005, 62:1100-1108.
61. Schmidt-Ott K.M., Barasch J. Kidney Int. 2008, 74:1004-1008.
62. Jagadeesh G., Balakumar P., Stockbridge N. Cell. Signal. 2012, 24:1583-1591.
63. Hahn A.W., Jonas U., Buehler F.R., Resink T.J. Biochem. Biophys. Res. Commun. 1993, 192:1260-1265.
64. Miura S., Imaizumi S., Saku K. Curr. Pharm. Des. 2013, 19:2981-2987.
65. Balakumar P., Sharma N., Kathuria S., Babbar L., Mahadevan N. Int. J. Recent Adv. Pharm. Res. 2011, 1:1-7.
66. Miura S. Curr. Pharm. Des. 2013, 19:2979-2980.
67. Danyel L.A., Schmerler P., Paulis L., Unger T., Steckelings U.M. Integ. Blood Press. Control 2013, 6:153-161.
68. Hunyady L., Catt K.J. Mol. Endocrinol. 2006, 20:953-970.
69. Yoshida T., Tabony A.M., Galvez S., Mitch W.E., Higashi Y., Sukhanov S., Delafontaine P. Int. J. Biochem. Cell. Biol. 2013, 45:2322-2332.
70. Ushio-Fukai M., Alexander R.W., Akers M., Lyons P.R., Lassègue B., Griendling K.K. Mol. Pharmacol. 1999, 55:142-149.
71. Garrido A.M., Griendling K.K. Mol. Cell. Endocrinol. 2009, 302:148-158.
72. DeWire S.M., Ahn S., Lefkowitz R.J., Shenoy S.K. Annu. Rev. Physiol. 2007, 69:483-510.
73. Wettschureck N., Offermanns S. Physiol. Rev. 2005, 85:1159-1204.
74. Tadevosyan A., Vaniotis G., Allen B.G., Hébert T.E., Nattel S. J. Physiol. 2012, 590:1313-1330.
75. Oldham W.M., Hamm H.E. Adv. Protein Chem. 2007, 74:67-93.
76. Fang Y., Lahiri J., Picard L. Drug Discov. Today 2003, 8:755-761.
77. Leifert W.R., Aloia A.L., Bucco O., McMurchie E.J. Mol. Membr. Biol. 2005, 22:507-517.
78. Barren B., Artemyev N.O. J. Neurosci. Res. 2007, 85:3505-3514.
79. Ribas C., Penela P., Murga C., Salcedo A., García-Hoz C., Jurado-Pueyo M., Aymerich I., Mayor F. Biochim. Biophys. Acta 2007, 1768:913-922.
80. Kovacs J.J., Hara M.R., Davenport C.L., Kim J., Lefkowitz R.J. Dev. Cell 2009, 17:443-458.
81. Wettschureck N., Rütten H., Zywietz A., Gehring D., Wilkie T.M., Chen J., Chien K.R., Offermanns S. Nat. Med. 2001, 7:1236-1240.
82. Balakumar P., Jagadeesh G. Pharmacol. Res. 2010, 62:365-383.
83. Yan C., Kim D., Aizawa T., Berk B.C. Arterioscler. Thromb. Vasc. Biol. 2003, 23:26-36.
84. Jin L., Ying Z., Hilgers R.H., Yin J., Zhao X., Imig J.D., Webb R.C. J. Pharmacol. Exp. Ther. 2006, 318:288-295.
85. Shin H.M., Je H.D., Gallant C., Tao T.C., Hartshorne D.J., Ito M., Morgan K.G. Circ. Res. 2002, 90:546-553.
86. Balakumar P., Kathuria S., Taneja G., Kalra S., Mahadevan N. J. Mol. Cell. Cardiol. 2012, 52:83-92.
87. Arimoto T., Takeishi Y., Takahashi H., Shishido T., Niizeki T., Koyama Y., Shiga R., Nozaki N., Nakajima O., Nishimaru K., Abe J., Endoh M., Walsh R.A., Goto K., Kubota I. Circulation 2006, 113:60-66.
88. Lassègue B., Alexander R.W., Clark M., Akers M., Griendling K.K. Biochem. J. 1993, 292:509-517.
89. Tsuchiya A., Kanno T., Nishizaki T. Life Sci. 2013, 93:240-246.
90. Sasaki T., Shishido T., Kadowaki S., Kitahara T., Suzuki S., Katoh S., Funayama A., Netsu S., Watanabe T., Goto K., Takeishi Y., Kubota I. Heart Vessels 2014, 29:110-118.
91. Takeishi Y., Goto K., Kubota I. Pharmacol. Ther. 2007, 115:352-359.
92. Niizeki T., Takeishi Y., Arimoto T., Takahashi H., Shishido T., Koyama Y., Goto K., Walsh R.A., Kubota I. Am. J. Physiol. Heart Circ. Physiol. 2007, 292:H1105-H1112.
93. Harada M., Takeishi Y., Arimoto T., Niizeki T., Kitahara T., Goto K., Walsh R.A., Kubota I. Circ. J. 2007, 71:276-282.
94. Pearson G., Robinson F., Beers Gibson T., Xu B.E., Karandikar M., Berman K., Cobb M.H. Endocr. Rev. 2001, 22:153-183.
95. Eguchi S., Inagami T. Regul. Pept. 2000, 91:13-20.
96. Shah B.H., Yesilkaya A., Olivares-Reyes J.A., Chen H.D., Hunyady L., Catt K.J. Mol. Endocrinol. 2004, 18:2035-2048.
97. Eguchi S., Dempsey P.J., Frank G.D., Motley E.D., Inagami T. J. Biol. Chem. 2001, 276:7957-7962.
98. Higuchi S., Ohtsu H., Suzuki H., Shirai H., Frank G.D., Eguchi S. Clin. Sci. (Lond.) 2007, 112:417-428.
99. Mifune M., Ohtsu H., Suzuki H., Nakashima H., Brailoiu E., Dun N.J., Frank G.D., Inagami T., Higashiyama S., Thomas W.G., Eckhart A.D., Dempsey P.J., Eguchi S. J. Biol. Chem. 2005, 280:26592-26599.
100. Ohtsu H., Dempsey P.J., Frank G.D., Brailoiu E., Higuchi S., Suzuki H., Nakashima H., Eguchi K., Eguchi S. Arterioscler. Thromb. Vasc. Biol. 2006, 26:e133-e137.
101. Takaguri A., Shirai H., Kimura K., Hinoki A., Eguchi K., Carlile-Klusacek M., Yang B., Rizzo V., Eguchi S. J. Mol. Cell. Cardiol. 2011, 50:545-551.
102. Eguchi S., Numaguchi K., Iwasaki H., Matsumoto T., Yamakawa T., Utsunomiya H., Motley E.D., Kawakatsu H., Owada K.M., Hirata Y., Marumo F., Inagami T. J. Biol. Chem. 1998, 273:8890-8896.
103. Seta K., Sadoshima J. J. Biol. Chem. 2003, 278:9019-9026.
104. Tanaka M., Nanba D., Mori S., Shiba F., Ishiguro H., Yoshino K., Matsuura N., Higashiyama S. J. Biol. Chem. 2004, 279:41950-41959.
105. Mori S., Tanaka M., Nanba D., Nishiwaki E., Ishiguro H., Higashiyama S., Matsuura N. J. Biol. Chem. 2003, 278:46029-46034.
106. Moriguchi Y., Matsubara H., Mori Y., Murasawa S., Masaki H., Maruyama K., et al. Circ. Res. 1999, 84:1073-1084.
107. Uchiyama-Tanaka Y., Matsubara H., Nozawa Y., Murasawa S., Mori Y., Kosaki A., et al. Kidney Int. 2001, 60:2153-2163.
108. Richards W.G., Sweeney W.E., Yoder B.K., Wilkinson J.E., Woychik R.P., Avner E.D. J. Clin. Invest. 1998, 101:935-939.
109. François H., Placier S., Flamant M., Tharaux P.L., Chansel D., Dussaule J.C., Chatziantoniou C. FASEB J. 2004, 18:926-928.
110. Pei Y., Scholey J., Thai K., Suzuki M., Cattran D. J. Clin. Invest. 1997, 100:814-820.
111. Nouwen E.J., De Broe M.E. Kidney Int. 1994, 45:1510-1521.
112. Breyer M.D., Redha R., Breyer J.A. Am. J. Physiol. 1990, 259:F553-F558.
113. Stocklin E., Botteri F., Groner B. J. Cell Biol. 1993, 122:199-208.
114. Lowden D.A1., Lindemann G.W., Merlino G., Barash B.D., Calvet J.P., Gattone V.H. J. Lab. Clin. Med. 1994, 124:386-394.
115. Lautrette A., Li S., Alili R., Sunnarborg S.W., Burtin M., Lee D.C., Friedlander G., Terzi F. Nat. Med. 2005, 11:867-874.
116. Dell K.M., Nemo R., Sweeney W.E., Levin J.I., Frost P., Avner E.D. Kidney Int. 2001, 60:1240-1248.
117. Tian Y., Smith R.D., Balla T., Catt K.J. Endocrinology 1998, 139:1801-1809.
118. Wei H., Ahn S., Shenoy S.K., Karnik S.S., Hunyady L., Luttrell L.M., Lefkowitz R.J. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:10782-10787.
119. Daub H., Wallasch C., Lankenau A., Herrlich A., Ullrich A. EMBO J. 1997, 16:7032-7044.
120. Heeneman S., Haendeler J., Saito Y., Ishida M., Angiotensin Berk B.C., II J. Biol. Chem. 2000, 275:15926-15932.
121. Linseman D.A., Benjamin C.W., Jones D.A. J. Biol. Chem. 1995, 270:12563-12568.
122. Mondorf U.F., Geiger H., Herrero M., Zeuzem S., Piiper A. FEBS Lett. 2000, 472:129-132.
123. Kim S., Zhan Y., Izumi Y., Yasumoto H., Yano M., Iwao H. Arterioscler. Thromb. Vasc. Biol. 2000, 20:2539-2545.
124. Kelly D.J., Cox A.J., Gow R.M., Zhang Y., Kemp B.E., Gilbert R.E. Hypertension 2004, 44:195-202.
125. Suzuki H., Kimura K., Shirai H., Eguchi K., Higuchi S., Hinoki A., et al. Arterioscler. Thromb. Vasc. Biol. 2009, 29:217-224.
126. Lassègue B., Alexander R.W., Clark M., Griendling K.K. Biochem. J. 1991, 276:19-25.
127. Touyz R.M., Schiffrin E.L. Hypertension 1999, 34:976-982.
128. McLaughlin J.N., Thulin C.D., Bray S.M., Martin M.M., Elton T.S., Willardson B.M. J. Biol. Chem. 2002, 277:34885-34895.
129. Brandes R.P., Kreuzer J. Cardiovasc. Res. 2005, 65:16-27.
130. Taura M., Miyano K., Minakami R., Kamakura S., Takeya R., Sumimoto H. Biochem. J. 2009, 419:329-338.
131. Balakumar P., Arora M.K., Reddy J., Anand-Srivastava M.B. J. Cardiovasc. Pharmacol. 2009, 54:129-138.
132. Iadecola C., Gorelick P.B. Stroke 2004, 35:348-350.
133. Balakumar P., Kaur T., Singh M. Toxicology 2008, 245:49-64.
134. Balakumar P., Kathuria S. Br. J. Pharmacol. 2012, 166:1981-1992.
135. Balakumar P., Taneja G. Free Radic. Biol. Med. 2012, 53:271-279.
136. Frank G.D., Eguchi S. Antioxid. Redox Signal. 2003, 5:771-780.
137. Seshiah P.N., Weber D.S., Rocic P., Valppu L., Taniyama Y., Griendling K.K. Circ. Res. 2002, 91:406-413.
138. Ushio-Fukai M., Griendling K.K., Becker P.L., Hilenski L., Halleran S., Alexander R.W. Arterioscler. Thromb. Vasc. Biol. 2001, 21:489-495.
139. Bokemeyer D., Schmitz U., Kramer H.J. Kidney Int. 2000, 58:549-558.
140. Touyz R.M., Schiffrin E.L. J. Hypertens. 2001, 19:1245-1254.
141. Aplin M., Bonde M.M., Hansen J.L. J. Mol. Cell. Cardiol. 2009, 46:15-24.
142. Moore C.A., Milano S.K., Benovic J.L. Annu. Rev. Physiol. 2007, 69:451-482.
143. Freedman N.J., Liggett S.B., Drachmann D.E., Pei G., Caron M.G., Lefkowitz R.J. J. Biol. Chem. 1995, 270:17953-17961.
144. Luttrell L.M., Lefkowitz R.J. J. Cell Sci. 2002, 115(Pt3):455-465.
145. Lefkowitz R.J., Shenoy S.K. Science 2005, 308:512-517.
146. Zimmerman B., Beautrait A., Aguila B., Charles R., Escher E., Claing A., Bouvier M., Laporte S.A. Sci. Signal. 2012, 5(221):ra33.
147. Perry S.J., Baillie G.S., Kohout T.A., McPhee I., Magiera M.M., Ang K.L., et al. Science 2002, 298:834-836.
148. Nelson C.D., Perry S.J., Regier D.S., Prescott S.M., Topham M.K., Lefkowitz R.J. Science 2007, 315:663-666.
149. Rajagopal K., Whalen E.J., Violin J.D., Stiber J.A., Rosenberg P.B., Premont R.T., Coffman T.M., Rockman H.A., Lefkowitz R.J. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:16284-16289.
150. Noma T., Lemaire A., Naga Prasad S.V., Barki-Harrington L., Tilley D.G., Chen J., et al. J. Clin. Invest. 2007, 117:2445-2458.
151. Violin J.D., DeWire S.M., Yamashita D., Rominger D.H., Nguyen L., Schiller K., Whalen E.J., Gowen M., Lark M.W. J. Pharmacol. Exp. Ther. 2010, 335:572-579.
152. Boerrigter G., Lark M.W., Whalen E.J., Soergel D.G., Violin J.D., Burnett J.C. Circ. Heart Fail. 2011, 4:770-778.
153. Boerrigter G., Soergel D.G., Violin J.D., Lark M.W., Burnett J.C. Circ. Heart Fail. 2012, 5:627-634.
154. Bathgate-Siryk A., Dabul S., Pandya K., Walklett K., Rengo G., Cannavo A., et al. Hypertension 2014, 63:404-412.
155. Ihle J.N. Cell 1996, 84:331-334.
156. Boengler K., Hilfiker-Kleiner D., Drexler H., Heusch G., Schulz R. Pharmacol. Ther. 2008, 120:172-185.
157. Booz G.W., Day J.N., Baker K.M. J. Mol. Cell. Cardiol. 2002, 34:1443-1453.
158. Satou R., Gonzalez-Villalobos R.A. JAKSTAT 2012, 1:250-256.
159. Marrero M.B., Schieffer B., Li B., Sun J., Harp J.B., Ling B.N. J. Biol. Chem. 1997, 272:24684-24690.
160. Pan J., Fukuda K., Kodama H., Makino S., Takahashi T., Sano M., Hori S., Ogawa S. Circ. Res. 1997, 81:611-617.
161. El-Adawi H., Deng L., Tramontano A., Smith S., Mascareno E., Ganguly K., Castillo R., El-Sherif N. Cardiovasc. Res. 2003, 57:129-138.
162. Frank G.D., Saito S., Motley E.D., Sasaki T., Ohba M., Kuroki T., Inagami T., Eguchi S. Mol. Endocrinol. 2002, 16:367-377.
163. Ali M.S., Sayeski P.P., Dirksen L.B., Hayzer D.J., Marrero M.B., Bernstein K.E. J. Biol. Chem. 1997, 272:23382-23388.
164. Venema R.C., Ju H., Venema V.J., Schieffer B., Harp J.B., Ling B.N., Eaton D.C., Marrero M.B. J. Biol. Chem. 1998, 273:7703-7708.
165. Marrero M.B., Schieffer B., Paxton W.G., Heerdt L., Berk B.C., Delafontaine P., Bernstein K.E. Nature 1995, 375:247-250.
166. Marrero M.B., Venema V.J., Ju H., Eaton D.C., Venema R.C. Am. J. Physiol. 1998, 275:C1216-C1223.
167. Doan T.N., Ali M.S., Bernstein K.E. J. Biol. Chem. 2001, 276:20954-20958.
168. Guilluy C., Brégeon J., Toumaniantz G., Rolli-Derkinderen M., Retailleau K., Loufrani L., et al. Nat. Med. 2010, 16:183-190.
169. Stephanou A., Brar B.K., Scarabelli T.M., Jonassen A.K., Yellon D.M., Marber M.S., et al. J. Biol. Chem. 2000, 275:10002-10008.
170. Kunisada K., Negoro S., Tone E., Funamoto M., Osugi T., Yamada S., Okaba M., Kishimoto T., Yamauchitakihara K. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:315-319.
171. Kirabo A., Kearns P.N., Jarajapu Y.P., Sasser J.M., Oh S.P., Grant M.B., Kasahara H., Cardounel A.J., Baylis C., Wagner K.U., Sayeski P.P. Cardiovasc. Res. 2011, 91:171-179.
172. Banes-Berceli A.K., Al-Azawi H., Proctor D., Qu H., Femminineo D., Hill-Pyror C., Webb R.C., Brands M.W. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011, 301:R1169-R1176.
173. Chang L., Yang R., Wang M., Liu J., Wang Y., Zhang H., Li Y. Am. J. Med. Sci. 2012, 343:220-226.
174. Balakumar P., Sharma N.K. Cell. Signal. 2012, 24:53-59.
175. Yang N., Luo M., Li R., Huang Y., Zhang R., Wu Q., Wang F., Li Y., Yu X. Nephrol. Dial. Transplant. 2008, 23:91-100.
176. Skeggs L.T., Kahn J.R., Shumway N.P. J. Exp. Med. 1956, 103:295-299.
177. Bumpus F.M., Schwarz H., Page I.H. Science 1957, 125:886-887.
178. Pals D.T., Denning G.S., Keenan R.E. Kidney Int. Suppl. 1979, 9:S7-S10.
179. Lin S.Y., Goodfriend T.L. Am. J. Physiol. 1970, 218:1319-1328.
180. Ferreira S.H. Br. J. Pharmacol. Chemother. 1965, 24:163-169.
181. Ferreira S.H., Bartelt D.C., Greene L.J. Biochemistry 1970, 9:2583-2593.
182. Ondetti M.A., Williams N.J., Sabo E.F., Pluscec J., Weaver E.R., Kocy O. Biochemistry 1971, 10:4033-4039.
183. Ondetti M.A., Rubin B., Cushman D.W. Science 1977, 196:441-444.
184. Kaufman M.B. P T 2013, 38:170-172.
185. Bhardwaj G. Expert Opin. Drug Disc. 2006, 1:609-618.
186. Dzau V.J., Baxter J.A., Cantin M., de Bold A., Ganten D., Gross K., et al. Hypertension 1987, 5:507-511.
187. Ferrario C.M., Brosnihan K.B., Diz D.I., Jaiswal N., Khosla M.C., Milsted A., Tallant E.A. Hypertension 1991, 18:III126-III133.
188. Ripley E., Hirsch A. Int. J. Nephrol. Renov. Dis. 2010, 3:93-98.
189. Nagata S., Kato J., Sasaki K., Minamino N., Eto T., Kitamura K. Biochem. Biophys. Res. Commun. 2006, 350:1026-1031.
190. Jensen C., Herold P., Brunner H.R. Nat. Rev. Drug Discov. 2008, 7:399-410.
191. Zaiken K., Cheng J.W. Clin. Ther. 2011, 33:1577-1589.
192. Balakumar P., Jagadeesh G. Mol. Cell. Endocrinol. 2014, 10.1530/JME-14-0125.