Targeting of cyclic AMP degradation to β2-adrenergic receptors by β-arrestins

Science

Volumn 298, Issue 5594, 2002, Pages 834-836

  Perry, Stephen J ^a   Baillie, George S ^a   Kohout, Trudy A ^a   McPhee, Ian ^a   Magiera, Maria M ^a   Ang, Kok Long ^a   Miller, William E ^a   McLean, Alison J ^a   Conti, Marco ^a   Houslay, Miles D ^a   Lefkowitz, Robert J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; DEGRADATION; ENZYMES; PROTEINS;

ADRENERGIC RECEPTORS;

NATURAL SCIENCES;

ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; PHOSPHODIESTERASE;

BIOCHEMISTRY; PROTEIN;

ADRENERGIC SYSTEM; ANIMAL CELL; ARTICLE; EMBRYO; ENZYME ACTIVATION; FIBROBLAST CULTURE; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; KIDNEY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SECOND MESSENGER; SIGNAL TRANSDUCTION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADRENERGIC BETA-AGONISTS; ANIMALS; ARRESTINS; CELL LINE; CELL MEMBRANE; COS CELLS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSOL; HUMANS; ISOENZYMES; ISOPROTERENOL; MICE; MUTATION; PRECIPITIN TESTS; RATS; RECEPTORS, ADRENERGIC, BETA-2; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 0037174646     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1074683     Document Type: Article

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21. M.D.H. is funded by the Medical Research Council (U.K.). R.J.L. is funded by NIH (HL16037) and the Howard Hughes Medical Institute. M. C. is funded by NIH (HD20788) and a grant from the Sandler Foundation. We thank K. Nobles for technical assistance and J. Beavo for the gift of the PDE5A1 expression construct.