Angiotensin-(1-7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy

Clinical Science

Volumn 120, Issue 8, 2011, Pages 335-345

  Velkoska, Elena ^a   Dean, Rachael G ^a   Griggs, Karen ^a   Burchill, Luke ^a   Burrell, Louise M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Angiotensin peptide; Cardiac fibrosis; Kidney failure; Renal mass reduction; Renin angiotensin system

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; ANGIOTENSIN[1-7]; DIPEPTIDYL CARBOXYPEPTIDASE; RAMIPRIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG INFUSION; ENZYME ACTIVITY; HEART HYPERTROPHY; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; HYPERTENSION; KIDNEY FAILURE; MALE; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ANGIOTENSIN I; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; CARDIOMEGALY; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HYPERTENSION; MALE; NEPHRECTOMY; PEPTIDE FRAGMENTS; PEPTIDYL-DIPEPTIDASE A; RAMIPRIL; RATS; RATS, SPRAGUE-DAWLEY; RENAL INSUFFICIENCY;

EID: 79951779192     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20100280     Document Type: Article

References (49)

1. Velez, J. C. (2009) The importance of the intrarenal renin-angiotensin system. Nat. Clin. Pract. Nephrol. 5, 89-100
2. Schiffrin, E. L., Lipman, M. L. and Mann, J. F. (2007) Chronic kidney disease: effects on the cardiovascular system. Circulation 116, 85-97
3. Burchill, L., Velkoska, E., Dean, R. G., Lew, R. A., Smith, A. I., Levidiotis, V. and Burrell, L. M. (2008) Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression. Exp. Physiol. 93, 622-630
4. Velkoska, E., Dean, R. G., Burchill, L. J., Levidiotis, V. and Burrell, L. M. (2010) Reduction in renal ACE2 expression in subtotal nephrectomy is ameliorated with ACE inhibition. Clin. Sci. 118, 269-279
5. Ferrario, C. M. (2006) Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation. Hypertension 47, 515-521
6. Tallant, E. A. and Clark, M. A. (2003) Molecular mechanisms of inhibition of vascular growth by angiotensin-(1-7). Hypertension 42, 574-579
7. Burrell, L. M., Johnston, C. I., Tikellis, C. and Cooper, M. E. (2004) ACE2, a new regulator of the renin-angiotensin system. Trends Endocrinol. Metab. 15, 166-169
8. Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., Donovan, M., Woolf, B., Robison, K., Jeyaseelan, R. et al. (2000) A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res. 87, -E9
9. Tipnis, S. R., Hooper, N. M., Hyde, R., Karran, E., Christie, G. and Turner, A. J. (2000) A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J. Biol. Chem. 275, 33238-33243
10. Santos, R. A., Simoes e Silva, A. C., Maric, C., Silva, D. M., Machado, R. P., de Buhr, I., Heringer-Walther, S., Pinheiro, S. V., Lopes, M. T., Bader, M. et al. (2003) Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc. Natl. Acad. Sci. U.S.A. 100, 8258-8263
11. Ferrario, C. M. (2010) New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism. Hypertension 55, 445-452
12. Lubel, J. S., Herath, C. B., Tchongue, J., Grace, J., Jia, Z., Spencer, K., Casley, D., Crowley, P., Sievert, W., Burrell, L. M. and Angus, P.W. (2009) Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat. Clin. Sci. 117, 375-386
13. Loot, A. E., Roks, A. J., Henning, R. H., Tio, R. A., Suurmeijer, A. J., Boomsma, F. and van Gilst, W. H. (2002) Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats. Circulation 105, 1548-1550
14. Benter, I. F., Yousif, M. H., Cojocel, C., Al-Maghrebi, M. and Diz, D. I. (2007) Angiotensin-(1-7) prevents diabetes-induced cardiovascular dysfunction. Am. J. Physiol. Heart Circ. Physiol. 292, H666-H672
15. Benter, I. F., Yousif, M. H., Anim, J. T., Cojocel, C. and Diz, D. I. (2006) Angiotensin-(1-7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME. Am. J. Physiol. Heart Circ. Physiol. 290, H684-H691
16. Shao, Y., He, M., Zhou, L., Yao, T., Huang, Y. and Lu, L. M. (2008) Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury. Acta Pharmacol. Sin. 29, 829-837
17. Dilauro, M., Zimpelmann, J., Robertson, S. J., Genest, D. and Burns, K. D. (2010) The effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease. Am. J. Physiol. Renal Physiol. 298, F1523-F1532
18. Burgelova, M., Vanourkova, Z., Thumova, M., Dvorak, P., Opocensky, M., Kramer, H. J., Zelizko, M., Maly, J., Bader, M. and Cervenka, L. (2009) Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension. J. Hypertens. 27, 1988-2000
19. Li, Y., Wu, J., He, Q., Shou, Z., Zhang, P., Pen, W., Zhu, Y. and Chen, J. (2009) Angiotensin (1-7) prevent heart dysfunction and left ventricular remodeling caused by renal dysfunction in 5/6 nephrectomy mice. Hypertens. Res. 32, 369-374
20. Ji, H., Menini, S., Zheng, W., Pesce, C., Wu, X. and Sandberg, K. (2008) Role of angiotensin-converting enzyme 2 and angiotensin(1-7) in 17β-oestradiol regulation of renal pathology in renal wrap hypertension in rats. Exp. Physiol. 93, 648-657
21. Kennedy, D. J., Elkareh, J., Shidyak, A., Shapiro, A. P., Smaili, S., Mutgi, K., Gupta, S., Tian, J., Morgan, E., Khouri, S. et al. (2008) Partial nephrectomy as a model for uremic cardiomyopathy in the mouse. Am. J. Physiol. Renal Physiol. 294, F450-F454
22. Herath, C. B.,Warner, F. J., Lubel, J. S., Dean, R. G., Jia, Z., Lew, R. A., Smith, A. I., Burrell, L. M. and Angus, P.W. (2007) Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis. J. Hepatol. 47, 387-395
23. Santos, R. A., Krieger, E. M. and Greene, L. J. (1985) An improved fluorometric assay of rat serum and plasma converting enzyme. Hypertension 7, 244-252 (Pubitemid 15093650)
24. Johnston, C. I., Mendelsohn, F. and Casley, D. (1971) Evaluation of renin and angiotensin assays and their clinical application. Med. J. Aust. 1, 126-128
25. Burrell, L. M., Risvanis, J., Kubota, E., Dean, R. G., MacDonald, P. S., Lu, S., Tikellis, C., Grant, S. L., Lew, R. A., Smith, A. I. et al. (2005) Myocardial infarction increases ACE2 expression in rat and humans. Eur. Heart J. 26, 369-375
26. Dean, R. G., Balding, L. C., Candido, R., Burns, W. C., Cao, Z., Twigg, S. M. and Burrell, L. M. (2005) Connective tissue growth factor and cardiac fibrosis after myocardial infarction. J. Histochem. Cytochem. 53, 1245-1256
27. Trask, A. J., Groban, L., Westwood, B. M., Varagic, J., Ganten, D., Gallagher, P. E., Chappell, M. C. and Ferrario, C. M. (2010) Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am. J. Hypertens. 23, 687-693
28. Yamada, K., Iyer, S. N., Chappell, M. C., Ganten, D. and Ferrario, C. M. (1998) Converting enzyme determines plasma clearance of angiotensin-(1-7). Hypertension 32, 496-502
29. Bindom, S. M. and Lazartigues, E. (2009) The sweeter side of ACE2: physiological evidence for a role in diabetes. Mol. Cell. Endocrinol. 302, 193-202
30. Brunner, H. R. and Gavras, H. (2006) Validation of in-vitro data by in-vivo evidence: the example of angiotensin (1-7). J. Hypertens. 24, 1919-1920
31. Esteban, V., Heringer-Walther, S., Sterner-Kock, A., de Bruin, R., Van Den Engel, S.,Wang, Y., Mezzano, S., Egido, J., Schultheiss, H. P., Ruiz-Ortega, M. and Walther, T. (2009) Angiotensin-(1-7) and the G protein-coupled receptor Mas are key players in renal inflammation. PLoS ONE 4, e5406
32. Su, Z., Zimpelmann, J. and Burns, K. D. (2006) Angiotensin-(1-7) inhibits angiotensin II-stimulated phosphorylation of MAP kinases in proximal tubular cells. Kidney Int. 69, 2212-2218
33. Zimpelmann, J. and Burns, K. D. (2009) Angiotensin-(1-7) activates growth stimulatory pathways in human mesangial cells. Am. J. Physiol. Renal Physiol. 296, F337-F346
34. Iwata, M., Cowling, R. T., Gurantz, D., Moore, C., Zhang, S., Yuan, J. X. and Greenberg, B. H. (2005) Angiotensin- (1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects. Am. J. Physiol. Heart Circ. Physiol. 289, H2356-H2363
35. van der Wouden, E. A., Ochodnicky, P., van Dokkum, R. P., Roks, A. J., Deelman, L. E., de Zeeuw, D. and Henning, R. H. (2006) The role of angiotensin(1-7) in renal vasculature of the rat. J. Hypertens. 24, 1971-1978
36. Moltzer, E., Verkuil, A. V., van Veghel, R., Danser, A. H. and van Esch, J. H. (2010) Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: loss of angiotensin II type 2 receptor-mediated vasodilation. Hypertension 55, 516-522
37. Zhang, J., Noble, N. A., Border, W. A. and Huang, Y. (2010) Infusion of angiotensin-(1-7) reduces glomerulosclerosis through counteracting angiotensin II in experimental glomerulonephritis. Am. J. Physiol. Renal Physiol. 298, F579-F588
38. Kostenis, E., Milligan, G., Christopoulos, A., Sanchez-Ferrer, C. F., Heringer-Walther, S., Sexton, P. M., Gembardt, F., Kellett, E., Martini, L., Vanderheyden, P. et al. (2005) G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor. Circulation 111, 1806-1813 (Pubitemid 40525146)
39. 2 receptors in the mouse heart. Hypertension 46, 937-942
40. Pinheiro, S. V., Ferreira, A. J., Kitten, G. T., da Silveira, K. D., da Silva, D. A., Santos, S. H., Gava, E., Castro, C. H., Magalhaes, J. A., da Mota, R. K. et al. (2009) Genetic deletion of the angiotensin-(1-7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria. Kidney Int. 75, 1184-1193
41. Burns, W. C., Velkoska, E., Dean, R. G., Burrell, L. M. and Thomas, M. C. (2010) Angiotensin II mediates epithelial-to-mesenchymal transformation in tubular cells by Ang-(1-7)/Mas-1 dependent pathways. Am. J. Physiol. Renal Physiol. 299, F585-F593
42. Grobe, J. L., Mecca, A. P., Mao, H. and Katovich, M. J. (2006) Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension. Am. J. Physiol. Heart Circ. Physiol. 290, H2417-H2423
43. Benter, I. F., Diz, D. I. and Ferrario, C. M. (1993) Cardiovascular actions of angiotensin(1-7). Peptides 14, 679-684
44. Chappell, M. C., Pirro, N. T., Sykes, A. and Ferrario, C. M. (1998) Metabolism of angiotensin-(1-7) by angiotensin-converting enzyme. Hypertension 31, 362-367
45. Koitka, A., Cooper, M. E., Thomas, M. C. and Tikellis, C. (2008) Angiotensin converting enzyme 2 in the kidney. Clin. Exp. Pharmacol. Physiol. 35, 420-425
46. Handa, R. K. (2000) Metabolism alters the selectivity of angiotensin-(1-7) receptor ligands for angiotensin receptors. J. Am. Soc. Nephrol. 11, 1377-1386
47. Ferreira, P. M., Souza Dos Santos, R. A. and Campagnole-Santos, M. J. (2007) Angiotensin-(3-7) pressor effect at the rostral ventrolateral medulla. Regul. Pept. 141, 168-174
48. 4 receptor system. Am. J. Physiol. 277, F75-F83
49. Ruiz-Ortega, M., Esteban, V. and Egido, J. (2007) The regulation of the inflammatory response through nuclear factor-κB pathway by angiotensin IV extends the role of the renin angiotensin system in cardiovascular diseases. Trends Cardiovasc. Med. 17, 19-25