Angiotensin II type 1 receptor blockade restores angiotensin-(1-7)-induced coronary vasodilation in hypertrophic rat hearts

Clinical Science

Volumn 125, Issue 9, 2013, Pages 449-459

  Souza, Álvaro P S ^a   Sobrinho, Deny B S ^a   Almeida, Jônathas F Q ^a   Alves, Gisele M M ^a   Macedo, Larissa M ^a   Porto, Juliana E ^a   Vêncio, Eneida F ^a   Colugnati, Diego B ^a   Santos, Robson A S ^b,c   Ferreira, Anderson J ^b,c   Mendes, Elizabeth P ^a,c   Castro, Carlos H ^a,c  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c National Institute of Science and Technology in Nanobiopharmaceutics   (Brazil)

Author keywords

Angiotensin II type 1 receptor (AT1 receptor); Angiotensin (1 7); Coronary vasodilation; Hypertrophic heart; Mas receptor

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN[1-7]; ANGIOTENSIN[1-7][7 DEXTRO ALANINE]; GUANYLATE CYCLASE INHIBITOR; LOSARTAN; N ETHYLCARBAMOYL 3 [4 (5 FORMYL 4 METHOXY 2 PHENYL 1 IMIDAZOLYLMETHYL)PHENYL] 5 ISOBUTYL 2 THIOPHENESULFONAMIDE; N(G) NITROARGININE METHYL ESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA COARCTATION; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DILATATION; DRUG MECHANISM; HEART HYPERTROPHY; IN VITRO STUDY; INCUBATION TIME; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHAM PROCEDURE; VASCULAR RING; VASODILATATION;

ANGIOTENSIN I; ANIMALS; CARDIOMEGALY; IMIDAZOLES; LOSARTAN; MALE; NG-NITROARGININE METHYL ESTER; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS; PYRIDINES; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, G-PROTEIN-COUPLED; VASODILATION;

EID: 84880673428     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20120519     Document Type: Article

References (53)

1. Dunn, F. G., and Pringle, S. D. (1993) Sudden cardiac death, ventricular arrhythmias, and hypertensive left ventricular hypertrophy. J. Hypertens. 11, 1003-1010
2. Reinier, K., Dervan, C., Singh, T., Uy-Evanado, A., Lai, S., Gunson, K., Jui, J., and Chugh, S. S. (2011) Increased left ventricular mass, and decreased left ventricular systolic function have independent pathways to ventricular arrhythmogenesis in coronary artery disease. Heart Rhythm 8, 1177-1182
3. Katholi, R. E., and Couri, D. M. (2011) Left ventricular hypertrophy: major risk factor in patients with hypertension: update, and practical clinical applications. Int. J. Hypertens. 2011, 95349
4. Shimada, Y., and Avkiran, M. (2002) Left, and right coronary circulation in left ventricular hypertrophy: effects of angiotensin converting enzyme inhibition. Circ. J. 66, 1168-1172
5. Yamamoto, H., Yamamoto, F., and Ichikawa, H. (2009) Enhanced coronary vascular turgor effect on post-ischemic diastolic function in hypertrophied hearts. Interact. Cardiovasc. Thoracic Surg. 9, 605-608
6. O'Keefe, D. D., Hoffman, J. I., Cheitlin, R., O'Neill, M. J., Allard, J. R., and Shapkin, E. (1978) Coronary blood flow in experimental canine left ventricular hypertrophy. Circ. Res. 43, 43-51
7. Wangler, R. D., Peters, K. G., Marcus, M. L., and Tomanek, R. J. (1982) Effects of duration, and severity of arterial hypertension, and cardiac hypertrophy on coronary vasodilator reserve. Circ. Res. 51, 10-18
8. Duncker, D. J., and Bache, R. J. (1997) Effect of chronotropic, and inotropic stimulation on the coronary pressure-flow relation in left ventricular hypertrophy. Basic Res. Cardiol. 92, 271-286
9. Isoyama, S., Sato, F., and Takishima, T. (1991) Effect of age on coronary circulation after imposition of pressure-overload in rats. Hypertension 17, 369-377
10. Boulanger, C. M. (1999) Secondary endothelial dysfunction: hypertension, and heart failure. J. Mol. Cell. Cardiol. 31, 39-49 11 Lavi, S., Yang, E. H., Prasad, A., Mathew, V., Barsness, G. W., Rihal, C. S., Lerman, L. O., and Lerman, A. (2008) The interaction between coronary endothelial dysfunction, local oxidative stress,, and endogenous nitric oxide in humans. Hypertension 51, 127-133
11. Lavi, S., Yang, E. H., Prasad, A., Mathew, V., Barsness, G. W., Rihal, C. S., Lerman, L. O., and Lerman, A. (2008) The interaction between coronary endothelial dysfunction, local oxidative stress,, and endogenous nitric oxide in humans. Hypertension 51, 127-133
12. Touyz, R. M. (2005) Molecular, and cellular mechanisms in vascular injury in hypertension: role of angiotensin II. Curr. Opin. Nephrol. Hypertens. 14, 125-131
13. Ainscough, J. F., Drinkhill, M. J., Sedo, A., Turner, N. A., Brooke, D. A., Balmforth, A. J., and Ball, S. G. (2009) Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy, and cardiac dysfunction. Cardiovasc. Res. 81, 592-600
14. Frohlich, E. D. (1989) Overview of hemodynamic, and non-hemodynamic factors associated with left ventricular hypertrophy. J. Mol. Cell. Cardiol. 21, 3-10
15. Frohlich, E. D. (2001) Renin-angiotensin system inhibition improves coronary flow reserve in hypertension. J. Cardiovasc. Pharmacol. 37 (Suppl. 1), S35-S39
16. Kinugawa, S., Post, H., Kaminski, P. M., Zhang, X., Xu, X., Huang, H., Recchia, F. A., Ochoa, M., Wolin, M. S., Kaley, G. et al. (2003) Coronary microvascular endothelial stunning after acute pressure overload in the conscious dog is caused by oxidant processes: the role of angiotensin II type 1 receptor, and NAD(P)H oxidase. Circulation 108, 2934-2940
17. Marangoni, R. A., Carmona, A. K., Passaglia, R. C., Nigro, D., Fortes, Z. B., and de Carvalho, M. H. (2006) Role of the kallikrein-kinin system in Ang-(1-7)-induced vasodilation in mesenteric arterioles of Wistar rats studied in vivo-in situ. Peptides 27, 1770-1775
18. Meng, W., and Busija, D. W. (1993) Comparative effects of angiotensin-(1-7), and angiotensin II on piglet pial arterioles. Stroke 24, 2041-2044
19. Santos, R. A., Simoese Silva, A. C., Maric, C., Silva, D. M., Machado, R. P., de Buhr, I., Heringer-Walther, S., Pinheiro, S. V., Lopes, M. T., Bader, M. et al. (2003) Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc. Natl. Acad. Sci. U.S.A. 100, 8258-8263
20. Brosnihan, K. B., Li, P., Tallant, E. A., and Ferrario, C. M. (1998) Angiotensin-(1-7): a novel vasodilator of the coronary circulation. Biol. Res. 31, 227-234
21. Castro, C. H., Santos, R. A., Ferreira, A. J., Bader, M., Alenina, N., and Almeida, A. P. (2005) Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with AT1, and AT2 receptors in the mouse heart. Hypertension 46, 937-942
22. van Esch, J. H., Oosterveer, C. R., Batenburg, W. W., van Veghel, R., and Jan Danser, A. H. (2008) Effects of angiotensin II, and its metabolites in the rat coronary vascular bed: is angiotensin III the preferred ligand of the angiotensin AT2 receptor? Eur. J. Pharmacol. 588, 286-293
23. Santos, R. A., Ferreira, A. J., Pinheiro, S. V., Sampaio, W. O., Touyz, R., and Campagnole-Santos, M. J. (2005) Angiotensin- (1-7), and its receptor as a potential targets for new cardiovascular drugs. Expert Opin. Invest. Drugs 14, 1019-1031
24. Iwata, M., Cowling, R. T., Yeo, S. J., and Greenberg, B. (2011) Targeting the ACE2-Ang-(1-7) pathway in cardiac fibroblasts to treat cardiac remodeling, and heart failure. J. Mol. Cell. Cardiol. 51, 542-547
25. Walters, P. E., Gaspari, T. A., and Widdop, R. E. (2005) Angiotensin-(1-7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats. Hypertension 45, 960-966 26 Gorelik, G., Carbini, L. A., and Scicli, A. G. (1998) Angiotensin 1-7 induces bradykinin-mediated relaxation in porcine coronary artery. J. Pharmacol. Exp. Ther. 286, 403-410
26. Gorelik, G., Carbini, L. A., and Scicli, A. G. (1998) Angiotensin 1-7 induces bradykinin-mediated relaxation in porcine coronary artery. J. Pharmacol. Exp. Ther. 286, 403-410
27. Silva, D. M., Vianna, H. R., Cortes, S. F., Campagnole-Santos, M. J., Santos, R. A., and Lemos, V. S. (2007) Evidence for a new angiotensin-(1-7) receptor subtype in the aorta of Sprague-Dawley rats. Peptides 28, 702-707
28. Brosnihan, K. B., Li, P., and Ferrario, C. M. (1996) Angiotensin- (1-7) dilates canine coronary arteries through kinins, and nitric oxide. Hypertension 27, 523-528
29. Porsti, I., Bara, A. T., Busse, R., and Hecker, M. (1994) Release of nitric oxide by angiotensin-(1-7) from porcine coronary endothelium: implications for a novel angiotensin receptor. Br. J. Pharmacol. 111, 652-654
30. Feterik, K., Smith, L., and Katusic, Z. S. (2000) Angiotensin-(1-7) causes endothelium-dependent relaxation in canine middle cerebral artery. Brain Res. 873, 75-82
31. Osei, S. Y., Ahima, R. S., Minkes, R. K., Weaver, J. P., Khosla, M. C., and Kadowitz, P. J. (1993) Differential responses to angiotensin-(1-7) in the feline mesenteric, and hindquarters vascular beds. Eur. J. Pharmacol. 234, 35-42
32. Ren, Y., Garvin, J. L., and Carretero, O. A. (2002) Vasodilator action of angiotensin-(1-7) on isolated rabbit afferent arterioles. Hypertension 39, 799-802
33. Oliveira, M. A., Fortes, Z. B., Santos, R. A., Kosla, M. C., and De Carvalho, M. H. (1999) Synergistic effect of angiotensin-(1-7) on bradykinin arteriolar dilation in vivo. Peptides 20, 1195-1201
34. Almeida, A. P., Frabregas, B. C., Madureira, M. M., Santos, R. J., Campagnole-Santos, M. J., and Santos, R. A. (2000) Angiotensin-(1-7) potentiates the coronary vasodilatatory effect of bradykinin in the isolated rat heart. Braz. J. Med. Biol. Res. 33, 709-713
35. Santos, R. A., Ferreira, A. J., Nadu, A. P., Braga, A. N., de Almeida, A. P., Campagnole-Santos, M. J., Baltatu, O., Iliescu, R., Reudelhuber, T. L., and Bader, M. (2004) Expression of an angiotensin-(1-7)-producing fusion protein produces cardioprotective effects in rats. Physiol. Genomics 17, 292-299
36. Ferreira, A. J., Castro, C. H., Guatimosim, S., Almeida, P. W., Gomes, E. R., Dias-Peixoto, M. F., Alves, M. N., Fagundes-Moura, C. R., Rentzsch, B., Gava, E. et al. (2010) Attenuation of isoproterenol-induced cardiac fibrosis in transgenic rats harboring an angiotensin-(1-7)-producing fusion protein in the heart. Ther. Adv. Cardiovasc. Dis. 4, 83-96
37. Moltzer, E., Verkuil, A. V., van Veghel, R., Danser, A. H., and van Esch, J. H. (2010) Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: loss of angiotensin II type 2 receptor-mediated vasodilation. Hypertension 55, 516-522
38. Zhang, C., Hein, T. W., Wang, W., and Kuo, L. (2003) Divergent roles of angiotensin II AT1, and AT2 receptors in modulating coronary microvascular function. Circ. Res. 92, 322-329
39. Traverse, J. H., Judd, D., and Bache, R. J. (1996) Dose-dependent effect of endothelin-1 on blood flow to normal, and collateraldependent myocardium. Circulation 93, 558-566
40. Kamezaki, F., Tasaki, H., Yamashita, K., Shibata, K., Hirakawa, N., Tsutsui, M., Kouzuma, R., Nagatomo, T., Adachi, T., and Otsuji, Y. (2007) Angiotensin receptor blocker improves coronary flow velocity reserve in hypertensive patients: comparison with calcium channel blocker. Hypertens. Res. 30, 699-706
41. Perrone-Filardi, P., Corrado, L., Brevetti, G., Silvestro, A., Dellegrottaglie, S., Cafiero, M., Caiazzo, G., Petretta, A., Maglione, A., Monda, C. et al. (2009) Effects of AT1 receptor antagonism with candesartan on endothelial function in patients with hypertension, and coronary artery disease. J. Clin. Hypertens. 11, 260-265
42. Michel, F. S., Man, G. S., Man, R. Y., and Vanhoutte, P. M. (2008) Hypertension, and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat. Br. J. Pharmacol. 155, 217-226
43. Cordellini, S. (1999) Endothelial dysfunction in DOCA-salt hypertension: possible involvement of prostaglandin endoperoxides. Gen. Pharmacol. 32, 315-320
44. Tang, E. H., and Vanhoutte, P. M. (2010) Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch. 459, 995-1004
45. AbdAlla, S., Lother, H., Abdel-tawab, A. M., and Quitterer, U. (2001) The angiotensin II AT2 receptor is an AT1 receptor antagonist. J. Biol. Chem. 276, 39721-39726
46. Kostenis, E., Milligan, G., Christopoulos, A., Sanchez-Ferrer, C. F., Heringer-Walther, S., Sexton, P. M., Gembardt, F., Kellett, E., Martini, L., Vanderheyden, P. et al. (2005) G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor. Circulation 111, 1806-1813
47. Akers, W. S., Cross, A., Speth, R., Dwoskin, L. P., and Cassis, L. A. (2000) Renin-angiotensin system, and sympathetic nervous system in cardiac pressure-overload hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 279, H2797-H2806
48. Suzuki, J., Matsubara, H., Urakami, M., and Inada, M. (1993) Rat angiotensin II (type 1A) receptor mRNA regulation, and subtype expression in myocardial growth, and hypertrophy. Circ. Res. 73, 439-447
49. Touyz, R. M., Endemann, D., He, G., Li, J. S., and Schiffrin, E. L. (1999) Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR. Hypertension 33, 366-372
50. Yayama, K., Horii, M., Hiyoshi, H., Takano, M., Okamoto, H., Kagota, S., and Kunitomo, M. (2004) Up-regulation of angiotensin II type 2 receptor in rat thoracic aorta by pressure-overload. J. Pharmacol. Exp. Ther. 308, 736-743
51. Sampaio, W. O., Souza dos Santos, R. A., Faria-Silva, R., da Mata Machado, L. T., Schiffrin, E. L., and Touyz, R. M. (2007) Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension 49, 185-192
52. Faria-Silva, R., Duarte, F. V., and Santos, R. A. (2005) Short-term angiotensin(1-7) receptor MAS stimulation improves endothelial function in normotensive rats. Hypertension 46, 948-952
53. Xu, P., Costa-Gonçalves, A. C., Todiras, M., Rabelo, L. A., Sampaio, W. O., Moura, M. M., Santos, S. S., Luft, F. C., Bader, M., Gross, V. et al. (2008) Endothelial dysfunction, and elevated blood pressure in MAS gene-deleted mice. Hypertension 51, 574-580