Angiotensin II receptor coupling to phospholipase D is mediated by the βγ subunits of heterotrimeric G proteins in vascular smooth muscle cells

Molecular Pharmacology

Volumn 55, Issue 1, 1999, Pages 142-149

  Ushio Fukai, Masuko ^a   Alexander, R Wayne ^a   Akers, Marjorie ^a   Lyons, P Reid ^a   Lassègue, Bernard ^a   Griendling, Kathy K ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOXIN; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN RECEPTOR; FLUORIDE SODIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); PERTUSSIS TOXIN; PHOSPHOLIPASE D; PROTEIN ANTIBODY; PROTEIN KINASE P60; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTROPORATION; ENZYME ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

EID: 0032896376     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.1.142     Document Type: Article

References (41)

1. Alexander RW, Brock TA, Gimbrone MA Jr. and Rittenhouse SE (1985) Angiotensin increases inositol trisphosphate and calcium in vascular smooth muscle. Hypertension 7:447-451.
2. Clapham DE and Neer EJ (1997) G protein βγ. Annu Rev Pharmacol Toxicol 37:167-203.
3. Colombo MI, Inglese J, D'Souza-Schorey C, Beron W and Stahl PD (1995) Heterotrimeric G proteins interact with the small GTPase ARF. Possibilities for the regulation of vesicular traffic. J Biol Chem 270:24564-24571.
4. Coso OA, Teramoto H, Simonds WF and Gutkind JS (1996) Signaling from G protein-coupled receptors to c-Jun kinase involves βγ subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J Biol Chem 271:3963-3966.
5. Exton JH (1996) Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36:481-509.
6. Exton JH (1997) New developments in phospholipase D. J Biol Chem 272:15579-15582.
7. Griendling KK, Minieri CA, Ollerenshaw JD and Alexander RW (1994) Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74:1141-1148.
8. Griendling KK, Rittenhouse SE, Brock TA, Ekstein LS, Gimbrone MA Jr and Alexander RW (1986) Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells. J Biol Chem 261:5901-5906.
9. Griendling KK, Taubman MB, Akers M, Mendlowitz M and Alexander RW (1991) Characterization of phosphatidylinositol-specific phospholipase C from cultured vascular smooth muscle cells. J Biol Chem 266:15498-15504.
10. Griendling KK, Ushio-Fukai M, Lassègue B and Alexander RW (1997) Angiotensin II signaling in vascular smooth muscle: New concepts. Hypertension 29[part 2]:366-373.
11. Harhammer R, Gohla A and Schultz G (1996) Interaction of G protein Gβγ dimers with small GTP-binding proteins of the Rho family. FEBS Lett 399:211-214.
12. 13. Science (Wash DC) 280:2112-2114.
13. Herrlich A, Kühn B, Grosse R, Schmid A, Schultz G and Gudermann T (1996) Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. J Biol Chem 271:16764-16772.
14. Houle MG, Kahn RA, Naccache PH and Bourgoin S (1995) ADP-ribosylation factor translocation correlates with potentiation of GTPγS-stimulated phospholipase D activity in membrane fractions of HL-60 cells. J Biol Chem 270:22795-22800.
15. Inglese J, Koch WJ, Touhara K and Lefkowitz RJ (1995) Gβγ interactions with PH domains and Ras-MAPK signaling pathways. Trends Biol Sci 20:151-156.
16. Inglese J, Luttrell LM, Iniguez-Lluhi JA, Touhara K, Koch WJ and Lefkowitz RJ (1994) Functionally active targeting domain of the β-adrenergic receptor kinase: An inhibitor of Gβγ-mediated stimulation of type II adenylyl cyclase. Proc Natl Acad Sci USA 91:3637-3641.
17. c-scr in vascular smooth muscle cells. Circ Res 77: 1053-1059.
18. Jiang H, Lu Z, Luo JQ, Wolfman A and Foster DA (1995a) Ras mediates the activation of phospholipase D by v-Src. J Biol Chem 270:6006-6009.
19. Jiang H, Luo JQ, Urano T, Frankel P, Lu Z, Foster DA and Feig LA (1995b) Involvement of Ral GTPase in v-Src-induced phospholipase D activation. Nature (London) 378:409-412.
20. 11 a-subunits in cultured vascular smooth muscle cells. Mol Pharmacol 49:96-104.
21. Koch WJ, Hawes BE, Allen LF and Lefkowitz RJ (1994a) Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by Gβγ activation of p21ras. Proc Natl Acad Sci USA 91:12706-12710.
22. Koch WJ, Hawes BE, Inglese J, Luttrell LM and Lefkowitz RJ (1994) Cellular expression of the carboxyl terminus of a G-protein coupled receptor kinase attenuates Gβγ-mediated signaling. J Biol Chem 269:6193-6197.
23. Koch WJ, Inglese J, Stone WC and Lefkowitz RJ (1993) The binding site for the βγ subunits of heterotrimeric G proteins on the β-adrenergic receptor kinase. J Biol Chem 268:8256-8260.
24. Kozasa T and Gilman AG (1996) Protein kinase C phosphorylates G12α and inhibits its interaction with Gβγ. J Biol Chem 271:12562-12567.
25. 13. Science (Wash DC) 280:2109-2111.
26. Lassègue B, Alexander RW, Clark M, Akers MA and Griendling KK (1993) Phosphatidylcholine is a major source of phosphatidic acid and diacylglycerol in angiotensin II-stimulated vascular smooth muscle cells. Biochem J 292:509-517.
27. Lassègue B, Alexander RW, Clark M and Griendling KK (1991) Angiotensin II-induced phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells. Regulation and localization. Biochem J 276:19-25.
28. + channel in heart. Nature (London) 325:321-326.
29. Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ and Lefkowitz RJ (1996) Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gβγ subunit-mediated activation of mitogen-activated protein kinases. J Biol Chem 271: 19443-19450.
30. 2+ channels in rat portal vein myocytes. J Biol Chem 272:23180-23185.
31. 2- in rat portal vein myocytes. J Biol Chem 272:10095-10102.
32. c-src antibodies inhibits the angiotensin II activation of phospholipase C-γ1 in rat aortic smooth muscle cells. J Biol Chem 270:15734-15738.
33. Meacci E, Vasta V, Faraoni P, Farnararo M and Bruni P (1995) Potentiated bradykinin-induced increase of 1,2-diacylglycerol generation and phospholipase D activity in human senescent fibroblasts. Biochem J 1995:799-803.
34. Olson SC, Bowman EP and Lambeth JD (1991) Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5′-O-(3-thiotriphosphate). J Biol Chem 266:17236-17242.
35. Pitcher JA, Inglese J, Higgins JB, Arriza JL, Casey PJ, Kim C, Benovic JL, Kwatra MM, Caron MG and Lefkowitz RJ (1992) Role of βγ subunits of G proteins in targeting the β-adrenergic receptor kinase to membrane-bound receptors. Science (Wash DC) 257:1264-1267.
36. 13 activates phospholipase D isozyme by a pathway requiring rho family GTPases. J Biol Chem 273:4823-4826.
37. Socorro L, Alexander RW and Griendling KK (1990) Cholera toxin modulation of angiotensin II-stimulated inositol phosphate production in cultured vascular smooth muscle cells. Biochem J 265:799-807.
38. 2+ release in Xenopus oocytes. J Biol Chem 270:30068-30074.
39. Timmermans PBMWM, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JAM and Smith RD (1993) Angiotensin II receptors and angiotensin II receptors antagonists. Pharmacol Rev 45:205-251.
40. 12, and βγ G protein subunits. J Biol Chem 273:19772-19777.
41. Ushio-Fukai M, Zafari AM, Fukui T, Ishizaka N and Griendling KK (1996) p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem 271:23317-23321.