메뉴 건너뛰기




Volumn 21, Issue 5, 2014, Pages 804-817

Bioreducible polycations as shuttles for therapeutic nucleic acid and protein transfection

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE; NANOCARRIER; NUCLEIC ACID; OLIGOMER; PEPTIDE; POLYCATION; POLYMER; PROTEIN; SMALL INTERFERING RNA; TOXIN; POLYAMINE; POLYCATIONS;

EID: 84904443084     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2013.5714     Document Type: Review
Times cited : (58)

References (131)
  • 1
    • 78650476432 scopus 로고    scopus 로고
    • The proton sponge: A trick to enter cells the viruses did not exploit
    • Behr JP. The proton sponge: a trick to enter cells the viruses did not exploit. Chimia 51: 34-36, 1997.
    • (1997) Chimia , vol.51 , pp. 34-36
    • Behr, J.P.1
  • 2
    • 84871918550 scopus 로고    scopus 로고
    • The possible "proton sponge" effect of polyethylenimine (PEI) does not include change in lysosomal pH
    • Benjaminsen RV, Mattebjerg MA, Henriksen JR, Moghimi SM, and Andresen TL. The possible "proton sponge" effect of polyethylenimine (PEI) does not include change in lysosomal pH. Mol Ther 21: 149-157, 2013.
    • (2013) Mol Ther , vol.21 , pp. 149-157
    • Benjaminsen, R.V.1    Mattebjerg, M.A.2    Henriksen, J.R.3    Moghimi, S.M.4    Andresen, T.L.5
  • 4
    • 35448973736 scopus 로고    scopus 로고
    • Breaking up the correlation between efficacy and toxicity for nonviral gene delivery
    • Breunig M, Lungwitz U, Liebl R, and Goepferich A. Breaking up the correlation between efficacy and toxicity for nonviral gene delivery. Proc Natl Acad Sci USA 104: 14454-14459, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14454-14459
    • Breunig, M.1    Lungwitz, U.2    Liebl, R.3    Goepferich, A.4
  • 6
    • 33751099034 scopus 로고    scopus 로고
    • RNAi therapeutics: A potential new class of pharmaceutical drugs
    • Bumcrot D, Manoharan M, Koteliansky V, and Sah DW. RNAi therapeutics: a potential new class of pharmaceutical drugs. Nat Chem Biol 2: 711-719, 2006.
    • (2006) Nat Chem Biol , vol.2 , pp. 711-719
    • Bumcrot, D.1    Manoharan, M.2    Koteliansky, V.3    Sah, D.W.4
  • 7
    • 41149086686 scopus 로고    scopus 로고
    • Extracellular barriers to in vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver
    • Burke RS and Pun SH. Extracellular barriers to in vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver. Bioconjug Chem 19: 693-704, 2008.
    • (2008) Bioconjug Chem , vol.19 , pp. 693-704
    • Burke, R.S.1    Pun, S.H.2
  • 8
    • 34347348305 scopus 로고    scopus 로고
    • PEG-SS-PPS: Reduction-sensitive disulfide block copolymer vesicles for intracellular drug delivery
    • Cerritelli S, Velluto D, and Hubbell JA. PEG-SS-PPS: reduction-sensitive disulfide block copolymer vesicles for intracellular drug delivery. Biomacromolecules 8: 1966-1972, 2007.
    • (2007) Biomacromolecules , vol.8 , pp. 1966-1972
    • Cerritelli, S.1    Velluto, D.2    Hubbell, J.A.3
  • 9
    • 77957961920 scopus 로고    scopus 로고
    • Design of an in vivo cleavable disulfide linker in recombinant fusion proteins
    • Chen X, Bai Y, Zaro JL, and Shen WC. Design of an in vivo cleavable disulfide linker in recombinant fusion proteins. Biotechniques 49: 513-518, 2010.
    • (2010) Biotechniques , vol.49 , pp. 513-518
    • Chen, X.1    Bai, Y.2    Zaro, J.L.3    Shen, W.C.4
  • 10
    • 17444404949 scopus 로고    scopus 로고
    • Chemical modification of gene silencing oligonucleotides for drug discovery and development
    • Chen X, Dudgeon N, Shen L, and Wang JH. Chemical modification of gene silencing oligonucleotides for drug discovery and development. Drug Discov Today 10: 587-593, 2005.
    • (2005) Drug Discov Today , vol.10 , pp. 587-593
    • Chen, X.1    Dudgeon, N.2    Shen, L.3    Wang, J.H.4
  • 11
    • 52049088251 scopus 로고    scopus 로고
    • Enhanced gene delivery using disulfide-crosslinked low molecular weight polyethylenimine with listeriolysin o-polyethylenimine disulfide conjugate
    • Choi S and Lee KD. Enhanced gene delivery using disulfide-crosslinked low molecular weight polyethylenimine with listeriolysin o-polyethylenimine disulfide conjugate. J Control Release 131: 70-76, 2008.
    • (2008) J Control Release , vol.131 , pp. 70-76
    • Choi, S.1    Lee, K.D.2
  • 13
    • 34848904314 scopus 로고    scopus 로고
    • Intracellular protein delivery with a dimerizable amphiphile for improved complex stability and prolonged protein release in the cytoplasm of adherent cell lines
    • Dalkara D, Chandrashekhar C, and Zuber G. Intracellular protein delivery with a dimerizable amphiphile for improved complex stability and prolonged protein release in the cytoplasm of adherent cell lines. J Control Release 116: 353-359, 2006.
    • (2006) J Control Release , vol.116 , pp. 353-359
    • Dalkara, D.1    Chandrashekhar, C.2    Zuber, G.3
  • 14
    • 0025316844 scopus 로고
    • Regulation of gene-expression invivo by liposome-mediated delivery of a purified transcription factor
    • Debs RJ, Freedman LP, Edmunds S, Gaensler KL, Duzgunes N, and Yamamoto KR. Regulation of gene-expression invivo by liposome-mediated delivery of a purified transcription factor. J Biol Chem 265: 10189-10192, 1990.
    • (1990) J Biol Chem , vol.265 , pp. 10189-10192
    • Debs, R.J.1    Freedman, L.P.2    Edmunds, S.3    Gaensler, K.L.4    Duzgunes, N.5    Yamamoto, K.R.6
  • 15
    • 0026387907 scopus 로고
    • Glutathione metabolism and its role in hepatotoxicity
    • DeLeve LD and Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther 52: 287-305, 1991.
    • (1991) Pharmacol Ther , vol.52 , pp. 287-305
    • Deleve, L.D.1    Kaplowitz, N.2
  • 17
    • 23944458820 scopus 로고    scopus 로고
    • Polyethyleneimine as a transmembrane carrier of fluorescently labeled proteins and antibodies
    • Didenko VV, Ngo H, and Baskin DS. Polyethyleneimine as a transmembrane carrier of fluorescently labeled proteins and antibodies. Anal Biochem 344: 168-173, 2005.
    • (2005) Anal Biochem , vol.344 , pp. 168-173
    • Didenko, V.V.1    Ngo, H.2    Baskin, D.S.3
  • 20
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498, 2001.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 21
    • 84861389565 scopus 로고    scopus 로고
    • Disulfide bonding in protein biophysics
    • Fass D. Disulfide bonding in protein biophysics. Annu Rev Biophys 41: 63-79, 2012.
    • (2012) Annu Rev Biophys , vol.41 , pp. 63-79
    • Fass, D.1
  • 22
    • 0025010857 scopus 로고
    • Cleavage of disulfide bonds in endocytosed macromolecules. A processing not associated with lysosomes or endosomes
    • Feener EP, Shen WC, and Ryser HJ. Cleavage of disulfide bonds in endocytosed macromolecules. A processing not associated with lysosomes or endosomes. J Biol Chem 265: 18780-18785, 1990.
    • (1990) J Biol Chem , vol.265 , pp. 18780-18785
    • Feener, E.P.1    Shen, W.C.2    Ryser, H.J.3
  • 24
    • 0036198635 scopus 로고    scopus 로고
    • A phase II study of the immunotoxin N901-blocked ricin in small-cell lung cancer
    • Fidias P, Grossbard M, and Lynch TJ, Jr. A phase II study of the immunotoxin N901-blocked ricin in small-cell lung cancer. Clin Lung Cancer 3: 219-222, 2002.
    • (2002) Clin Lung Cancer , vol.3 , pp. 219-222
    • Fidias, P.1    Grossbard, M.2    Lynch Jr., T.J.3
  • 26
    • 0141569730 scopus 로고    scopus 로고
    • A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery
    • Forrest ML, Koerber JT, and Pack DW. A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery. Bioconjug Chem 14: 934-940, 2003.
    • (2003) Bioconjug Chem , vol.14 , pp. 934-940
    • Forrest, M.L.1    Koerber, J.T.2    Pack, D.W.3
  • 27
    • 0024262589 scopus 로고
    • Cellular uptake of the tat protein from human immunodeficiency virus
    • Frankel AD and Pabo CO. Cellular uptake of the tat protein from human immunodeficiency virus. Cell 55: 1189-1193, 1988.
    • (1988) Cell , vol.55 , pp. 1189-1193
    • Frankel, A.D.1    Pabo, C.O.2
  • 29
    • 84868680314 scopus 로고    scopus 로고
    • Stabilization of polyplexes via polymer crosslinking for efficient siRNA delivery
    • Frohlich T, Edinger D, Russ V, and Wagner E. Stabilization of polyplexes via polymer crosslinking for efficient siRNA delivery. Eur J Pharm Sci 47: 914-920, 2012.
    • (2012) Eur J Pharm Sci , vol.47 , pp. 914-920
    • Frohlich, T.1    Edinger, D.2    Russ, V.3    Wagner, E.4
  • 31
    • 0035214028 scopus 로고    scopus 로고
    • Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine
    • Gosselin MA, Guo W, and Lee RJ. Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine. Bioconjug Chem 12: 989-994, 2001.
    • (2001) Bioconjug Chem , vol.12 , pp. 989-994
    • Gosselin, M.A.1    Guo, W.2    Lee, R.J.3
  • 32
    • 80053481644 scopus 로고    scopus 로고
    • Interaction of poly(ethylenimine)-DNA polyplexes with mitochondria: Implications for a mechanism of cytotoxicity
    • Grandinetti G, Ingle NP, and Reineke TM. Interaction of poly(ethylenimine)-DNA polyplexes with mitochondria: implications for a mechanism of cytotoxicity. Mol Pharm 8: 1709-1719, 2011.
    • (2011) Mol Pharm , vol.8 , pp. 1709-1719
    • Grandinetti, G.1    Ingle, N.P.2    Reineke, T.M.3
  • 33
    • 0024209811 scopus 로고
    • Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein
    • Green M and Loewenstein PM. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein. Cell 55: 1179-1188, 1988.
    • (1988) Cell , vol.55 , pp. 1179-1188
    • Green, M.1    Loewenstein, P.M.2
  • 34
    • 0034294817 scopus 로고    scopus 로고
    • Development of biomaterials for gene therapy
    • Han S, Mahato RI, Sung YK, and Kim SW. Development of biomaterials for gene therapy. Mol Ther 2: 302-317, 2000.
    • (2000) Mol Ther , vol.2 , pp. 302-317
    • Han, S.1    Mahato, R.I.2    Sung, Y.K.3    Kim, S.W.4
  • 35
    • 78650770524 scopus 로고    scopus 로고
    • Polymers for control freaks: Sequence-defined poly(amidoamine)s and their biomedical applications
    • Hartmann L. Polymers for Control Freaks: Sequence-Defined Poly(amidoamine)s and Their Biomedical Applications. Macromol Chem Phys 212: 8-13, 2011.
    • (2011) Macromol Chem Phys , vol.212 , pp. 8-13
    • Hartmann, L.1
  • 36
    • 53849102257 scopus 로고    scopus 로고
    • Tailor-made Poly(amidoamine)s for controlled complexation and condensation of DNA
    • Hartmann L, Hafele S, Peschka-Suss R, Antonietti M, and Borner HG. Tailor-made Poly(amidoamine)s for controlled complexation and condensation of DNA. Chemistry 14: 2025-2033, 2008.
    • (2008) Chemistry , vol.14 , pp. 2025-2033
    • Hartmann, L.1    Hafele, S.2    Peschka-Suss, R.3    Antonietti, M.4    Borner, H.G.5
  • 37
    • 36048937620 scopus 로고    scopus 로고
    • Sequence positioning of disulfide linkages to program the degradation of monodisperse Poly(amidoamines)
    • Hartmann L, Häfele S, Peschka-Süss R, Antonietti M, and Börner HG. Sequence positioning of disulfide linkages to program the degradation of monodisperse Poly(amidoamines). Macromolecules 40: 7771-7776, 2007.
    • (2007) Macromolecules , vol.40 , pp. 7771-7776
    • Hartmann, L.1    Häfele, S.2    Peschka-Süss, R.3    Antonietti, M.4    Börner, H.G.5
  • 38
    • 33646356469 scopus 로고    scopus 로고
    • Solid-phase supported polymer synthesis of sequencedefined, multifunctional poly(amidoamines)
    • Hartmann L, Krause E, Antonietti M, and Borner HG. Solid-phase supported polymer synthesis of sequencedefined, multifunctional poly(amidoamines). Biomacromolecules 7: 1239-1244, 2006.
    • (2006) Biomacromolecules , vol.7 , pp. 1239-1244
    • Hartmann, L.1    Krause, E.2    Antonietti, M.3    Borner, H.G.4
  • 39
    • 0029187491 scopus 로고
    • Thioredoxin and thioredoxin reductase
    • Holmgren A and Bjornstedt M. Thioredoxin and thioredoxin reductase. Methods Enzymol 252: 199-208, 1995.
    • (1995) Methods Enzymol , vol.252 , pp. 199-208
    • Holmgren, A.1    Bjornstedt, M.2
  • 40
    • 79960963683 scopus 로고    scopus 로고
    • MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma
    • Ibrahim AF, Weirauch U, Thomas M, Grunweller A, Hartmann RK, and Aigner A. MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma. Cancer Res 71: 5214-5224, 2011.
    • (2011) Cancer Res , vol.71 , pp. 5214-5224
    • Ibrahim, A.F.1    Weirauch, U.2    Thomas, M.3    Grunweller, A.4    Hartmann, R.K.5    Aigner, A.6
  • 41
    • 3242707528 scopus 로고    scopus 로고
    • In situ single cell observation by fluorescence resonance energy transfer reveals fast intracytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine
    • Itaka K, Harada A, Yamasaki Y, Nakamura K, Kawaguchi H, and Kataoka K. In situ single cell observation by fluorescence resonance energy transfer reveals fast intracytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine. J Gene Med 6: 76-84, 2004.
    • (2004) J Gene Med , vol.6 , pp. 76-84
    • Itaka, K.1    Harada, A.2    Yamasaki, Y.3    Nakamura, K.4    Kawaguchi, H.5    Kataoka, K.6
  • 43
    • 0032575366 scopus 로고    scopus 로고
    • Glutathione measurement in human plasma. Evaluation of sample collection, storage and derivatization conditions for analysis of dansyl derivatives by HPLC
    • Jones DP, Carlson JL, Samiec PS, Sternberg P, Jr., Mody VC, Jr., Reed RL, and Brown LA. Glutathione measurement in human plasma. Evaluation of sample collection, storage and derivatization conditions for analysis of dansyl derivatives by HPLC. Clin Chim Acta 275: 175-184, 1998.
    • (1998) Clin Chim Acta , vol.275 , pp. 175-184
    • Jones, D.P.1    Carlson, J.L.2    Samiec, P.S.3    Sternberg Jr., P.4    Mody Jr., V.C.5    Reed, R.L.6    Brown, L.A.7
  • 44
    • 3142634760 scopus 로고    scopus 로고
    • SiRNAs at RISC
    • Joshua-Tor L. siRNAs at RISC. Structure 12: 1120-1122, 2004.
    • (2004) Structure , vol.12 , pp. 1120-1122
    • Joshua-Tor, L.1
  • 45
    • 77955394635 scopus 로고    scopus 로고
    • Synthesis of a pH-sensitive nitrilotriacetic linker to peptide transduction domains to enable intracellular delivery of histidine imidazole ring-containing macromolecules
    • June RK, Gogoi K, Eguchi A, Cui XS, and Dowdy SF. Synthesis of a pH-sensitive nitrilotriacetic linker to peptide transduction domains to enable intracellular delivery of histidine imidazole ring-containing macromolecules. J Am Chem Soc 132: 10680-10682, 2010.
    • (2010) J Am Chem Soc , vol.132 , pp. 10680-10682
    • June, R.K.1    Gogoi, K.2    Eguchi, A.3    Cui, X.S.4    Dowdy, S.F.5
  • 46
    • 36248943575 scopus 로고    scopus 로고
    • Smart" drug carriers: PEGylated TATp-modified pH-sensitive liposomes
    • Kale AA and Torchilin VP. "Smart" drug carriers: PEGylated TATp-modified pH-sensitive liposomes. J Liposome Res 17: 197-203, 2007.
    • (2007) J Liposome Res , vol.17 , pp. 197-203
    • Kale, A.A.1    Torchilin, V.P.'.'.2
  • 48
    • 79551687886 scopus 로고    scopus 로고
    • Bioreducible polymers for gene delivery
    • Kim TI and Kim SW. Bioreducible polymers for gene delivery. Reactive Funct Polym 71: 344-349, 2011.
    • (2011) Reactive Funct Polym , vol.71 , pp. 344-349
    • Kim, T.I.1    Kim, S.W.2
  • 49
    • 33749013859 scopus 로고    scopus 로고
    • Gene carriers based on hexanediol diacrylate linked oligoethylenimine: Effect of chemical structure of polymer on biological properties
    • Kloeckner J, Bruzzano S, Ogris M, and Wagner E. Gene carriers based on hexanediol diacrylate linked oligoethylenimine: effect of chemical structure of polymer on biological properties. Bioconjug Chem 17: 1339-1345, 2006.
    • (2006) Bioconjug Chem , vol.17 , pp. 1339-1345
    • Kloeckner, J.1    Bruzzano, S.2    Ogris, M.3    Wagner, E.4
  • 50
    • 34547153677 scopus 로고    scopus 로고
    • An acetal-based PEGylation reagent for pHsensitive shielding of DNA polyplexes
    • Knorr V, Allmendinger L, Walker GF, Paintner FF, and Wagner E. An acetal-based PEGylation reagent for pHsensitive shielding of DNA polyplexes. Bioconjug Chem 18: 1218-1225, 2007.
    • (2007) Bioconjug Chem , vol.18 , pp. 1218-1225
    • Knorr, V.1    Allmendinger, L.2    Walker, G.F.3    Paintner, F.F.4    Wagner, E.5
  • 51
    • 57149123140 scopus 로고    scopus 로고
    • An acid sensitive ketalbased polyethylene glycol-oligoethylenimine copolymer mediates improved transfection efficiency at reduced toxicity
    • Knorr V, Ogris M, and Wagner E. An acid sensitive ketalbased polyethylene glycol-oligoethylenimine copolymer mediates improved transfection efficiency at reduced toxicity. Pharm Res 25: 2937-2945, 2008.
    • (2008) Pharm Res , vol.25 , pp. 2937-2945
    • Knorr, V.1    Ogris, M.2    Wagner, E.3
  • 54
    • 77957737792 scopus 로고    scopus 로고
    • Efficient delivery of payload into tumor cells in a controlled manner by TAT and thiolytic cleavable PEG co-modified liposomes
    • Kuai R, Yuan W, Qin Y, Chen H, Tang J, Yuan M, Zhang Z, and He Q. Efficient delivery of payload into tumor cells in a controlled manner by TAT and thiolytic cleavable PEG co-modified liposomes. Mol Pharm 7: 1816-1826, 2010.
    • (2010) Mol Pharm , vol.7 , pp. 1816-1826
    • Kuai, R.1    Yuan, W.2    Qin, Y.3    Chen, H.4    Tang, J.5    Yuan, M.6    Zhang, Z.7    He, Q.8
  • 56
    • 0142072936 scopus 로고    scopus 로고
    • Novel shielded transferrinpolyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer
    • Kursa M, Walker GF, Roessler V, Ogris M, Roedl W, Kircheis R, and Wagner E. Novel shielded transferrinpolyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer. Bioconjug Chem 14: 222-231, 2003.
    • (2003) Bioconjug Chem , vol.14 , pp. 222-231
    • Kursa, M.1    Walker, G.F.2    Roessler, V.3    Ogris, M.4    Roedl, W.5    Kircheis, R.6    Wagner, E.7
  • 57
    • 79952765801 scopus 로고    scopus 로고
    • Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery
    • Kwok A and Hart SL. Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery. Nanomedicine 7: 210-219, 2011.
    • (2011) Nanomedicine , vol.7 , pp. 210-219
    • Kwok, A.1    Hart, S.L.2
  • 58
    • 75549089094 scopus 로고    scopus 로고
    • Stability and cellular uptake of polymerized siRNA (poly-siRNA)/ polyethylenimine (PEI) complexes for efficient gene silencing
    • Lee SY, Huh MS, Lee S, Lee SJ, Chung H, Park JH, Oh YK, Choi K, Kim K, and Kwon IC. Stability and cellular uptake of polymerized siRNA (poly-siRNA)/polyethylenimine (PEI) complexes for efficient gene silencing. J Control Release 141: 339-346, 2010.
    • (2010) J Control Release , vol.141 , pp. 339-346
    • Lee, S.Y.1    Huh, M.S.2    Lee, S.3    Lee, S.J.4    Chung, H.5    Park, J.H.6    Oh, Y.K.7    Choi, K.8    Kim, K.9    Kwon, I.C.10
  • 59
    • 77950220028 scopus 로고    scopus 로고
    • Efficient delivery of bioactive antibodies into the cytoplasm of living cells by chargeconversional polyion complex micelles
    • Lee Y, Ishii T, Kim HJ, Nishiyama N, Hayakawa Y, Itaka K, and Kataoka K. Efficient delivery of bioactive antibodies into the cytoplasm of living cells by chargeconversional polyion complex micelles. Angew Chem Int Ed Engl 49: 2552-2555, 2010.
    • (2010) Angew Chem Int Ed Engl , vol.49 , pp. 2552-2555
    • Lee, Y.1    Ishii, T.2    Kim, H.J.3    Nishiyama, N.4    Hayakawa, Y.5    Itaka, K.6    Kataoka, K.7
  • 60
    • 0022492783 scopus 로고
    • In vivo administration of lymphocytespecific monoclonal antibodies in nonhuman primates. in vivo stability of disulfide-linked immunotoxin conjugates
    • Letvin NL, Goldmacher VS, Ritz J, Yetz JM, Schlossman SF, and Lambert JM. In vivo administration of lymphocytespecific monoclonal antibodies in nonhuman primates. In vivo stability of disulfide-linked immunotoxin conjugates. J Clin Invest 77: 977-984, 1986.
    • (1986) J Clin Invest , vol.77 , pp. 977-984
    • Letvin, N.L.1    Goldmacher, V.S.2    Ritz, J.3    Yetz, J.M.4    Schlossman, S.F.5    Lambert, J.M.6
  • 65
    • 84870510788 scopus 로고    scopus 로고
    • Sequence defined disulfide-linked shuttle for strongly enhanced intracellular protein delivery
    • Maier K, Martin I, and Wagner E. Sequence defined disulfide-linked shuttle for strongly enhanced intracellular protein delivery. Mol Pharm 9: 3560-3568, 2012.
    • (2012) Mol Pharm , vol.9 , pp. 3560-3568
    • Maier, K.1    Martin, I.2    Wagner, E.3
  • 66
    • 84862573729 scopus 로고    scopus 로고
    • Acid-labile traceless click linker for protein transduction
    • Maier K and Wagner E. Acid-labile traceless click linker for protein transduction. J Am Chem Soc 134: 10169-10173, 2012.
    • (2012) J Am Chem Soc , vol.134 , pp. 10169-10173
    • Maier, K.1    Wagner, E.2
  • 68
    • 0034616214 scopus 로고    scopus 로고
    • A potent new class of reductively activated peptide gene delivery agents
    • McKenzie DL, Kwok KY, and Rice KG. A potent new class of reductively activated peptide gene delivery agents. J Biol Chem 275: 9970-9977, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 9970-9977
    • McKenzie, D.L.1    Kwok, K.Y.2    Rice, K.G.3
  • 70
    • 67249151969 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of a bioresponsive and endosomolytic siRNA-polymer conjugate
    • Meyer M, Dohmen C, Philipp A, Kiener D, Maiwald G, Scheu C, Ogris M, and Wagner E. Synthesis and biological evaluation of a bioresponsive and endosomolytic siRNA-polymer conjugate. Mol Pharm 6: 752-762, 2009.
    • (2009) Mol Pharm , vol.6 , pp. 752-762
    • Meyer, M.1    Dohmen, C.2    Philipp, A.3    Kiener, D.4    Maiwald, G.5    Scheu, C.6    Ogris, M.7    Wagner, E.8
  • 71
    • 41449109039 scopus 로고    scopus 로고
    • Breathing life into polycations: Functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery
    • Meyer M, Philipp A, Oskuee R, Schmidt C, and Wagner E. Breathing life into polycations: functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery. J Am Chem Soc 130: 3272-3273, 2008.
    • (2008) J Am Chem Soc , vol.130 , pp. 3272-3273
    • Meyer, M.1    Philipp, A.2    Oskuee, R.3    Schmidt, C.4    Wagner, E.5
  • 72
    • 33748673542 scopus 로고    scopus 로고
    • PH-responsive shielding of nonviral gene vectors
    • Meyer M and Wagner E. pH-responsive shielding of nonviral gene vectors. Expert Opin Drug Deliv 3: 563-571, 2006.
    • (2006) Expert Opin Drug Deliv , vol.3 , pp. 563-571
    • Meyer, M.1    Wagner, E.2
  • 73
    • 0033137012 scopus 로고    scopus 로고
    • Efficient gene transfer by histidylated polylysine/pDNA complexes
    • Midoux P and Monsigny M. Efficient gene transfer by histidylated polylysine/pDNA complexes. Bioconjug Chem 10: 406-411, 1999.
    • (1999) Bioconjug Chem , vol.10 , pp. 406-411
    • Midoux, P.1    Monsigny, M.2
  • 74
    • 19444372923 scopus 로고    scopus 로고
    • A two-stage poly(ethylenimine)-mediated cytotoxicity: Implications for gene transfer/ therapy
    • Moghimi SM, Symonds P, Murray JC, Hunter AC, Debska G, and Szewczyk A. A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/ therapy. Mol Ther 11: 990-995, 2005.
    • (2005) Mol Ther , vol.11 , pp. 990-995
    • Moghimi, S.M.1    Symonds, P.2    Murray, J.C.3    Hunter, A.C.4    Debska, G.5    Szewczyk, A.6
  • 75
    • 77249154018 scopus 로고    scopus 로고
    • Multimeric small interfering ribonucleic acid for highly efficient sequencespecific gene silencing
    • Mok H, Lee SH, Park JW, and Park TG. Multimeric small interfering ribonucleic acid for highly efficient sequencespecific gene silencing. Nat Mater 9: 272-278, 2010.
    • (2010) Nat Mater , vol.9 , pp. 272-278
    • Mok, H.1    Lee, S.H.2    Park, J.W.3    Park, T.G.4
  • 76
    • 78549278709 scopus 로고    scopus 로고
    • Pyridylhydrazonebased PEGylation for pH-reversible lipopolyplex shielding
    • Nie Y, GüntherM, Gu Z, andWagner E. Pyridylhydrazonebased PEGylation for pH-reversible lipopolyplex shielding. Biomaterials 32: 858-869, 2011.
    • (2011) Biomaterials , vol.32 , pp. 858-869
    • Nie, Y.1    Günther, M.2    Gu, Z.3    Wagner, E.4
  • 77
    • 0033210414 scopus 로고    scopus 로고
    • Protein disulfide isomerase: The multifunctional redox chaperone of the endoplasmic reticulum
    • Noiva R. Protein disulfide isomerase: the multifunctional redox chaperone of the endoplasmic reticulum. Semin Cell Dev Biol 10: 481-493, 1999.
    • (1999) Semin Cell Dev Biol , vol.10 , pp. 481-493
    • Noiva, R.1
  • 78
    • 0000483941 scopus 로고    scopus 로고
    • Translocation of the catalytic domain of diphtheria toxin across planar phospholipid bilayers by its own T domain
    • Oh KJ, Senzel L, Collier RJ, and Finkelstein A. Translocation of the catalytic domain of diphtheria toxin across planar phospholipid bilayers by its own T domain. Proc Natl Acad Sci USA 96: 8467-8470, 1999.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8467-8470
    • Oh, K.J.1    Senzel, L.2    Collier, R.J.3    Finkelstein, A.4
  • 81
    • 0034650606 scopus 로고    scopus 로고
    • Histidylated oligolysines increase the transmembrane passage and the biological activity of antisense oligonucleotides
    • Pichon C, Roufai MB, Monsigny M, and Midoux P. Histidylated oligolysines increase the transmembrane passage and the biological activity of antisense oligonucleotides. Nucleic Acids Res 28: 504-512, 2000.
    • (2000) Nucleic Acids Res , vol.28 , pp. 504-512
    • Pichon, C.1    Roufai, M.B.2    Monsigny, M.3    Midoux, P.4
  • 82
    • 84879078076 scopus 로고    scopus 로고
    • FGFR-targeted gene delivery mediated by supramolecular assembly between beta-cyclodextrin-crosslinked PEI and redox-sensitive PEG
    • Ping Y, Hu Q, Tang G, and Li J. FGFR-targeted gene delivery mediated by supramolecular assembly between beta-cyclodextrin-crosslinked PEI and redox-sensitive PEG. Biomaterials 34: 6482-6494, 2013.
    • (2013) Biomaterials , vol.34 , pp. 6482-6494
    • Ping, Y.1    Hu, Q.2    Tang, G.3    Li, J.4
  • 83
    • 84872100030 scopus 로고    scopus 로고
    • The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals
    • Pirazzini M, Bordin F, Rossetto O, Shone CC, Binz T, and Montecucco C. The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals. FEBS Lett 587: 150-155, 2013.
    • (2013) FEBS Lett , vol.587 , pp. 150-155
    • Pirazzini, M.1    Bordin, F.2    Rossetto, O.3    Shone, C.C.4    Binz, T.5    Montecucco, C.6
  • 84
    • 0029789793 scopus 로고    scopus 로고
    • Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery
    • Plank C, Mechtler K, Szoka FC, Jr., and Wagner E. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum Gene Ther 7: 1437-1446, 1996.
    • (1996) Hum Gene Ther , vol.7 , pp. 1437-1446
    • Plank, C.1    Mechtler, K.2    Szoka Jr., F.C.3    Wagner, E.4
  • 85
    • 0033948268 scopus 로고    scopus 로고
    • Messenger proteins: Homeoproteins. TAT and others
    • Prochiantz A. Messenger proteins: homeoproteins, TAT and others. Curr Opin Cell Biol 12: 400-406, 2000.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 400-406
    • Prochiantz, A.1
  • 86
    • 0345668477 scopus 로고    scopus 로고
    • The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex
    • Ratts R, Zeng H, Berg EA, Blue C, McComb ME, Costello CE, vanderSpek JC, and Murphy JR. The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex. J Cell Biol 160: 1139-1150, 2003.
    • (2003) J Cell Biol , vol.160 , pp. 1139-1150
    • Ratts, R.1    Zeng, H.2    Berg, E.A.3    Blue, C.4    McComb, M.E.5    Costello, C.E.6    Vanderspek, J.C.7    Murphy, J.R.8
  • 87
  • 89
    • 37249070918 scopus 로고    scopus 로고
    • Novel degradable oligoethylenimine acrylate ester-based pseudodendrimers for in vitro and in vivo gene transfer
    • Russ V, Elfberg H, Thoma C, Kloeckner J, Ogris M, and Wagner E. Novel degradable oligoethylenimine acrylate ester-based pseudodendrimers for in vitro and in vivo gene transfer. Gene Ther 15: 18-29, 2008.
    • (2008) Gene Ther , vol.15 , pp. 18-29
    • Russ, V.1    Elfberg, H.2    Thoma, C.3    Kloeckner, J.4    Ogris, M.5    Wagner, E.6
  • 90
    • 0037265560 scopus 로고    scopus 로고
    • Enhanced cytosolic delivery of plasmid DNA by a sulfhydryl-activatable listeriolysin O/protamine conjugate utilizing cellular reducing potential
    • Saito G, Amidon GL, and Lee KD. Enhanced cytosolic delivery of plasmid DNA by a sulfhydryl-activatable listeriolysin O/protamine conjugate utilizing cellular reducing potential. Gene Ther 10: 72-83, 2003.
    • (2003) Gene Ther , vol.10 , pp. 72-83
    • Saito, G.1    Amidon, G.L.2    Lee, K.D.3
  • 91
    • 0347926091 scopus 로고    scopus 로고
    • Drug delivery strategy utilizing conjugation via reversible disulfide linkages: Role and site of cellular reducing activities
    • Saito G, Swanson JA, and Lee KD. Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities. Adv Drug Deliv Rev 55: 199-215, 2003.
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 199-215
    • Saito, G.1    Swanson, J.A.2    Lee, K.D.3
  • 92
    • 84870236447 scopus 로고    scopus 로고
    • Sequence-defined four-arm oligo(ethanamino)amides for pDNA and siRNA delivery: Impact of building blocks on efficacy
    • Salcher EE, Kos P, Frohlich T, Badgujar N, Scheible M, and Wagner E. Sequence-defined four-arm oligo(ethanamino)amides for pDNA and siRNA delivery: Impact of building blocks on efficacy. J Control Release 164: 380-386, 2012.
    • (2012) J Control Release , vol.164 , pp. 380-386
    • Salcher, E.E.1    Kos, P.2    Frohlich, T.3    Badgujar, N.4    Scheible, M.5    Wagner, E.6
  • 93
    • 77949741829 scopus 로고    scopus 로고
    • Intracellular transduction using cell-penetrating peptides
    • Sawant R and Torchilin V. Intracellular transduction using cell-penetrating peptides. Mol Biosyst 6: 628-640, 2010.
    • (2010) Mol Biosyst , vol.6 , pp. 628-640
    • Sawant, R.1    Torchilin, V.2
  • 94
    • 0035371184 scopus 로고    scopus 로고
    • Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    • Schafer FQ and Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 30: 1191-1212, 2001.
    • (2001) Free Radic Biol Med , vol.30 , pp. 1191-1212
    • Schafer, F.Q.1    Buettner, G.R.2
  • 95
    • 0034607160 scopus 로고    scopus 로고
    • Vector unpacking as a potential barrier for receptormediated polyplex gene delivery
    • Schaffer DV, Fidelman NA, Dan N, and Lauffenburger DA. Vector unpacking as a potential barrier for receptormediated polyplex gene delivery. Biotechnol Bioeng 67: 598-606, 2000.
    • (2000) Biotechnol Bioeng , vol.67 , pp. 598-606
    • Schaffer, D.V.1    Fidelman, N.A.2    Dan, N.3    Lauffenburger, D.A.4
  • 96
    • 79953173288 scopus 로고    scopus 로고
    • Novel Fmocpolyamino acids for solid-phase synthesis of defined polyamidoamines
    • Schaffert D, Badgujar N, and Wagner E. Novel Fmocpolyamino acids for solid-phase synthesis of defined polyamidoamines. Org Lett 13: 1586-1589, 2011.
    • (2011) Org Lett , vol.13 , pp. 1586-1589
    • Schaffert, D.1    Badgujar, N.2    Wagner, E.3
  • 98
    • 84862652274 scopus 로고    scopus 로고
    • New sequencedefined polyaminoamides with tailored endosomolytic properties for plasmid DNA delivery
    • Schaffert D, Troiber C, and Wagner E. New sequencedefined polyaminoamides with tailored endosomolytic properties for plasmid DNA delivery. Bioconjug Chem 23: 1157-1165, 2012.
    • (2012) Bioconjug Chem , vol.23 , pp. 1157-1165
    • Schaffert, D.1    Troiber, C.2    Wagner, E.3
  • 102
    • 84862659504 scopus 로고    scopus 로고
    • Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers
    • Scholz C and Wagner E. Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers. J Control Release 161: 554-565, 2012.
    • (2012) J Control Release , vol.161 , pp. 554-565
    • Scholz, C.1    Wagner, E.2
  • 103
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • Schwarze SR, Ho A, Vocero-Akbani A, and Dowdy SF. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285: 1569-1572, 1999.
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 104
    • 84863923771 scopus 로고    scopus 로고
    • Bioreducible polymers for gene silencing and delivery
    • Son S, Namgung R, Kim J, Singha K, and Kim WJ. Bioreducible polymers for gene silencing and delivery. Acc Chem Res 45: 1100-1112, 2012.
    • (2012) Acc Chem Res , vol.45 , pp. 1100-1112
    • Son, S.1    Namgung, R.2    Kim, J.3    Singha, K.4    Kim, W.J.5
  • 105
    • 0242414440 scopus 로고    scopus 로고
    • Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes
    • Sonawane ND, Szoka FC, Jr., and Verkman AS. Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes. J Biol Chem 278: 44826-44831, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 44826-44831
    • Sonawane, N.D.1    Szoka Jr., F.C.2    Verkman, A.S.3
  • 106
    • 56649103707 scopus 로고    scopus 로고
    • Formulations for delivery of therapeutic proteins
    • Stolnik S and Shakesheff K. Formulations for delivery of therapeutic proteins. Biotechnol Lett 31: 1-11, 2009.
    • (2009) Biotechnol Lett , vol.31 , pp. 1-11
    • Stolnik, S.1    Shakesheff, K.2
  • 107
    • 69849089755 scopus 로고    scopus 로고
    • Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin
    • Sun H, Guo B, Cheng R, Meng F, Liu H, and Zhong Z. Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin. Biomaterials 30: 6358-6366, 2009.
    • (2009) Biomaterials , vol.30 , pp. 6358-6366
    • Sun, H.1    Guo, B.2    Cheng, R.3    Meng, F.4    Liu, H.5    Zhong, Z.6
  • 109
    • 17644401347 scopus 로고    scopus 로고
    • Cross-linked small polyethylenimines: While still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo
    • Thomas M, Ge Q, Lu JJ, Chen J, and Klibanov AM. Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo. Pharm Res 22: 373-380, 2005.
    • (2005) Pharm Res , vol.22 , pp. 373-380
    • Thomas, M.1    Ge, Q.2    Lu, J.J.3    Chen, J.4    Klibanov, A.M.5
  • 112
    • 0035937408 scopus 로고    scopus 로고
    • Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin
    • Tsai B, Rodighiero C, Lencer WI, and Rapoport TA. Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin. Cell 104: 937-948, 2001.
    • (2001) Cell , vol.104 , pp. 937-948
    • Tsai, B.1    Rodighiero, C.2    Lencer, W.I.3    Rapoport, T.A.4
  • 113
    • 0035795428 scopus 로고    scopus 로고
    • RNA interference and small interfering RNAs
    • Tuschl T. RNA interference and small interfering RNAs. Chembiochem 2: 239-245, 2001.
    • (2001) Chembiochem , vol.2 , pp. 239-245
    • Tuschl, T.1
  • 115
    • 0034602124 scopus 로고    scopus 로고
    • Characterization of commercially available and synthesized polyethylenimines for gene delivery
    • von Harpe A, Petersen H, Li Y, and Kissel T. Characterization of commercially available and synthesized polyethylenimines for gene delivery. J Control Release 69: 309-322, 2000.
    • (2000) J Control Release , vol.69 , pp. 309-322
    • Von Harpe, A.1    Petersen, H.2    Li, Y.3    Kissel, T.4
  • 116
    • 34248136491 scopus 로고    scopus 로고
    • Programmed drug delivery: Nanosystems for tumor targeting
    • Wagner E. Programmed drug delivery: nanosystems for tumor targeting. Expert Opin Biol Ther 7: 587-593, 2007.
    • (2007) Expert Opin Biol Ther , vol.7 , pp. 587-593
    • Wagner, E.1
  • 117
    • 84862902835 scopus 로고    scopus 로고
    • Polymers for siRNA delivery: Inspired by viruses to be targeted, dynamic, and precise
    • Wagner E. Polymers for siRNA Delivery: Inspired by Viruses to be Targeted, Dynamic, and Precise. Acc Chem Res 45: 1005-1013, 2012.
    • (2012) Acc Chem Res , vol.45 , pp. 1005-1013
    • Wagner, E.1
  • 118
    • 84885332173 scopus 로고    scopus 로고
    • Biomaterials in RNAi therapeutics: Quo vadis?
    • Wagner E. Biomaterials in RNAi therapeutics: quo vadis? Biomater Sci 1: 804-809, 2013.
    • (2013) Biomater Sci , vol.1 , pp. 804-809
    • Wagner, E.1
  • 119
    • 33747839612 scopus 로고    scopus 로고
    • Gene delivery using polymer therapeutics
    • Wagner E and Kloeckner J. Gene delivery using polymer therapeutics. Adv Polym Sci 192: 135-173, 2006.
    • (2006) Adv Polym Sci , vol.192 , pp. 135-173
    • Wagner, E.1    Kloeckner, J.2
  • 120
    • 84857620109 scopus 로고    scopus 로고
    • Endoplasmic reticulum-dependent redox reactions control endoplasmic reticulum-associated degradation and pathogen entry
    • Walczak CP, Bernardi KM, and Tsai B. Endoplasmic reticulum-dependent redox reactions control endoplasmic reticulum-associated degradation and pathogen entry. Antioxid Redox Signal 16: 809-818, 2012.
    • (2012) Antioxid Redox Signal , vol.16 , pp. 809-818
    • Walczak, C.P.1    Bernardi, K.M.2    Tsai, B.3
  • 121
    • 14044252938 scopus 로고    scopus 로고
    • Toward synthetic viruses: Endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo
    • Walker GF, Fella C, Pelisek J, Fahrmeir J, Boeckle S, Ogris M, and Wagner E. Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo. Mol Ther 11: 418-425, 2005.
    • (2005) Mol Ther , vol.11 , pp. 418-425
    • Walker, G.F.1    Fella, C.2    Pelisek, J.3    Fahrmeir, J.4    Boeckle, S.5    Ogris, M.6    Wagner, E.7
  • 122
    • 61349171236 scopus 로고    scopus 로고
    • A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery
    • Wang X-L, Xu R, and Lu Z-R. A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery. J Control Release 134: 207-213, 2009.
    • (2009) J Control Release , vol.134 , pp. 207-213
    • Wang, X.-L.1    Xu, R.2    Lu, Z.-R.3
  • 123
    • 77956288440 scopus 로고    scopus 로고
    • Cholera toxin: An intracellular journey into the cytosol by way of the endoplasmic reticulum
    • Wernick NL, Chinnapen DJ, Cho JA, and Lencer WI. Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. Toxins (Basel) 2: 310-325, 2010.
    • (2010) Toxins (Basel) , vol.2 , pp. 310-325
    • Wernick, N.L.1    Chinnapen, D.J.2    Cho, J.A.3    Lencer, W.I.4
  • 124
    • 0030005946 scopus 로고    scopus 로고
    • Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA 723
    • Wolfert MA and Seymour LW. Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA 723. Gene Ther 3: 269-273, 1996.
    • (1996) Gene Ther , vol.3 , pp. 269-273
    • Wolfert, M.A.1    Seymour, L.W.2
  • 125
    • 80051986258 scopus 로고    scopus 로고
    • Interplay of chemical microenvironment and redox environment on thiol-disulfide exchange kinetics
    • Wu C, Belenda C, Leroux JC, and Gauthier MA. Interplay of chemical microenvironment and redox environment on thiol-disulfide exchange kinetics. Chemistry 17: 10064-10070, 2011.
    • (2011) Chemistry , vol.17 , pp. 10064-10070
    • Wu, C.1    Belenda, C.2    Leroux, J.C.3    Gauthier, M.A.4
  • 126
    • 84870230241 scopus 로고    scopus 로고
    • Twin disulfides for orthogonal disulfide pairing and the directed folding of multicyclic peptides
    • Wu C, Leroux JC, and Gauthier MA. Twin disulfides for orthogonal disulfide pairing and the directed folding of multicyclic peptides. Nat Chem 4: 1044-1049, 2012.
    • (2012) Nat Chem , vol.4 , pp. 1044-1049
    • Wu, C.1    Leroux, J.C.2    Gauthier, M.A.3
  • 127
    • 0033771566 scopus 로고    scopus 로고
    • Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats
    • Xia CQ, Wang J, and Shen WC. Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats. J Pharmacol Exp Ther 295: 594-600, 2000.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 594-600
    • Xia, C.Q.1    Wang, J.2    Shen, W.C.3
  • 128
    • 84862682262 scopus 로고    scopus 로고
    • Disulfidecontaining brushed polyethylenimine derivative synthesized by click chemistry for nonviral gene delivery
    • Zhang G, Liu J, Yang Q, Zhuo R, and Jiang X. Disulfidecontaining brushed polyethylenimine derivative synthesized by click chemistry for nonviral gene delivery. Bioconjug Chem, 23: 1290-1299, 2012.
    • (2012) Bioconjug Chem , vol.23 , pp. 1290-1299
    • Zhang, G.1    Liu, J.2    Yang, Q.3    Zhuo, R.4    Jiang, X.5
  • 129
    • 0033582456 scopus 로고    scopus 로고
    • Chain length of the polylysine in receptortargeted gene transfer complexes affects duration of reporter gene expression both in vitro and in vivo
    • Ziady AG, Ferkol T, Dawson DV, Perlmutter DH, and Davis PB. Chain length of the polylysine in receptortargeted gene transfer complexes affects duration of reporter gene expression both in vitro and in vivo. J Biol Chem 274: 4908-4916, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 4908-4916
    • Ziady, A.G.1    Ferkol, T.2    Dawson, D.V.3    Perlmutter, D.H.4    Davis, P.B.5
  • 130
    • 0035997509 scopus 로고    scopus 로고
    • The lower-generation polypropylenimine dendrimers are effective gene-transfer agents
    • Zinselmeyer BH, Mackay SP, Schatzlein AG, and Uchegbu IF. The lower-generation polypropylenimine dendrimers are effective gene-transfer agents. Pharm Res 19: 960-967, 2002.
    • (2002) Pharm Res , vol.19 , pp. 960-967
    • Zinselmeyer, B.H.1    Mackay, S.P.2    Schatzlein, A.G.3    Uchegbu, I.F.4
  • 131
    • 0034152683 scopus 로고    scopus 로고
    • Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse
    • Zou SM, Erbacher P, Remy JS, and Behr JP. Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse. J Gene Med 2: 128-134, 2000.
    • (2000) J Gene Med , vol.2 , pp. 128-134
    • Zou, S.M.1    Erbacher, P.2    Remy, J.S.3    Behr, J.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.