A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery

Journal of Controlled Release

Volumn 134, Issue 3, 2009, Pages 207-213

  Wang, Xu Li ^a   Xu, Rongzuo ^a   Lu, Zheng Rong ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

EHCO; Endosomal escape; pH sensitive amphiphilicity; RNAi; Targeted siRNA delivery

Indexed keywords

EHCO; ENDOSOMAL ESCAPE; PH-SENSITIVE AMPHIPHILICITY; RNAI; TARGETED SIRNA DELIVERY;

AMINES; CYTOLOGY; FUNCTIONAL POLYMERS; GENETIC ENGINEERING; NANOPARTICLES; PEPTIDES; POLYETHYLENE GLYCOLS; POTENTIOMETRIC SENSORS; SURFACE ACTIVE AGENTS;

CELL MEMBRANES;

AMPHOPHILE; BOMBESIN; BOMBESIN RECEPTOR; MACROGOL 3400; MACROGOL DERIVATIVE; MALEIMIDE; N (1 AMINOETHYL)IMINOBIS[N (OLEICYLCYSTEINYLHISTINYL 1 AMINOETHYL)PROPIONAMIDE]; NANOPARTICLE; PROPIONAMIDE DERIVATIVE; SMALL INTERFERING RNA; SURFACTANT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOOXIDATION; CELL MEMBRANE; CELL VIABILITY; CHO CELL; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; ENDOCYTOSIS; FLOW CYTOMETRY; GENE SILENCING; HEMOLYSIS; INTERNALIZATION; MEMBRANE DAMAGE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PH; POLYMERIZATION; PRIORITY JOURNAL;

ANIMALS; BOMBESIN; CELL MEMBRANE; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; CYTOPLASM; DIPEPTIDES; DRUG CARRIERS; ENDOSOMES; ERYTHROCYTES; GENE SILENCING; HEMOLYSIS; HYDROGEN-ION CONCENTRATION; LIGANDS; MOLECULAR STRUCTURE; NANOPARTICLES; PEPTIDE FRAGMENTS; PROTEIN BINDING; RATS; RECEPTORS, BOMBESIN; RNA, SMALL INTERFERING; SURFACE-ACTIVE AGENTS;

EID: 61349171236     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.11.010     Document Type: Article

References (31)

1. Hannon G. RNA interference. Nature 418 (2002) 244-251
2. Soutschek J., Akinc A., Bramlage B., Charisse K., Constien R., Donoghue M., Elbashir S., Geick A., Hadwiger P., Harborth J., John M., Kesavan V., Lavine G., Pandey R.K., Racie T., Rajeev K.G., Rohl I., Toudjarska I., Wang G., Wuschko S., Bumcrot D., Koteliansky V., Limmer S., Manoharan M., and Vornlocher H.P. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432 (2004) 173-178
3. Kleinman M.E., Yamada K., Takeda A., Chandrasekaran V., Nozaki M., Baffi J.Z., Albuquerque R.J.C., Yamasaki S., Itaya M., Pan Y.Z., Appukuttan B., Gibbs D., Yang Z.L., Kariko K., Ambati B.K., Wilgus T.A., DiPietro L.A., Sakurai E., Zhang K., Smith J.R., Taylor E.W., and Ambati J. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 452 (2008) 591-597
4. Zuber G., Dauty E., Nothisen M., Belguise P., and Behr J.P. Towards synthetic viruses. Adv. Drug Deliv. Rev. 52 (2001) 245-253
5. Sonawane N.D., Szoka F.C., and Verkman A.S. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J. Biol. Chem. 278 (2003) 44826-44831
6. Cho Y.W., Kim J.D., and Park K. Polycation gene delivery systems: escape from endosomes to cytosol. J. Pharm. Pharmacol. 55 (2003) 721-734
7. Murthy N., Campbell J., Fausto N., Hoffman A.S., and Stayton P.S. Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides. J. Control. Release 89 (2003) 365-374
8. Behlke M.A. Progress towards in vivo use of siRNAs. Mol. Ther. 13 (2006) 644-670
9. Demeneix B., Hassani Z., and Behr J.P. Towards multifunctional synthetic vectors. Curr. Gene Ther. 4 (2004) 445-455
10. Li S.D., Chono S., and Huang L. Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles. J. Control. Release 126 (2008) 77-84
11. Li W., and Szoka Jr. F.C. Lipid-based nanoparticles for nucleic acid delivery. Pharm. Res. 24 (2007) 438-449
12. Pirollo K.F., and Chang E.H. Targeted delivery of small interfering RNA: approaching effective cancer therapies. Cancer Res. 68 (2008) 1247-1250
13. Pirollo K.F., Rait A., Zhou Q., Hwang S.H., Dagata J.A., Zon G., Hogrefe R.I., Palchik G., and Chang E.H. Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system. Cancer Res. 67 (2007) 2938-2943
14. Song E.W., Zhu P.C., Lee S.K., Chowdhury D., Kussman S., Dykxhoorn D.M., Feng Y., Palliser D., Weiner D.B., Shankar P., Marasco W.A., and Lieberman J. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat. Biotechnol. 23 (2005) 709-717
15. Hu-Lieskovan S., Heidel J.D., Bartlett D.W., Davis M.E., and Triche T.J. Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res. 65 (2005) 8984-8992
16. Cardoso A.L., Simoes S., de Almeida L.P., Pelisek J., Culmsee C., Wagner E., and de Lima M.C.P. siRNA delivery by a transferrin-associated lipid-based vector: a non-viral strategy to mediate gene silencing. J. Gene Med. 9 (2007) 170-183
17. Schiffelers R., Ansari A., Xu J., Zhou Q., Tang Q., Storm G., Molema G., Lu P., Scaria P., and Woodle M. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res. 32 (2004) e149
18. Li S.D., Chen Y.C., Hackett M.J., and Huang L. Tumor-targeted delivery of siRNA by self-assembled nanoparticles. Mol. Ther. 16 (2008) 163-169
19. Wang X.L., Nguyen T., Gillespie D., Jensen R., and Lu Z.R. A multifunctional and reversibly polymerizable carrier for efficient siRNA delivery. Biomaterials 29 (2008) 15-22
20. Wang X.L., Ramusovic S., Nguyen T., and Lu Z.R. Novel polymerizable surfactants with pH-sensitive amphiphilicity and cell membrane disruption for efficient siRNA delivery. Bioconjugate Chem. 18 (2007) 2169-2177
21. Ciani L., Casini A., Gabbiani C., Ristori S., Messori L., and Martini G. DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniques. Biophys Chemist. 127 (2007) 213-220
22. Rogers B.E., Manna D.D., and Safavy A. In vitro and in vivo evaluation of a 64Cu-labeled polyethylene glycol-bombesin conjugate. Cancer Biother. Radiopharm. 19 (2004) 25-34
23. Zhou J.H., Chen J., Mokotoff M., Zhong R.K., Shultz L.D., and Ball E.D. Bombesin/gastrin-releasing peptide receptor: a potential target for antibody-mediated therapy of small cell lung cancer. Clin. Cancer Res. 9 (2003) 4953-4960
24. Zhou J.H., Chen J., Zhong R.K., Mokotoff M., Shultz L.D., and Ball E.D. Targeting gastrin-releasing peptide receptors on small cell lung cancer cells with a bispecific molecule that activates polyclonal T lymphocytes. Clin. Cancer Res. 12 (2006) 2224-2231
25. Heppeler A., Froidevaux S., Eberle A.N., and Maecke H.R. Receptor targeting for tumor localisation and therapy with radiopeptides. Curr. Med. Chem. 7 (2000) 971-994
26. Reubi J.C., Wenger S., Schmuckli-Maurer J., Schaer J.C., and Gugger M. Bombesin receptor subtypes in human cancers: detection with the universal radioligand (125)I-[D-TYR(6), beta-ALA(11), PHE(13), NLE(14)] bombesin(6-14). Clin. Cancer Res. 8 (2002) 1139-1146
27. Prasanphanich A.F., Nanda P.K., Rold T.L., Ma L.X., Lewis M.R., Garrison J.C., Hoffman T.J., Sieckman G.L., Figueroa S.D., and Smith C.J. [64Cu-NOTA-8-Aoc-BBN(7-14)NH2] targeting vector for positron-emission tomography imaging of gastrin-releasing peptide receptor-expressing tissues. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 12462-12467
28. Brough S.J., Jerman J.C., Jewitt F., and Smart D. Characterisation of an endogenous bombesin receptor in CHO/DG44 cells. Eur. J. Pharmacol. 409 (2000) 259-263
29. Miyata K., Fukushima S., Nishiyama N., Yamasaki Y., and Kataoka K. PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection efficacy. J. Control. Release 122 (2007) 252-260
30. Kim S.H., Jeong J.H., Lee S.H., Kim S.W., and Park T.G. PEG conjugated VEGF siRNA for anti-angiogenic gene therapy. J. Control. Release 116 (2006) 123-129
31. McNamara J.O., Andrechek E.R., Wang Y., D Viles K., Rempel R.E., Gilboa E., Sullenger B.A., and Giangrande P.H. Nat. Biotechnol. 24 (2006) 1005