A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery

Bioconjugate Chemistry

Volumn 14, Issue 5, 2003, Pages 934-940

  Forrest, M Laird ^a   Koerber, James T ^a   Pack, Daniel W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; DEGRADATION; EFFICIENCY; GENE EXPRESSION; GENE THERAPY;

DELIVERY METHODS; DIACRYLATES; GENE DELIVERY; HUMAN GENE THERAPY; IMMUNOGENICITY; LOW TOXICITY; NON-TOXICITY; POLY(ETHYLENIMINE); POLYCATIONS; SYNTHESISED;

GENE TRANSFER;

POLYCATION; POLYETHYLENEIMINE DERIVATIVE; POLYMER;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DEGRADATION; DNA BINDING; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; IMMUNOGENICITY;

EID: 0141569730     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc034014g     Document Type: Article

References (32)

1. Verma, I. M., and Somia, N. (1997) Gene therapy promises, problems and prospects. Nature 389, 239-242.
2. Godbey, W. T., Wu, K. K., and Mikos, A. G. (1999) Poly(ethylenimine) and its role in gene delivery. J. Controlled Release 60, 149-160.
3. Lim, Y.-B., Kim, S.-M., Suh, H., and Park, J.-S. (2002) Biodegradable, endosome disruptive, and cationic network-type polymer as a highly efficient and nontoxic gene delivery carrier. Bioconjugate Chem. 13, 952-957.
4. Fischer, D., Bieber, T., Li, Y., Elsässer, H.-P., and Kissel, T. (1999) A novel nonviral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm. Res. 16, 1273-1279.
5. Gosselin, M. A., Guo, W., and Lee, R. J. (2001) Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine. Bioconjugate Chem. 2001, 989-994.
6. Lim, Y. B., Han, S. O., Kong, H. U., Lee, Y., Park, J. S., Jeong, B., and Kim, S. W. (2000) Biodegradable polyester, poly[α -(4-aminobutyl)-L-glycolic acid], as a nontoxic gene carrier. Pharm. Res. 17, 811-816.
7. Lim, Y.-B., Choi, Y. H., and Park, J.-S. (1999) A self-destroying polycationic polymer: Biodegradable poly(4-hydroxy-L-proline ester). J. Am. Chem. Soc. 121, 5633-5639.
8. Lim, Y.-B., Kim, C.-H., Kim, K., Kim, S. W., and Park, J.-S. (2000) Development of a safe gene delivery system using biodegradable polymer, poly[α-(4-aminobutyl)-L-glycolic acid]. J. Am. Chem. Soc. 122, 6524-6525.
9. Lim, Y.-B., Kim, S.-M., Lee, Y., Lee, W.-K., Yang, T.-G., Lee, M.-J., Suh, H., and Park, J.-S. (2001) Cationic hyperbranched poly(amino ester): A novel class of DNA condensing molecule with cationic surface, biodegradable three-dimensional structure, and tertiary amine groups in the interior. J. Am. Chem. Soc. 123, 2460-2461.
10. Putnam, D., and Langer, R. (1999) Poly(4-hydroxy-L-proline ester): Low-temperature polycondensation and plasmid DNA complexation. Macromolecules 32, 3658-3662.
11. Lynn, D. M., Anderson, D. G., Putnam, D., and Langer, R. (2001) Accelerated discovery of synthetic transfection vectors: Parallel synthesis and screening of a degradable polymer library. J. Am. Chem. Soc. 123, 8155-8156.
12. Lynn, D. M., and Langer, R. (2000) Degradable poly(β-amino esters): synthesis, characterization, and self-assembly with plasmid DNA. J. Am. Chem. Soc. 122, 10761-10768.
13. Pichon, C., LeCam, E., Guérin, B., Coulaud, D., Delain, E., and Midoux, P. (2002) Poly[Lys-(AEDTP)]: A cationic polymer that allows dissociation of pDNA/cationic polymer complexes in a reductive medium and enhances polyfection. Bioconjugate Chem. 13, 76-82.
14. Ahn, C.-H., Chae, S. Y., Bae, Y. H., and Kim, S. W. (2002) Biodegradable poly(ethylenimine) for plasmid DNA delivery. J. Controlled Release 80, 273-282.
15. Stevens, M. G., and Olsen, S. (1993) Comparative analysis of using MTT and XTT in colorimetric assays for quantitating bovine neutrophil bactericidal activity. J. Immunol. Methods 157, 225-231.
16. Remy, J.-S., Abdallah, B., Zanta, M. A., Boussif, O., Behr, J.-P., and Demeneix, B. (1998) Gene transfer with lipospermines and polyethylenimines. Adv. Drug Deliv. Rev. 30, 85-95.
17. Bieber, T., and Elsässer, H.-P. (2001) Preparation of a low molecular weight polyethylenimine for efficient cell transfection. Biotechniques 30, 74-81.
18. Godbey, W. T., Wu, K. K., and Mikos, A. G. (1999) Size matters: molecular weight affects the efficiency of poly(ethylenimine) as gene delivery vehicle. J. Biomed. Mater. Res. 45, 268-275.
19. Dunlap, D. D., Maggi, A., Soria, M. R., and Monaco, L. (1997) Nanoscopic structure of DNA condensed for gene delivery. Nucleic Acids Res. 25, 3095-3101.
20. Liu, G., Molas, M., Grossmann, G. A., Pasumarthy, M., Perales, J. C., Cooper, M. J., and Hanson, R. W. (2001) Biological properties of poly-L-lysine-DNA complexes generated by cooperative binding of the polycation. J. Biol. Chem. 276, 34379-34387.
21. Boussif, O., Zanta, M. A., and Behr, J.-P. (1996) Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold. Gene Ther. 3, 1074-1080.
22. Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., and Behr, J.-P. (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine. Proc. Natl. Acad. Sci. U.S.A. 92, 7297-7301.
23. Godbey, W. T., Barry, M. A., Saggau, P., Wu, K. K., and Mikos, A. G. (2000) Poly(ethylenimine)-mediated transfection: a new paradigm for gene delivery. J. Biomed. Mater. Res. 51, 321-328.
24. Pack, D. W., Putnam, D., and Langer, R. (1999) Design of imidazole-containing endosomolytic biopolymers for gene delivery. Biotechnol. Bioeng. 67, 217-223.
25. Godbey, W. T., Wu, K. K., and Mikos, A. G. (1997) Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle. Proceed. Int. Symp. Control. Relat. Bioact. Mater. 25, 230-231.
26. Protocols by Vector. J. Gene Med. (http://www.wiley.co.uk/genetherapy/clinical/). Accessed Jan. 3, 2003.
27. Perales, J. C., Ferkol, T., Molas, M., and Hanson, R. W. (1994) An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes. Eur. J. Biochem. 226, 255-266.
28. Hwang, S. J., and Davis, M. E. (2001) Cationic polymers for gene delivery: Designs for overcoming barriers to systemic administration. Curr. Opin. Biotechnol. 3, 183-191.
29. Pack, D. W. (2001) Gene delivery polymers, in Encyclopedia of Polymer Science and Technology (J. I. Kroschwitz, Ed.) John Wiley & Sons, Inc., New York.
30. Ryser, H. J.-P. (1967) A membrane effect of basic polymers dependent on molecular size. Nature 215, 934-936.
31. Erbacher, P., Roche, A. C., Monsigny, M., and Midoux, P. (1997) The reduction of the positive charges of polylysine by partial gluconoylation increases the transfection efficiency of polylysine/DNA complexes. Biochim. Biophys. Acta 1324, 27-36.
32. Banaszczyk, M. G., Lollo, C. P., Kwoh, D. Y., Phillips, A. T., Amini, A., Wu, D. P., Mullen, P. M., Coffin, C. C., Brostoff, S. W., and Carlo, D. J. (1999) Poly-L-lysine-graft-PEG-comb-type polycation copolymers for gene delivery. J. Macromol. Sci., Pure Appl. Chem. 36, 1061-1084.