The lower-generation polypropylenimine dendrimers are effective gene-transfer agents

Pharmaceutical Research

Volumn 19, Issue 7, 2002, Pages 960-967

  Zinselmeyer, B H ^a,b   Mackay, S P ^a   Schatzlein, A G ^b   Uchegbu, I F ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Astramol; Cytotoxicity; Gene delivery; Molecular modeling; Polypropylenimine dendrimers

Indexed keywords

BETA GALACTOSIDASE; DENDRIMER; ETHIDIUM BROMIDE; N [1 (2,3 DIOLEOYLOXY)PROPYL] N,N,N TRIMETHYLAMMONIUM METHYL SULFATE; POLYPROPYLENE; POLYPROPYLENEIMINE; TRIMETHYLAMMONIUM SALT DERIVATIVE; UNCLASSIFIED DRUG; DNA; IMINE;

ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; FLUORESCENCE; GENE DELIVERY SYSTEM; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; PLASMID; PRIORITY JOURNAL; REPORTER GENE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; ESCHERICHIA COLI; GENETICS; METHODOLOGY;

COMPARATIVE STUDY; DNA; DRUG DELIVERY SYSTEMS; ESCHERICHIA COLI; GENE TRANSFER TECHNIQUES; HUMAN; IMINES; MODELS, MOLECULAR; POLYPROPYLENES; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED; HUMANS;

EID: 0035997509     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016458104359     Document Type: Article

References (30)

1. Human gene therapy
2. Gene therapy - Promises, problems and prospects
3. Viral vector systems for gene therapy
4. Lipofection - A highly efficient, lipid-mediated DNA-transfection procedure
5. Enhanced gene expression in mouse lung by prolonging the retention time of intravenously injected plasmid DNA
6. Transferrin-polycation-mediated introduction of DNA into human leukemic cells: Stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels
7. Polycation-based DNA complexes for tumour-targeted gene delivery in vivo
8. Preliminary characterization of novel amino acid based polymeric vesicles as gene and drug delivery agents
9. Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers
10. In vitro gene delivery by degraded polyamidoamine dendrimers
11. Preparation of water soluble cationic phosphorus containing dendrimers as DNA transfecting agents
12. Acid-base properties of poly(propylene imine) dendrimers
13. Polypropylenimine dendrimers: Improved synthesis and characterization
14. DNA complexing with polyamidoamine dendrimers: Implications for transfection
15. Enhancement of dendrimer-mediated transfection using synthetic lung surfactant exosurf neonatal in vitro
16. Novel cationic lipidic peptide dendrimer vectors - In vitro gene delivery
17. Poly(propyleneimine) dendrimers as pH-sensitive controlled- release systems
18. Dendrimers: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of I- 125-labelled polyamidoamine dendrimers in vivo
19. Interaction of Astramol poly(propyleneimine) dendrimers with linear polyanions
20. Evaluation of polyplexes as gene transfer agents
21. Use of ethidium bromide for separation and determination of nucleic acids of various conformational forms and measurement of their associated enzymes
22. Molecular modelling of polyamidoamine (PAMAM) Starburst dendrimers
23. Using ethidium bromide to probe the interactions between DNA and dendrimers
24. Biochemical characterisation of polycation-induced cytotoxicity to human vascular endothelial cells
25. About dendrimers: Structure, physical properties and applications
26. Efficient transfer of genetic material into mammalian-cells using starburst polyamidoamine dendrimers
27. Size matters: Molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle
28. In vitro gene delivery mediated by chitosan. Effect of pH, serum, and molecular mass of chitosan on the transfection efficiency