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Volumn 33, Issue 9, 2005, Pages 1-16

A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; GREEN FLUORESCENT PROTEIN; HISTIDINE; MESSENGER RNA; NUCLEIC ACID; POLYCATION; POLYETHYLENEIMINE; POLYLYSINE; PROTEIN P75; SMALL INTERFERING RNA;

EID: 27244449312     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gni085     Document Type: Article
Times cited : (203)

References (54)
  • 1
    • 3242677639 scopus 로고    scopus 로고
    • siRNAs: Applications in functional genomics and potential as therapeutics
    • Dorsett, Y. and Tuschl, T. (2004) siRNAs: Applications in functional genomics and potential as therapeutics. Nature Rev. Drug. Discov., 3, 318-329.
    • (2004) Nature Rev. Drug Discov. , vol.3 , pp. 318-329
    • Dorsett, Y.1    Tuschl, T.2
  • 2
    • 0037136924 scopus 로고    scopus 로고
    • Gene therapy for SCID - A complication after remarkable progress
    • Buckley, R.H. (2002) Gene therapy for SCID - a complication after remarkable progress. Lancet, 360, 1185-1186.
    • (2002) Lancet , vol.360 , pp. 1185-1186
    • Buckley, R.H.1
  • 3
    • 0037590036 scopus 로고    scopus 로고
    • French gene therapy group reports on the adverse event in a clinical trial of gene therapy for X-linked severe combined immune deficiency (X-SCID)
    • European Society of Gene Therapy
    • European Society of Gene Therapy (2003). French gene therapy group reports on the adverse event in a clinical trial of gene therapy for X-linked severe combined immune deficiency (X-SCID). J. Gene Med., 5, 82-84.
    • (2003) J. Gene Med. , vol.5 , pp. 82-84
  • 6
    • 0025313130 scopus 로고
    • Transferrin-polycation-mediated introduction of DNA into human leukemic cells: Stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels
    • Cotten, M., Langle-Rouault, F., Kirlappos, H., Wagner, E., Mechtler, K., Zenke, M., Beug, H. and Birnstiel, M.L. (1990) Transferrin-polycation-mediated introduction of DNA into human leukemic cells: Stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proc. Natl Acad. Sci. USA, 87, 4033-4037.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 4033-4037
    • Cotten, M.1    Langle-Rouault, F.2    Kirlappos, H.3    Wagner, E.4    Mechtler, K.5    Zenke, M.6    Beug, H.7    Birnstiel, M.L.8
  • 7
    • 0034607160 scopus 로고    scopus 로고
    • Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery
    • Schaffer, D.V., Fidelman, N.A., Dan, N. and Lauffenburger, D.A. (2000) Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Biotechnol. Bioeng., 67, 598-606.
    • (2000) Biotechnol. Bioeng. , vol.67 , pp. 598-606
    • Schaffer, D.V.1    Fidelman, N.A.2    Dan, N.3    Lauffenburger, D.A.4
  • 8
    • 0036371914 scopus 로고    scopus 로고
    • Side-effects of a systemic injection of linear polyethylenimine-DNA complexes
    • Chollet, P., Favrot, M.C., Hurbin, A. and Coll, J.L. (2002) Side-effects of a systemic injection of linear polyethylenimine-DNA complexes. J. Gene Med., 4, 84-91.
    • (2002) J. Gene Med. , vol.4 , pp. 84-91
    • Chollet, P.1    Favrot, M.C.2    Hurbin, A.3    Coll, J.L.4
  • 9
    • 0032959729 scopus 로고    scopus 로고
    • Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery
    • Dash, P.R., Read, M.L., Barrett, L.B., Wolfert, M.A. and Seymour, L.W. (1999) Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery. Gene Ther., 6, 643-650.
    • (1999) Gene Ther. , vol.6 , pp. 643-650
    • Dash, P.R.1    Read, M.L.2    Barrett, L.B.3    Wolfert, M.A.4    Seymour, L.W.5
  • 11
    • 0035871674 scopus 로고    scopus 로고
    • Systemic circulation of poly(L-lysine)/DNA: Differential circulation in mice and rats and the implications for human gene therapy
    • Ward, C.M., Read, M.L. and Seymour, L.W. (2001) Systemic circulation of poly(L-lysine)/DNA: Differential circulation in mice and rats and the implications for human gene therapy. Blood, 97, 2221-2229.
    • (2001) Blood , vol.97 , pp. 2221-2229
    • Ward, C.M.1    Read, M.L.2    Seymour, L.W.3
  • 12
    • 0042827496 scopus 로고    scopus 로고
    • Stimuli-responsive gene delivery vector
    • Oupicky, D. and Diwadkar, V. (2003) Stimuli-responsive gene delivery vector. Curr. Opin. Mol. Ther., 5, 345-350.
    • (2003) Curr. Opin. Mol. Ther. , vol.5 , pp. 345-350
    • Oupicky, D.1    Diwadkar, V.2
  • 13
    • 0038563848 scopus 로고    scopus 로고
    • Vectors based on reducible polycations facilitate intracellular release of nucleic acids
    • Read, M.L., Bremner, K.H., Oupicky, D., Green, N.K., Searle, P.F. and Seymour, L.W. (2003) Vectors based on reducible polycations facilitate intracellular release of nucleic acids. J. Gene Med., 5, 232-245.
    • (2003) J. Gene Med. , vol.5 , pp. 232-245
    • Read, M.L.1    Bremner, K.H.2    Oupicky, D.3    Green, N.K.4    Searle, P.F.5    Seymour, L.W.6
  • 14
    • 0034616214 scopus 로고    scopus 로고
    • A potent new class of reductively activated peptide gene delivery agents
    • McKenzie, D.L., Kwok, K.Y. and Rice,K.G. (2000) A potent new class of reductively activated peptide gene delivery agents. J. Biol. Chem., 275, 9970-9977.
    • (2000) J. Biol. Chem. , vol.275 , pp. 9970-9977
    • McKenzie, D.L.1    Kwok, K.Y.2    Rice, K.G.3
  • 16
    • 0027963412 scopus 로고
    • Immunocytochemical comparison of cultured normal epithelial prostatic cells with prostatic tissue sections
    • Cussenot, O., Berthon, P., Cochand-Priollet, B., Maitland, N.J. and Le Duc, A. (1994) Immunocytochemical comparison of cultured normal epithelial prostatic cells with prostatic tissue sections. Exp. Cell Res., 214, 83-92.
    • (1994) Exp. Cell Res. , vol.214 , pp. 83-92
    • Cussenot, O.1    Berthon, P.2    Cochand-Priollet, B.3    Maitland, N.J.4    Le Duc, A.5
  • 17
    • 0028861476 scopus 로고
    • Functional expression of SV40 in normal human prostatic epithelial and fibroblastic cells - Differentiation pattern of nontumorigenic cell lines
    • Berthon, P., Cussenot, O., Hopwood, L., Leduc, A. and Maitland, N.J. (1995) Functional expression of SV40 in normal human prostatic epithelial and fibroblastic cells - differentiation pattern of nontumorigenic cell lines. Int. J. Oncol., 6, 333-343.
    • (1995) Int. J. Oncol. , vol.6 , pp. 333-343
    • Berthon, P.1    Cussenot, O.2    Hopwood, L.3    Leduc, A.4    Maitland, N.J.5
  • 18
    • 0034657782 scopus 로고    scopus 로고
    • Human dendritic cells transfected with RNA encoding prostate specific antigen stimulate prostate-specific CTL responses in vitro
    • Heiser, A., Dahm, P., Yancey, D.R., Maurice, M.A., Boczkowski, D., Nair, S.K., Gilboa, E. and Vieweg, J. (2000) Human dendritic cells transfected with RNA encoding prostate specific antigen stimulate prostate-specific CTL responses in vitro. J. Immunol., 164, 5508-5514.
    • (2000) J. Immunol. , vol.164 , pp. 5508-5514
    • Heiser, A.1    Dahm, P.2    Yancey, D.R.3    Maurice, M.A.4    Boczkowski, D.5    Nair, S.K.6    Gilboa, E.7    Vieweg, J.8
  • 19
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K. and Tuschl, T. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 411, 494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 20
    • 0037045229 scopus 로고    scopus 로고
    • Laterally stabilized complexes of DNA with linear reducible polycations: Strategy for triggered intracellular activation of DNA delivery vectors
    • Oupicky, D., Parker, A.L. and Seymour, L.W. (2002) Laterally stabilized complexes of DNA with linear reducible polycations: Strategy for triggered intracellular activation of DNA delivery vectors. J. Am. Chem. Soc., 124, 8-9.
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 8-9
    • Oupicky, D.1    Parker, A.L.2    Seymour, L.W.3
  • 21
    • 27244447205 scopus 로고    scopus 로고
    • Methods for studying formation of polycation-DNA complexes and properties useful for gene delivery
    • Findeis, M. (ed.). Humana Press, NJ
    • Read, M.L., Bettinger, T. and Oupicky, D. (2001) Methods for studying formation of polycation-DNA complexes and properties useful for gene delivery. In Findeis, M. (ed.). Nonviral Vectors for Gene Therapy. Humana Press, NJ, Vol. 65, pp. 131-148.
    • (2001) Nonviral Vectors for Gene Therapy , vol.65 , pp. 131-148
    • Read, M.L.1    Bettinger, T.2    Oupicky, D.3
  • 22
    • 0038544289 scopus 로고    scopus 로고
    • Evaluation of fluorescent dyes for measuring intracellular glutathione content in primary cultures of human neurons and neuroblastoma SH-SY5Y
    • Sebastia, J., Cristofol, R., Martin, M., Rodriguez-Farre, E. and Sanfeliu, C. (2003) Evaluation of fluorescent dyes for measuring intracellular glutathione content in primary cultures of human neurons and neuroblastoma SH-SY5Y. Cytometry, 51A, 16-25.
    • (2003) Cytometry , vol.51 A , pp. 16-25
    • Sebastia, J.1    Cristofol, R.2    Martin, M.3    Rodriguez-Farre, E.4    Sanfeliu, C.5
  • 23
    • 19744372388 scopus 로고    scopus 로고
    • Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis
    • Akinc, A., Thomas, M., Klibanov, A.M. and Langer, R. (2005) Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J. Gene Med., 7, 657-663.
    • (2005) J. Gene Med. , vol.7 , pp. 657-663
    • Akinc, A.1    Thomas, M.2    Klibanov, A.M.3    Langer, R.4
  • 24
    • 0037069319 scopus 로고    scopus 로고
    • Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells
    • Thomas, M. and Klihanov, A.M. (2002) Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells. Proc. Natl Acad. Sci. USA, 99, 14640-14645.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14640-14645
    • Thomas, M.1    Klihanov, A.M.2
  • 25
    • 0035028337 scopus 로고    scopus 로고
    • Recent developments in RNA-based strategies for cancer gene therapy
    • Bettinger, T. and Read, M.L. (2001) Recent developments in RNA-based strategies for cancer gene therapy. Curr. Opin. Mol. Ther., 3, 116-124.
    • (2001) Curr. Opin. Mol. Ther. , vol.3 , pp. 116-124
    • Bettinger, T.1    Read, M.L.2
  • 26
    • 0035883853 scopus 로고    scopus 로고
    • Peptide-mediated RNA delivery: A novel approach for enhanced transfection of primary and post-mitotic cells
    • Bettinger, T., Carlisle, R.C., Read, M.L., Ogris, M. and Seymour, L.W. (2001) Peptide-mediated RNA delivery: A novel approach for enhanced transfection of primary and post-mitotic cells. Nucleic Acids Res., 29, 3882-3891.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 3882-3891
    • Bettinger, T.1    Carlisle, R.C.2    Read, M.L.3    Ogris, M.4    Seymour, L.W.5
  • 27
    • 0037038435 scopus 로고    scopus 로고
    • P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
    • Wang, K.C., Kim, J.A., Sivasankaran, R., Segal, R. and He, Z. (2002) P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature, 420, 74-78.
    • (2002) Nature , vol.420 , pp. 74-78
    • Wang, K.C.1    Kim, J.A.2    Sivasankaran, R.3    Segal, R.4    He, Z.5
  • 28
    • 0036897583 scopus 로고    scopus 로고
    • A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein
    • Wong, S.T., Henley, J.R., Kanning, K.C., Huang, K.H., Bothwell, M. and Poo, M.M. (2002) A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nature Neurosci., 5, 1302-1308.
    • (2002) Nature Neurosci. , vol.5 , pp. 1302-1308
    • Wong, S.T.1    Henley, J.R.2    Kanning, K.C.3    Huang, K.H.4    Bothwell, M.5    Poo, M.M.6
  • 29
    • 2442693021 scopus 로고    scopus 로고
    • Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: Expression, receptor signaling, and correlation with axon regeneration
    • Sandvig, A., Berry, M., Barrett, L.B., Butt, A. and Logan, A. (2004) Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration. Glia, 46, 225-251.
    • (2004) Glia , vol.46 , pp. 225-251
    • Sandvig, A.1    Berry, M.2    Barrett, L.B.3    Butt, A.4    Logan, A.5
  • 31
    • 14644437069 scopus 로고    scopus 로고
    • Disinhibition of neurotrophin-induced dorsal root ganglion cell neurite outgrowth on CNS myelin by siRNA-mediated knockdown of NgR, p75(NTR) and Rho-A
    • Ahmed, Z., Dent, R.G., Suggate, E.L., Barrett, L.B., Seabright, R.J., Berry, M. and Logan, A. (2005) Disinhibition of neurotrophin-induced dorsal root ganglion cell neurite outgrowth on CNS myelin by siRNA-mediated knockdown of NgR, p75(NTR) and Rho-A. Mol. Cell Neurosci., 28, 509-523.
    • (2005) Mol. Cell Neurosci. , vol.28 , pp. 509-523
    • Ahmed, Z.1    Dent, R.G.2    Suggate, E.L.3    Barrett, L.B.4    Seabright, R.J.5    Berry, M.6    Logan, A.7
  • 32
    • 15444373116 scopus 로고    scopus 로고
    • RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
    • Urban-Klein, B., Werth, S., Abuharbeid, S., Czubayko, F. and Aigner, A. (2005) RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther., 12, 461-466.
    • (2005) Gene Ther. , vol.12 , pp. 461-466
    • Urban-Klein, B.1    Werth, S.2    Abuharbeid, S.3    Czubayko, F.4    Aigner, A.5
  • 33
    • 0031788165 scopus 로고    scopus 로고
    • The size of DNA/transferrin-PEI complexes is an important for gene expression in cultured cells
    • Ogris, M., Steinlein, P., Kursa, M., Mechtler, K., Kircheis, R. and Wagner, E. (1998) The size of DNA/transferrin-PEI complexes is an important for gene expression in cultured cells. Gene Ther., 5, 1425-1433.
    • (1998) Gene Ther. , vol.5 , pp. 1425-1433
    • Ogris, M.1    Steinlein, P.2    Kursa, M.3    Mechtler, K.4    Kircheis, R.5    Wagner, E.6
  • 34
    • 11844290850 scopus 로고    scopus 로고
    • Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer
    • Boeckle, S., von Gersdorff, K., van der Piepen, S., Culmsee, C., Wagner, E. and Ogris, M, (2004) Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer. J. Gene Med., 6, 1102-1111.
    • (2004) J. Gene Med. , vol.6 , pp. 1102-1111
    • Boeckle, S.1    von Gersdorff, K.2    van der Piepen, S.3    Culmsee, C.4    Wagner, E.5    Ogris, M.6
  • 35
    • 0037437033 scopus 로고    scopus 로고
    • Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: Comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine
    • Kunath, K., von Harpe, A., Fischer, D., Petersen, H., Bickel, U., Voigt, K. and Kissel, T. (2003) Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: Comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine. J. Control Release, 89, 113-125.
    • (2003) J. Control Release , vol.89 , pp. 113-125
    • Kunath, K.1    von Harpe, A.2    Fischer, D.3    Petersen, H.4    Bickel, U.5    Voigt, K.6    Kissel, T.7
  • 38
    • 0025297898 scopus 로고
    • Receptor-mediated endocytosis of transferrin-polycation conjugates: An efficient way to introduce DNA into hematopoietic cells
    • Zenke, M., Steinlein, P., Wagner, E., Cotten, M., Beug, H. and Birnstiel, M.L. (1990) Receptor-mediated endocytosis of transferrin-polycation conjugates: An efficient way to introduce DNA into hematopoietic cells. Proc. Natl Acad. Sci. USA, 87, 3655-3659.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3655-3659
    • Zenke, M.1    Steinlein, P.2    Wagner, E.3    Cotten, M.4    Beug, H.5    Birnstiel, M.L.6
  • 39
    • 0034635467 scopus 로고    scopus 로고
    • Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin
    • Dash, P.R., Read, M.L., Fisher, K.D., Howard, K.A., Wolfert, M., Oupicky, D., Subr, V., Strohalm, J., Ulbrich, K. and Seymour, L.W. (2000) Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin. J. Biol. Chem., 275, 3793-3802.
    • (2000) J. Biol. Chem. , vol.275 , pp. 3793-3802
    • Dash, P.R.1    Read, M.L.2    Fisher, K.D.3    Howard, K.A.4    Wolfert, M.5    Oupicky, D.6    Subr, V.7    Strohalm, J.8    Ulbrich, K.9    Seymour, L.W.10
  • 40
    • 0036665417 scopus 로고    scopus 로고
    • On the kinetics of polyplex endocytic trafficking: Implications for gene delivery vector design
    • Forrest, M.L. and Pack, D.W. (2002) On the kinetics of polyplex endocytic trafficking: Implications for gene delivery vector design. Mol. Ther., 6, 57-66.
    • (2002) Mol. Ther. , vol.6 , pp. 57-66
    • Forrest, M.L.1    Pack, D.W.2
  • 41
    • 85034620865 scopus 로고
    • pH-dependent fusion of liposomes using titratable polycations
    • Uster, P.S. and Deamer, D.W. (1985) pH-dependent fusion of liposomes using titratable polycations. Biochemistry, 24, 1-8.
    • (1985) Biochemistry , vol.24 , pp. 1-8
    • Uster, P.S.1    Deamer, D.W.2
  • 42
    • 0021200295 scopus 로고
    • Polyhistidine mediates an acid-dependent fusion of negatively charged liposomes
    • Wang, C.Y. and Huang, L. (1984) Polyhistidine mediates an acid-dependent fusion of negatively charged liposomes. Biochemistry, 23, 4409-4416.
    • (1984) Biochemistry , vol.23 , pp. 4409-4416
    • Wang, C.Y.1    Huang, L.2
  • 43
    • 0036579817 scopus 로고    scopus 로고
    • Intracellular processing and stability of DNA complexed with histidylated polylysine conjugates
    • Goncalves, C., Pichon, C., Guerin, B. and Midoux, P. (2002) Intracellular processing and stability of DNA complexed with histidylated polylysine conjugates. J. Gene Med., 4, 271-281.
    • (2002) J. Gene Med. , vol.4 , pp. 271-281
    • Goncalves, C.1    Pichon, C.2    Guerin, B.3    Midoux, P.4
  • 44
    • 0033646067 scopus 로고    scopus 로고
    • Low molecular weight disulfide cross-linking peptides as nonviral gene delivery carriers
    • McKenzie, D.L., Smiley, E., Kwok, K.Y. and Rice, K.G. (2000) Low molecular weight disulfide cross-linking peptides as nonviral gene delivery carriers. Bioconjug. Chem., 11, 901-909.
    • (2000) Bioconjug. Chem. , vol.11 , pp. 901-909
    • McKenzie, D.L.1    Smiley, E.2    Kwok, K.Y.3    Rice, K.G.4
  • 45
    • 27244457081 scopus 로고    scopus 로고
    • Barriers to synthetic gene delivery
    • Read, M.L., Logan, A. and Seymour, L.W. (2005) Barriers to synthetic gene delivery. Adv Genet., 53, 19-46.
    • (2005) Adv. Genet. , vol.53 , pp. 19-46
    • Read, M.L.1    Logan, A.2    Seymour, L.W.3
  • 47
    • 0034001784 scopus 로고    scopus 로고
    • RNA transfected dendritic cells as cancer vaccines
    • Mitchell, D.A. and Nair, S.K. (2000) RNA transfected dendritic cells as cancer vaccines. Curr. Opin. Mol. Ther., 2, 176-181.
    • (2000) Curr. Opin. Mol. Ther. , vol.2 , pp. 176-181
    • Mitchell, D.A.1    Nair, S.K.2
  • 48
    • 8544231403 scopus 로고    scopus 로고
    • Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation
    • Davidson, T.J., Harel, S., Arboleda, V.A., Prunell, G.F., Shelanski, M.L., Greene, L.A. and Troy, C.M. (2004) Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation. J. Neurosci., 24, 10040-10046.
    • (2004) J. Neurosci. , vol.24 , pp. 10040-10046
    • Davidson, T.J.1    Harel, S.2    Arboleda, V.A.3    Prunell, G.F.4    Shelanski, M.L.5    Greene, L.A.6    Troy, C.M.7
  • 49
    • 0037592877 scopus 로고    scopus 로고
    • Insight into the mechanism of the peptide-based gene delivery system MPG: Implications for delivery of siRNA into mammalian cells
    • Simeoni, F., Morris, M.C., Heitz, F. and Divita, G. (2003) Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells. Nucleic Acids Res., 31, 2717-2724.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2717-2724
    • Simeoni, F.1    Morris, M.C.2    Heitz, F.3    Divita, G.4
  • 50
    • 0035286969 scopus 로고    scopus 로고
    • Polyethylenimine-mediated gene delivery: A mechanistic study
    • Kichler, A., Leborgne, C., Coeytaux, E. and Danos, O. (2001) Polyethylenimine-mediated gene delivery: A mechanistic study. J. Gene Med., 3, 135-144.
    • (2001) J. Gene Med. , vol.3 , pp. 135-144
    • Kichler, A.1    Leborgne, C.2    Coeytaux, E.3    Danos, O.4
  • 52
    • 0036740007 scopus 로고    scopus 로고
    • Biodegradable, endosome disruptive, and cationic network-type polymer as a highly efficient and nontoxic gene delivery carrier
    • Lim, Y.B., Kim, S.M., Suh, H. and Park, J.S. (2002) Biodegradable, endosome disruptive, and cationic network-type polymer as a highly efficient and nontoxic gene delivery carrier. Bioconjug. Chem., 13, 952-957.
    • (2002) Bioconjug. Chem. , vol.13 , pp. 952-957
    • Lim, Y.B.1    Kim, S.M.2    Suh, H.3    Park, J.S.4
  • 53
    • 0035214028 scopus 로고    scopus 로고
    • Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine
    • Gosselin, M.A., Guo, W. and Lee, R.J. (2001) Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine. Bioconjug. Chem., 12, 989-994.
    • (2001) Bioconjug. Chem. , vol.12 , pp. 989-994
    • Gosselin, M.A.1    Guo, W.2    Lee, R.J.3
  • 54
    • 0032910232 scopus 로고    scopus 로고
    • In vitro cytotoxicity of poly(amidoamine)s: Relevance to DNA delivery
    • Hill, I.R., Garnett, M.C., Bignotti, F. and Davis, S.S. (1999) In vitro cytotoxicity of poly(amidoamine)s: Relevance to DNA delivery. Biochim. Biophys. Acta, 1427, 161-174.
    • (1999) Biochim. Biophys. Acta , vol.1427 , pp. 161-174
    • Hill, I.R.1    Garnett, M.C.2    Bignotti, F.3    Davis, S.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.