메뉴 건너뛰기




Volumn 24, Issue 8, 2014, Pages 409-425

PharmGKB summary: Very important pharmacogene information for N-acetyltransferase 2

Author keywords

acetylation; acetylator; drug toxicity; genotype; metabolism; N acetyltransferase 1; N acetyltransferase 2; pharmacogenetics; pharmacokinetics

Indexed keywords

ACYLTRANSFERASE; ARYLAMINE ACETYLTRANSFERASE; CAFFEINE; HYDRALAZINE; ISONIAZID; N ACETYLTRANSFERASE 1; SALAZOSULFAPYRIDINE; SULFAMETHOXAZOLE; UNCLASSIFIED DRUG;

EID: 84904397825     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0000000000000062     Document Type: Article
Times cited : (106)

References (210)
  • 1
    • 84904389070 scopus 로고    scopus 로고
    • International Union of Biochemistry and Molecular Biology (IUBMB) Nomenclature Committee Available at Accessed 13 August 2013
    • International Union of Biochemistry and Molecular Biology (IUBMB) Nomenclature Committee. Recommendations for Enzyme Nomenclature. Available at: http://www.chem.qmul.ac.uk/iubmb/enzyme/. [Accessed 13 August 2013].
    • Recommendations for Enzyme Nomenclature
  • 2
    • 67649243788 scopus 로고    scopus 로고
    • N-acetyltransferase SNPs: Emerging concepts serve as a paradigm for understanding complexities of personalized medicine
    • Hein DW. N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine. Expert Opin Drug Metab Toxicol 2009; 5:353-366.
    • (2009) Expert Opin Drug Metab Toxicol , vol.5 , pp. 353-366
    • Hein, D.W.1
  • 3
    • 61549138129 scopus 로고    scopus 로고
    • Update on the pharmacogenetics of NATs: Structural considerations
    • Stanley LA, Sim E. Update on the pharmacogenetics of NATs: structural considerations. Pharmacogenomics 2008; 9:1673-1693.
    • (2008) Pharmacogenomics , vol.9 , pp. 1673-1693
    • Stanley, L.A.1    Sim, E.2
  • 4
    • 84863762626 scopus 로고    scopus 로고
    • Arylamine N-acetyltransferases-from drug metabolism and pharmacogenetics to identification of novel targets for pharmacological intervention
    • Sim E, Fakis G, Laurieri N, Boukouvala S. Arylamine N-acetyltransferases- from drug metabolism and pharmacogenetics to identification of novel targets for pharmacological intervention. Adv Pharmacol 2012; 63:169-205.
    • (2012) Adv Pharmacol , vol.63 , pp. 169-205
    • Sim, E.1    Fakis, G.2    Laurieri, N.3    Boukouvala, S.4
  • 5
    • 56349101750 scopus 로고    scopus 로고
    • Arylamine N-acetyltransferases: Structural and functional implications of polymorphisms
    • Sim E, Lack N, Wang CJ, Long H, Westwood I, Fullam E, Kawamura A. Arylamine N-acetyltransferases: structural and functional implications of polymorphisms. Toxicology 2008; 254:170-183.
    • (2008) Toxicology , vol.254 , pp. 170-183
    • Sim, E.1    Lack, N.2    Wang, C.J.3    Long, H.4    Westwood, I.5    Fullam, E.6    Kawamura, A.7
  • 6
    • 84874635344 scopus 로고    scopus 로고
    • Rapid birth-and-death evolution of the xenobiotic metabolizing NAT gene family in vertebrates with evidence of adaptive selection
    • Sabbagh A, Marin J, Veyssiere C, Lecompte E, Boukouvala S, Poloni ES, et al. Rapid birth-and-death evolution of the xenobiotic metabolizing NAT gene family in vertebrates with evidence of adaptive selection. BMC Evol Biol 2013; 13:62.
    • (2013) BMC Evol Biol , vol.13 , pp. 62
    • Sabbagh, A.1    Marin, J.2    Veyssiere, C.3    Lecompte, E.4    Boukouvala, S.5    Poloni, E.S.6
  • 7
    • 84899926132 scopus 로고    scopus 로고
    • Arylamine N-acetyltransferases: From drug metabolism and pharmacogenetics to drug discovery
    • Sim E, Abuhammad A, Ryan A. Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol 2014; 171:2705-2725.
    • (2014) Br J Pharmacol , vol.171 , pp. 2705-2725
    • Sim, E.1    Abuhammad, A.2    Ryan, A.3
  • 9
    • 47749150680 scopus 로고    scopus 로고
    • Structures of human arylamine N-acetyltransferases
    • Grant DM. Structures of human arylamine N-acetyltransferases. Curr Drug Metab 2008; 9:465-470.
    • (2008) Curr Drug Metab , vol.9 , pp. 465-470
    • Grant, D.M.1
  • 10
    • 79952796042 scopus 로고    scopus 로고
    • Regulation of phase II biotransformation enzymes by steroid hormones
    • Kohalmy K, Vrzal R. Regulation of phase II biotransformation enzymes by steroid hormones. Curr Drug Metab 2011; 12:104-123.
    • (2011) Curr Drug Metab , vol.12 , pp. 104-123
    • Kohalmy, K.1    Vrzal, R.2
  • 12
    • 83455199225 scopus 로고    scopus 로고
    • Arylamine N-acetyltransferase 1: A novel drug target in cancer development
    • Butcher NJ, Minchin RF. Arylamine N-acetyltransferase 1: a novel drug target in cancer development. Pharmacol Rev 2012; 64:147-165.
    • (2012) Pharmacol Rev , vol.64 , pp. 147-165
    • Butcher, N.J.1    Minchin, R.F.2
  • 13
    • 34247323530 scopus 로고    scopus 로고
    • Identification of N-acetyltransferase 2 (NAT2) transcription start sites and quantitation of NAT2-specific mRNA in human tissues
    • Husain A, Zhang X, Doll MA, States JC, Barker DF, Hein DW. Identification of N-acetyltransferase 2 (NAT2) transcription start sites and quantitation of NAT2-specific mRNA in human tissues. Drug Metab Dispos 2007; 35:721-727.
    • (2007) Drug Metab Dispos , vol.35 , pp. 721-727
    • Husain, A.1    Zhang, X.2    Doll, M.A.3    States, J.C.4    Barker, D.F.5    Hein, D.W.6
  • 14
    • 0025344002 scopus 로고
    • Human arylamine N-acetyltransferase genes: Isolation, chromosomal localization, and functional expression
    • Blum M, Grant DM, McBride W, Heim M, Meyer UA. Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression. DNA Cell Biol 1990; 9:193-203.
    • (1990) DNA Cell Biol , vol.9 , pp. 193-203
    • Blum, M.1    Grant, D.M.2    McBride, W.3    Heim, M.4    Meyer, U.A.5
  • 16
    • 17144376746 scopus 로고    scopus 로고
    • Genomic organization of human arylamine N-acetyltransferase Type i reveals alternative promoters that generate different 5′-UTR splice variants with altered translational activities
    • Butcher NJ, Arulpragasam A, Goh HL, Davey T, Minchin RF. Genomic organization of human arylamine N-acetyltransferase Type I reveals alternative promoters that generate different 5′-UTR splice variants with altered translational activities. Biochem J 2005; 387:119-127.
    • (2005) Biochem J , vol.387 , pp. 119-127
    • Butcher, N.J.1    Arulpragasam, A.2    Goh, H.L.3    Davey, T.4    Minchin, R.F.5
  • 17
    • 18744390038 scopus 로고    scopus 로고
    • Structural analysis of the genes for human arylamine N-acetyltransferases and characterisation of alternative transcripts
    • Boukouvala S, Sim E. Structural analysis of the genes for human arylamine N-acetyltransferases and characterisation of alternative transcripts. Basic Clin Pharmacol Toxicol 2005; 96:343-351.
    • (2005) Basic Clin Pharmacol Toxicol , vol.96 , pp. 343-351
    • Boukouvala, S.1    Sim, E.2
  • 18
    • 3242787887 scopus 로고    scopus 로고
    • Identification of the major promoter and non-coding exons of the human arylamine N-acetyltransferase 1 gene (NAT1)
    • Husain A, Barker DF, States JC, Doll MA, Hein DW. Identification of the major promoter and non-coding exons of the human arylamine N-acetyltransferase 1 gene (NAT1). Pharmacogenetics 2004; 14:397-406.
    • (2004) Pharmacogenetics , vol.14 , pp. 397-406
    • Husain, A.1    Barker, D.F.2    States, J.C.3    Doll, M.A.4    Hein, D.W.5
  • 19
    • 0025880699 scopus 로고
    • Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases
    • Ebisawa T, Deguchi T. Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases. Biochem Biophys Res Commun 1991; 177:1252-1257.
    • (1991) Biochem Biophys Res Commun , vol.177 , pp. 1252-1257
    • Ebisawa, T.1    Deguchi, T.2
  • 20
    • 84904406112 scopus 로고    scopus 로고
    • National Center for Biotechnology Information (NCBI), U.S. National Library of Medicine Available at Accessed 13 August 2013
    • National Center for Biotechnology Information (NCBI), U.S. National Library of Medicine. NCBI Gene ID: 9 (NAT1). Available at: http://www. ncbi.nlm.nih.gov/gene/9. [Accessed 13 August 2013].
    • NCBI Gene ID: 9 (NAT1)
  • 21
    • 84904392529 scopus 로고    scopus 로고
    • National Center for Biotechnology Information (NCBI), U.S. National Library of Medicine Available at Accessed 13 August 2013
    • National Center for Biotechnology Information (NCBI), U.S. National Library of Medicine. NCBI Gene ID: 10 (NAT2). Available at: http://www. ncbi.nlm.nih.gov/gene/10 [Accessed 13 August 2013].
    • NCBI Gene ID: 10 (NAT2)
  • 22
    • 35648947442 scopus 로고    scopus 로고
    • Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases
    • Wu H, Dombrovsky L, Tempel W, Martin F, Loppnau P, Goodfellow GH, et al. Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases. J Biol Chem 2007; 282:30189-30197.
    • (2007) J Biol Chem , vol.282 , pp. 30189-30197
    • Wu, H.1    Dombrovsky, L.2    Tempel, W.3    Martin, F.4    Loppnau, P.5    Goodfellow, G.H.6
  • 25
    • 84871809033 scopus 로고    scopus 로고
    • Arylamine N-acetyltransferase Gene Nomenclature Committee Available at Accessed 13 August 2013
    • Arylamine N-acetyltransferase Gene Nomenclature Committee. Background. Available at: http://nat.mbg.duth.gr/background-2013.html. [Accessed 13 August 2013].
    • Background
  • 27
    • 33344457433 scopus 로고    scopus 로고
    • Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes
    • Patin E, Barreiro LB, Sabeti PC, Austerlitz F, Luca F, Sajantila A, et al. Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes. Am J Hum Genet 2006; 78:423-436.
    • (2006) Am J Hum Genet , vol.78 , pp. 423-436
    • Patin, E.1    Barreiro, L.B.2    Sabeti, P.C.3    Austerlitz, F.4    Luca, F.5    Sajantila, A.6
  • 28
    • 80455158333 scopus 로고    scopus 로고
    • Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations
    • Mortensen HM, Froment A, Lema G, Bodo JM, Ibrahim M, Nyambo TB, et al. Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations. Pharmacogenomics 2011; 12:1545-1558.
    • (2011) Pharmacogenomics , vol.12 , pp. 1545-1558
    • Mortensen, H.M.1    Froment, A.2    Lema, G.3    Bodo, J.M.4    Ibrahim, M.5    Nyambo, T.B.6
  • 29
    • 78651076990 scopus 로고    scopus 로고
    • Global patterns of genetic diversity and signals of natural selection for human ADME genes
    • Li J, Zhang L, Zhou H, Stoneking M, Tang K. Global patterns of genetic diversity and signals of natural selection for human ADME genes. Hum Mol Genet 2011; 20:528-540.
    • (2011) Hum Mol Genet , vol.20 , pp. 528-540
    • Li, J.1    Zhang, L.2    Zhou, H.3    Stoneking, M.4    Tang, K.5
  • 30
    • 47749095050 scopus 로고    scopus 로고
    • Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2
    • Walraven JM, Zang Y, Trent JO, Hein DW. Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2. Curr Drug Metab 2008; 9:471-486.
    • (2008) Curr Drug Metab , vol.9 , pp. 471-486
    • Walraven, J.M.1    Zang, Y.2    Trent, J.O.3    Hein, D.W.4
  • 31
    • 36048978699 scopus 로고    scopus 로고
    • Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus
    • Soejima M, Sugiura T, Kawaguchi Y, Kawamoto M, Katsumata Y, Takagi K, et al. Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus. Arthritis Res Ther 2007; 9:R23.
    • (2007) Arthritis Res Ther , vol.9
    • Soejima, M.1    Sugiura, T.2    Kawaguchi, Y.3    Kawamoto, M.4    Katsumata, Y.5    Takagi, K.6
  • 32
    • 84866098991 scopus 로고    scopus 로고
    • The differential effect of NAT2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotype
    • Ruiz JD, Martínez C, Anderson K, Gross M, Lang NP, García-Martin E, Agúndez JA. The differential effect of NAT2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotype. PLoS One 2012; 7:e44629.
    • (2012) PLoS One , vol.7
    • Ruiz, J.D.1    Martínez, C.2    Anderson, K.3    Gross, M.4    Lang, N.P.5    García-Martin, E.6    Agúndez, J.A.7
  • 33
    • 0029117480 scopus 로고
    • Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: Effects of 7 specific NAT2 nucleic acid substitutions
    • Hein DW, Doll MA, Rustan TD, Ferguson RJ. Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions. Cancer Res 1995; 55:3531-3536.
    • (1995) Cancer Res , vol.55 , pp. 3531-3536
    • Hein, D.W.1    Doll, M.A.2    Rustan, T.D.3    Ferguson, R.J.4
  • 35
    • 84890549520 scopus 로고    scopus 로고
    • Refinement of the prediction of N-acetyltransferase 2 (NAT2) phenotypes with respect to enzyme activity and urinary bladder cancer risk
    • Selinski S, Blaszkewicz M, Ickstadt K, Hengstler JG, Golka K. Refinement of the prediction of N-acetyltransferase 2 (NAT2) phenotypes with respect to enzyme activity and urinary bladder cancer risk. Arch Toxicol 2013; 87:2129-2139.
    • (2013) Arch Toxicol , vol.87 , pp. 2129-2139
    • Selinski, S.1    Blaszkewicz, M.2    Ickstadt, K.3    Hengstler, J.G.4    Golka, K.5
  • 36
    • 0014644734 scopus 로고
    • An improved and simplified method of detecting the acetylator phenotype
    • Evans DA. An improved and simplified method of detecting the acetylator phenotype. J Med Genet 1969; 6:405-407.
    • (1969) J Med Genet , vol.6 , pp. 405-407
    • Evans, D.A.1
  • 39
    • 0025231840 scopus 로고
    • Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver
    • Grant DM, Mörike K, Eichelbaum M, Meyer UA. Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver. J Clin Invest 1990; 85:968-972.
    • (1990) J Clin Invest , vol.85 , pp. 968-972
    • Grant, D.M.1    Mörike, K.2    Eichelbaum, M.3    Meyer, U.A.4
  • 41
    • 84880673426 scopus 로고    scopus 로고
    • Association of N-acetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug-induced hepatotoxicity in Western India
    • Gupta VH, Amarapurkar DN, Singh M, Sasi P, Joshi JM, Baijal R, et al. Association of N-acetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug-induced hepatotoxicity in Western India. J Gastroenterol Hepatol 2013; 28:1368-1374.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 1368-1374
    • Gupta, V.H.1    Amarapurkar, D.N.2    Singh, M.3    Sasi, P.4    Joshi, J.M.5    Baijal, R.6
  • 42
    • 83755195441 scopus 로고    scopus 로고
    • Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes
    • Hein DW, Doll MA. Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes. Pharmacogenomics 2012; 13:31-41.
    • (2012) Pharmacogenomics , vol.13 , pp. 31-41
    • Hein, D.W.1    Doll, M.A.2
  • 43
    • 84862006775 scopus 로고    scopus 로고
    • Accuracy of NAT2 SNP genotyping panels to infer acetylator phenotypes in African, Asian, Amerindian and admixed populations
    • author reply 855
    • Suarez-Kurtz G, Vargens DD, Sortica VA, Hutz MH. Accuracy of NAT2 SNP genotyping panels to infer acetylator phenotypes in African, Asian, Amerindian and admixed populations. Pharmacogenomics 2012; 13:851-854, author reply 855.
    • (2012) Pharmacogenomics , vol.13 , pp. 851-854
    • Suarez-Kurtz, G.1    Vargens, D.D.2    Sortica, V.A.3    Hutz, M.H.4
  • 44
    • 83755195441 scopus 로고    scopus 로고
    • A four-SNP NAT2 genotyping panel recommended to infer human acetylator phenotype
    • Hein DW, Doll MA. A four-SNP NAT2 genotyping panel recommended to infer human acetylator phenotype. Pharmacogenomics 2012; 13:31-41.
    • (2012) Pharmacogenomics , vol.13 , pp. 31-41
    • Hein, D.W.1    Doll, M.A.2
  • 45
    • 34548063942 scopus 로고    scopus 로고
    • Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2
    • Zang Y, Doll MA, Zhao S, States JC, Hein DW. Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2. Carcinogenesis 2007; 28:1665-1671.
    • (2007) Carcinogenesis , vol.28 , pp. 1665-1671
    • Zang, Y.1    Doll, M.A.2    Zhao, S.3    States, J.C.4    Hein, D.W.5
  • 46
    • 80053325945 scopus 로고    scopus 로고
    • Effects of single nucleotide polymorphisms on human N-acetyltransferase 2 structure and dynamics by molecular dynamics simulation
    • Rajasekaran M, Abirami S, Chen C. Effects of single nucleotide polymorphisms on human N-acetyltransferase 2 structure and dynamics by molecular dynamics simulation. PLoS One 2011; 6:e25801.
    • (2011) PLoS One , vol.6
    • Rajasekaran, M.1    Abirami, S.2    Chen, C.3
  • 47
    • 44449178208 scopus 로고    scopus 로고
    • Association of slow N-acetyltransferase 2 profile and anti-TB drug-induced hepatotoxicity in patients from Southern Brazil
    • Possuelo LG, Castelan JA, de Brito TC, Ribeiro AW, Cafrune PI, Picon PD, et al. Association of slow N-acetyltransferase 2 profile and anti-TB drug-induced hepatotoxicity in patients from Southern Brazil. Eur J Clin Pharmacol 2008; 64:673-681.
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 673-681
    • Possuelo, L.G.1    Castelan, J.A.2    De Brito, T.C.3    Ribeiro, A.W.4    Cafrune, P.I.5    Picon, P.D.6
  • 48
    • 65249083918 scopus 로고    scopus 로고
    • Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam
    • Olivera M, Martinez C, Gervasini G, Carrillo JA, Ramos S, Benítez J, et al. Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam. Drug Metab Lett 2007; 1:3-5.
    • (2007) Drug Metab Lett , vol.1 , pp. 3-5
    • Olivera, M.1    Martinez, C.2    Gervasini, G.3    Carrillo, J.A.4    Ramos, S.5    Benítez, J.6
  • 49
    • 70649093029 scopus 로고    scopus 로고
    • Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis
    • Kim SH, Kim SH, Bahn JW, Kim YK, Chang YS, Shin ES, et al. Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis. Pharmacogenomics 2009; 10:1767-1779.
    • (2009) Pharmacogenomics , vol.10 , pp. 1767-1779
    • Kim, S.H.1    Kim, S.H.2    Bahn, J.W.3    Kim, Y.K.4    Chang, Y.S.5    Shin, E.S.6
  • 50
    • 84867504367 scopus 로고    scopus 로고
    • Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatotoxicity in Tunisian patients with tuberculosis
    • Ben Mahmoud L, Ghozzi H, Kamoun A, Hakim A, Hachicha H, Hammami S, et al. Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatotoxicity in Tunisian patients with tuberculosis. Pathol Biol (Paris) 2012; 60:324-330.
    • (2012) Pathol Biol (Paris) , vol.60 , pp. 324-330
    • Ben Mahmoud, L.1    Ghozzi, H.2    Kamoun, A.3    Hakim, A.4    Hachicha, H.5    Hammami, S.6
  • 51
    • 63449124050 scopus 로고    scopus 로고
    • Determining the relation between N-acetyltransferase-2 acetylator phenotype and antituberculosis drug induced hepatitis by molecular biologic tests
    • Bozok Cetinta? V, Erer OF, Kosova B, Ozdemir I, Topçuo?lu N, Akto?u S, Ero?lu Z. Determining the relation between N-acetyltransferase-2 acetylator phenotype and antituberculosis drug induced hepatitis by molecular biologic tests. Tuberk Toraks 2008; 56:81-86.
    • (2008) Tuberk Toraks , vol.56 , pp. 81-86
    • Bozok Cetinta, V.1    Erer, O.F.2    Kosova, B.3    Ozdemir, I.4    Topçuolu, N.5    Aktou, S.6    Erolu, Z.7
  • 52
    • 84861678115 scopus 로고    scopus 로고
    • NAT2 and CYP2E1 polymorphisms associated with antituberculosis drug-induced hepatotoxicity in Chinese patients
    • An HR, Wu XQ, Wang ZY, Zhang JX, Liang Y. NAT2 and CYP2E1 polymorphisms associated with antituberculosis drug-induced hepatotoxicity in Chinese patients. Clin Exp Pharmacol Physiol 2012; 39:535-543.
    • (2012) Clin Exp Pharmacol Physiol , vol.39 , pp. 535-543
    • An, H.R.1    Wu, X.Q.2    Wang, Z.Y.3    Zhang, J.X.4    Liang, Y.5
  • 53
    • 80053569299 scopus 로고    scopus 로고
    • Alcohol, smoking, and caffeine in relation to fecundability, with effect modification by NAT2
    • Taylor KC, Small CM, Dominguez CE, Murray LE, Tang W, Wilson MM, et al. Alcohol, smoking, and caffeine in relation to fecundability, with effect modification by NAT2. Ann Epidemiol 2011; 21:864-872.
    • (2011) Ann Epidemiol , vol.21 , pp. 864-872
    • Taylor, K.C.1    Small, C.M.2    Dominguez, C.E.3    Murray, L.E.4    Tang, W.5    Wilson, M.M.6
  • 54
    • 77950881900 scopus 로고    scopus 로고
    • NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis
    • Lee SW, Chung LS, Huang HH, Chuang TY, Liou YH, Wu LS. NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis. Int J Tuberc Lung Dis 2010; 14:622-626.
    • (2010) Int J Tuberc Lung Dis , vol.14 , pp. 622-626
    • Lee, S.W.1    Chung, L.S.2    Huang, H.H.3    Chuang, T.Y.4    Liou, Y.H.5    Wu, L.S.6
  • 55
    • 73449088743 scopus 로고    scopus 로고
    • Low N-acetyltransferase 2 activity in isoniazidassociated acute hepatitis requiring liver transplantation
    • Cramer JP, Lohse AW, Burchard GD, Fischer L, Nashan B, Zimmermann M, et al. Low N-acetyltransferase 2 activity in isoniazidassociated acute hepatitis requiring liver transplantation. Transpl Int 2010; 23:231-233.
    • (2010) Transpl Int , vol.23 , pp. 231-233
    • Cramer, J.P.1    Lohse, A.W.2    Burchard, G.D.3    Fischer, L.4    Nashan, B.5    Zimmermann, M.6
  • 56
    • 69249130069 scopus 로고    scopus 로고
    • Genotype and phenotype of NAT2 and the occurrence of adverse drug reactions in Mexican individuals to an isoniazid-based prophylactic chemotherapy for tuberculosis
    • Diaz-Molina R, Cornejo-Bravo JM, Ramos-Ibarra MA, Estrada-Guzman JD, Morales-Arango O, Reyes-Báez R, et al. Genotype and phenotype of NAT2 and the occurrence of adverse drug reactions in Mexican individuals to an isoniazid-based prophylactic chemotherapy for tuberculosis. Mol Med Rep 2008; 1:875-879.
    • (2008) Mol Med Rep , vol.1 , pp. 875-879
    • Diaz-Molina, R.1    Cornejo-Bravo, J.M.2    Ramos-Ibarra, M.A.3    Estrada-Guzman, J.D.4    Morales-Arango, O.5    Reyes-Báez, R.6
  • 57
    • 0034797313 scopus 로고    scopus 로고
    • Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation
    • Roy B, Chowdhury A, Kundu S, Santra A, Dey B, Chakraborty M, Majumder PP. Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation. J Gastroenterol Hepatol 2001; 16:1033-1037.
    • (2001) J Gastroenterol Hepatol , vol.16 , pp. 1033-1037
    • Roy, B.1    Chowdhury, A.2    Kundu, S.3    Santra, A.4    Dey, B.5    Chakraborty, M.6    Majumder, P.P.7
  • 58
    • 77952886405 scopus 로고    scopus 로고
    • A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform
    • Deeken JF, Cormier T, Price DK, Sissung TM, Steinberg SM, Tran K, et al. A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform. Pharmacogenomics J 2010; 10:191-199.
    • (2010) Pharmacogenomics J , vol.10 , pp. 191-199
    • Deeken, J.F.1    Cormier, T.2    Price, D.K.3    Sissung, T.M.4    Steinberg, S.M.5    Tran, K.6
  • 59
  • 60
    • 79955484827 scopus 로고    scopus 로고
    • A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background
    • García-Closas M, Hein DW, Silverman D, Malats N, Yeager M, Jacobs K, et al. A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background. Pharmacogenet Genomics 2011; 21:231-236.
    • (2011) Pharmacogenet Genomics , vol.21 , pp. 231-236
    • García-Closas, M.1    Hein, D.W.2    Silverman, D.3    Malats, N.4    Yeager, M.5    Jacobs, K.6
  • 61
    • 84874930659 scopus 로고    scopus 로고
    • The NAT2 tag SNP rs1495741 correlates with the susceptibility of antituberculosis drug-induced hepatotoxicity
    • Ho HT, Wang TH, Hsiong CH, Perng WC, Wang NC, Huang TY, et al. The NAT2 tag SNP rs1495741 correlates with the susceptibility of antituberculosis drug-induced hepatotoxicity. Pharmacogenet Genomics 2013; 23:200-207.
    • (2013) Pharmacogenet Genomics , vol.23 , pp. 200-207
    • Ho, H.T.1    Wang, T.H.2    Hsiong, C.H.3    Perng, W.C.4    Wang, N.C.5    Huang, T.Y.6
  • 62
    • 77954371492 scopus 로고    scopus 로고
    • Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics
    • Kim JM, Park BL, Park SM, Lee SH, Kim MO, Jung S, et al. Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics. Pharmacogenomics 2010; 11:951-958.
    • (2010) Pharmacogenomics , vol.11 , pp. 951-958
    • Kim, J.M.1    Park, B.L.2    Park, S.M.3    Lee, S.H.4    Kim, M.O.5    Jung, S.6
  • 64
    • 78851470285 scopus 로고    scopus 로고
    • Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis
    • Bose PD, Sarma MP, Medhi S, Das BC, Husain SA, Kar P. Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis. J Gastroenterol Hepatol 2011; 26:312-318.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 312-318
    • Bose, P.D.1    Sarma, M.P.2    Medhi, S.3    Das, B.C.4    Husain, S.A.5    Kar, P.6
  • 65
    • 0037380862 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis
    • Huang YS, Chern HD, Su WJ, Wu JC, Chang SC, Chiang CH, et al. Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. Hepatology 2003; 37:924-930.
    • (2003) Hepatology , vol.37 , pp. 924-930
    • Huang, Y.S.1    Chern, H.D.2    Su, W.J.3    Wu, J.C.4    Chang, S.C.5    Chiang, C.H.6
  • 66
    • 79960620587 scopus 로고    scopus 로고
    • Association of isoniazid-metabolizing enzyme genotypes and isoniazid-induced hepatotoxicity in tuberculosis patients
    • Sotsuka T, Sasaki Y, Hirai S, Yamagishi F, Ueno K. Association of isoniazid-metabolizing enzyme genotypes and isoniazid-induced hepatotoxicity in tuberculosis patients. In vivo 2011; 25:803-812.
    • (2011) Vivo , vol.25 , pp. 803-812
    • Sotsuka, T.1    Sasaki, Y.2    Hirai, S.3    Yamagishi, F.4    Ueno, K.5
  • 67
    • 33746777960 scopus 로고    scopus 로고
    • Sub-Saharan African coding sequence variation and haplotype diversity at the NAT2 gene
    • Patin E, Harmant C, Kidd KK, Kidd J, Froment A, Mehdi SQ, et al. Sub-Saharan African coding sequence variation and haplotype diversity at the NAT2 gene. Hum Mutat 2006; 27:720.
    • (2006) Hum Mutat , vol.27 , pp. 720
    • Patin, E.1    Harmant, C.2    Kidd, K.K.3    Kidd, J.4    Froment, A.5    Mehdi, S.Q.6
  • 68
    • 38449121822 scopus 로고    scopus 로고
    • Population genetic diversity of the NAT2 gene supports a role of acetylation in human adaptation to farming in Central Asia
    • Magalon H, Patin E, Austerlitz F, Hegay T, Aldashev A, Quintana-Murci L, Heyer E. Population genetic diversity of the NAT2 gene supports a role of acetylation in human adaptation to farming in Central Asia. Eur J Hum Genet 2008; 16:243-251.
    • (2008) Eur J Hum Genet , vol.16 , pp. 243-251
    • Magalon, H.1    Patin, E.2    Austerlitz, F.3    Hegay, T.4    Aldashev, A.5    Quintana-Murci, L.6    Heyer, E.7
  • 70
    • 79953743009 scopus 로고    scopus 로고
    • Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: A worldwide population survey
    • Sabbagh A, Darlu P, Crouau-Roy B, Poloni ES. Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey. PLoS One 2011; 6:e18507.
    • (2011) PLoS One , vol.6
    • Sabbagh, A.1    Darlu, P.2    Crouau-Roy, B.3    Poloni, E.S.4
  • 71
    • 84873663885 scopus 로고    scopus 로고
    • NAT2 sequence polymorphisms and acetylation profiles in Indians
    • Khan N, Pande V, Das A. NAT2 sequence polymorphisms and acetylation profiles in Indians. Pharmacogenomics 2013; 14:289-303.
    • (2013) Pharmacogenomics , vol.14 , pp. 289-303
    • Khan, N.1    Pande, V.2    Das, A.3
  • 72
    • 52749085010 scopus 로고    scopus 로고
    • Functional effects of single nucleotide polymorphisms in the coding region of human N-acetyltransferase 1
    • Zhu Y, Hein DW. Functional effects of single nucleotide polymorphisms in the coding region of human N-acetyltransferase 1. Pharmacogenomics J 2008; 8:339-348.
    • (2008) Pharmacogenomics J , vol.8 , pp. 339-348
    • Zhu, Y.1    Hein, D.W.2
  • 73
    • 47749149964 scopus 로고    scopus 로고
    • Effect of environmental substances on the activity of arylamine N-acetyltransferases
    • Rodrigues-Lima F, Dairou J, Dupret JM. Effect of environmental substances on the activity of arylamine N-acetyltransferases. Curr Drug Metab 2008; 9:505-509.
    • (2008) Curr Drug Metab , vol.9 , pp. 505-509
    • Rodrigues-Lima, F.1    Dairou, J.2    Dupret, J.M.3
  • 74
    • 47849124636 scopus 로고    scopus 로고
    • Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms
    • García-Martín E. Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms. Curr Drug Metab 2008; 9:487-497.
    • (2008) Curr Drug Metab , vol.9 , pp. 487-497
    • García-Martín, E.1
  • 75
    • 33644902345 scopus 로고    scopus 로고
    • Adverse reactions to first-line antituberculosis drugs
    • Forget EJ, Menzies D. Adverse reactions to first-line antituberculosis drugs. Expert Opin Drug Saf 2006; 5:231-249.
    • (2006) Expert Opin Drug Saf , vol.5 , pp. 231-249
    • Forget, E.J.1    Menzies, D.2
  • 77
    • 36949027885 scopus 로고    scopus 로고
    • Isoniazid: Metabolic aspects and toxicological correlates
    • Preziosi P. Isoniazid: metabolic aspects and toxicological correlates. Curr Drug Metab 2007; 8:839-851.
    • (2007) Curr Drug Metab , vol.8 , pp. 839-851
    • Preziosi, P.1
  • 79
    • 84455161882 scopus 로고    scopus 로고
    • A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD + adduct
    • Mahapatra S, Woolhiser LK, Lenaerts AJ, Johnson JL, Eisenach KD, Joloba ML, et al. A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD + adduct. Antimicrob Agents Chemother 2012; 56:28-35.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 28-35
    • Mahapatra, S.1    Woolhiser, L.K.2    Lenaerts, A.J.3    Johnson, J.L.4    Eisenach, K.D.5    Joloba, M.L.6
  • 80
    • 84855908033 scopus 로고    scopus 로고
    • Genetic association studies in drug-induced liver injury
    • Daly AK, Day CP. Genetic association studies in drug-induced liver injury. Drug Metab Rev 2012; 44:116-126.
    • (2012) Drug Metab Rev , vol.44 , pp. 116-126
    • Daly, A.K.1    Day, C.P.2
  • 81
    • 45749141585 scopus 로고    scopus 로고
    • Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and glutathione-S- transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients
    • Fukino K, Sasaki Y, Hirai S, Nakamura T, Hashimoto M, Yamagishi F, Ueno K. Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients. J Toxicol Sci 2008; 33:187-195.
    • (2008) J Toxicol Sci , vol.33 , pp. 187-195
    • Fukino, K.1    Sasaki, Y.2    Hirai, S.3    Nakamura, T.4    Hashimoto, M.5    Yamagishi, F.6    Ueno, K.7
  • 83
    • 33845637216 scopus 로고    scopus 로고
    • A novel mechanism for drug-induced liver failure: Inhibition of histone acetylation by hydralazine derivatives
    • Murata K, Hamada M, Sugimoto K, Nakano T. A novel mechanism for drug-induced liver failure: inhibition of histone acetylation by hydralazine derivatives. J Hepatol 2007; 46:322-329.
    • (2007) J Hepatol , vol.46 , pp. 322-329
    • Murata, K.1    Hamada, M.2    Sugimoto, K.3    Nakano, T.4
  • 86
    • 84874081787 scopus 로고    scopus 로고
    • Hair analysis for determination of isoniazid concentrations and acetylator phenotype during antituberculous treatment
    • Eisenhut M, Thieme D, Schmid D, Fieseler S, Sachs H. Hair analysis for determination of isoniazid concentrations and acetylator phenotype during antituberculous treatment. Tuberc Res Treat 2012; 2012:327027.
    • (2012) Tuberc Res Treat , vol.2012 , pp. 327027
    • Eisenhut, M.1    Thieme, D.2    Schmid, D.3    Fieseler, S.4    Sachs, H.5
  • 89
    • 35348922264 scopus 로고    scopus 로고
    • Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis
    • Cho HJ, Koh WJ, Ryu YJ, Ki CS, Nam MH, Kim JW, Lee SY. Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis. Tuberculosis (Edinb) 2007; 87:551-556.
    • (2007) Tuberculosis (Edinb) , vol.87 , pp. 551-556
    • Cho, H.J.1    Koh, W.J.2    Ryu, Y.J.3    Ki, C.S.4    Nam, M.H.5    Kim, J.W.6    Lee, S.Y.7
  • 90
    • 80053962830 scopus 로고    scopus 로고
    • Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients
    • Teixeira RL, Morato G, Cabello PH, Muniz LM, Moreira Ada S, Kritski AL, et al. Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients. Mem Inst Oswaldo Cruz 2011; 106:716-724.
    • (2011) Mem Inst Oswaldo Cruz , vol.106 , pp. 716-724
    • Teixeira, R.L.1    Morato, G.2    Cabello, P.H.3    Muniz, L.M.4    Moreira Ada, S.5    Kritski, A.L.6
  • 91
    • 84872788104 scopus 로고    scopus 로고
    • Sex, ethnicity and slow acetylator profile are the major causes of hepatotoxicity induced by antituberculosis drugs
    • Chamorro JG, Castagnino JP, Musella RM, Nogueras M, Aranda FM, Frías A, et al. Sex, ethnicity and slow acetylator profile are the major causes of hepatotoxicity induced by antituberculosis drugs. J Gastroenterol Hepatol 2013; 28:323-328.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 323-328
    • Chamorro, J.G.1    Castagnino, J.P.2    Musella, R.M.3    Nogueras, M.4    Aranda, F.M.5    Frías, A.6
  • 92
    • 84862869146 scopus 로고    scopus 로고
    • Comparison between acetylator phenotype and genotype polymorphism of N-acetyltransferase-2 in tuberculosis patients
    • Rana SV, Ola RP, Sharma SK, Arora SK, Sinha SK, Pandhi P, Singh K. Comparison between acetylator phenotype and genotype polymorphism of N-acetyltransferase-2 in tuberculosis patients. Hepatol Int 2012; 6:397-402.
    • (2012) Hepatol Int , vol.6 , pp. 397-402
    • Rana, S.V.1    Ola, R.P.2    Sharma, S.K.3    Arora, S.K.4    Sinha, S.K.5    Pandhi, P.6    Singh, K.7
  • 93
    • 79551652905 scopus 로고    scopus 로고
    • Association of N-acetyltransferase-2 genotypes and anti-tuberculosis induced liver injury; First case-controlled study from Iran
    • Khalili H, Fouladdel S, Sistanizad M, Hajiabdolbaghi M, Azizi E. Association of N-acetyltransferase-2 genotypes and anti-tuberculosis induced liver injury; first case-controlled study from Iran. Curr Drug Saf 2011; 6:17-22.
    • (2011) Curr Drug Saf , vol.6 , pp. 17-22
    • Khalili, H.1    Fouladdel, S.2    Sistanizad, M.3    Hajiabdolbaghi, M.4    Azizi, E.5
  • 94
    • 17644441355 scopus 로고    scopus 로고
    • Slow N-acetyltransferase 2 genotype affects the incidence of isoniazid and rifampicin-induced hepatotoxicity
    • Ohno M, Yamaguchi I, Yamamoto I, Fukuda T, Yokota S, Maekura R, et al. Slow N-acetyltransferase 2 genotype affects the incidence of isoniazid and rifampicin-induced hepatotoxicity. Int J Tuberc Lung Dis 2000; 4:256-261.
    • (2000) Int J Tuberc Lung Dis , vol.4 , pp. 256-261
    • Ohno, M.1    Yamaguchi, I.2    Yamamoto, I.3    Fukuda, T.4    Yokota, S.5    Maekura, R.6
  • 95
    • 0036202380 scopus 로고    scopus 로고
    • Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis
    • Huang YS, Chern HD, Su WJ, Wu JC, Lai SL, Yang SY, et al. Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis. Hepatology 2002; 35:883-889.
    • (2002) Hepatology , vol.35 , pp. 883-889
    • Huang, Y.S.1    Chern, H.D.2    Su, W.J.3    Wu, J.C.4    Lai, S.L.5    Yang, S.Y.6
  • 96
    • 33746873652 scopus 로고    scopus 로고
    • DNA microarray genotyping of N-acetyltransferase 2 polymorphism using carbodiimide as the linker for assessment of isoniazid hepatotoxicity
    • Shimizu Y, Dobashi K, Mita Y, Endou K, Moriya S, Osano K, et al. DNA microarray genotyping of N-acetyltransferase 2 polymorphism using carbodiimide as the linker for assessment of isoniazid hepatotoxicity. Tuberculosis (Edinb) 2006; 86:374-381.
    • (2006) Tuberculosis (Edinb) , vol.86 , pp. 374-381
    • Shimizu, Y.1    Dobashi, K.2    Mita, Y.3    Endou, K.4    Moriya, S.5    Osano, K.6
  • 97
    • 82755165151 scopus 로고    scopus 로고
    • Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients
    • Yimer G, Ueda N, Habtewold A, Amogne W, Suda A, Riedel KD, et al. Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients. PLoS One 2011; 6:e27810.
    • (2011) PLoS One , vol.6
    • Yimer, G.1    Ueda, N.2    Habtewold, A.3    Amogne, W.4    Suda, A.5    Riedel, K.D.6
  • 98
    • 84864878582 scopus 로고    scopus 로고
    • Genetic interaction between NAT2, GSTM1, GSTT1, CYP2E1, and environmental factors is associated with adverse reactions to anti-tuberculosis drugs
    • Costa GN, Magno LA, Santana CV, Konstantinovas C, Saito ST, Machado M, et al. Genetic interaction between NAT2, GSTM1, GSTT1, CYP2E1, and environmental factors is associated with adverse reactions to anti-tuberculosis drugs. Mol Diagn Ther 2012; 16:241-250.
    • (2012) Mol Diagn Ther , vol.16 , pp. 241-250
    • Costa, G.N.1    Magno, L.A.2    Santana, C.V.3    Konstantinovas, C.4    Saito, S.T.5    MacHado, M.6
  • 100
    • 70649115521 scopus 로고    scopus 로고
    • Genetic variations of NAT2 and CYP2E1 and isoniazid hepatotoxicity in a diverse population
    • Yamada S, Tang M, Richardson K, Halaschek-Wiener J, Chan M, Cook VJ, et al. Genetic variations of NAT2 and CYP2E1 and isoniazid hepatotoxicity in a diverse population. Pharmacogenomics 2009; 10:1433-1445.
    • (2009) Pharmacogenomics , vol.10 , pp. 1433-1445
    • Yamada, S.1    Tang, M.2    Richardson, K.3    Halaschek-Wiener, J.4    Chan, M.5    Cook, V.J.6
  • 101
    • 84865340613 scopus 로고    scopus 로고
    • NAT2 genetic polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in Chinese community population
    • Lv X, Tang S, Xia Y, Zhang Y, Wu S, Yang Z, et al. NAT2 genetic polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in Chinese community population. Ann Hepatol 2012; 11:700-707.
    • (2012) Ann Hepatol , vol.11 , pp. 700-707
    • Lv, X.1    Tang, S.2    Xia, Y.3    Zhang, Y.4    Wu, S.5    Yang, Z.6
  • 103
    • 33645858545 scopus 로고    scopus 로고
    • Predisposition of antituberculosis drug induced hepatotoxicity by cytochrome P450 2E1 genotype and haplotype in pediatric patients
    • Roy B, Ghosh SK, Sutradhar D, Sikdar N, Mazumder S, Barman S. Predisposition of antituberculosis drug induced hepatotoxicity by cytochrome P450 2E1 genotype and haplotype in pediatric patients. J Gastroenterol Hepatol 2006; 21:784-786.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 784-786
    • Roy, B.1    Ghosh, S.K.2    Sutradhar, D.3    Sikdar, N.4    Mazumder, S.5    Barman, S.6
  • 105
    • 84867650304 scopus 로고    scopus 로고
    • Pharmacogenetic study of drugmetabolising enzyme polymorphisms on the risk of anti-tuberculosis druginduced liver injury: A meta-analysis
    • Cai Y, Yi J, Zhou C, Shen X. Pharmacogenetic study of drugmetabolising enzyme polymorphisms on the risk of anti-tuberculosis druginduced liver injury: a meta-analysis. PLoS One 2012; 7:e47769.
    • (2012) PLoS One , vol.7
    • Cai, Y.1    Yi, J.2    Zhou, C.3    Shen, X.4
  • 106
    • 84878404733 scopus 로고    scopus 로고
    • Slow N-acetyltransferase 2 genotype contributes to anti-tuberculosis drug-induced hepatotoxicity: A meta-analysis
    • Du H, Chen X, Fang Y, Yan O, Xu H, Li L, et al. Slow N-acetyltransferase 2 genotype contributes to anti-tuberculosis drug-induced hepatotoxicity: a meta-analysis. Mol Biol Rep 2013; 40:3591-3596.
    • (2013) Mol Biol Rep , vol.40 , pp. 3591-3596
    • Du, H.1    Chen, X.2    Fang, Y.3    Yan, O.4    Xu, H.5    Li, L.6
  • 107
    • 51149118041 scopus 로고    scopus 로고
    • Drug-metabolising enzyme polymorphisms and predisposition to anti-tuberculosis drug-induced liver injury: A meta-analysis
    • Sun F, Chen Y, Xiang Y, Zhan S. Drug-metabolising enzyme polymorphisms and predisposition to anti-tuberculosis drug-induced liver injury: a meta-analysis. Int J Tuberc Lung Dis 2008; 12:994-1002.
    • (2008) Int J Tuberc Lung Dis , vol.12 , pp. 994-1002
    • Sun, F.1    Chen, Y.2    Xiang, Y.3    Zhan, S.4
  • 108
    • 84859706085 scopus 로고    scopus 로고
    • NAT2 polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury: A metaanalysis
    • Wang PY, Xie SY, Hao Q, Zhang C, Jiang BF. NAT2 polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury: a metaanalysis. Int J Tuberc Lung Dis 2012; 16:589-595.
    • (2012) Int J Tuberc Lung Dis , vol.16 , pp. 589-595
    • Wang, P.Y.1    Xie, S.Y.2    Hao, Q.3    Zhang, C.4    Jiang, B.F.5
  • 109
    • 84879461332 scopus 로고    scopus 로고
    • NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: A randomized controlled trial for pharmacogenetics-based therapy
    • Azuma J, Ohno M, Kubota R, Yokota S, Nagai T, Tsuyuguchi K, et al. NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: a randomized controlled trial for pharmacogenetics-based therapy. Eur J Clin Pharmacol 2013; 69:1091-1101.
    • (2013) Eur J Clin Pharmacol , vol.69 , pp. 1091-1101
    • Azuma, J.1    Ohno, M.2    Kubota, R.3    Yokota, S.4    Nagai, T.5    Tsuyuguchi, K.6
  • 110
    • 84904395504 scopus 로고    scopus 로고
    • Remedyrepack Inc Available at Accessed 5 March 2013
    • Remedyrepack Inc. Isoniazid tablet drug label. Available at: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid =8920d813-dc88-456d-8607- 47a0156a4b4b. [Accessed 5 March 2013].
    • Isoniazid Tablet Drug Label
  • 111
    • 84904389071 scopus 로고    scopus 로고
    • Eon Labs Inc Available at Accessed May 2014
    • Eon Labs, Inc. Isoniazid tablet. Available at: http://dailymed.nlm.nih. gov/dailymed/lookup.cfm?setid=1553312b-ed76-421c-a055-2579bdcf366c. [Accessed May 2014].
    • Isoniazid Tablet
  • 112
    • 84904389072 scopus 로고    scopus 로고
    • Available at Accessed 25 October 2013
    • PharmGKB drug labels page for isoniazid. Available at: http://www. pharmgkb.org/drug/PA450112?tabType = tabDrugLabels. [Accessed 25 October 2013].
    • PharmGKB Drug Labels Page for Isoniazid
  • 113
    • 41449111996 scopus 로고    scopus 로고
    • Diagnosis and management of HIV drug hypersensitivity
    • Davis CM, Shearer WT. Diagnosis and management of HIV drug hypersensitivity. J Allergy Clin Immunol 2008; 121:826-832, e825.
    • (2008) J Allergy Clin Immunol , vol.121 , Issue.826-832
    • Davis, C.M.1    Shearer, W.T.2
  • 115
    • 0030199251 scopus 로고    scopus 로고
    • Adverse events from drug therapy for human immunodeficiency virus disease
    • Moore RD, Fortgang I, Keruly J, Chaisson RE. Adverse events from drug therapy for human immunodeficiency virus disease. Am J Med 1996; 101:34-40.
    • (1996) Am J Med , vol.101 , pp. 34-40
    • Moore, R.D.1    Fortgang, I.2    Keruly, J.3    Chaisson, R.E.4
  • 116
    • 0033371831 scopus 로고    scopus 로고
    • Hypersensitivity reactions to high-dose co-trimoxazole in HIV-infected Malaysian and Scottish patients
    • Pakianathan MR, Kamarulzaman A, Ismail R, McMillan A, Scott GR. Hypersensitivity reactions to high-dose co-trimoxazole in HIV-infected Malaysian and Scottish patients. AIDS 1999; 13:1787-1788.
    • (1999) AIDS , vol.13 , pp. 1787-1788
    • Pakianathan, M.R.1    Kamarulzaman, A.2    Ismail, R.3    McMillan, A.4    Scott, G.R.5
  • 117
    • 0345628578 scopus 로고    scopus 로고
    • The arylamine N-acetyltransferase (NAT2) polymorphism and the risk of adverse reactions to co-trimoxazole in children
    • Zieli?ska E, Niewiarowski W, Bodalski J. The arylamine N-acetyltransferase (NAT2) polymorphism and the risk of adverse reactions to co-trimoxazole in children. Eur J Clin Pharmacol 1998; 54:779-785.
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 779-785
    • Zieliska, E.1    Niewiarowski, W.2    Bodalski, J.3
  • 118
    • 84866327058 scopus 로고    scopus 로고
    • Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity
    • Sacco JC, Abouraya M, Motsinger-Reif A, Yale SH, McCarty CA, Trepanier LA. Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity. Pharmacogenet Genomics 2012; 22:733-740.
    • (2012) Pharmacogenet Genomics , vol.22 , pp. 733-740
    • Sacco, J.C.1    Abouraya, M.2    Motsinger-Reif, A.3    Yale, S.H.4    McCarty, C.A.5    Trepanier, L.A.6
  • 119
    • 84883193885 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing
    • Clinical Pharmacogenetics Implementation Consortium
    • Leckband SG, Kelsoe JR, Dunnenberger HM, George AL Jr, Tran E, Berger R, et al. Clinical Pharmacogenetics Implementation Consortium. Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing. Clin Pharmacol Ther 2013; 94:324-328.
    • (2013) Clin Pharmacol Ther , vol.94 , pp. 324-328
    • Leckband, S.G.1    Kelsoe, J.R.2    Dunnenberger, H.M.3    George Jr., A.L.4    Tran, E.5    Berger, R.6
  • 121
    • 0033656847 scopus 로고    scopus 로고
    • Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity
    • Pirmohamed M, Alfirevic A, Vilar J, Stalford A, Wilkins EG, Sim E, Park BK. Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity. Pharmacogenetics 2000; 10:705-713.
    • (2000) Pharmacogenetics , vol.10 , pp. 705-713
    • Pirmohamed, M.1    Alfirevic, A.2    Vilar, J.3    Stalford, A.4    Wilkins, E.G.5    Sim, E.6    Park, B.K.7
  • 123
    • 0036000311 scopus 로고    scopus 로고
    • Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity
    • O'Neil WM, MacArthur RD, Farrough MJ, Doll MA, Fretland AJ, Hein DW, et al. Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity. J Clin Pharmacol 2002; 42:613-619.
    • (2002) J Clin Pharmacol , vol.42 , pp. 613-619
    • O'Neil, W.M.1    MacArthur, R.D.2    Farrough, M.J.3    Doll, M.A.4    Fretland, A.J.5    Hein, D.W.6
  • 124
    • 0034521474 scopus 로고    scopus 로고
    • Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS
    • Wolkenstein P, Loriot MA, Aractingi S, Cabelguenne A, Beaune P, Chosidow O. Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS. Pharmacogenetics 2000; 10:821-828.
    • (2000) Pharmacogenetics , vol.10 , pp. 821-828
    • Wolkenstein, P.1    Loriot, M.A.2    Aractingi, S.3    Cabelguenne, A.4    Beaune, P.5    Chosidow, O.6
  • 126
    • 0028219748 scopus 로고
    • Acetylation phenotype and cutaneous hypersensitivity to trimethoprimsulphamethoxazole in HIV-infected patients
    • Carr A, Gross AS, Hoskins JM, Penny R, Cooper DA. Acetylation phenotype and cutaneous hypersensitivity to trimethoprimsulphamethoxazole in HIV-infected patients. AIDS 1994; 8:333-337.
    • (1994) AIDS , vol.8 , pp. 333-337
    • Carr, A.1    Gross, A.S.2    Hoskins, J.M.3    Penny, R.4    Cooper, D.A.5
  • 128
    • 47749150312 scopus 로고    scopus 로고
    • Human N-acetyltransferases and drug-induced hepatotoxicity
    • Makarova SI. Human N-acetyltransferases and drug-induced hepatotoxicity. Curr Drug Metab 2008; 9:538-545.
    • (2008) Curr Drug Metab , vol.9 , pp. 538-545
    • Makarova, S.I.1
  • 129
    • 0017612048 scopus 로고
    • Metabolism of hydralazine
    • Israili ZH, Dayton PG. Metabolism of hydralazine. Drug Metab Rev 1977; 6:283-305.
    • (1977) Drug Metab Rev , vol.6 , pp. 283-305
    • Zh, I.1    Dayton, P.G.2
  • 131
    • 34548395116 scopus 로고    scopus 로고
    • A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors
    • Candelaria M, Gallardo-Rincon D, Arce C, Cetina L, Aguilar-Ponce JL, Arrieta O, et al. A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors. Ann Oncol 2007; 18:1529-1538.
    • (2007) Ann Oncol , vol.18 , pp. 1529-1538
    • Candelaria, M.1    Gallardo-Rincon, D.2    Arce, C.3    Cetina, L.4    Aguilar-Ponce, J.L.5    Arrieta, O.6
  • 134
    • 61549112191 scopus 로고    scopus 로고
    • Epigenomics and breast cancer
    • Lo PK, Sukumar S. Epigenomics and breast cancer. Pharmacogenomics 2008; 9:1879-1902.
    • (2008) Pharmacogenomics , vol.9 , pp. 1879-1902
    • Lo, P.K.1    Sukumar, S.2
  • 135
    • 0021813284 scopus 로고
    • N-acetylation pharmacogenetics
    • Weber WW, Hein DW. N-acetylation pharmacogenetics. Pharmacol Rev 1985; 37:25-79.
    • (1985) Pharmacol Rev , vol.37 , pp. 25-79
    • Weber, W.W.1    Hein, D.W.2
  • 136
    • 0029068479 scopus 로고
    • Acetylation and its role in the mutagenicity of the antihypertensive agent hydralazine
    • Lemke LE, McQueen CA. Acetylation and its role in the mutagenicity of the antihypertensive agent hydralazine. Drug Metab Dispos 1995; 23:559-565.
    • (1995) Drug Metab Dispos , vol.23 , pp. 559-565
    • Lemke, L.E.1    McQueen, C.A.2
  • 137
    • 80052216583 scopus 로고    scopus 로고
    • Pharmacokinetics of hydralazine, an antihypertensive and DNA-demethylating agent, using controlled-release formulations designed for use in dosing schedules based on the acetylator phenotype
    • Gonzalez-Fierro A, Vasquez-Bahena D, Taja-Chayeb L, Vidal S, Trejo-Becerril C, Pérez-Cardenas E, et al. Pharmacokinetics of hydralazine, an antihypertensive and DNA-demethylating agent, using controlled-release formulations designed for use in dosing schedules based on the acetylator phenotype. Int J Clin Pharmacol Ther 2011; 49:519-524.
    • (2011) Int J Clin Pharmacol Ther , vol.49 , pp. 519-524
    • Gonzalez-Fierro, A.1    Vasquez-Bahena, D.2    Taja-Chayeb, L.3    Vidal, S.4    Trejo-Becerril, C.5    Pérez-Cardenas, E.6
  • 138
    • 0026892629 scopus 로고
    • Acetylation status using hydralazine in African hypertensives at Kenyatta National Hospital
    • Rashid JR, Kofi T, Juma FD. Acetylation status using hydralazine in African hypertensives at Kenyatta National Hospital. East Afr Med J 1992; 69:406-408.
    • (1992) East Afr Med J , vol.69 , pp. 406-408
    • Rashid, J.R.1    Kofi, T.2    Juma, F.D.3
  • 139
    • 84893068653 scopus 로고    scopus 로고
    • Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension
    • Spinasse LB, Santos AR, Suffys PN, Muxfeldt ES, Salles GF. Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension. Pharmacogenomics 2014; 15:169-178.
    • (2014) Pharmacogenomics , vol.15 , pp. 169-178
    • Spinasse, L.B.1    Santos, A.R.2    Suffys, P.N.3    Muxfeldt, E.S.4    Salles, G.F.5
  • 140
    • 0024988880 scopus 로고
    • The effects of oral hydralazine on blood pressure, cardiac output and peripheral resistance with respect to dose, age and acetylator status
    • Rowell NP, Clark K. The effects of oral hydralazine on blood pressure, cardiac output and peripheral resistance with respect to dose, age and acetylator status. Radiother Oncol 1990; 18:293-298.
    • (1990) Radiother Oncol , vol.18 , pp. 293-298
    • Rowell, N.P.1    Clark, K.2
  • 142
    • 84904388584 scopus 로고    scopus 로고
    • Arbor Pharmaceuticals Inc. Available at Accessed 26 March 2013
    • Arbor Pharmaceuticals Inc. BIDIL (hydralazine hydrochloride and isosorbide dinitrate) tablet, film coated. Available at: http://dailymed.nlm. nih.gov/dailymed/lookup.cfm?setid= e1e63cd5-d1e4-4af5-bad5-1ad41ea46b00. [Accessed 26 March 2013].
    • BIDIL (Hydralazine Hydrochloride and Isosorbide Dinitrate) Tablet Film Coated
  • 144
    • 79955395000 scopus 로고    scopus 로고
    • Drug-induced lupus erythematosus: Incidence, management and prevention
    • Chang C, Gershwin ME. Drug-induced lupus erythematosus: incidence, management and prevention. Drug Saf 2011; 34:357-374.
    • (2011) Drug Saf , vol.34 , pp. 357-374
    • Chang, C.1    Gershwin, M.E.2
  • 145
    • 0021165629 scopus 로고
    • Drugs that induce systemic lupus erythematosus inhibit complement component C4
    • Sim E, Gill EW, Sim RB. Drugs that induce systemic lupus erythematosus inhibit complement component C4. Lancet 1984; 2:422-424.
    • (1984) Lancet , vol.2 , pp. 422-424
    • Sim, E.1    Gill, E.W.2    Sim, R.B.3
  • 146
    • 77649184584 scopus 로고    scopus 로고
    • The complement system in systemic autoimmune disease
    • Chen M, Daha MR, Kallenberg CG. The complement system in systemic autoimmune disease. J Autoimmun 2010; 34:J276-J286.
    • (2010) J Autoimmun , vol.34
    • Chen, M.1    Daha, M.R.2    Kallenberg, C.G.3
  • 147
    • 34247630966 scopus 로고    scopus 로고
    • Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus
    • Mazari L, Ouarzane M, Zouali M. Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus. Proc Natl Acad Sci USA 2007; 104:6317-6322.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6317-6322
    • Mazari, L.1    Ouarzane, M.2    Zouali, M.3
  • 148
    • 79952233097 scopus 로고    scopus 로고
    • Loss of histone acetyltransferase cofactor transformation/transcription domain-associated protein impairs liver regeneration after toxic injury
    • Shukla V, Cuenin C, Dubey N, Herceg Z. Loss of histone acetyltransferase cofactor transformation/transcription domain-associated protein impairs liver regeneration after toxic injury. Hepatology 2011; 53:954-963.
    • (2011) Hepatology , vol.53 , pp. 954-963
    • Shukla, V.1    Cuenin, C.2    Dubey, N.3    Herceg, Z.4
  • 149
    • 80052853209 scopus 로고    scopus 로고
    • Activation of inactive hepatocytes through histone acetylation: A mechanism for functional compensation after massive loss of hepatocytes
    • Shi Y, Sun H, Bao J, Zhou P, Zhang J, Li L, Bu H. Activation of inactive hepatocytes through histone acetylation: a mechanism for functional compensation after massive loss of hepatocytes. Am J Pathol 2011; 179:1138-1147.
    • (2011) Am J Pathol , vol.179 , pp. 1138-1147
    • Shi, Y.1    Sun, H.2    Bao, J.3    Zhou, P.4    Zhang, J.5    Li, L.6    Bu, H.7
  • 150
    • 78651287426 scopus 로고    scopus 로고
    • DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs
    • Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, et al. DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs. Nucleic Acids Res 2011; 39:D1035-D1041.
    • (2011) Nucleic Acids Res , vol.39
    • Knox, C.1    Law, V.2    Jewison, T.3    Liu, P.4    Ly, S.5    Frolkis, A.6
  • 153
    • 0017151106 scopus 로고
    • Clinical pharmacokinetics of sulphasalazine
    • Das KM, Dubin R. Clinical pharmacokinetics of sulphasalazine. Clin Pharmacokinet 1976; 1:406-425.
    • (1976) Clin Pharmacokinet , vol.1 , pp. 406-425
    • Das, K.M.1    Dubin, R.2
  • 154
    • 0015348162 scopus 로고
    • The role of intestinal bacteria in the metabolism of salicylazosulfapyridine
    • Peppercorn MA, Goldman P. The role of intestinal bacteria in the metabolism of salicylazosulfapyridine. J Pharmacol Exp Ther 1972; 181:555-562.
    • (1972) J Pharmacol Exp Ther , vol.181 , pp. 555-562
    • Peppercorn, M.A.1    Goldman, P.2
  • 155
    • 84904389066 scopus 로고    scopus 로고
    • Available at Accessed 13 August 2013
    • DrugBank: sulfasalazine DB00795. Available at: http://www.drugbank.ca/ drugs/DB00795. [Accessed 13 August 2013].
    • DrugBank: Sulfasalazine DB00795
  • 156
    • 45549106377 scopus 로고    scopus 로고
    • Pharmacogenetic characterization of sulfasalazine disposition based on NAT2 and ABCG2 (BCRP) gene polymorphisms in humans
    • Yamasaki Y, Ieiri I, Kusuhara H, Sasaki T, Kimura M, Tabuchi H, et al. Pharmacogenetic characterization of sulfasalazine disposition based on NAT2 and ABCG2 (BCRP) gene polymorphisms in humans. Clin Pharmacol Ther 2008; 84:95-103.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 95-103
    • Yamasaki, Y.1    Ieiri, I.2    Kusuhara, H.3    Sasaki, T.4    Kimura, M.5    Tabuchi, H.6
  • 157
    • 67651091328 scopus 로고    scopus 로고
    • Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population
    • Ma JJ, Liu CG, Li JH, Cao XM, Sun SL, Yao X. Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population. Clin Chim Acta 2009; 407:30-35.
    • (2009) Clin Chim Acta , vol.407 , pp. 30-35
    • Ma, J.J.1    Liu, C.G.2    Li, J.H.3    Cao, X.M.4    Sun, S.L.5    Yao, X.6
  • 159
    • 41849110551 scopus 로고    scopus 로고
    • Prospective study of the association between NAT2 gene haplotypes and severe adverse events with sulfasalazine therapy in patients with rheumatoid arthritis
    • Soejima M, Kawaguchi Y, Hara M, Kamatani N. Prospective study of the association between NAT2 gene haplotypes and severe adverse events with sulfasalazine therapy in patients with rheumatoid arthritis. J Rheumatol 2008; 35:724.
    • (2008) J Rheumatol , vol.35 , pp. 724
    • Soejima, M.1    Kawaguchi, Y.2    Hara, M.3    Kamatani, N.4
  • 161
    • 0021151820 scopus 로고
    • A simple test for acetylator phenotype using caffeine
    • Grant DM, Tang BK, Kalow W. A simple test for acetylator phenotype using caffeine. Br J Clin Pharmacol 1984; 17:459-464.
    • (1984) Br J Clin Pharmacol , vol.17 , pp. 459-464
    • Grant, D.M.1    Tang, B.K.2    Kalow, W.3
  • 162
    • 33847079175 scopus 로고    scopus 로고
    • In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios
    • Begas E, Kouvaras E, Tsakalof A, Papakosta S, Asprodini EK. In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios. Biomed Chromatogr 2007; 21:190-200.
    • (2007) Biomed Chromatogr , vol.21 , pp. 190-200
    • Begas, E.1    Kouvaras, E.2    Tsakalof, A.3    Papakosta, S.4    Asprodini, E.K.5
  • 163
    • 84870455236 scopus 로고    scopus 로고
    • Comparison of N-acetyltransferase-2 enzyme genotypephenotype and xanthine oxidase enzyme activity between Swedes and Koreans
    • Djordjevic N, Carrillo JA, Roh HK, Karlsson S, Ueda N, Bertilsson L, Aklillu E. Comparison of N-acetyltransferase-2 enzyme genotypephenotype and xanthine oxidase enzyme activity between Swedes and Koreans. J Clin Pharmacol 2012; 52:1527-1534.
    • (2012) J Clin Pharmacol , vol.52 , pp. 1527-1534
    • Djordjevic, N.1    Carrillo, J.A.2    Roh, H.K.3    Karlsson, S.4    Ueda, N.5    Bertilsson, L.6    Aklillu, E.7
  • 164
    • 79958796617 scopus 로고    scopus 로고
    • N-Acetyltransferase-2 (NAT2) gene polymorphisms and enzyme activity in Serbs: Unprecedented high prevalence of rapid acetylators in a White population
    • Djordjevic N, Carrillo JA, Ueda N, Gervasini G, Fukasawa T, Suda A, et al. N-Acetyltransferase-2 (NAT2) gene polymorphisms and enzyme activity in Serbs: unprecedented high prevalence of rapid acetylators in a White population. J Clin Pharmacol 2011; 51:994-1003.
    • (2011) J Clin Pharmacol , vol.51 , pp. 994-1003
    • Djordjevic, N.1    Carrillo, J.A.2    Ueda, N.3    Gervasini, G.4    Fukasawa, T.5    Suda, A.6
  • 166
    • 84894903618 scopus 로고    scopus 로고
    • Determination of urine caffeine and its metabolites by use of high-performance liquid chromatography-tandem mass spectrometry: Estimating dietary caffeine exposure and metabolic phenotyping in population studies
    • Rybak ME, Pao CI, Pfeiffer CM. Determination of urine caffeine and its metabolites by use of high-performance liquid chromatography-tandem mass spectrometry: estimating dietary caffeine exposure and metabolic phenotyping in population studies. Anal Bioanal Chem 2014; 406:771-784.
    • (2014) Anal Bioanal Chem , vol.406 , pp. 771-784
    • Rybak, M.E.1    Pao, C.I.2    Pfeiffer, C.M.3
  • 167
    • 33845287618 scopus 로고    scopus 로고
    • Concordance between the deduced acetylation status generated by high-speed: Realtime PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay
    • Rihs HP, John A, Scherenberg M, Seidel A, Brüning T. Concordance between the deduced acetylation status generated by high-speed: realtime PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay. Clin Chim Acta 2007; 376:240-243.
    • (2007) Clin Chim Acta , vol.376 , pp. 240-243
    • Rihs, H.P.1    John, A.2    Scherenberg, M.3    Seidel, A.4    Brüning, T.5
  • 168
    • 0034467572 scopus 로고    scopus 로고
    • Correlation between acetylation phenotype and genotype in Chinese women
    • Zhao B, Seow A, Lee EJ, Lee HP. Correlation between acetylation phenotype and genotype in Chinese women. Eur J Clin Pharmacol 2000; 56:689-692.
    • (2000) Eur J Clin Pharmacol , vol.56 , pp. 689-692
    • Zhao, B.1    Seow, A.2    Lee, E.J.3    Lee, H.P.4
  • 169
    • 0030850564 scopus 로고    scopus 로고
    • N-acetylation among HIV-positive patients and patients with AIDS: When is fast fast and slow slow?
    • O'Neil WM, Gilfix BM, DiGirolamo A, Tsoukas CM, Wainer IW. N-acetylation among HIV-positive patients and patients with AIDS: when is fast, fast and slow, slow? Clin Pharmacol Ther 1997; 62:261-271.
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 261-271
    • O'Neil, W.M.1    Gilfix, B.M.2    Digirolamo, A.3    Tsoukas, C.M.4    Wainer, I.W.5
  • 170
    • 0029163589 scopus 로고
    • Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: Correlation with phenotypic activity
    • Cascorbi I, Drakoulis N, Brockmöller J, Maurer A, Sperling K, Roots I. Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity. Am J Hum Genet 1995; 57:581-592.
    • (1995) Am J Hum Genet , vol.57 , pp. 581-592
    • Cascorbi, I.1    Drakoulis, N.2    Brockmöller, J.3    Maurer, A.4    Sperling, K.5    Roots, I.6
  • 173
    • 0345549570 scopus 로고    scopus 로고
    • Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug
    • Vrtic F, Haefeli WE, Drewe J, Krahenbühl S, Wenk M. Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug. Br J Clin Pharmacol 2003; 55:191-198.
    • (2003) Br J Clin Pharmacol , vol.55 , pp. 191-198
    • Vrtic, F.1    Haefeli, W.E.2    Drewe, J.3    Krahenbühl, S.4    Wenk, M.5
  • 174
    • 84878517121 scopus 로고    scopus 로고
    • Association of genotypes of carcinogen-metabolizing enzymes and smoking status with bladder cancer in a Japanese population
    • Cui X, Lu X, Hiura M, Omori H, Miyazaki W, Katoh T. Association of genotypes of carcinogen-metabolizing enzymes and smoking status with bladder cancer in a Japanese population. Environ Health Prev Med 2013; 18:136-142.
    • (2013) Environ Health Prev Med , vol.18 , pp. 136-142
    • Cui, X.1    Lu, X.2    Hiura, M.3    Omori, H.4    Miyazaki, W.5    Katoh, T.6
  • 177
    • 34447522033 scopus 로고    scopus 로고
    • Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: Meta-analysis, historical refinements of the hypothesis, and lessons learned
    • Rothman N, Garcia-Closas M, Hein DW. Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: meta-analysis, historical refinements of the hypothesis, and lessons learned. Int J Epidemiol 2007; 36:23-28.
    • (2007) Int J Epidemiol , vol.36 , pp. 23-28
    • Rothman, N.1    Garcia-Closas, M.2    Hein, D.W.3
  • 178
    • 84878385173 scopus 로고    scopus 로고
    • N-acetyltransferase 1 polymorphism and bladder cancer susceptibility: A meta-analysis of epidemiological studies
    • Wu K, Wang X, Xie Z, Liu Z, Lu Y. N-acetyltransferase 1 polymorphism and bladder cancer susceptibility: a meta-analysis of epidemiological studies. J Int Med Res 2013; 41:31-37.
    • (2013) J Int Med Res , vol.41 , pp. 31-37
    • Wu, K.1    Wang, X.2    Xie, Z.3    Liu, Z.4    Lu, Y.5
  • 181
    • 84866246303 scopus 로고    scopus 로고
    • N-acetyltransferase 1 (NAT1) genotype: A risk factor for urinary bladder cancer in a Lebanese population
    • Yassine IA, Kobeissi L, Jabbour ME, Dhaini HR. N-acetyltransferase 1 (NAT1) genotype: a risk factor for urinary bladder cancer in a Lebanese population. J Oncol 2012; 2012:512976.
    • (2012) J Oncol , vol.2012 , pp. 512976
    • Yassine, I.A.1    Kobeissi, L.2    Jabbour, M.E.3    Dhaini, H.R.4
  • 182
    • 26444618665 scopus 로고    scopus 로고
    • Arylamine N-acetyltransferases: What we learn from genes and genomes
    • Boukouvala S, Fakis G. Arylamine N-acetyltransferases: what we learn from genes and genomes. Drug Metab Rev 2005; 37:511-564.
    • (2005) Drug Metab Rev , vol.37 , pp. 511-564
    • Boukouvala, S.1    Fakis, G.2
  • 183
    • 47749085094 scopus 로고    scopus 로고
    • Polymorphisms of human N-acetyltransferases and cancer risk
    • Agúndez JA. Polymorphisms of human N-acetyltransferases and cancer risk. Curr Drug Metab 2008; 9:520-531.
    • (2008) Curr Drug Metab , vol.9 , pp. 520-531
    • Agúndez, J.A.1
  • 184
    • 84898819786 scopus 로고    scopus 로고
    • N-acetyltransferase 2 genetic variants confer the susceptibility to head and neck carcinoma: Evidence from 23 case-control studies
    • Zhang L, Xiang Z, Hao R, Li R, Zhu Y. N-acetyltransferase 2 genetic variants confer the susceptibility to head and neck carcinoma: evidence from 23 case-control studies. Tumour Biol 2014; 35:3585-3595.
    • (2014) Tumour Biol , vol.35 , pp. 3585-3595
    • Zhang, L.1    Xiang, Z.2    Hao, R.3    Li, R.4    Zhu, Y.5
  • 185
    • 84879101410 scopus 로고    scopus 로고
    • Genetic polymorphisms of CYP2E1, GST, and NAT2 enzymes are not associated with risk of breast cancer in a sample of Lebanese women
    • Zgheib NK, Shamseddine AA, Geryess E, Tfayli A, Bazarbachi A, Salem Z, et al. Genetic polymorphisms of CYP2E1, GST, and NAT2 enzymes are not associated with risk of breast cancer in a sample of Lebanese women. Mutat Res 2013; 747-748:40-47.
    • (2013) Mutat Res , vol.747-748 , pp. 40-47
    • Zgheib, N.K.1    Shamseddine, A.A.2    Geryess, E.3    Tfayli, A.4    Bazarbachi, A.5    Salem, Z.6
  • 187
    • 34547498552 scopus 로고    scopus 로고
    • Association of genetic polymorphisms of N-acetyltransferase 2 and susceptibility to esophageal cancer in north Indian population
    • Jain M, Kumar S, Lal P, Tiwari A, Ghoshal UC, Mittal B. Association of genetic polymorphisms of N-acetyltransferase 2 and susceptibility to esophageal cancer in north Indian population. Cancer Invest 2007; 25:340-346.
    • (2007) Cancer Invest , vol.25 , pp. 340-346
    • Jain, M.1    Kumar, S.2    Lal, P.3    Tiwari, A.4    Ghoshal, U.C.5    Mittal, B.6
  • 188
    • 70349089654 scopus 로고    scopus 로고
    • Association of NAT2 gene polymorphisms with susceptibility to esophageal and gastric cancers in the Kashmir Valley
    • Malik MA, Upadhyay R, Modi DR, Zargar SA, Mittal B. Association of NAT2 gene polymorphisms with susceptibility to esophageal and gastric cancers in the Kashmir Valley. Arch Med Res 2009; 40:416-423.
    • (2009) Arch Med Res , vol.40 , pp. 416-423
    • Malik, M.A.1    Upadhyay, R.2    Modi, D.R.3    Zargar, S.A.4    Mittal, B.5
  • 189
    • 84896789247 scopus 로고    scopus 로고
    • N-acetyltransferase 2 polymorphisms and risk of esophageal cancer in a Chinese population
    • Wang L, Tang W, Chen S, Sun Y, Fan Y, Shi Y, et al. N-acetyltransferase 2 polymorphisms and risk of esophageal cancer in a Chinese population. PLoS One 2014; 9:e87783.
    • (2014) PLoS One , vol.9
    • Wang, L.1    Tang, W.2    Chen, S.3    Sun, Y.4    Fan, Y.5    Shi, Y.6
  • 190
    • 84871795082 scopus 로고    scopus 로고
    • Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: A pooled analysis within the InterLymph consortium
    • Gibson TM, Smedby KE, Skibola CF, Hein DW, Slager SL, de Sanjose S, et al. Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium. Cancer Causes Control 2013; 24:125-134.
    • (2013) Cancer Causes Control , vol.24 , pp. 125-134
    • Gibson, T.M.1    Smedby, K.E.2    Skibola, C.F.3    Hein, D.W.4    Slager, S.L.5    De Sanjose, S.6
  • 191
    • 39449127911 scopus 로고    scopus 로고
    • Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk
    • Shin A, Shrubsole MJ, Rice JM, Cai Q, Doll MA, Long J, et al. Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk. Cancer Epidemiol Biomarkers Prev 2008; 17:320-329.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 320-329
    • Shin, A.1    Shrubsole, M.J.2    Rice, J.M.3    Cai, Q.4    Doll, M.A.5    Long, J.6
  • 192
    • 84872699097 scopus 로고    scopus 로고
    • Systematic review: Diet-gene interactions and the risk of colorectal cancer
    • Andersen V, Holst R, Vogel U. Systematic review: diet-gene interactions and the risk of colorectal cancer. Aliment Pharmacol Ther 2013; 37:383-391.
    • (2013) Aliment Pharmacol Ther , vol.37 , pp. 383-391
    • Andersen, V.1    Holst, R.2    Vogel, U.3
  • 193
    • 84856579677 scopus 로고    scopus 로고
    • Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct
    • Millner LM, Doll MA, Stepp MW, States JC, Hein DW. Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct. Carcinogenesis 2012; 33:348-355.
    • (2012) Carcinogenesis , vol.33 , pp. 348-355
    • Millner, L.M.1    Doll, M.A.2    Stepp, M.W.3    States, J.C.4    Hein, D.W.5
  • 194
    • 47649088476 scopus 로고    scopus 로고
    • Arylamine N-acetyltransferases: From structure to function
    • Sim E, Walters K, Boukouvala S. Arylamine N-acetyltransferases: from structure to function. Drug Metab Rev 2008; 40:479-510.
    • (2008) Drug Metab Rev , vol.40 , pp. 479-510
    • Sim, E.1    Walters, K.2    Boukouvala, S.3
  • 195
    • 12444303338 scopus 로고    scopus 로고
    • Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro
    • Adam PJ, Berry J, Loader JA, Tyson KL, Craggs G, Smith P, et al. Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro. Mol Cancer Res 2003; 1:826-835.
    • (2003) Mol Cancer Res , vol.1 , pp. 826-835
    • Adam, P.J.1    Berry, J.2    Loader, J.A.3    Tyson, K.L.4    Craggs, G.5    Smith, P.6
  • 196
    • 77949353335 scopus 로고    scopus 로고
    • Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker
    • Laurieri N, Crawford MH, Kawamura A, Westwood IM, Robinson J, Fletcher AM, et al. Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker. J Am Chem Soc 2010; 132:3238-3239.
    • (2010) J Am Chem Soc , vol.132 , pp. 3238-3239
    • Laurieri, N.1    Crawford, M.H.2    Kawamura, A.3    Westwood, I.M.4    Robinson, J.5    Fletcher, A.M.6
  • 197
    • 79951796583 scopus 로고    scopus 로고
    • RNAimediated knock-down of arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition
    • Tiang JM, Butcher NJ, Cullinane C, Humbert PO, Minchin RF. RNAimediated knock-down of arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition. PLoS One 2011; 6:e17031.
    • (2011) PLoS One , vol.6
    • Tiang, J.M.1    Butcher, N.J.2    Cullinane, C.3    Humbert, P.O.4    Minchin, R.F.5
  • 198
    • 77249105346 scopus 로고    scopus 로고
    • Small molecule inhibition of arylamine N-acetyltransferase Type i inhibits proliferation and invasiveness of MDAMB-231 breast cancer cells
    • Tiang JM, Butcher NJ, Minchin RF. Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDAMB-231 breast cancer cells. Biochem Biophys Res Commun 2010; 393:95-100.
    • (2010) Biochem Biophys Res Commun , vol.393 , pp. 95-100
    • Tiang, J.M.1    Butcher, N.J.2    Minchin, R.F.3
  • 199
    • 58549100461 scopus 로고    scopus 로고
    • Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2
    • Russell AJ, Westwood IM, Crawford MH, Robinson J, Kawamura A, Redfield C, et al. Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2. Bioorg Med Chem 2009; 17:905-918.
    • (2009) Bioorg Med Chem , vol.17 , pp. 905-918
    • Russell, A.J.1    Westwood, I.M.2    Crawford, M.H.3    Robinson, J.4    Kawamura, A.5    Redfield, C.6
  • 200
    • 44249120547 scopus 로고    scopus 로고
    • Identification of the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 as a new target of cisplatin in breast cancer cells: Molecular and cellular mechanisms of inhibition
    • Ragunathan N, Dairou J, Pluvinage B, Martins M, Petit E, Janel N, et al. Identification of the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 as a new target of cisplatin in breast cancer cells: molecular and cellular mechanisms of inhibition. Mol Pharmacol 2008; 73:1761-1768.
    • (2008) Mol Pharmacol , vol.73 , pp. 1761-1768
    • Ragunathan, N.1    Dairou, J.2    Pluvinage, B.3    Martins, M.4    Petit, E.5    Janel, N.6
  • 201
    • 0041307168 scopus 로고    scopus 로고
    • Tamoxifen inhibits arylamine N-acetyltransferase activity and DNA-2-aminofluorene adduct in human leukemia HL-60 cells
    • Lu KH, Lin KL, Hsia TC, Hung CF, Chou MC, Hsiao YM, Chung JG. Tamoxifen inhibits arylamine N-acetyltransferase activity and DNA-2-aminofluorene adduct in human leukemia HL-60 cells. Res Commun Mol Pathol Pharmacol 2001; 109:319-331.
    • (2001) Res Commun Mol Pathol Pharmacol , vol.109 , pp. 319-331
    • Lu, K.H.1    Lin, K.L.2    Hsia, T.C.3    Hung, C.F.4    Chou, M.C.5    Hsiao, Y.M.6    Chung, J.G.7
  • 202
    • 34447291564 scopus 로고    scopus 로고
    • Effects of tamoxifen on DNA adduct formation and arylamines N-acetyltransferase activity in human breast cancer cells
    • Lee JH, Lu HF, Wang DY, Chen DR, Su CC, Chen YS, et al. Effects of tamoxifen on DNA adduct formation and arylamines N-acetyltransferase activity in human breast cancer cells. Res Commun Mol Pathol Pharmacol 2004; 115-116:217-233.
    • (2004) Res Commun Mol Pathol Pharmacol , vol.115-116 , pp. 217-233
    • Lee, J.H.1    Lu, H.F.2    Wang, D.Y.3    Chen, D.R.4    Su, C.C.5    Chen, Y.S.6
  • 203
    • 84856240667 scopus 로고    scopus 로고
    • Amonafide: A future in treatment of resistant and secondary acute myeloid leukemia?
    • Freeman CL, Swords R, Giles FJ. Amonafide: a future in treatment of resistant and secondary acute myeloid leukemia? Expert Rev Hematol 2012; 5:17-26.
    • (2012) Expert Rev Hematol , vol.5 , pp. 17-26
    • Freeman, C.L.1    Swords, R.2    Giles, F.J.3
  • 204
    • 0035057872 scopus 로고    scopus 로고
    • Pharmacogenetics of anticancer agents: Lessons from amonafide and irinotecan
    • Innocenti F, Iyer L, Ratain MJ. Pharmacogenetics of anticancer agents: lessons from amonafide and irinotecan. Drug Metab Dispos 2001; 29:596-600.
    • (2001) Drug Metab Dispos , vol.29 , pp. 596-600
    • Innocenti, F.1    Iyer, L.2    Ratain, M.J.3
  • 208
    • 0029919926 scopus 로고    scopus 로고
    • Individualized dosing of amonafide based on a pharmacodynamic model incorporating acetylator phenotype and gender
    • Ratain MJ, Mick R, Janisch L, Berezin F, Schilsky RL, Vogelzang NJ, Kut M. Individualized dosing of amonafide based on a pharmacodynamic model incorporating acetylator phenotype and gender. Pharmacogenetics 1996; 6:93-101.
    • (1996) Pharmacogenetics , vol.6 , pp. 93-101
    • Ratain, M.J.1    Mick, R.2    Janisch, L.3    Berezin, F.4    Schilsky, R.L.5    Vogelzang, N.J.6    Kut, M.7
  • 209
    • 47749083130 scopus 로고    scopus 로고
    • Influence of polymorphic N-acetyltransferases on nonmalignant spontaneous disorders and on response to drugs
    • Ladero JM. Influence of polymorphic N-acetyltransferases on nonmalignant spontaneous disorders and on response to drugs. Curr Drug Metab 2008; 9:532-537.
    • (2008) Curr Drug Metab , vol.9 , pp. 532-537
    • Ladero, J.M.1
  • 210
    • 47749156802 scopus 로고    scopus 로고
    • N-acetyltransferases as markers for asthma and allergic/atopic disorders
    • Batra J, Ghosh B. N-acetyltransferases as markers for asthma and allergic/atopic disorders. Curr Drug Metab 2008; 9:546-553.
    • (2008) Curr Drug Metab , vol.9 , pp. 546-553
    • Batra, J.1    Ghosh, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.