N-Acetyltransferase 2 polymorphism in patients infected with human immunodeficiency virus

Clinical Pharmacology and Therapeutics

Volumn 60, Issue 1, 1996, Pages 62-67

  Kaufmann, Gilbert R ^b   Wenk, Markus ^b   Taeschner, Walter ^b   Peterli, Bettina ^b   Gyr, Klaus ^b   Meyer, Urs A ^b   Haefeli, Walter E ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; CAFFEINE;

ACETYLATOR PHENOTYPE; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG METABOLISM; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL;

EID: 0029739044     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(96)90168-X     Document Type: Article

References (18)

1. Evans DA. Genetic factors in drug therapy: clinical and molecular pharmacogenetics. Cambridge: Cambridge University Press 1993;5:211-85.
2. Blum M, Demierre A, Grant DM, Heim M, Meyer UA. Molecular mechanism of slow acetylation of drugs and carcinogens in humans. Proc Natl Acad Sci USA 1991;88:5237-41.
3. Bell DA, Taylor JA, Butler MA, Stephens EA, Wiest J, Brubaker LH, et al. Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans. Carcinogenesis 1993;14:1689-92.
4. Carr A, Gross AS, Hoskins JM, Penny R, Cooper DA. Acetylation phenotype and cutaneous hypersensitivity to trimethoprim-sulfamethoxazole in HIV-infected patients. AIDS 1994;8:333-7.
5. Rieder MJ, Shear NH, Kanee BK, Tang BK, Spielberg SP. Prominence of slow acetylator phenotype among patients with sulfonamide hypersensitivity. Clin Pharmacol Ther 1991;49:13-7.
6. Lee BL, Wong D, Benowitz NL, Sullam PM. Altered patterns of drug metabolism in patients with acquired immunodeficiency syndrome. Clin Pharmacol Ther 1993;53:529-35.
7. Centers for Disease Control and Prevention. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR 1992;41(RR-17):1-19.
8. Grant DM, Tang BK, Kalow W. A simple test for acetylator phenotype using caffeine. Br J Clin Pharmacol 1984;17:459-64.
9. Graf T, Broly F, Hoffmann F, Probst M, Meyer UA, Howald H. Prediction of phenotype for acetylation and for debrisoquine hydroxylation by DNA tests in healthy human volunteers. Eur J Clin Pharmacol 1992;43:399-403.
10. Lin HJ, Chun-Ya H, Bruce KL, Steven H. Slow acetylator mutations in human polymorphic N-acetyltransferase gene in 786 Asians, blacks, Hispanics and whites: application to metabolic epidemiology. Am J Hum Genet 1993;52:827-34.
11. Vatsis KP, Martell KJ, Weber WW. Diverse point mutations in the human gene for polymorphic N-acetyltransferase. Proc Natl Acad Sci USA 1991;88: 6333-7.
12. Zysset T, Peretti E. Effect of concomitant isoniazid administration on determination of acetylator phenotype by sulphadimidine. Eur J Clin Pharmacol 1986; 30:463-6.
13. Ahmad RA, Rogers HJ, Vandenburg M, Wright P. Effects of concurrent administration of other substrates of N-acetyltransferase on dapsone acetylation. Br J Clin Pharmacol 1981;12:83-6.
14. Lunde PKM, Frislid K, Hansteen V. Disease and acetylation polymorphism. Clin Pharmacokinet 1977; 2:182-97.
15. Hardy BG, Lemieux C, Walker SE, Bertle W. Interindividual and intraindividual variability in acetylation: characterization with caffeine. Clin Pharmacol Ther 1988;44:152-7.
16. Shastri RA. Undernourished adults and acetylation phenotype. Int J Clin Pharmacol Ther Toxicol 1982; 20:194-6.
17. Carr A, Swanson C, Penny R. Clinical and laboratory markers of hypersensitivity to trimethoprim-sulfamethoxazole in patients with pneumocystis carinii pneumonia and AIDS. J Infect Dis 1993;167:180-5.
18. Lee BL, Median I, Benowitz NL, Jacob P, Wofsky C, Mills J. Dapsone, trimethoprim, and sulphamethoxazole plasma levels during treatment of pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 1989;110: 606-11.