Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation

Journal of Gastroenterology and Hepatology (Australia)

Volumn 16, Issue 9, 2001, Pages 1033-1037

  Roy, Bidyut ^a   Chowdhury, Abhijit ^b   Kundu, Somnath ^b   Santra, Amal ^b   Dey, Badal ^a   Chakraborty, Madan ^a   Majumder, Partha P ^a  

^a INDIAN STATISTICAL INSTITUTE   (India)

^b INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Antituberculosis drug induced hepatotoxicity; Genetic susceptibility; Glutathione S transferase M1; Glutathione S transferase T1; N acetyltransferase type 2; Polymorphism

Indexed keywords

ACYLTRANSFERASE; DNA; GLUTATHIONE TRANSFERASE; ISOENZYME; ISONIAZID; N ACETYLTRANSFERASE TYPE 2; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; HEREDITY; HUMAN; LIVER TOXICITY; MALE; MONONUCLEAR CELL; MUTATION RATE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RISK FACTOR; TUBERCULOSIS;

EID: 0034797313     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.2001.02585.x     Document Type: Article

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