Predisposition of antituberculosis drug induced hepatotoxicity by cytochrome P450 2E1 genotype and haplotype in pediatric patients [4]

Journal of Gastroenterology and Hepatology (Australia)

Volumn 21, Issue 4, 2006, Pages 784-786

  Roy, Bidyut ^a   Ghosh, Sanat Kumar ^b   Sutradhar, Debabrata ^a   Sikdar, Nilabja ^a   Mazumder, Santasree ^c   Barman, Santanu ^c  

^a INDIAN STATISTICAL INSTITUTE   (India)

^b Dr BC Roy Memorial Hospital for Children   (India)

^c INSTITUTE OF CHILD HEALTH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2E1; ETHAMBUTOL; ISONIAZID; PYRAZINAMIDE; RIFAMPICIN; TUBERCULOSTATIC AGENT;

GENOTYPE; HAPLOTYPE; HUMAN; LETTER; LIVER TOXICITY; PEDIATRICS; PRIORITY JOURNAL; SEX DIFFERENCE; TUBERCULOSIS; TUBERCULOUS MENINGITIS;

EID: 33645858545     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2006.04197.x     Document Type: Letter

References (5)

1. Ohno M Yamaguchi I Yamamoto I et al. Slow N-acetyltransferase 2 genotype affects the incidence of isoniazid and rifampicin-induced hepatotoxicity. Int. J. Tuberc. Lung Dis. 2000 4 256 61.
2. Huang YS Chern HD Su WJ et al. Polymorphisms of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis. Hepatology 2002 35 883 9.
3. Huang YS Chern HD Su WJ et al. Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. Hepatology 2003 37 925 30.
4. Ohkawa K Hashiguchi M Ohno K et al. Risk factors for antituberculous chemotherapy-induced hepatotoxicity in Japanese pediatric patients. Clin. Pharmacol. Ther. 2002 72 220 6.
5. Singh J Garg PK Thakur VS Tandon RK. Antituberculosis treatment induced hepatotoxicity: Does acetylation status matter? Indian J. Physiol. Pharmacol. 1995 39 43 6.