Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations

Pharmacogenomics

Volumn 12, Issue 11, 2011, Pages 1545-1558

  Mortensen, Holly M ^a,b   Froment, Alain ^c   Lema, Godfrey ^d   Bodo, Jean Marie ^e   Ibrahim, Muntaser ^f   Nyambo, Thomas B ^d   Omar, Sabah A ^g   Tishkoff, Sarah A ^a,h  

^a Bldg 142   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

^d MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^e Ministre de la Recherche Scientifique et de LInnovation   (Cameroon)

^f UNIVERSITY OF KHARTOUM   (Sudan)

^g KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^h UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Africa; arylamine N acetyltransferase; drug metabolizing enzyme loci; natural selection; xenobiotic metabolizing loci

Indexed keywords

ACYLTRANSFERASE; ARYLAMINE ACETYLTRANSFERASE; N ACETYLTRANSFERASE 1; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; ISOENZYME; N-ACETYLTRANSFERASE 1; NAT2 PROTEIN, HUMAN; XENOBIOTIC AGENT;

3' UNTRANSLATED REGION; ACETYLATOR PHENOTYPE; AFRICAN; ARTICLE; CONTROLLED STUDY; ETHNIC GROUP; GENE; GENE LOCUS; GENETIC VARIABILITY; GEOGRAPHIC DISTRIBUTION; HAPLOTYPE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; N ACETYLTRANSFERASE 1 GENE; N ACETYLTRANSFERASE 2 GENE; NATP1 PSEUDOGENE; NATURAL SELECTION; NUCLEOTIDE SEQUENCE; POPULATION DIFFERENTIATION; POPULATION GENETICS; PSEUDOGENE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; AFRICA; ASIA; DNA SEQUENCE; EUROPE; GENETIC SELECTION; GENETICS; METABOLISM; MIDDLE EAST; PHENOTYPE; POPULATION; WESTERN HEMISPHERE;

3' UNTRANSLATED REGIONS; AFRICA; AMERICAS; ARYLAMINE N-ACETYLTRANSFERASE; ASIA; EUROPE; GENETIC VARIATION; HAPLOTYPES; HUMANS; ISOENZYMES; MIDDLE EAST; PHENOTYPE; POPULATION; PSEUDOGENES; SELECTION, GENETIC; SEQUENCE ANALYSIS, DNA; XENOBIOTICS;

EID: 80455158333     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.11.88     Document Type: Article

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