-
1
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouyssegur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature, 2006, 441: 437-443.
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
2
-
-
84865589453
-
Hallmarks of cancer: of all cancer cells, all the time?
-
Floor SL, Dumont JE, Maenhaut C, Raspe E. Hallmarks of cancer: of all cancer cells, all the time? Trends Mol Med, 2012, 18: 509-515.
-
(2012)
Trends Mol Med
, vol.18
, pp. 509-515
-
-
Floor, S.L.1
Dumont, J.E.2
Maenhaut, C.3
Raspe, E.4
-
3
-
-
84858590826
-
Accessories to the crime: functions of cells recruited to the tumor microenvironment
-
Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell, 2012, 21: 309-322.
-
(2012)
Cancer Cell
, vol.21
, pp. 309-322
-
-
Hanahan, D.1
Coussens, L.M.2
-
4
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell, 2012, 148: 399-408.
-
(2012)
Cell
, vol.148
, pp. 399-408
-
-
Semenza, G.L.1
-
5
-
-
84865429409
-
Passing the baton: the HIF switch
-
Koh MY, Powis G. Passing the baton: the HIF switch. Trends Biochem Sci, 2012, 37: 364-372.
-
(2012)
Trends Biochem Sci
, vol.37
, pp. 364-372
-
-
Koh, M.Y.1
Powis, G.2
-
6
-
-
66349121718
-
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3l via their BH3 domains
-
Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouyssegur J, Mazure NM. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3l via their BH3 domains. Mol Cell Biol, 2009, 29: 2570-2581.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2570-2581
-
-
Bellot, G.1
Garcia-Medina, R.2
Gounon, P.3
Chiche, J.4
Roux, D.5
Pouyssegur, J.6
Mazure, N.M.7
-
7
-
-
84883319645
-
Hypoxic retinal muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4
-
Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, Montaner S, Sodhi A. Hypoxic retinal muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proc Natl Acad Sci USA, 2013, 110: E3425-3434.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
-
-
Xin, X.1
Rodrigues, M.2
Umapathi, M.3
Kashiwabuchi, F.4
Ma, T.5
Babapoor-Farrokhran, S.6
Wang, S.7
Hu, J.8
Bhutto, I.9
Welsbie, D.S.10
Duh, E.J.11
Handa, J.T.12
Eberhart, C.G.13
Lutty, G.14
Semenza, G.L.15
Montaner, S.16
Sodhi, A.17
-
8
-
-
80052277906
-
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
-
Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM, Pan F. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell, 2011, 146: 772-784.
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
Barbi, J.2
Yang, H.Y.3
Jinasena, D.4
Yu, H.5
Zheng, Y.6
Bordman, Z.7
Fu, J.8
Kim, Y.9
Yen, H.R.10
Luo, W.11
Zeller, K.12
Shimoda, L.13
Topalian, S.L.14
Semenza, G.L.15
Dang, C.V.16
Pardoll, D.M.17
Pan, F.18
-
9
-
-
33947724515
-
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
-
Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell, 2007, 129: 111-122.
-
(2007)
Cell
, vol.129
, pp. 111-122
-
-
Fukuda, R.1
Zhang, H.2
Kim, J.W.3
Shimoda, L.4
Dang, C.V.5
Semenza, G.L.6
-
10
-
-
77953184918
-
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
-
Sendoel A, Kohler I, Fellmann C, Lowe SW, Hengartner MO. HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature, 2010, 465: 577-583.
-
(2010)
Nature
, vol.465
, pp. 577-583
-
-
Sendoel, A.1
Kohler, I.2
Fellmann, C.3
Lowe, S.W.4
Hengartner, M.O.5
-
11
-
-
84862487817
-
Targeted genes and interacting proteins of hypoxia inducible factor-1
-
Liu W, Shen SM, Zhao XY, Chen GQ. Targeted genes and interacting proteins of hypoxia inducible factor-1. Int J Biochem Mol Biol, 2012, 3: 165-178.
-
(2012)
Int J Biochem Mol Biol
, vol.3
, pp. 165-178
-
-
Liu, W.1
Shen, S.M.2
Zhao, X.Y.3
Chen, G.Q.4
-
12
-
-
80054691501
-
Synergistic induction of galectin-1 by CCAAT/enhancer binding protein alpha and hypoxia-inducible factor 1alpha and its role in differentiation of acute myeloid leukemic cells
-
Zhao XY, Zhao KW, Jiang Y, Zhao M, Chen GQ. Synergistic induction of galectin-1 by CCAAT/enhancer binding protein alpha and hypoxia-inducible factor 1alpha and its role in differentiation of acute myeloid leukemic cells. J Biol Chem, 2011, 286: 36808-36819.
-
(2011)
J Biol Chem
, vol.286
, pp. 36808-36819
-
-
Zhao, X.Y.1
Zhao, K.W.2
Jiang, Y.3
Zhao, M.4
Chen, G.Q.5
-
13
-
-
77955387572
-
Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells
-
Zhao XY, Chen TT, Xia L, Guo M, Xu Y, Yue F, Jiang Y, Chen GQ, Zhao KW. Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells. Carcinogenesis, 2010, 31: 1367-1375.
-
(2010)
Carcinogenesis
, vol.31
, pp. 1367-1375
-
-
Zhao, X.Y.1
Chen, T.T.2
Xia, L.3
Guo, M.4
Xu, Y.5
Yue, F.6
Jiang, Y.7
Chen, G.Q.8
Zhao, K.W.9
-
14
-
-
68549136915
-
Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells
-
Liao SH, Zhao XY, Han YH, Zhang J, Wang LS, Xia L, Zhao KW, Zheng Y, Guo M, Chen GQ. Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells. Proteomics, 2009, 9: 3901-3912.
-
(2009)
Proteomics
, vol.9
, pp. 3901-3912
-
-
Liao, S.H.1
Zhao, X.Y.2
Han, Y.H.3
Zhang, J.4
Wang, L.S.5
Xia, L.6
Zhao, K.W.7
Zheng, Y.8
Guo, M.9
Chen, G.Q.10
-
15
-
-
84934436863
-
Hypoxia-inducible factors: post-translational crosstalk of signaling pathways
-
Dimova EY, Kietzmann T. Hypoxia-inducible factors: post-translational crosstalk of signaling pathways. Methods Mol Biol, 2010, 647: 215-236.
-
(2010)
Methods Mol Biol
, vol.647
, pp. 215-236
-
-
Dimova, E.Y.1
Kietzmann, T.2
-
16
-
-
77955499804
-
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha
-
Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell, 2010, 38: 864-878.
-
(2010)
Mol Cell
, vol.38
, pp. 864-878
-
-
Lim, J.H.1
Lee, Y.M.2
Chun, Y.S.3
Chen, J.4
Kim, J.E.5
Park, J.W.6
-
17
-
-
84892387361
-
Cbx4 governs HIF-1alpha to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity
-
Li J, Xu Y, Long XD, Wang W, Jiao HK, Mei Z, Yin QQ, Ma LN, Zhou AW, Wang LS, Yao M, Xia Q, Chen GQ. Cbx4 governs HIF-1alpha to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity. Cancer Cell, 2014, 25: 118-131.
-
(2014)
Cancer Cell
, vol.25
, pp. 118-131
-
-
Li, J.1
Xu, Y.2
Long, X.D.3
Wang, W.4
Jiao, H.K.5
Mei, Z.6
Yin, Q.Q.7
Ma, L.N.8
Zhou, A.W.9
Wang, L.S.10
Yao, M.11
Xia, Q.12
Chen, G.Q.13
-
19
-
-
0032538797
-
Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha
-
Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H, Poellinger L. Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J, 1998, 17: 6573-6586.
-
(1998)
EMBO J
, vol.17
, pp. 6573-6586
-
-
Kallio, P.J.1
Okamoto, K.2
O'Brien, S.3
Carrero, P.4
Makino, Y.5
Tanaka, H.6
Poellinger, L.7
-
20
-
-
0030787469
-
Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension
-
Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. J Biol Chem, 1997, 272: 19253-19260.
-
(1997)
J Biol Chem
, vol.272
, pp. 19253-19260
-
-
Jiang, B.H.1
Zheng, J.Z.2
Leung, S.W.3
Roe, R.4
Semenza, G.L.5
-
21
-
-
0030937718
-
Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit
-
Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit. J Biol Chem, 1997, 272: 11205-11214.
-
(1997)
J Biol Chem
, vol.272
, pp. 11205-11214
-
-
Pugh, C.W.1
O'Rourke, J.F.2
Nagao, M.3
Gleadle, J.M.4
Ratcliffe, P.J.5
-
22
-
-
0033118983
-
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300
-
Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y. Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J, 1999, 18: 1905-1914.
-
(1999)
EMBO J
, vol.18
, pp. 1905-1914
-
-
Ema, M.1
Hirota, K.2
Mimura, J.3
Abe, H.4
Yodoi, J.5
Sogawa, K.6
Poellinger, L.7
Fujii-Kuriyama, Y.8
-
24
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science, 2001, 292: 468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
von Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
25
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
-
Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J, 2001, 20: 5197-5206.
-
(2001)
EMBO J
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
Willam, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
26
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature, 1999, 399: 271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
27
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol, 2000, 2: 423-427.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
Hoffman, M.A.4
Kim, T.Y.5
Huang, L.E.6
Pavletich, N.7
Chau, V.8
Kaelin, W.G.9
-
28
-
-
0037035851
-
Structure of an HIF-1alpha-PVHl complex: hydroxyproline recognition in signaling
-
Min JH, Yang H, Ivan M, Gertler F, Kaelin WG Jr., Pavletich NP. Structure of an HIF-1alpha-PVHl complex: hydroxyproline recognition in signaling. Science, 2002, 296: 1886-1889.
-
(2002)
Science
, vol.296
, pp. 1886-1889
-
-
Min, J.H.1
Yang, H.2
Ivan, M.3
Gertler, F.4
Kaelin Jr., W.G.5
Pavletich, N.P.6
-
29
-
-
43649093915
-
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
-
Kaelin WG Jr., Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell, 2008, 30: 393-402.
-
(2008)
Mol Cell
, vol.30
, pp. 393-402
-
-
Kaelin Jr., W.G.1
Ratcliffe, P.J.2
-
30
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
-
Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL, Bedi A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev, 2000, 14: 34-44.
-
(2000)
Genes Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
31
-
-
0037016769
-
Jab1 interacts directly with HIF-1alpha and regulates its stability
-
Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, Bae SK, Park JW, Kim KR, Kim KW. Jab1 interacts directly with HIF-1alpha and regulates its stability. J Biol Chem, 2002, 277: 9-12.
-
(2002)
J Biol Chem
, vol.277
, pp. 9-12
-
-
Bae, M.K.1
Ahn, M.Y.2
Jeong, J.W.3
Bae, M.H.4
Lee, Y.M.5
Bae, S.K.6
Park, J.W.7
Kim, K.R.8
Kim, K.W.9
-
32
-
-
84889661553
-
Metabolic alteration in tumorigenesis
-
Yang H, Xiong Y, Guan K. Metabolic alteration in tumorigenesis. Sci China Life Sci, 2013, 56: 1067-1075.
-
(2013)
Sci China Life Sci
, vol.56
, pp. 1067-1075
-
-
Yang, H.1
Xiong, Y.2
Guan, K.3
-
33
-
-
84863982875
-
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
-
Montagner M, Enzo E, Forcato M, Zanconato F, Parenti A, Rampazzo E, Basso G, Leo G, Rosato A, Bicciato S, Cordenonsi M, Piccolo S. SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors. Nature, 2012, 487: 380-384.
-
(2012)
Nature
, vol.487
, pp. 380-384
-
-
Montagner, M.1
Enzo, E.2
Forcato, M.3
Zanconato, F.4
Parenti, A.5
Rampazzo, E.6
Basso, G.7
Leo, G.8
Rosato, A.9
Bicciato, S.10
Cordenonsi, M.11
Piccolo, S.12
-
34
-
-
33644780111
-
Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha
-
Kong X, Lin Z, Liang D, Fath D, Sang N, Caro J. Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. Mol Cell Biol, 2006, 26: 2019-2028.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2019-2028
-
-
Kong, X.1
Lin, Z.2
Liang, D.3
Fath, D.4
Sang, N.5
Caro, J.6
-
35
-
-
0035336677
-
Protein modification by SUMO
-
Hay RT. Protein modification by SUMO. Trends Biochem Sci, 2001, 26: 332-333.
-
(2001)
Trends Biochem Sci
, vol.26
, pp. 332-333
-
-
Hay, R.T.1
-
36
-
-
3943099375
-
Protein modification by SUMO
-
Johnson ES. Protein modification by SUMO. Annu Rev Biochem, 2004, 73: 355-382.
-
(2004)
Annu Rev Biochem
, vol.73
, pp. 355-382
-
-
Johnson, E.S.1
-
37
-
-
15944406765
-
SUMO: a history of modification
-
Hay RT. SUMO: a history of modification. Mol Cell, 2005, 18: 1-12.
-
(2005)
Mol Cell
, vol.18
, pp. 1-12
-
-
Hay, R.T.1
-
38
-
-
28444448039
-
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice
-
Nacerddine K, Lehembre F, Bhaumik M, Artus J, Cohen-Tannoudji M, Babinet C, Pandolfi PP, Dejean A. The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. Dev Cell, 2005, 9: 769-779.
-
(2005)
Dev Cell
, vol.9
, pp. 769-779
-
-
Nacerddine, K.1
Lehembre, F.2
Bhaumik, M.3
Artus, J.4
Cohen-Tannoudji, M.5
Babinet, C.6
Pandolfi, P.P.7
Dejean, A.8
-
39
-
-
24344445216
-
Something about SUMO inhibits transcription
-
Gill G. Something about SUMO inhibits transcription. Curr Opin Genet Dev, 2005, 15: 536-541.
-
(2005)
Curr Opin Genet Dev
, vol.15
, pp. 536-541
-
-
Gill, G.1
-
41
-
-
14244260623
-
Defining the SUMO-modified proteome by multiple approaches in saccharomyces cerevisiae
-
Hannich JT, Lewis A, Kroetz MB, Li SJ, Heide H, Emili A, Hochstrasser M. Defining the SUMO-modified proteome by multiple approaches in saccharomyces cerevisiae. J Biol Chem, 2005, 280: 4102-4110.
-
(2005)
J Biol Chem
, vol.280
, pp. 4102-4110
-
-
Hannich, J.T.1
Lewis, A.2
Kroetz, M.B.3
Li, S.J.4
Heide, H.5
Emili, A.6
Hochstrasser, M.7
-
42
-
-
0034680441
-
Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif
-
Minty A, Dumont X, Kaghad M, Caput D. Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif. J Biol Chem, 2000, 275: 36316-36323.
-
(2000)
J Biol Chem
, vol.275
, pp. 36316-36323
-
-
Minty, A.1
Dumont, X.2
Kaghad, M.3
Caput, D.4
-
43
-
-
5144219680
-
Identification of a SUMO-binding motif that recognizes sumo-modified proteins
-
Song J, Durrin LK, Wilkinson TA, Krontiris TG, Chen Y. Identification of a SUMO-binding motif that recognizes sumo-modified proteins. Proc Natl Acad Sci USA, 2004, 101: 14373-14378.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 14373-14378
-
-
Song, J.1
Durrin, L.K.2
Wilkinson, T.A.3
Krontiris, T.G.4
Chen, Y.5
-
44
-
-
28844455305
-
Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation
-
Song J, Zhang Z, Hu W, Chen Y. Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation. J Biol Chem, 2005, 280: 40122-40129.
-
(2005)
J Biol Chem
, vol.280
, pp. 40122-40129
-
-
Song, J.1
Zhang, Z.2
Hu, W.3
Chen, Y.4
-
45
-
-
64749093273
-
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex
-
Ouyang J, Shi Y, Valin A, Xuan Y, Gill G. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. Mol Cell, 2009, 34: 145-154.
-
(2009)
Mol Cell
, vol.34
, pp. 145-154
-
-
Ouyang, J.1
Shi, Y.2
Valin, A.3
Xuan, Y.4
Gill, G.5
-
46
-
-
4744353220
-
Sumoylation increases HIF-1alpha stability and its transcriptional activity
-
Bae SH, Jeong JW, Park JA, Kim SH, Bae MK, Choi SJ, Kim KW. Sumoylation increases HIF-1alpha stability and its transcriptional activity. Biochem Biophys Res Commun, 2004, 324: 394-400.
-
(2004)
Biochem Biophys Res Commun
, vol.324
, pp. 394-400
-
-
Bae, S.H.1
Jeong, J.W.2
Park, J.A.3
Kim, S.H.4
Bae, M.K.5
Choi, S.J.6
Kim, K.W.7
-
47
-
-
34447249876
-
Sumoylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity
-
Berta MA, Mazure N, Hattab M, Pouyssegur J, Brahimi-Horn MC. Sumoylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity. Biochem Biophys Res Commun, 2007, 360: 646-652.
-
(2007)
Biochem Biophys Res Commun
, vol.360
, pp. 646-652
-
-
Berta, M.A.1
Mazure, N.2
Hattab, M.3
Pouyssegur, J.4
Brahimi-Horn, M.C.5
-
48
-
-
35348904953
-
Rsume, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia
-
Carbia-Nagashima A, Gerez J, Perez-Castro C, Paez-Pereda M, Silberstein S, Stalla GK, Holsboer F, Arzt E. Rsume, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Cell, 2007, 131: 309-323.
-
(2007)
Cell
, vol.131
, pp. 309-323
-
-
Carbia-Nagashima, A.1
Gerez, J.2
Perez-Castro, C.3
Paez-Pereda, M.4
Silberstein, S.5
Stalla, G.K.6
Holsboer, F.7
Arzt, E.8
-
49
-
-
35548935098
-
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
-
Cheng J, Kang X, Zhang S, Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell, 2007, 131: 584-595.
-
(2007)
Cell
, vol.131
, pp. 584-595
-
-
Cheng, J.1
Kang, X.2
Zhang, S.3
Yeh, E.T.4
-
50
-
-
77958020584
-
Piasy stimulates HIF1alpha sumoylation and negatively regulates HIF1alpha activity in response to hypoxia
-
Kang X, Li J, Zou Y, Yi J, Zhang H, Cao M, Yeh ET, Cheng J. Piasy stimulates HIF1alpha sumoylation and negatively regulates HIF1alpha activity in response to hypoxia. Oncogene, 2010, 29: 5568-5578.
-
(2010)
Oncogene
, vol.29
, pp. 5568-5578
-
-
Kang, X.1
Li, J.2
Zou, Y.3
Yi, J.4
Zhang, H.5
Cao, M.6
Yeh, E.T.7
Cheng, J.8
-
52
-
-
0037418829
-
The polycomb protein Pc2 is a SUMO E3
-
Kagey MH, Melhuish TA, Wotton D. The polycomb protein Pc2 is a SUMO E3. Cell, 2003, 113: 127-137.
-
(2003)
Cell
, vol.113
, pp. 127-137
-
-
Kagey, M.H.1
Melhuish, T.A.2
Wotton, D.3
-
53
-
-
34447127473
-
Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a
-
Li B, Zhou J, Liu P, Hu J, Jin H, Shimono Y, Takahashi M, Xu G. Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a. Biochem J, 2007, 405: 369-378.
-
(2007)
Biochem J
, vol.405
, pp. 369-378
-
-
Li, B.1
Zhou, J.2
Liu, P.3
Hu, J.4
Jin, H.5
Shimono, Y.6
Takahashi, M.7
Xu, G.8
-
54
-
-
27444442397
-
Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin
-
Long J, Zuo D, Park M. Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. J Biol Chem, 2005, 280: 35477-35489.
-
(2005)
J Biol Chem
, vol.280
, pp. 35477-35489
-
-
Long, J.1
Zuo, D.2
Park, M.3
-
55
-
-
70350357067
-
SUMO-dependent regulation of centrin-2
-
Klein UR, Nigg EA. SUMO-dependent regulation of centrin-2. J Cell Sci, 2009, 122: 3312-3321.
-
(2009)
J Cell Sci
, vol.122
, pp. 3312-3321
-
-
Klein, U.R.1
Nigg, E.A.2
-
56
-
-
33749058094
-
Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2
-
Roscic A, Moller A, Calzado MA, Renner F, Wimmer VC, Gresko E, Ludi KS, Schmitz ML. Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2. Mol Cell, 2006, 24: 77-89.
-
(2006)
Mol Cell
, vol.24
, pp. 77-89
-
-
Roscic, A.1
Moller, A.2
Calzado, M.A.3
Renner, F.4
Wimmer, V.C.5
Gresko, E.6
Ludi, K.S.7
Schmitz, M.L.8
-
57
-
-
77649328923
-
A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity
-
Merrill JC, Melhuish TA, Kagey MH, Yang SH, Sharrocks AD, Wotton D. A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity. PLoS ONE, 2010, 5: e8794.
-
(2010)
PLoS ONE
, vol.5
-
-
Merrill, J.C.1
Melhuish, T.A.2
Kagey, M.H.3
Yang, S.H.4
Sharrocks, A.D.5
Wotton, D.6
-
58
-
-
77950643586
-
The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif
-
Yang SH, Sharrocks AD. The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif. Mol Cell Biol, 2010, 30: 2193-2205.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 2193-2205
-
-
Yang, S.H.1
Sharrocks, A.D.2
-
59
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer, 2003, 3: 721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
60
-
-
77955505569
-
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms
-
Bawa-Khalfe T, Cheng J, Lin SH, Ittmann MM, Yeh ET. SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. J Biol Chem, 2010, 285: 25859-25866.
-
(2010)
J Biol Chem
, vol.285
, pp. 25859-25866
-
-
Bawa-Khalfe, T.1
Cheng, J.2
Lin, S.H.3
Ittmann, M.M.4
Yeh, E.T.5
-
61
-
-
84877621274
-
SUMO-specific protease 1 promotes prostate cancer progression and metastasis
-
Wang Q, Xia N, Li T, Xu Y, Zou Y, Zuo Y, Fan Q, Bawa-Khalfe T, Yeh ET, Cheng J. SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene, 2013, 32: 2493-2498.
-
(2013)
Oncogene
, vol.32
, pp. 2493-2498
-
-
Wang, Q.1
Xia, N.2
Li, T.3
Xu, Y.4
Zou, Y.5
Zuo, Y.6
Fan, Q.7
Bawa-Khalfe, T.8
Yeh, E.T.9
Cheng, J.10
-
62
-
-
84872686565
-
Down-regulation of SENP1 expression increases apoptosis of Burkitt lymphoma cells
-
Huang BB, Gao QM, Liang W, Xiu B, Zhang WJ, Liang AB. Down-regulation of SENP1 expression increases apoptosis of Burkitt lymphoma cells. Asian Pac J Cancer Prev, 2012, 13: 2045-2049.
-
(2012)
Asian Pac J Cancer Prev
, vol.13
, pp. 2045-2049
-
-
Huang, B.B.1
Gao, Q.M.2
Liang, W.3
Xiu, B.4
Zhang, W.J.5
Liang, A.B.6
-
63
-
-
79954436128
-
Overexpression of SUMO-1 in hepatocellular carcinoma: a latent target for diagnosis and therapy of hepatoma
-
Guo WH, Yuan LH, Xiao ZH, Liu D, Zhang JX. Overexpression of SUMO-1 in hepatocellular carcinoma: a latent target for diagnosis and therapy of hepatoma. J Cancer Res Clin Oncol, 2011, 137: 533-541.
-
(2011)
J Cancer Res Clin Oncol
, vol.137
, pp. 533-541
-
-
Guo, W.H.1
Yuan, L.H.2
Xiao, Z.H.3
Liu, D.4
Zhang, J.X.5
-
64
-
-
84892795727
-
Chromobox homolog 4 is correlated with prognosis and tumor cell growth in hepatocellular carcinoma
-
Wang B, Tang J, Liao D, Wang G, Zhang M, Sang Y, Cao J, Wu Y, Zhang R, Li S, Ding W, Zhang G, Kang T. Chromobox homolog 4 is correlated with prognosis and tumor cell growth in hepatocellular carcinoma. Ann Surg Oncol, 2013, 20(Suppl 3): S684-692.
-
(2013)
Ann Surg Oncol
, vol.20
, Issue.SUPPL. 3
-
-
Wang, B.1
Tang, J.2
Liao, D.3
Wang, G.4
Zhang, M.5
Sang, Y.6
Cao, J.7
Wu, Y.8
Zhang, R.9
Li, S.10
Ding, W.11
Zhang, G.12
Kang, T.13
-
65
-
-
84901978546
-
Polycomb chromobox 4 enhances migration and pulmonary metastasis of hepatocellular carcinoma cell line MHHC97L
-
Mei Z, Jiao HK, Wang W, Li J, Chen GQ, Xu Y. Polycomb chromobox 4 enhances migration and pulmonary metastasis of hepatocellular carcinoma cell line MHHC97L. Sci China Life Sci, 2014, 57: 610-617.
-
(2014)
Sci China Life Sci
, vol.57
, pp. 610-617
-
-
Mei, Z.1
Jiao, H.K.2
Wang, W.3
Li, J.4
Chen, G.Q.5
Xu, Y.6
-
66
-
-
84870608916
-
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
-
Luo W, Chang R, Zhong J, Pandey A, Semenza GL. Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proc Natl Acad Sci USA, 2012, 109: E3367-3376.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
-
-
Luo, W.1
Chang, R.2
Zhong, J.3
Pandey, A.4
Semenza, G.L.5
-
67
-
-
84878831596
-
HIF1α employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia
-
Galbraith MD, Allen MA, Bensard CL, Wang X, Schwinn MK, Qin B, Long HW, Daniels DL, Hahn WC, Dowell RD, Espinosa JM. HIF1α employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell, 2013, 153: 1327-1339.
-
(2013)
Cell
, vol.153
, pp. 1327-1339
-
-
Galbraith, M.D.1
Allen, M.A.2
Bensard, C.L.3
Wang, X.4
Schwinn, M.K.5
Qin, B.6
Long, H.W.7
Daniels, D.L.8
Hahn, W.C.9
Dowell, R.D.10
Espinosa, J.M.11
-
68
-
-
4744368147
-
Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity
-
Kato H, Tamamizu-Kato S, Shibasaki F. Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J Biol Chem, 2004, 279: 41966-41974.
-
(2004)
J Biol Chem
, vol.279
, pp. 41966-41974
-
-
Kato, H.1
Tamamizu-Kato, S.2
Shibasaki, F.3
-
69
-
-
20444363269
-
Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha
-
Jiang Y, Xue ZH, Shen WZ, Du KM, Yan H, Yu Y, Peng ZG, Song MG, Tong JH, Chen Z, Huang Y, Lubbert M, Chen GQ. Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha. Leukemia, 2005, 19: 1239-1247.
-
(2005)
Leukemia
, vol.19
, pp. 1239-1247
-
-
Jiang, Y.1
Xue, Z.H.2
Shen, W.Z.3
Du, K.M.4
Yan, H.5
Yu, Y.6
Peng, Z.G.7
Song, M.G.8
Tong, J.H.9
Chen, Z.10
Huang, Y.11
Lubbert, M.12
Chen, G.Q.13
-
70
-
-
54349102038
-
Accumulation of hypoxia-inducible factor-1 alpha protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid
-
Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ. Accumulation of hypoxia-inducible factor-1 alpha protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid. Haematologica, 2008, 93: 1480-1487.
-
(2008)
Haematologica
, vol.93
, pp. 1480-1487
-
-
Zhang, J.1
Song, L.P.2
Huang, Y.3
Zhao, Q.4
Zhao, K.W.5
Chen, G.Q.6
-
71
-
-
84873715596
-
HIF-1alpha downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation
-
He M, Wang QY, Yin QQ, Tang J, Lu Y, Zhou CX, Duan CW, Hong DL, Tanaka T, Chen GQ, Zhao Q. HIF-1alpha downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation. Cell Death Differ, 2013, 20: 408-418.
-
(2013)
Cell Death Differ
, vol.20
, pp. 408-418
-
-
He, M.1
Wang, Q.Y.2
Yin, Q.Q.3
Tang, J.4
Lu, Y.5
Zhou, C.X.6
Duan, C.W.7
Hong, D.L.8
Tanaka, T.9
Chen, G.Q.10
Zhao, Q.11
-
72
-
-
33746880650
-
Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation
-
Nguyen-Khac F, Della Valle V, Lopez RG, Ravet E, Mauchauffe M, Friedman AD, Huang LE, Fichelson S, Ghysdael J, Bernard OA. Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation. Oncogene, 2006, 25: 4840-4847.
-
(2006)
Oncogene
, vol.25
, pp. 4840-4847
-
-
Nguyen-Khac, F.1
Della Valle, V.2
Lopez, R.G.3
Ravet, E.4
Mauchauffe, M.5
Friedman, A.D.6
Huang, L.E.7
Fichelson, S.8
Ghysdael, J.9
Bernard, O.A.10
-
73
-
-
33646544066
-
Effects of tiron, 4,5-dihydroxy-1,3-benzene disulfonic acid, on human promyelotic hl-60 leukemia cell differentiation and death
-
Kim JS, Cho EW, Chung HW, Kim IG. Effects of tiron, 4, 5-dihydroxy-1, 3-benzene disulfonic acid, on human promyelotic hl-60 leukemia cell differentiation and death. Toxicology, 2006, 223: 36-45.
-
(2006)
Toxicology
, vol.223
, pp. 36-45
-
-
Kim, J.S.1
Cho, E.W.2
Chung, H.W.3
Kim, I.G.4
-
74
-
-
10744229867
-
Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: Possible mediation of hypoxia-inducible factor-1alpha
-
Huang Y, Du KM, Xue ZH, Yan H, Li D, Liu W, Chen Z, Zhao Q, Tong JH, Zhu YS, Chen GQ. Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: Possible mediation of hypoxia-inducible factor-1alpha. Leukemia, 2003, 17: 2065-2073.
-
(2003)
Leukemia
, vol.17
, pp. 2065-2073
-
-
Huang, Y.1
Du, K.M.2
Xue, Z.H.3
Yan, H.4
Li, D.5
Liu, W.6
Chen, Z.7
Zhao, Q.8
Tong, J.H.9
Zhu, Y.S.10
Chen, G.Q.11
-
75
-
-
30444434288
-
Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia
-
Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Blood, 2006, 107: 698-707.
-
(2006)
Blood
, vol.107
, pp. 698-707
-
-
Liu, W.1
Guo, M.2
Xu, Y.B.3
Li, D.4
Zhou, Z.N.5
Wu, Y.L.6
Chen, Z.7
Kogan, S.C.8
Chen, G.Q.9
-
76
-
-
0016298348
-
Correlation of leukemia mortality rates with altitude in the United States
-
Eckhoff ND, Shultis JK, Clack RW, Ramer ER. Correlation of leukemia mortality rates with altitude in the United States. Health Phys, 1974, 27: 377-380.
-
(1974)
Health Phys
, vol.27
, pp. 377-380
-
-
Eckhoff, N.D.1
Shultis, J.K.2
Clack, R.W.3
Ramer, E.R.4
-
77
-
-
84875496294
-
(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
-
Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley GS, Root DE, Ebert BL, Kaelin WG Jr. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science, 2013, 339: 1621-1625.
-
(2013)
Science
, vol.339
, pp. 1621-1625
-
-
Losman, J.A.1
Looper, R.E.2
Koivunen, P.3
Lee, S.4
Schneider, R.K.5
McMahon, C.6
Cowley, G.S.7
Root, D.E.8
Ebert, B.L.9
Kaelin Jr., W.G.10
-
78
-
-
0023567347
-
Altitude, radiation, and mortal ity from cancer and heart disease
-
Weinberg CR, Brown KG, Hoel DG. Altitude, radiation, and mortal ity from cancer and heart disease. Radiat Res, 1987, 112: 381-390.
-
(1987)
Radiat Res
, vol.112
, pp. 381-390
-
-
Weinberg, C.R.1
Brown, K.G.2
Hoel, D.G.3
-
79
-
-
84876889621
-
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
-
Losman JA, Kaelin WG Jr. What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev, 2013, 27: 836-852.
-
(2013)
Genes Dev
, vol.27
, pp. 836-852
-
-
Losman, J.A.1
Kaelin Jr., W.G.2
-
80
-
-
38349000624
-
Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent
-
Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ. Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene, 2008, 27: 519-527.
-
(2008)
Oncogene
, vol.27
, pp. 519-527
-
-
Song, L.P.1
Zhang, J.2
Wu, S.F.3
Huang, Y.4
Zhao, Q.5
Cao, J.P.6
Wu, Y.L.7
Wang, L.S.8
Chen, G.Q.9
-
81
-
-
0035047652
-
AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia
-
Pabst T, Mueller BU, Harakawa N, Schoch C, Haferlach T, Behre G, Hiddemann W, Zhang DE, Tenen DG. AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia. Nat Med, 2001, 7: 444-451.
-
(2001)
Nat Med
, vol.7
, pp. 444-451
-
-
Pabst, T.1
Mueller, B.U.2
Harakawa, N.3
Schoch, C.4
Haferlach, T.5
Behre, G.6
Hiddemann, W.7
Zhang, D.E.8
Tenen, D.G.9
-
82
-
-
38749099057
-
Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1alpha
-
Peng ZG, Zhou MY, Huang Y, Qiu JH, Wang LS, Liao SH, Dong S, Chen GQ. Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1alpha. Oncogene, 2008, 27: 839-847.
-
(2008)
Oncogene
, vol.27
, pp. 839-847
-
-
Peng, Z.G.1
Zhou, M.Y.2
Huang, Y.3
Qiu, J.H.4
Wang, L.S.5
Liao, S.H.6
Dong, S.7
Chen, G.Q.8
-
83
-
-
40549130675
-
CCAAT/enhancer-binding protein alpha antagonizes transcriptional activity of hypoxia-inducible factor 1 alpha with direct protein-protein interaction
-
Yang L, Jiang Y, Wu SF, Zhou MY, Wu YL, Chen GQ. CCAAT/enhancer-binding protein alpha antagonizes transcriptional activity of hypoxia-inducible factor 1 alpha with direct protein-protein interaction. Carcinogenesis, 2008, 29: 291-298.
-
(2008)
Carcinogenesis
, vol.29
, pp. 291-298
-
-
Yang, L.1
Jiang, Y.2
Wu, S.F.3
Zhou, M.Y.4
Wu, Y.L.5
Chen, G.Q.6
|