-
1
-
-
33747621613
-
Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1
-
Semenza,G.L. (2006) Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1. Exp. Physiol. 91, 803-406.
-
(2006)
Exp. Physiol
, vol.91
, pp. 803-406
-
-
Semenza, G.L.1
-
2
-
-
33749362031
-
Inhibiting hypoxia-inducible factor 1 for cancer therapy
-
Melillo,G. (2006) Inhibiting hypoxia-inducible factor 1 for cancer therapy. Mol. Cancer Res., 4, 601-605.
-
(2006)
Mol. Cancer Res
, vol.4
, pp. 601-605
-
-
Melillo, G.1
-
3
-
-
0034145215
-
Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis [review]
-
Minet,E. et al. (2000) Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis [review]. Int. J. Mol. Med., 5, 253-259.
-
(2000)
Int. J. Mol. Med
, vol.5
, pp. 253-259
-
-
Minet, E.1
-
4
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh,M. et al. (2000) Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell Biol., 2, 423-427.
-
(2000)
Nat. Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
-
5
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell,P.H. et al. (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature, 399, 271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
-
6
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola,P. et al. (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science, 292, 468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
-
7
-
-
18744375998
-
Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
-
Jeong,J.W. et al. (2002) Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell, 111, 709-720.
-
(2002)
Cell
, vol.111
, pp. 709-720
-
-
Jeong, J.W.1
-
8
-
-
34047272690
-
Regulation of HIF-1a1pha stability through S-nitrosylation
-
Li,F. et al. (2007) Regulation of HIF-1a1pha stability through S-nitrosylation. Mol. Cell, 26, 63-74.
-
(2007)
Mol. Cell
, vol.26
, pp. 63-74
-
-
Li, F.1
-
9
-
-
0034006016
-
HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
-
Semenza,G.L. (2000) HIF-1: Mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol., 88 1474-1480.
-
(2000)
J. Appl. Physiol
, vol.88
, pp. 1474-1480
-
-
Semenza, G.L.1
-
10
-
-
20444419781
-
Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1alpha protein
-
Xue,Z.H. et al. (2005) Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1alpha protein. Biochem. Biophys. Res. Commun., 332, 1140-1145.
-
(2005)
Biochem. Biophys. Res. Commun
, vol.332
, pp. 1140-1145
-
-
Xue, Z.H.1
-
11
-
-
20444363269
-
Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha
-
Jiang,Y. et al. (2005) Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha. Leukemia, 19, 1239-1247.
-
(2005)
Leukemia
, vol.19
, pp. 1239-1247
-
-
Jiang, Y.1
-
12
-
-
10744229867
-
Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: Possible mediation of hypoxia-inducible factor-1alpha
-
Huang,Y. et al. (2003) Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: Possible mediation of hypoxia-inducible factor-1alpha. Leukemia, 17, 2065-2073.
-
(2003)
Leukemia
, vol.17
, pp. 2065-2073
-
-
Huang, Y.1
-
13
-
-
30444434288
-
Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia
-
Liu,W. et al. (2006) Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Blood, 107, 698-707.
-
(2006)
Blood
, vol.107
, pp. 698-707
-
-
Liu, W.1
-
14
-
-
33746880650
-
Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation
-
Nguyen-Khac,F. et al. (2006) Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation. Oncogene, 25, 4840-4847.
-
(2006)
Oncogene
, vol.25
, pp. 4840-4847
-
-
Nguyen-Khac, F.1
-
15
-
-
38749143757
-
Hypoxia-inducible factor-1a-induced differentiation of myeloid leukemic cells is its transcriptional activity independent
-
Jul 16: [Epub ahead of print
-
Song,L. et al. (2007) Hypoxia-inducible factor-1a-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene, Jul 16: [Epub ahead of print].
-
(2007)
Oncogene
-
-
Song, L.1
-
16
-
-
33646544066
-
Effects of Tiron, 4,5-dihydroxy-1,3-benzene disulfonic acid, on human promyelotic HL-60 leukemia cell differentiation and death
-
Kim,J.S. et al. (2006) Effects of Tiron, 4,5-dihydroxy-1,3-benzene disulfonic acid, on human promyelotic HL-60 leukemia cell differentiation and death. Toxicology, 223, 36-45.
-
(2006)
Toxicology
, vol.223
, pp. 36-45
-
-
Kim, J.S.1
-
17
-
-
0031835661
-
CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
-
Radomska,H.S. et al. (1998) CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol. Cell Biol., 18, 4301-4314.
-
(1998)
Mol. Cell Biol
, vol.18
, pp. 4301-4314
-
-
Radomska, H.S.1
-
18
-
-
0036683653
-
CCAAT/enhancer-binding proteins: Structure, function and regulation
-
Ramji,D.P. et al. (2002) CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem. J., 365, 561-575.
-
(2002)
Biochem. J
, vol.365
, pp. 561-575
-
-
Ramji, D.P.1
-
19
-
-
33746861562
-
C/EBPalpha: A tumour suppressor in multiple tissues?
-
Schuster,M.B. et al. (2006) C/EBPalpha: A tumour suppressor in multiple tissues? Biochim. Biophys. Acta, 1766, 88-103.
-
(2006)
Biochim. Biophys. Acta
, vol.1766
, pp. 88-103
-
-
Schuster, M.B.1
-
20
-
-
0031000736
-
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
-
Ema,M. et al. (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl Acad. Sci. USA, 94, 4273-4278.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 4273-4278
-
-
Ema, M.1
-
21
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza,G.L. et al. (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell Biol., 12, 5447-5454.
-
(1992)
Mol. Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
-
22
-
-
9444260940
-
Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: Its role in leukemic cell differentiation
-
Zhao,K.W. et al. (2004) Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: Its role in leukemic cell differentiation. Blood, 104, 3731-3738.
-
(2004)
Blood
, vol.104
, pp. 3731-3738
-
-
Zhao, K.W.1
-
23
-
-
33750630119
-
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
-
Holmquist-Mengelbier,L. et al. (2006) Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell, 10, 413-423.
-
(2006)
Cancer Cell
, vol.10
, pp. 413-423
-
-
Holmquist-Mengelbier, L.1
-
24
-
-
33646673603
-
HIF-1 activation during tumor progression: Implications and consequences]
-
Lauzier,M.C. et al. (2006) [HIF-1 activation during tumor progression: Implications and consequences]. Bull. Cancer, 93 349-356.
-
(2006)
Bull. Cancer
, vol.93
, pp. 349-356
-
-
Lauzier, M.C.1
-
25
-
-
0029944965
-
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
-
Jiang,B.H. et al. (1996) Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J. Biol. Chem., 271, 17771-17778.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 17771-17778
-
-
Jiang, B.H.1
-
26
-
-
33846315497
-
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
-
Ehrismann,D. et al. (2007) Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem. J., 401, 227-234.
-
(2007)
Biochem. J
, vol.401
, pp. 227-234
-
-
Ehrismann, D.1
-
27
-
-
0032749463
-
Hypoxia-induced activation of FHF-1: Role of HIF-1alpha-Hsp90 interaction
-
Minet,E. et al. (1999) Hypoxia-induced activation of FHF-1: Role of HIF-1alpha-Hsp90 interaction. FEBS Lett., 460, 251-256.
-
(1999)
FEBS Lett
, vol.460
, pp. 251-256
-
-
Minet, E.1
-
28
-
-
33947217823
-
Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
-
Kaidi,A. et al. (2007) Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat. Cell Biol., 9, 210-217.
-
(2007)
Nat. Cell Biol
, vol.9
, pp. 210-217
-
-
Kaidi, A.1
-
29
-
-
31444444162
-
Integration of oxygen signaling at the consensus HRE
-
Wenger,R.H. et al. (2005) Integration of oxygen signaling at the consensus HRE. Sci. STKE., 2005, re12.
-
(2005)
Sci. STKE
, vol.2005
-
-
Wenger, R.H.1
-
30
-
-
3142631736
-
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
-
Koshiji,M. et al. (2004) HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J., 23, 1949-1956.
-
(2004)
EMBO J
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
-
31
-
-
34247614521
-
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
-
Zhang,H. et al. (2007) HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell, 11, 407-420.
-
(2007)
Cancer Cell
, vol.11
, pp. 407-420
-
-
Zhang, H.1
-
32
-
-
0034982567
-
Transcription factors that regulate growth and differentiation of myeloid cells
-
Nagamura-Inoue,T. et al. (2001) Transcription factors that regulate growth and differentiation of myeloid cells. Int. Rev. Immunol., 20, 83-105.
-
(2001)
Int. Rev. Immunol
, vol.20
, pp. 83-105
-
-
Nagamura-Inoue, T.1
-
33
-
-
33846622099
-
Transcription factors in myeloid development: Balancing differentiation with transformation
-
Rosenbauer,F. et al. (2007) Transcription factors in myeloid development: Balancing differentiation with transformation. Nat. Rev. Immunol., 7, 105-117.
-
(2007)
Nat. Rev. Immunol
, vol.7
, pp. 105-117
-
-
Rosenbauer, F.1
-
34
-
-
0031806532
-
Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1
-
Petrovick,M.S. et al. (1998) Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1. Mol. Cell Biol., 18, 3915-3925.
-
(1998)
Mol. Cell Biol
, vol.18
, pp. 3915-3925
-
-
Petrovick, M.S.1
-
35
-
-
33745047783
-
Combinatorial action of RUNX1 and PU.1 in the regulation of hematopoiesis
-
Saunthararajah,Y. et al. (2006) Combinatorial action of RUNX1 and PU.1 in the regulation of hematopoiesis. Crit. Rev. Eukaryot. Gene Expr., 16, 183-192.
-
(2006)
Crit. Rev. Eukaryot. Gene Expr
, vol.16
, pp. 183-192
-
-
Saunthararajah, Y.1
-
36
-
-
0030024112
-
CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter
-
Zhang,D.E. et al. (1996) CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol. Cell Biol., 16, 1231-1240.
-
(1996)
Mol. Cell Biol
, vol.16
, pp. 1231-1240
-
-
Zhang, D.E.1
-
37
-
-
0242693950
-
Role of AML1/Runx1 in the pathogenesis of hematological malignancies
-
Kurokawa,M. et al. (2003) Role of AML1/Runx1 in the pathogenesis of hematological malignancies. Cancer Sci., 94, 841-846.
-
(2003)
Cancer Sci
, vol.94
, pp. 841-846
-
-
Kurokawa, M.1
-
38
-
-
21544465306
-
Role of transcription factors C/ EBPalpha and PU.1 in normal hematopoiesis and leukemia
-
Koschmieder,S. et al. (2005) Role of transcription factors C/ EBPalpha and PU.1 in normal hematopoiesis and leukemia. Int. J. Hematol., 81, 368-377.
-
(2005)
Int. J. Hematol
, vol.81
, pp. 368-377
-
-
Koschmieder, S.1
-
39
-
-
34447554805
-
Hypoxia inducible factor-1 alpha and leukemic cell differentiation
-
Chen,G.Q. et al. (2006) Hypoxia inducible factor-1 alpha and leukemic cell differentiation. Sheng Li Xue Bao, 58, 5-13.
-
(2006)
Sheng Li Xue Bao
, vol.58
, pp. 5-13
-
-
Chen, G.Q.1
-
40
-
-
40549083287
-
Acute myeloid leukemia-1 antagonizes transcriptional activity of hypoxia inducible factor-1a protein through direct protein-protein interaction
-
Aug 6: [Epub ahead of print
-
Peng,Z.G. et al. (2007) Acute myeloid leukemia-1 antagonizes transcriptional activity of hypoxia inducible factor-1a protein through direct protein-protein interaction. Oncogene, Aug 6: [Epub ahead of print].
-
(2007)
Oncogene
-
-
Peng, Z.G.1
-
41
-
-
85087576596
-
Relationship between degradation of PML-RARalpha and differentiation
-
Naoe,T. et al. (1999) Relationship between degradation of PML-RARalpha and differentiation. Blood, 94, 1478-1479.
-
(1999)
Blood
, vol.94
, pp. 1478-1479
-
-
Naoe, T.1
-
42
-
-
33747488399
-
PML inhibits HIF-1alpha translation and neo-angiogenesis through repression of mTOR
-
Bernardi,R. et al. (2006) PML inhibits HIF-1alpha translation and neo-angiogenesis through repression of mTOR. Nature, 442, 779-785.
-
(2006)
Nature
, vol.442
, pp. 779-785
-
-
Bernardi, R.1
-
43
-
-
0042763564
-
HIF-1 in cell cycle regulation, apoptosis, and tumor progression
-
Goda,N. et al. (2003) HIF-1 in cell cycle regulation, apoptosis, and tumor progression. Antioxid. Redox Signal., 5, 467-473.
-
(2003)
Antioxid. Redox Signal
, vol.5
, pp. 467-473
-
-
Goda, N.1
-
44
-
-
4444311880
-
Hypoxia inducible factor-1alpha as a cancer drug target
-
Powis,G. et al. (2004) Hypoxia inducible factor-1alpha as a cancer drug target. Mol. Cancer Ther., 3, 647-654.
-
(2004)
Mol. Cancer Ther
, vol.3
, pp. 647-654
-
-
Powis, G.1
-
45
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
-
Talks,K.L. et al. (2000) The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157, 411-421.
-
(2000)
Am. J. Pathol
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
-
46
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong,H. et al. (1999) Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res., 59, 5830-5835.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
-
47
-
-
33846870322
-
Role of hypoxia-inducible factor-1alpha as a cancer therapy target
-
Patiar,S. et al. (2006) Role of hypoxia-inducible factor-1alpha as a cancer therapy target. Endocr Relat. Cancer, 13 (suppl. 1), S61-S75.
-
(2006)
Endocr Relat. Cancer
, vol.13
, Issue.SUPPL. 1
-
-
Patiar, S.1
-
48
-
-
33847676808
-
Immunohistochemical analysis of C/ EBPalpha in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: A correlative study of E3590
-
Costa,D.B. et al. (2007) Immunohistochemical analysis of C/ EBPalpha in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: A correlative study of E3590. Lung Cancer, 56, 97-103.
-
(2007)
Lung Cancer
, vol.56
, pp. 97-103
-
-
Costa, D.B.1
-
49
-
-
0036618423
-
Decreased expression of the CCAAT/ enhancer binding protein alpha gene involved in hepatocyte proliferation in human hepatocellular carcinomas
-
Tomizawa,M. et al. (2002) Decreased expression of the CCAAT/ enhancer binding protein alpha gene involved in hepatocyte proliferation in human hepatocellular carcinomas. Int. J. Mol. Med., 9, 597-600.
-
(2002)
Int. J. Mol. Med
, vol.9
, pp. 597-600
-
-
Tomizawa, M.1
-
50
-
-
13444271570
-
Diminished expression of C/EBPalpha in skin carcinomas is linked to oncogenic Ras and reexpression of C/EBPalpha in carcinoma cells inhibits proliferation
-
Shim,M. et al. (2005) Diminished expression of C/EBPalpha in skin carcinomas is linked to oncogenic Ras and reexpression of C/EBPalpha in carcinoma cells inhibits proliferation. Cancer Res., 65, 861-867.
-
(2005)
Cancer Res
, vol.65
, pp. 861-867
-
-
Shim, M.1
-
51
-
-
18244397460
-
Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer
-
Gery,S. et al. (2005) Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer. Clin. Cancer Res., 11, 3184-3190.
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 3184-3190
-
-
Gery, S.1
-
52
-
-
33644958558
-
Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer
-
Tada,Y. et al. (2006) Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer. J. Natl Cancer Inst., 98, 396-406.
-
(2006)
J. Natl Cancer Inst
, vol.98
, pp. 396-406
-
-
Tada, Y.1
|