-
1
-
-
0036359548
-
Hypoxia-a key regulatory factor in tumour growth
-
Harris,A.L. (2002) Hypoxia-a key regulatory factor in tumour growth. Nat. Rev. Cancer, 2, 38-47.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
2
-
-
54049134838
-
Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis
-
Vaupel,P. (2008) Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis. Oncologist, 13 (suppl. 3), 21-26.
-
(2008)
Oncologist
, vol.13
, Issue.SUPPL. 3
, pp. 21-26
-
-
Vaupel, P.1
-
3
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loophelix-PAS heterodimer regulated by cellular O2 tension
-
Wang,G.L. et al. (1995) Hypoxia-inducible factor 1 is a basic-helix-loophelix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl Acad. Sci. USA, 92, 5510-5514.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
-
4
-
-
35148828429
-
Hypoxia-inducible factor 1 (HIF-1) pathway
-
Semenza,G.L. (2007) Hypoxia-inducible factor 1 (HIF-1) pathway. Sci. STKE, 2007, cm8.
-
(2007)
Sci. STKE
, vol.2007
-
-
Semenza, G.L.1
-
5
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola,P. et al. (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science, 292, 468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
-
6
-
-
10744229867
-
Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha
-
Huang,Y. et al. (2003) Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha. Leukemia, 17, 2065-2073.
-
(2003)
Leukemia
, vol.17
, pp. 2065-2073
-
-
Huang, Y.1
-
7
-
-
38349000624
-
Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent
-
Song,L.P. et al. (2008) Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene, 27, 519-527.
-
(2008)
Oncogene
, vol.27
, pp. 519-527
-
-
Song, L.P.1
-
8
-
-
31444444162
-
Integration of oxygen signaling at the consensus HRE
-
Wenger,R.H. et al. (2005) Integration of oxygen signaling at the consensus HRE. Sci. STKE, 2005, re12.
-
(2005)
Sci. STKE
, vol.2005
-
-
Wenger, R.H.1
-
9
-
-
68549136915
-
Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells
-
Liao,S.H. et al. (2009) Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells. Proteomics, 9, 3901-3912.
-
(2009)
Proteomics
, vol.9
, pp. 3901-3912
-
-
Liao, S.H.1
-
10
-
-
23644448721
-
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability
-
Isaacs,J.S. et al. (2005) HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell, 8, 143-153.
-
(2005)
Cancer Cell
, vol.8
, pp. 143-153
-
-
Isaacs, J.S.1
-
11
-
-
16644373473
-
Role of VHL gene mutation in human cancer
-
Kim,W.Y. et al. (2004) Role of VHL gene mutation in human cancer. J. Clin. Oncol., 22, 4991-5004.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 4991-5004
-
-
Kim, W.Y.1
-
12
-
-
62049086265
-
Hypoxia-associated p38 mitogen-activated protein kinase-mediated androgen receptor activation and increased HIF1alpha levels contribute to emergence of an aggressive phenotype in prostate cancer
-
Khandrika,L. et al. (2009) Hypoxia-associated p38 mitogen-activated protein kinase-mediated androgen receptor activation and increased HIF1alpha levels contribute to emergence of an aggressive phenotype in prostate cancer. Oncogene, 28, 1248-1260.
-
(2009)
Oncogene
, vol.28
, pp. 1248-1260
-
-
Khandrika, L.1
-
13
-
-
54049115847
-
Role of Hypoxia-inducible factor-1 alpha and Survivin in colorectal carcinoma progression
-
Fan,L.F. et al. (2008) Role of Hypoxia-inducible factor-1 alpha and Survivin in colorectal carcinoma progression. Int. J. Colorectal Dis., 23, 1057-1064.
-
(2008)
Int. J. Colorectal Dis.
, vol.23
, pp. 1057-1064
-
-
Fan, L.F.1
-
14
-
-
45949085841
-
Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells
-
Hsieh,S.H. et al. (2008) Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells. Oncogene, 27, 3746-3753.
-
(2008)
Oncogene
, vol.27
, pp. 3746-3753
-
-
Hsieh, S.H.1
-
15
-
-
24644488689
-
Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia
-
Funasaka,T. et al. (2005) Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia. Faseb J., 19, 1422-1430.
-
(2005)
Faseb J.
, vol.19
, pp. 1422-1430
-
-
Funasaka, T.1
-
16
-
-
0028261522
-
Galectins: a family of animal beta-galactosidebinding lectins
-
Barondes,S.H. et al. (1994) Galectins: a family of animal beta-galactosidebinding lectins. Cell, 76, 597-598.
-
(1994)
Cell
, vol.76
, pp. 597-598
-
-
Barondes, S.H.1
-
17
-
-
11144241063
-
Galectins as modulators of tumour progression
-
Liu,F.T. et al. (2005) Galectins as modulators of tumour progression. Nat. Rev. Cancer, 5, 29-41.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 29-41
-
-
Liu, F.T.1
-
18
-
-
34247849243
-
Significant coexpression of GLUT-1, Bcl-xL, and Bax in colorectal cancer
-
Wincewicz,A. et al. (2007) Significant coexpression of GLUT-1, Bcl-xL, and Bax in colorectal cancer. Ann. N. Y. Acad. Sci., 1095, 53-61.
-
(2007)
Ann. N. Y. Acad. Sci.
, vol.1095
, pp. 53-61
-
-
Wincewicz, A.1
-
19
-
-
68849105996
-
Expression of galectin-1 in malignant tumors
-
Demydenko,D. et al. (2009) Expression of galectin-1 in malignant tumors. Exp. Oncol., 31, 74-79.
-
(2009)
Exp. Oncol.
, vol.31
, pp. 74-79
-
-
Demydenko, D.1
-
20
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza,G.L. (2003) Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer, 3, 721-732.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
21
-
-
35548935098
-
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
-
Cheng,J. et al. (2007) SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell, 131, 584-595.
-
(2007)
Cell
, vol.131
, pp. 584-595
-
-
Cheng, J.1
-
22
-
-
0034326273
-
Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
-
Elson,D.A. et al. (2000) Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res., 60, 6189-6195.
-
(2000)
Cancer Res.
, vol.60
, pp. 6189-6195
-
-
Elson, D.A.1
-
23
-
-
40949142209
-
The role of hypoxia-inducible factors in tumorigenesis
-
Rankin,E.B. et al. (2008) The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ., 15, 678-685.
-
(2008)
Cell Death Differ.
, vol.15
, pp. 678-685
-
-
Rankin, E.B.1
-
24
-
-
0037374289
-
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1
-
Krishnamachary,B. et al. (2003) Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res., 63, 1138-1143.
-
(2003)
Cancer Res.
, vol.63
, pp. 1138-1143
-
-
Krishnamachary, B.1
-
25
-
-
33645090169
-
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
-
Krishnamachary,B. et al. (2006) Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res., 66, 2725-2731.
-
(2006)
Cancer Res.
, vol.66
, pp. 2725-2731
-
-
Krishnamachary, B.1
-
26
-
-
33846223947
-
Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension
-
Case,D. et al. (2007) Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol., 292, L154-L164.
-
(2007)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.292
-
-
Case, D.1
-
27
-
-
33144460217
-
Galectin-1: A link between tumor hypoxia and tumor immune privilege
-
Le,Q.T. et al. (2005) Galectin-1: a link between tumor hypoxia and tumor immune privilege. J. Clin. Oncol., 23, 8932-8941.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 8932-8941
-
-
Le, Q.T.1
-
28
-
-
43449117183
-
Evidence of galectin-1 involvement in glioma chemoresistance
-
Le Mercier,M. et al. (2008) Evidence of galectin-1 involvement in glioma chemoresistance. Toxicol. Appl. Pharmacol., 229, 172-183.
-
(2008)
Toxicol. Appl. Pharmacol.
, vol.229
, pp. 172-183
-
-
Le Mercier, M.1
-
29
-
-
34547842084
-
Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas
-
Le,Q.T. et al. (2007) Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. Int. J. Radiat. Oncol. Biol. Phys., 69, 167-175.
-
(2007)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.69
, pp. 167-175
-
-
Le, Q.T.1
-
30
-
-
0037454758
-
Upregulation of galectins-1 and -3 in human colon cancer and their role in regulating cell migration
-
Hittelet,A. et al. (2003) Upregulation of galectins-1 and -3 in human colon cancer and their role in regulating cell migration. Int. J. Cancer, 103, 370-379.
-
(2003)
Int. J. Cancer
, vol.103
, pp. 370-379
-
-
Hittelet, A.1
-
31
-
-
0344559105
-
Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting
-
Nagy,N. et al. (2003) Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting. Cancer, 97, 1849-1858.
-
(2003)
Cancer
, vol.97
, pp. 1849-1858
-
-
Nagy, N.1
-
32
-
-
37549032776
-
The interplay between MYC and HIF in cancer
-
Dang,C.V. et al. (2008) The interplay between MYC and HIF in cancer. Nat. Rev. Cancer, 8, 51-56.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 51-56
-
-
Dang, C.V.1
-
33
-
-
40549130675
-
CCAAT/enhancer-binding protein alpha antagonizes transcriptional activity of hypoxia-inducible factor 1 alpha with direct protein-protein interaction
-
Yang,L. et al. (2008) CCAAT/enhancer-binding protein alpha antagonizes transcriptional activity of hypoxia-inducible factor 1 alpha with direct protein-protein interaction. Carcinogenesis, 29, 291-298.
-
(2008)
Carcinogenesis
, vol.29
, pp. 291-298
-
-
Yang, L.1
-
34
-
-
70350363090
-
An essential role of the HIF-1alpha-c-Myc axis in malignant progression
-
Yoo,Y.G. et al. (2009) An essential role of the HIF-1alpha-c-Myc axis in malignant progression. Ann. N. Y. Acad. Sci., 1177, 198-204.
-
(2009)
Ann. N. Y. Acad. Sci.
, vol.1177
, pp. 198-204
-
-
Yoo, Y.G.1
-
35
-
-
38749099057
-
Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1alpha
-
Peng,Z.G. et al. (2008) Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1alpha. Oncogene, vol. 27, 839-847.
-
(2008)
Oncogene
, vol.27
, pp. 839-847
-
-
Peng, Z.G.1
-
36
-
-
45449112374
-
Galectins: structure, function and therapeutic potential
-
Yang,R.Y. et al. (2008) Galectins: structure, function and therapeutic potential. Expert Rev. Mol. Med., 10, e17.
-
(2008)
Expert Rev. Mol. Med.
, vol.10
-
-
Yang, R.Y.1
-
37
-
-
33749556658
-
Galectin-1: A small protein with major functions
-
Camby,I. et al. (2006) Galectin-1: a small protein with major functions. Glycobiology, 16, 137R-157R.
-
(2006)
Glycobiology
, vol.16
-
-
Camby, I.1
-
38
-
-
33750474852
-
Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy
-
Thijssen,V.L. et al. (2006) Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc. Natl Acad. Sci. USA, 103, 15975-15980.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 15975-15980
-
-
Thijssen, V.L.1
-
39
-
-
34447136940
-
Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival
-
Elola,M.T. et al. (2007) Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Cell. Mol. Life Sci., 64, 1679-1700.
-
(2007)
Cell. Mol. Life Sci.
, vol.64
, pp. 1679-1700
-
-
Elola, M.T.1
-
40
-
-
34247354630
-
Lack of galectin-1 results in defects in myoblast fusion and muscle regeneration
-
Georgiadis,V. et al. (2007) Lack of galectin-1 results in defects in myoblast fusion and muscle regeneration. Dev. Dyn., 236, 1014-1024.
-
(2007)
Dev. Dyn.
, vol.236
, pp. 1014-1024
-
-
Georgiadis, V.1
-
41
-
-
34247397364
-
Galectin-1 expression in cancer-associated stromal cells correlates tumor invasiveness and tumor progression in breast cancer
-
Jung,E.J. et al. (2007) Galectin-1 expression in cancer-associated stromal cells correlates tumor invasiveness and tumor progression in breast cancer. Int. J. Cancer, 120, 2331-2338.
-
(2007)
Int. J. Cancer
, vol.120
, pp. 2331-2338
-
-
Jung, E.J.1
-
42
-
-
62549096778
-
Galectin-1-mediated tumor invasion and metastasis, up-regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons
-
Wu,M.H. et al. (2009) Galectin-1-mediated tumor invasion and metastasis, up-regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons. Mol. Cancer Res., 7, 311-318.
-
(2009)
Mol. Cancer Res.
, vol.7
, pp. 311-318
-
-
Wu, M.H.1
-
43
-
-
0027945617
-
Concomitant increases in galectin-1 and its glycoconjugate ligands (carcinoembryonic antigen, lamp-1, and lamp-2) in cultured human colon carcinoma cells by sodium butyrate
-
Ohannesian,D.W. et al. (1994) Concomitant increases in galectin-1 and its glycoconjugate ligands (carcinoembryonic antigen, lamp-1, and lamp-2) in cultured human colon carcinoma cells by sodium butyrate. Cancer Res., 54, 5992-6000.
-
(1994)
Cancer Res.
, vol.54
, pp. 5992-6000
-
-
Ohannesian, D.W.1
-
44
-
-
58149478525
-
HIF-1alpha and HIF-2alpha have divergent roles in colon cancer
-
Imamura,T. et al. (2009) HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int. J. Cancer, 124, 763-771.
-
(2009)
Int. J. Cancer
, vol.124
, pp. 763-771
-
-
Imamura, T.1
|