Sex differences in cognitive impairment and Alzheimer's disease

Frontiers in Neuroendocrinology

Volumn 35, Issue 3, 2014, Pages 385-403

  Li, Rena ^a   Singh, Meharvan ^b  

^a ROSKAMP INSTITUTE   (United States)

^b UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

Alzheimer's disease; Cognition; Gender; Sex difference; Steroid hormones

Indexed keywords

ANDROGEN; ESTROGEN; GESTAGEN; MEDROXYPROGESTERONE ACETATE; PROGESTERONE; SEX HORMONE; TESTOSTERONE;

ADULTHOOD; AGING; ALZHEIMER DISEASE; BRAIN DAMAGE; BRAIN EDEMA; BRAIN INFARCTION; BRAIN PROTECTION; COGNITION; COGNITIVE DEFECT; DEPRESSION; DIABETES MELLITUS; DRUG MECHANISM; GENETIC ASSOCIATION; GENETIC RISK; HEART DISEASE; HORMONE ACTION; HUMAN; MENTAL PERFORMANCE; NEUROPROTECTION; NONHUMAN; OBESITY; PERINATAL PERIOD; PRIORITY JOURNAL; PUBERTY; REVIEW; SEX DIFFERENCE; SPATIAL MEMORY; SPATIAL MEMORY TEST; TASK PERFORMANCE; TRANSLATIONAL RESEARCH; VERBAL MEMORY; WORKING MEMORY; ANIMAL; COGNITION DISORDERS; METABOLISM; PHYSIOLOGY; SEXUAL DEVELOPMENT;

ALZHEIMER DISEASE; ANIMALS; COGNITION; COGNITION DISORDERS; GONADAL STEROID HORMONES; HUMANS; SEX CHARACTERISTICS;

EID: 84903775420     PISSN: 00913022     EISSN: 10956808     Source Type: Journal    
DOI: 10.1016/j.yfrne.2014.01.002     Document Type: Review

References (348)

1. Adams M.R., Register T.C., Golden D.L., Wagner J.D., Williams J.K. Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 1997, 17:217-221.
2. Ahlbom E., Grandison L., Bonfoco E., Zhivotovsky B., Ceccatelli S. Androgen treatment of neonatal rats decreases susceptibility of cerebellar granule neurons to oxidative stress in vitro. Eur. J. Neurosci. 1999, 11:1285-1291.
3. Ahlbom E., Prins G.S., Ceccatelli S. Testosterone protects cerebellar granule cells from oxidative stress-induced cell death through a receptor mediated mechanism. Brain Res. 2001, 892:255-262.
4. Alkayed N.J., Harukuni I., Kimes A.S., London E.D., Traystman R.J., Hurn P.D. Gender-linked brain injury in experimental stroke. Stroke 1998, 29:159-165. discussion 166.
5. Amtul Z., Wang L., Westaway D., Rozmahel R.F. Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease. Neuroscience 2010, 169:781-786.
6. Anastasio T.J. Exploring the contribution of estrogen to amyloid-Beta regulation: a novel multifactorial computational modeling approach. Front. Pharmacol. 2013, 4:16.
7. Ancelin M.L., Ripoche E., Dupuy A.M., Barberger-Gateau P., Auriacombe S., Rouaud O., Berr C., Carriere I., Ritchie K. Sex differences in the associations between lipid levels and incident dementia. J. Alzheimers Dis. 2013, 34:519-528.
8. Anderson G.L., Limacher M., Assaf A.R., Bassford T., Beresford S.A., Black H., Bonds D., Brunner R., Brzyski R., Caan B., Chlebowski R., Curb D., Gass M., Hays J., Heiss G., Hendrix S., Howard B.V., Hsia J., Hubbell A., Jackson R., Johnson K.C., Judd H., Kotchen J.M., Kuller L., LaCroix A.Z., Lane D., Langer R.D., Lasser N., Lewis C.E., Manson J., Margolis K., Ockene J., O'Sullivan M.J., Phillips L., Prentice R.L., Ritenbaugh C., Robbins J., Rossouw J.E., Sarto G., Stefanick M.L., Van Horn L., Wactawski-Wende J., Wallace R., Wassertheil-Smoller S. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 2004, 291:1701-1712.
9. Andreano J.M., Cahill L. Sex influences on the neurobiology of learning and memory. Learn. Mem. 2009, 16:248-266.
10. Ardila A., Rosselli M., Matute E., Inozemtseva O. Gender differences in cognitive development. Dev. Psychol. 2011, 47:984-990.
11. Aronson M.K., Ooi W.L., Morgenstern H., Hafner A., Masur D., Crystal H., Frishman W.H., Fisher D., Katzman R. Women, myocardial infarction, and dementia in the very old. Neurology 1990, 40:1102-1106.
12. Astur R.S., Ortiz M.L., Sutherland R.J. A characterization of performance by men and women in a virtual Morris water task: a large and reliable sex difference. Behav. Brain Res. 1998, 93:185-190.
13. Attella M.J., Nattinville A., Stein D.G. Hormonal state affects recovery from frontal cortex lesions in adult female rats. Behav. Neural Biol. 1987, 48:352-367.
14. Bachman D.L., Wolf P.A., Linn R., Knoefel J.E., Cobb J., Belanger A., D'Agostino R.B., White L.R. Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study. Neurology 1992, 42:115-119.
15. Bakker J., Baum M.J. Role for estradiol in female-typical brain and behavioral sexual differentiation. Front. Neuroendocrinol. 2008, 29:1-16.
16. Bakker J., Brand T., van Ophemert J., Slob A.K. Hormonal regulation of adult partner preference behavior in neonatally ATD-treated male rats. Behav. Neurosci. 1993, 107:480-487.
17. Bakker J., van Ophemert J., Timmerman M.A., de Jong F.H., Slob A.K. Endogenous reproductive hormones and nocturnal rhythms in partner preference and sexual behavior of ATD-treated male rats. Neuroendocrinology 1995, 62:396-405.
18. Banuelos C., Gilbert R.J., Montgomery K.S., Fincher A.S., Wang H., Frye G.D., Setlow B., Bizon J.L. Altered spatial learning and delay discounting in a rat model of human third trimester binge ethanol exposure. Behav. Pharmacol. 2012, 23:54-65.
19. Bao A.M., Swaab D.F. Sexual differentiation of the human brain: relation to gender identity, sexual orientation and neuropsychiatric disorders. Front. Neuroendocrinol. 2011, 32:214-226.
20. Barense M.D., Bussey T.J., Lee A.C., Rogers T.T., Davies R.R., Saksida L.M., Murray E.A., Graham K.S. Functional specialization in the human medial temporal lobe. J. Neurosci. 2005, 25:10239-10246.
21. Barha C.K., Galea L.A. Motherhood alters the cellular response to estrogens in the hippocampus later in life. Neurobiol. Aging 2011, 32:2091-2095.
22. Barron A.M., Pike C.J. Sex hormones, aging, and Alzheimer's disease. Front. Biosci. (Elite Ed.) 2012, 4:976-997.
23. Bayir H., Marion D.W., Puccio A.M., Wisniewski S.R., Janesko K.L., Clark R.S., Kochanek P.M. Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients. J. Neurotrauma 2004, 21:1-8.
24. Beatty W.W. Sex difference in geographical knowledge: driving experience is not essential. J. Int. Neuropsychol. Soc. 2002, 8:804-810.
25. Behl C., Skutella T., Lezoualc'h F., Post A., Widmann M., Newton C.J., Holsboer F. Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol. Pharmacol. 1997, 51:535-541.
26. Beltz A.M., Berenbaum S.A. Cognitive effects of variations in pubertal timing: is puberty a period of brain organization for human sex-typed cognition?. Horm. Behav. 2013, 63:823-828.
27. Berenbaum S.A., Baxter L., Seidenberg M., Hermann B. Role of the hippocampus in sex differences in verbal memory: memory outcome following left anterior temporal lobectomy. Neuropsychology 1997, 11:585-591.
28. Berenbaum S.A., Bryk K.L., Beltz A.M. Early androgen effects on spatial and mechanical abilities: evidence from congenital adrenal hyperplasia. Behav. Neurosci. 2012, 126:86-96.
29. Berta P., Hawkins J.R., Sinclair A.H., Taylor A., Griffiths B.L., Goodfellow P.N., Fellous M. Genetic evidence equating SRY and the testis-determining factor. Nature 1990, 348:448-450.
30. Beydoun M.A., Beydoun H.A., Kaufman J.S., An Y., Resnick S.M., O'Brien R., Ferrucci L., Zonderman A.B. Apolipoprotein E epsilon4 allele interacts with sex and cognitive status to influence all-cause and cause-specific mortality in U.S. older adults. J. Am. Geriatr. Soc. 2013, 61:525-534.
31. Bishop J., Simpkins J.W. Estradiol treatment increases viability of glioma and neuroblastoma cells in vitro. Mol. Cell. Neurosci. 1994, 5:303-308.
32. Bookheimer S., Burggren A. APOE-4 genotype and neurophysiological vulnerability to Alzheimer's and cognitive aging. Annu. Rev. Clin. Psychol. 2009, 5:343-362.
33. Bracco L., Bessi V., Alari F., Sforza A., Barilaro A., Marinoni M. Cerebral hemodynamic lateralization during memory tasks as assessed by functional transcranial Doppler (fTCD) sonography: effects of gender and healthy aging. Cortex 2011, 47:750-758.
34. Bramen J.E., Hranilovich J.A., Dahl R.E., Forbes E.E., Chen J., Toga A.W., Dinov I.D., Worthman C.M., Sowell E.R. Puberty influences medial temporal lobe and cortical gray matter maturation differently in boys than girls matched for sexual maturity. Cereb. Cortex 2011, 21:636-646.
35. Brown J.M., Wiggins J., Dong H., Harvey R., Richardson F., Hunter K., Dawson K., Parker R.A. The hard Test Your Memory. Evaluation of a short cognitive test to detect mild Alzheimer's disease and amnestic mild cognitive impairment. Int. J. Geriatr. Psychiatry 2013.
36. Burkitt J., Widman D., Saucier D.M. Evidence for the influence of testosterone in the performance of spatial navigation in a virtual water maze in women but not in men. Horm. Behav. 2007, 51:649-654.
37. Butchart J., Birch B., Bassily R., Wolfe L., Holmes C. Male sex hormones and systemic inflammation in Alzheimer disease. Alzheimer Dis. Assoc. Disord. 2013, 27:153-156.
38. Cagliani R., Guerini F.R., Rubio-Acero R., Baglio F., Forni D., Agliardi C., Griffanti L., Fumagalli M., Pozzoli U., Riva S., Calabrese E., Sikora M., Casals F., Comi G.P., Bresolin N., Caceres M., Clerici M., Sironi M. Long-standing balancing selection in the THBS4 gene: influence on sex-specific brain expression and gray matter volumes in Alzheimer disease. Hum. Mutat. 2013, 34:743-753.
39. Cahill L. His brain, her brain. Sci. Am. 2005, 292:40-47.
40. Callahan M.J., Lipinski W.J., Bian F., Durham R.A., Pack A., Walker L.C. Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice. Am. J. Pathol. 2001, 158:1173-1177.
41. Carroll J.C., Rosario E.R., Villamagna A., Pike C.J. Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice. Endocrinology 2010, 151:2713-2722.
42. Carter C.L., Resnick E.M., Mallampalli M., Kalbarczyk A. Sex and gender differences in Alzheimer's disease: recommendations for future research. J. Womens Health (Larchmt) 2012, 21:1018-1023.
43. Caruso A., Di Giorgi Gerevini V., Castiglione M., Marinell F., Tomassini V., Pozzilli C., Caricasole A., Bruno V., Caciagli F., Moretti A., Nicoletti F., Melchiorri D. Testosterone amplifies excitotoxic damage of cultured oligodendrocytes. J. Neurochem. 2004, 88:1179-1185.
44. Cervantes M., Gonzalez-Vidal M.D., Ruelas R., Escobar A., Morali G. Neuroprotective effects of progesterone on damage elicited by acute global cerebral ischemia in neurons of the caudate nucleus. Arch. Med. Res. 2002, 33:6-14.
45. Chai X.J., Jacobs L.F. Sex differences in directional cue use in a virtual landscape. Behav. Neurosci. 2009, 123:276-283.
46. Chen J., Chopp M., Li Y. Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat. J. Neurol. Sci. 1999, 171:24-30.
47. Chen J., Xu W., Jiang H. 17 beta-estradiol protects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acids. Anesth. Analg. 2001, 92:1520-1523.
48. Cherrier M.M., Matsumoto A.M., Amory J.K., Asthana S., Bremner W., Peskind E.R., Raskind M.A., Craft S. Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment. Neurology 2005, 64:2063-2068.
49. Chow C., Epp J.R., Lieblich S.E., Barha C.K., Galea L.A. Sex differences in neurogenesis and activation of new neurons in response to spatial learning and memory. Psychoneuroendocrinology 2013, 38:1236-1250.
50. Christie G.J., Cook C.M., Ward B.J., Tata M.S., Sutherland J., Sutherland R.J., Saucier D.M. Mental rotational ability is correlated with spatial but not verbal working memory performance and P300 amplitude in males. PLoS ONE 2013, 8:e57390.
51. Clark A.S., MacLusky N.J., Goldman-Rakic P.S. Androgen binding and metabolism in the cerebral cortex of the developing rhesus monkey. Endocrinology 1988, 123:932-940.
52. Connor P.D., Sampson P.D., Bookstein F.L., Barr H.M., Streissguth A.P. Direct and indirect effects of prenatal alcohol damage on executive function. Dev. Neuropsychol. 2000, 18:331-354.
53. Cosgrove K.P., Mazure C.M., Staley J.K. Evolving knowledge of sex differences in brain structure, function, and chemistry. Biol. Psychiatry 2007, 62:847-855.
54. Cost K.T., Williams-Yee Z.N., Fustok J.N., Dohanich G.P. Sex differences in object-in-place memory of adult rats. Behav. Neurosci. 2012, 126:457-464.
55. Courvoisier D.S., Renaud O., Geiser C., Paschke K., Gaudy K., Jordan K. Sex hormones and mental rotation: an intensive longitudinal investigation. Horm. Behav. 2013, 63:345-351.
56. Cowie C.C., Harris M.I., Eberhardt M.S. Frequency and determinants of screening for diabetes in the U.S. Diabetes Care 1994, 17:1158-1163.
57. Cui J., Randell E., Renouf J., Sun G., Han F.Y., Younghusband B., Xie Y.G. Gender dependent association of thrombospondin-4 A387P polymorphism with myocardial infarction. Arterioscler. Thromb. Vasc. Biol. 2004, 24:e183-e184.
58. Cui J., Shen Y., Li R. Estrogen synthesis and signaling pathways during aging: from periphery to brain. Trends Mol. Med. 2013, 19:197-209.
59. Culmsee C., Vedder H., Ravati A., Junker V., Otto D., Ahlemeyer B., Krieg J.C., Krieglstein J. Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: evidence for a receptor-independent antioxidative mechanism. J. Cereb. Blood Flow Metab. 1999, 19:1263-1269.
60. Cunningham R.L., Macheda T., Watts L.T., Poteet E., Singh M., Roberts J.L., Giuffrida A. Androgens exacerbate motor asymmetry in male rats with unilateral 6-hydroxydopamine lesion. Horm. Behav. 2011, 60:617-624.
61. Dal Forno G., Palermo M.T., Donohue J.E., Karagiozis H., Zonderman A.B., Kawas C.H. Depressive symptoms, sex, and risk for Alzheimer's disease. Ann. Neurol. 2005, 57:381-387.
62. Dang T.N., Dobson-Stone C., Glaros E.N., Kim W.S., Hallupp M., Bartley L., Piguet O., Hodges J.R., Halliday G.M., Double K.L., Schofield P.R., Crouch P.J., Kwok J.B. Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model. Dis. Models Mech. 2013, 6:1198-1204.
63. Davis E.C., Shryne J.E., Gorski R.A. A revised critical period for the sexual differentiation of the sexually dimorphic nucleus of the preoptic area in the rat. Neuroendocrinology 1995, 62:579-585.
64. De Deyn P.P., Goeman J., Vervaet A., Dourcy-Belle-Rose B., Van Dam D., Geerts E. Prevalence and incidence of dementia among 75-80-year-old community-dwelling elderly in different districts of Antwerp, Belgium: the Antwerp Cognition (ANCOG) Study. Clin. Neurol. Neurosurg. 2011, 113:736-745.
65. de Frias C.M., Nilsson L.G., Herlitz A. Sex differences in cognition are stable over a 10-year period in adulthood and old age. Neuropsychol. Dev. Cogn. B: Aging Neuropsychol. Cogn. 2006, 13:574-587.
66. Dere E., Huston J.P., De Souza Silva M.A. The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents. Neurosci. Biobehav. Rev. 2007, 31:673-704.
67. Diniz B.S., Butters M.A., Albert S.M., Dew M.A., Reynolds C.F. Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies. Br. J. Psychiatry 2013, 202:329-335.
68. Dong, Y., Gan, D.Z., Tay, S.Z., Koay, W.I., Collinson, S.L., Hilal, S., Venketasubramanian, N., Chen, C., 2013. Patterns of neuropsychological impairment in Alzheimer's disease and mixed dementia. J. Neurol. Sci.
69. Doraiswamy P.M., Bieber F., Kaiser L., Krishnan K.R., Reuning-Scherer J., Gulanski B. The Alzheimer's Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials. Neurology 1997, 48:1511-1517.
70. Driscoll I., Hamilton D.A., Yeo R.A., Brooks W.M., Sutherland R.J. Virtual navigation in humans: the impact of age, sex, and hormones on place learning. Horm. Behav. 2005, 47:326-335.
71. Du L., Bayir H., Lai Y., Zhang X., Kochanek P.M., Watkins S.C., Graham S.H., Clark R.S. Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. J. Biol. Chem. 2004, 279:38563-38570.
72. Dubal D.B., Kashon M.L., Pettigrew L.C., Ren J.M., Finklestein S.P., Rau S.W., Wise P.M. Estradiol protects against ischemic injury. J. Cereb. Blood Flow Metab. 1998, 18:1253-1258.
73. Dye R.V., Miller K.J., Singer E.J., Levine A.J. Hormone replacement therapy and risk for neurodegenerative diseases. Int. J. Alzheimers Dis. 2012, 2012:258454.
74. Epp J.R., Galea L.A. Hippocampus-dependent strategy choice predicts low levels of cell proliferation in the dentate gyrus. Neurobiol. Learn. Mem. 2009, 91:437-446.
75. Epting L.K., Overman W.H. Sex-sensitive tasks in men and women: a search for performance fluctuations across the menstrual cycle. Behav. Neurosci. 1998, 112:1304-1317.
76. Espeland M.A., Rapp S.R., Shumaker S.A., Brunner R., Manson J.E., Sherwin B.B., Hsia J., Margolis K.L., Hogan P.E., Wallace R., Dailey M., Freeman R., Hays J. Conjugated equine estrogens and global cognitive function in postmenopausal women: women's Health Initiative Memory Study. JAMA 2004, 291:2959-2968.
77. Falkeborn M., Persson I., Terent A., Adami H.O., Lithell H., Bergstrom R. Hormone replacement therapy and the risk of stroke. Follow-up of a population-based cohort in Sweden. Arch. Intern. Med. 1993, 153:1201-1209.
78. Fallah N., Mitnitski A., Middleton L., Rockwood K. Modeling the impact of sex on how exercise is associated with cognitive changes and death in older Canadians. Neuroepidemiology 2009, 33:47-54.
79. Feldman H.A., Longcope C., Derby C.A., Johannes C.B., Araujo A.B., Coviello A.D., Bremner W.J., McKinlay J.B. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J. Clin. Endocrinol. Metab. 2002, 87:589-598.
80. Fester L., Prange-Kiel J., Zhou L., Blittersdorf B.V., Bohm J., Jarry H., Schumacher M., Rune G.M. Estrogen-regulated synaptogenesis in the hippocampus: sexual dimorphism in vivo but not in vitro. J. Steroid Biochem. Mol. Biol. 2012, 131:24-29.
81. Finucane F.F., Madans J.H., Bush T.L., Wolf P.H., Kleinman J.C. Decreased risk of stroke among postmenopausal hormone users. Results from a national cohort. Arch. Intern. Med. 1993, 153:73-79.
82. Fleisher A., Grundman M., Jack C.R., Petersen R.C., Taylor C., Kim H.T., Schiller D.H., Bagwell V., Sencakova D., Weiner M.F., DeCarli C., DeKosky S.T., van Dyck C.H., Thal L.J. Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment. Arch. Neurol. 2005, 62:953-957.
83. Frisch S., Dukart J., Vogt B., Horstmann A., Becker G., Villringer A., Barthel H., Sabri O., Muller K., Schroeter M.L. Dissociating memory networks in early Alzheimer's disease and frontotemporal lobar degeneration - a combined study of hypometabolism and atrophy. PLoS ONE 2013, 8:e55251.
84. Frye C.A., Walf A.A. Effects of progesterone administration and APPswe+PSEN1Deltae9 mutation for cognitive performance of mid-aged mice. Neurobiol. Learn. Mem. 2008, 89:17-26.
85. Fukuda K., Yao H., Ibayashi S., Nakahara T., Uchimura H., Fujishima M., Hall E.D. Ovariectomy exacerbates and estrogen replacement attenuates photothrombotic focal ischemic brain injury in rats. Stroke 2000, 31:155-160.
86. Gale E.A., Gillespie K.M. Diabetes and gender. Diabetologia 2001, 44:3-15.
87. Gale S.D., Baxter L., Connor D.J., Herring A., Comer J. Sex differences on the Rey Auditory Verbal Learning Test and the Brief Visuospatial Memory Test-Revised in the elderly: normative data in 172 participants. J. Clin. Exp. Neuropsychol. 2007, 29:561-567.
88. Galea, L.A., Wainwright, S.R., Roes, M.M., Duarte-Guterman, P., Chow, C., Hamson, D.K., 2013. Sex, hormones, and neurogenesis in the hippocampus: hormonal modulation of neurogenesis and potential functional implications. J. Neuroendocrinol.
89. Gambrell R.D. The role of hormones in the etiology and prevention of endometrial cancer. Clin. Obstet Gynaecol. 1986, 13:695-723.
90. Gao S., Hendrie H.C., Hall K.S., Hui S. The relationships between age, sex, and the incidence of dementia and Alzheimer disease: a meta-analysis. Arch. Gen. Psychiatry 1998, 55:809-815.
91. Garcia-Segura L.M., Azcoitia I., DonCarlos L.L. Neuroprotection by estradiol. Prog. Neurobiol. 2001, 63:29-60.
92. Geerlings M.I., Ruitenberg A., Witteman J.C., van Swieten J.C., Hofman A., van Duijn C.M., Breteler M.M., Launer L.J. Reproductive period and risk of dementia in postmenopausal women. JAMA 2001, 285:1475-1481.
93. Gerstorf D., Herlitz A., Smith J. Stability of sex differences in cognition in advanced old age: the role of education and attrition. J. Gerontol. B Psychol. Sci. Soc. Sci. 2006, 61:P245-P249.
94. Gibbs R.B., Nelson D., Anthony M.S., Clarkson T.B. Effects of long-term hormone replacement and of tibolone on choline acetyltransferase and acetylcholinesterase activities in the brains of ovariectomized, cynomologus monkeys. Neuroscience 2002, 113:907-914.
95. Giedd J.N., Snell J.W., Lange N., Rajapakse J.C., Casey B.J., Kozuch P.L., Vaituzis A.C., Vauss Y.C., Hamburger S.D., Kaysen D., Rapoport J.L. Quantitative magnetic resonance imaging of human brain development: ages 4-18. Cereb. Cortex 1996, 6:551-560.
96. Giedd J.N., Clasen L.S., Wallace G.L., Lenroot R.K., Lerch J.P., Wells E.M., Blumenthal J.D., Nelson J.E., Tossell J.W., Stayer C., Evans A.C., Samango-Sprouse C.A. XXY (Klinefelter syndrome): a pediatric quantitative brain magnetic resonance imaging case-control study. Pediatrics 2007, 119:e232-e240.
97. Giedd J.N., Raznahan A., Mills K.L., Lenroot R.K. Review: magnetic resonance imaging of male/female differences in human adolescent brain anatomy. Biol. Sex Differ. 2012, 3:19.
98. Giovagnoli A.R., Erbetta A., Reati F., Bugiani O. Differential neuropsychological patterns of frontal variant frontotemporal dementia and Alzheimer's disease in a study of diagnostic concordance. Neuropsychologia 2008, 46:1495-1504.
99. Gizewski E.R., Krause E., Wanke I., Forsting M., Senf W. Gender-specific cerebral activation during cognitive tasks using functional MRI: comparison of women in mid-luteal phase and men. Neuroradiology 2006, 48:14-20.
100. Gonzalez Deniselle M.C., Lopez Costa J.J., Gonzalez S.L., Labombarda F., Garay L., Guennoun R., Schumacher M., De Nicola A.F. Basis of progesterone protection in spinal cord neurodegeneration. J. Steroid Biochem. Mol. Biol. 2002, 83:199-209.
101. Gonzalez Deniselle M.C., Lopez-Costa J.J., Saavedra J.P., Pietranera L., Gonzalez S.L., Garay L., Guennoun R., Schumacher M., De Nicola A.F. Progesterone neuroprotection in the Wobbler mouse, a genetic model of spinal cord motor neuron disease. Neurobiol. Dis. 2002, 11:457-468.
102. Goodman Y., Bruce A.J., Cheng B., Mattson M.P. Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons. J. Neurochem. 1996, 66:1836-1844.
103. Gorski R.A., Gordon J.H., Shryne J.E., Southam A.M. Evidence for a morphological sex difference within the medial preoptic area of the rat brain. Brain Res. 1978, 148:333-346.
104. Gouras G.K., Xu H., Gross R.S., Greenfield J.P., Hai B., Wang R., Greengard P. Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides. Proc. Natl. Acad. Sci. USA 2000, 97:1202-1205.
105. Graber J.A., Lewinsohn P.M., Seeley J.R., Brooks-Gunn J. Is psychopathology associated with the timing of pubertal development?. J. Am. Acad. Child Adolesc. Psychiatry 1997, 36:1768-1776.
106. Green P.S., Simpkins J.W. Neuroprotective effects of estrogens: potential mechanisms of action. Int. J. Dev. Neurosci. 2000, 18:347-358.
107. Griksiene R., Ruksenas O. Effects of hormonal contraceptives on mental rotation and verbal fluency. Psychoneuroendocrinology 2011, 36:1239-1248.
108. Groswasser Z., Cohen M., Keren O. Female TBI patients recover better than males. Brain Inj. 1998, 12:805-808.
109. Hackenberg R., Hofmann J., Wolff G., Holzel F., Schulz K.D. Down-regulation of androgen receptor by progestins and interference with estrogenic or androgenic stimulation of mammary carcinoma cell growth. J. Cancer Res. Clin. Oncol. 1990, 116:492-498.
110. Hammond J., Le Q., Goodyer C., Gelfand M., Trifiro M., LeBlanc A. Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons. J. Neurochem. 2001, 77:1319-1326.
111. Hampson E. Variations in sex-related cognitive abilities across the menstrual cycle. Brain Cogn. 1990, 14:26-43.
112. Harrison F.E., Hosseini A.H., McDonald M.P. Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks. Behav. Brain Res. 2009, 198:247-251.
113. Hart S.J., Davenport M.L., Hooper S.R., Belger A. Visuospatial executive function in Turner syndrome: functional MRI and neurocognitive findings. Brain 2006, 129:1125-1136.
114. Hausmann M., Slabbekoorn D., Van Goozen S.H., Cohen-Kettenis P.T., Gunturkun O. Sex hormones affect spatial abilities during the menstrual cycle. Behav. Neurosci. 2000, 114:1245-1250.
115. Hawk T., Zhang Y.Q., Rajakumar G., Day A.L., Simpkins J.W. Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats. Brain Res. 1998, 796:296-298.
116. Heinzel S., Metzger F.G., Ehlis A.C., Korell R., Alboji A., Haeussinger F.B., Hagen K., Maetzler W., Eschweiler G.W., Berg D., Fallgatter A.J. Aging-related cortical reorganization of verbal fluency processing: a functional near-infrared spectroscopy study. Neurobiol. Aging 2013, 34:439-450.
117. Henderson V.W., Buckwalter J.G. Cognitive deficits of men and women with Alzheimer's disease. Neurology 1994, 44:90-96.
118. Henderson B.E., Paganini-Hill A., Ross R.K. Decreased mortality in users of estrogen replacement therapy. Arch. Intern. Med. 1991, 151:75-78.
119. Henderson V.W., Paganini-Hill A., Emanuel C.K., Dunn M.E., Buckwalter J.G. Estrogen replacement therapy in older women. Comparisons between Alzheimer's disease cases and nondemented control subjects. Arch. Neurol. 1994, 51:896-900.
120. Herlitz A., Reuterskiold L., Loven J., Thilers P.P., Rehnman J. Cognitive sex differences are not magnified as a function of age, sex hormones, or puberty development during early adolescence. Dev. Neuropsychol. 2013, 38:167-179.
121. Herrera-Guzman I., Pena-Casanova J., Lara J.P., Gudayol-Ferre E., Bohm P. Influence of age, sex, and education on the Visual Object and Space Perception Battery (VOSP) in a healthy normal elderly population. Clin. Neuropsychol. 2004, 18:385-394.
122. Heuer, H.W., Mirsky, J.B., Kong, E.L., Dickerson, B.C., Miller, B.L., Kramer, J.H., Boxer, A.L., 2013. Antisaccade task reflects cortical involvement in mild cognitive impairment. Neurology.
123. Hill C.A., Threlkeld S.W., Fitch R.H. Early testosterone modulated sex differences in behavioral outcome following neonatal hypoxia ischemia in rats. Int. J. Dev. Neurosci. 2011, 29:381-388.
124. Hirvonen E. Progestins. Maturitas 1996, 23(Suppl.):S13-S18.
125. Hogervorst, E., 2013. Effects of gonadal hormones on cognitive behavior in elderly men and women. J. Neuroendocrinol.
126. Hogervorst E., Williams J., Budge M., Barnetson L., Combrinck M., Smith A.D. Serum total testosterone is lower in men with Alzheimer's disease. Neuro Endocrinol. Lett. 2001, 22:163-168.
127. Hojo Y., Higo S., Kawato S., Hatanaka Y., Ooishi Y., Murakami G., Ishii H., Komatsuzaki Y., Ogiue-Ikeda M., Mukai H., Kimoto T. Hippocampal synthesis of sex steroids and corticosteroids: essential for modulation of synaptic plasticity. Front. Endocrinol. (Lausanne) 2011, 2:43.
128. Holland, D., Desikan, R.S., Dale, A.M., McEvoy, L.K., 2013. Higher rates of decline for women and apolipoprotein E {varepsilon}4 carriers. AJNR Am. J. Neuroradiol.
129. Honda K., Sawada H., Kihara T., Urushitani M., Nakamizo T., Akaike A., Shimohama S. Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. J. Neurosci. Res. 2000, 60:321-327.
130. Horstink M.W., Strijks E., Dluzen D.E. Estrogen and Parkinson's disease. Adv. Neurol. 2003, 91:107-114.
131. Hsia J., Langer R.D., Manson J.E., Kuller L., Johnson K.C., Hendrix S.L., Pettinger M., Heckbert S.R., Greep N., Crawford S., Eaton C.B., Kostis J.B., Caralis P., Prentice R. Conjugated equine estrogens and coronary heart disease: the Women's Health Initiative. Arch. Intern. Med. 2006, 166:357-365.
132. Hugdahl K., Thomsen T., Ersland L. Sex differences in visuo-spatial processing: an fMRI study of mental rotation. Neuropsychologia 2006, 44:1575-1583.
133. Ibanez C., Shields S.A., El-Etr M., Leonelli E., Magnaghi V., Li W.W., Sim F.J., Baulieu E.E., Melcangi R.C., Schumacher M., Franklin R.J. Steroids and the reversal of age-associated changes in myelination and remyelination. Prog. Neurobiol. 2003, 71:49-56.
134. Irvine K., Laws K.R., Gale T.M., Kondel T.K. Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis. J. Clin. Exp. Neuropsychol. 2012, 34:989-998.
135. Ismail N., Garas P., Blaustein J.D. Long-term effects of pubertal stressors on female sexual receptivity and estrogen receptor-alpha expression in CD-1 female mice. Horm. Behav. 2011, 59:565-571.
136. Jaffe A.B., Toran-Allerand C.D., Greengard P., Gandy S.E. Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. J. Biol. Chem. 1994, 269:13065-13068.
137. Jansen P., Heil M. Gender differences in mental rotation across adulthood. Exp. Aging Res. 2010, 36:94-104.
138. Jansen, P., Kaltner, S., 2013. Object-based and egocentric mental rotation performance in older adults: the importance of gender differences and motor ability. Neuropsychol. Dev. Cogn. B Aging Neuropsychol. Cogn.
139. Jayaraman A., Carroll J.C., Morgan T.E., Lin S., Zhao L., Arimoto J.M., Murphy M.P., Beckett T.L., Finch C.E., Brinton R.D., Pike C.J. 17beta-estradiol and progesterone regulate expression of beta-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology 2012, 153:5467-5479.
140. Jiang N., Chopp M., Stein D., Feit H. Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats. Brain Res. 1996, 735:101-107.
141. Jodhka P.K., Kaur P., Underwood W., Lydon J.P., Singh M. The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression. Endocrinology 2009, 150:3162-3168.
142. Jorm A.F., Korten A.E., Henderson A.S. The prevalence of dementia: a quantitative integration of the literature. Acta Psychiatr. Scand. 1987, 76:465-479.
143. Jung J.I., Ladd T.B., Kukar T., Price A.R., Moore B.D., Koo E.H., Golde T.E., Felsenstein K.M. Steroids as gamma-secretase modulators. FASEB J. 2013, 27:3775-3785.
144. Junpeng, M., Huang, S., Qin, S., 2011. Progesterone for acute traumatic brain injury. Cochrane Database Syst. Rev., CD008409.
145. Kaur P., Jodhka P.K., Underwood W.A., Bowles C.A., de Fiebre N.C., de Fiebre C.M., Singh M. Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants. J. Neurosci. Res. 2007, 85:2441-2449.
146. Keeley R.J., Tyndall A.V., Scott G.A., Saucier D.M. Sex difference in cue strategy in a modified version of the Morris water task: correlations between brain and behaviour. PLoS ONE 2013, 8:e69727.
147. Kenny A.M., Fabregas G., Song C., Biskup B., Bellantonio S. Effects of testosterone on behavior, depression, and cognitive function in older men with mild cognitive loss. J. Gerontol. A Biol. Sci. Med. Sci. 2004, 59:75-78.
148. Kesler S.R., Garrett A., Bender B., Yankowitz J., Zeng S.M., Reiss A.L. Amygdala and hippocampal volumes in Turner syndrome: a high-resolution MRI study of X-monosomy. Neuropsychologia 2004, 42:1971-1978.
149. Kessler R.C., McGonagle K.A., Swartz M., Blazer D.G., Nelson C.B. Sex and depression in the National Comorbidity Survey. I: lifetime prevalence, chronicity and recurrence. J. Affect. Disord. 1993, 29:85-96.
150. Kessler R.C., McGonagle K.A., Zhao S., Nelson C.B., Hughes M., Eshleman S., Wittchen H.U., Kendler K.S. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch. Gen. Psychiatry 1994, 51:8-19.
151. Kessler R.C., Berglund P., Demler O., Jin R., Merikangas K.R., Walters E.E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 2005, 62:593-602.
152. Khashan A.S., Abel K.M., McNamee R., Pedersen M.G., Webb R.T., Baker P.N., Kenny L.C., Mortensen P.B. Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events. Arch. Gen. Psychiatry 2008, 65:146-152.
153. Kimura D., Clarke P.G. Women's advantage on verbal memory is not restricted to concrete words. Psychol. Rep. 2002, 91:1137-1142.
154. Kimura D., Seal B.N. Sex differences in recall of real or nonsense words. Psychol. Rep. 2003, 93:263-264.
155. Kinney D.K., Miller A.M., Crowley D.J., Huang E., Gerber E. Autism prevalence following prenatal exposure to hurricanes and tropical storms in Louisiana. J. Autism Dev. Disord. 2008, 38:481-488.
156. Koolschijn P.C., Crone E.A. Sex differences and structural brain maturation from childhood to early adulthood. Dev. Cogn. Neurosci. 2013, 5:106-118.
157. Koopman P. The genetics and biology of vertebrate sex determination. Cell 2001, 105:843-847.
158. Koubovec D., Ronacher K., Stubsrud E., Louw A., Hapgood J.P. Synthetic progestins used in HRT have different glucocorticoid agonist properties. Mol. Cell. Endocrinol. 2005, 242:23-32.
159. Kramar E.A., Chen L.Y., Lauterborn J.C., Simmons D.A., Gall C.M., Lynch G. BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. Neurobiol. Aging 2012, 33:708-719.
160. Kumon Y., Kim S.C., Tompkins P., Stevens A., Sakaki S., Loftus C.M. Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia. J. Neurosurg. 2000, 92:848-852.
161. LaBuda C.J., Mellgren R.L., Hale R.L. Sex differences in the acquisition of a radial maze task in the CD-1 mouse. Physiol. Behav. 2002, 76:213-217.
162. Lange-Kuttner C., Ebersbach M. Girls in detail, boys in shape: gender differences when drawing cubes in depth. Br. J. Psychol. 2013, 104:413-437.
163. Lee A.C., Rudebeck S.R. Investigating the interaction between spatial perception and working memory in the human medial temporal lobe. J. Cogn. Neurosci. 2010, 22:2823-2835.
164. Lee N.R., Wallace G.L., Clasen L.S., Lenroot R.K., Blumenthal J.D., White S.L., Celano M.J., Giedd J.N. Executive function in young males with Klinefelter (XXY) syndrome with and without comorbid attention-deficit/hyperactivity disorder. J. Int. Neuropsychol. Soc. 2011, 1-9.
165. Leung L., Andrews-Zwilling Y., Yoon S.Y., Jain S., Ring K., Dai J., Wang M.M., Tong L., Walker D., Huang Y. Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice. PLoS ONE 2012, 7:e53569.
166. Levin-Allerhand J.A., Lominska C.E., Wang J., Smith J.D. 17Alpha-estradiol and 17beta-estradiol treatments are effective in lowering cerebral amyloid-beta levels in AbetaPPSWE transgenic mice. J. Alzheimers Dis. 2002, 4:449-457.
167. Levine S.C., Huttenlocher J., Taylor A., Langrock A. Early sex differences in spatial skill. Dev. Psychol. 1999, 35:940-949.
168. Levy L.J., Astur R.S., Frick K.M. Men and women differ in object memory but not performance of a virtual radial maze. Behav. Neurosci. 2005, 119:853-862.
169. Lewin C., Wolgers G., Herlitz A. Sex differences favoring women in verbal but not in visuospatial episodic memory. Neuropsychology 2001, 15:165-173.
170. Li R., Shen Y., Yang L.B., Lue L.F., Finch C., Rogers J. Estrogen enhances uptake of amyloid beta-protein by microglia derived from the human cortex. J. Neurochem. 2000, 75:1447-1454.
171. Li S., Kang L., Zhang C., Xie G., Li N., Zhang Y., Du J., Cui H. Effects of dihydrotestosterone on synaptic plasticity of hippocampus in male SAMP8 mice. Exp. Gerontol. 2013, 48:778-785.
172. Li R., Cui J., Jothishankar B., Shen J., He P., Shen Y. Early reproductive experiences in females make differences in cognitive function later in life. J. Alzheimers Dis. 2013, 34:589-594.
173. Liang K., Yang L., Yin C., Xiao Z., Zhang J., Liu Y., Huang J. Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin. J. Biol. Chem. 2010, 285:935-942.
174. Libon D.J., Xie S.X., Moore P., Farmer J., Antani S., McCawley G., Cross K., Grossman M. Patterns of neuropsychological impairment in frontotemporal dementia. Neurology 2007, 68:369-375.
175. Linn M.C., Petersen A.C. Emergence and characterization of sex differences in spatial ability: a meta-analysis. Child Dev. 1985, 56:1479-1498.
176. Littleton-Kearney M.T., Klaus J.A., Hurn P.D. Effects of combined oral conjugated estrogens and medroxyprogesterone acetate on brain infarction size after experimental stroke in rat. J. Cereb. Blood Flow Metab. 2005, 25:421-426.
177. Liu R., Sui X., Laditka J.N., Church T.S., Colabianchi N., Hussey J., Blair S.N. Cardiorespiratory fitness as a predictor of dementia mortality in men and women. Med. Sci. Sports Exerc. 2012, 44:253-259.
178. Liverman C.T., Blazer D.G. Testosterone and Aging: Clinical Research Directions 2004, The National Academies Press, Washington, DC.
179. Long J., He P., Shen Y., Li R. New evidence of mitochondria dysfunction in the female Alzheimer's disease brain: deficiency of estrogen receptor-beta. J. Alzheimers Dis. 2012, 30:545-558.
180. Lu P.H., Masterman D.A., Mulnard R., Cotman C., Miller B., Yaffe K., Reback E., Porter V., Swerdloff R., Cummings J.L. Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men. Arch. Neurol. 2006, 63:177-185.
181. Lund T.D., Lephart E.D. Manipulation of prenatal hormones and dietary phytoestrogens during adulthood alter the sexually dimorphic expression of visual spatial memory. BMC Neurosci. 2001, 2:21.
182. Maguire E.A., Burgess N., O'Keefe J. Human spatial navigation: cognitive maps, sexual dimorphism, and neural substrates. Curr. Opin. Neurobiol. 1999, 9:171-177.
183. Maki P.M., Zonderman A.B., Resnick S.M. Enhanced verbal memory in nondemented elderly women receiving hormone-replacement therapy. Am. J. Psychiatry 2001, 158:227-233.
184. Malinowski J.C. Mental rotation and real-world wayfinding. Percept. Mot. Skills 2001, 92:19-30.
185. Malinowski J.C., Gillespie W.T. Individual differences in performance on a large-scale, real-world wayfinding task. J. Environ. Psychol. 2001, 21:73-82.
186. Mann V.A., Sasanuma S., Sakuma N., Masaki S. Sex differences in cognitive abilities: a cross-cultural perspective. Neuropsychologia 1990, 28:1063-1077.
187. Manson J.E., Hsia J., Johnson K.C., Rossouw J.E., Assaf A.R., Lasser N.L., Trevisan M., Black H.R., Heckbert S.R., Detrano R., Strickland O.L., Wong N.D., Crouse J.R., Stein E., Cushman M. Estrogen plus progestin and the risk of coronary heart disease. N. Engl. J. Med. 2003, 349:523-534.
188. Manthey D., Heck S., Engert S., Behl C. Estrogen induces a rapid secretion of amyloid beta precursor protein via the mitogen-activated protein kinase pathway. Eur. J. Biochem. 2001, 268:4285-4291.
189. Mantyla T. Gender differences in multitasking reflect spatial ability. Psychol. Sci. 2013, 24:514-520.
190. Marder K., Tang M.X., Alfaro B., Mejia H., Cote L., Jacobs D., Stern Y., Sano M., Mayeux R. Postmenopausal estrogen use and Parkinson's disease with and without dementia. Neurology 1998, 50:1141-1143.
191. Martin D.M., Wittert G., Burns N.R., McPherson J. Endogenous testosterone levels, mental rotation performance, and constituent abilities in middle-to-older aged men. Horm. Behav. 2008, 53:431-441.
192. Mathuranath P.S., Nestor P.J., Berrios G.E., Rakowicz W., Hodges J.R. A brief cognitive test battery to differentiate Alzheimer's disease and frontotemporal dementia. Neurology 2000, 55:1613-1620.
193. Maylor E.A., Reimers S., Choi J., Collaer M.L., Peters M., Silverman I. Gender and sexual orientation differences in cognition across adulthood: age is kinder to women than to men regardless of sexual orientation. Arch. Sex. Behav. 2007, 36:235-249.
194. McAllister C., Long J., Bowers A., Walker A., Cao P., Honda S., Harada N., Staufenbiel M., Shen Y., Li R. Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment. J. Neurosci. 2010, 30:7326-7334.
195. McClure R.E., Barha C.K., Galea L.A. 17beta-Estradiol, but not estrone, increases the survival and activation of new neurons in the hippocampus in response to spatial memory in adult female rats. Horm. Behav. 2013, 63:144-157.
196. McGivern R.F., Huston J.P., Byrd D., King T., Siegle G.J., Reilly J. Sex differences in visual recognition memory: support for a sex-related difference in attention in adults and children. Brain Cogn. 1997, 34:323-336.
197. McGivern R.F., Adams B., Handa R.J., Pineda J.A. Men and women exhibit a differential bias for processing movement versus objects. PLoS ONE 2012, 7:e32238.
198. McGugin R.W., Richler J.J., Herzmann G., Speegle M., Gauthier I. The Vanderbilt Expertise Test reveals domain-general and domain-specific sex effects in object recognition. Vision. Res. 2012, 69:10-22.
199. Mendelowitsch A., Ritz M.F., Ros J., Langemann H., Gratzl O. 17beta-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: a new neuroprotective pathway. Brain Res. 2001, 901:230-236.
200. Mihalick S.M., Crandall J.E., Langlois J.C., Krienke J.D., Dube W.V. Prenatal ethanol exposure, generalized learning impairment, and medial prefrontal cortical deficits in rats. Neurotoxicol. Teratol. 2001, 23:453-462.
201. Mittelstrass K., Ried J.S., Yu Z., Krumsiek J., Gieger C., Prehn C., Roemisch-Margl W., Polonikov A., Peters A., Theis F.J., Meitinger T., Kronenberg F., Weidinger S., Wichmann H.E., Suhre K., Wang-Sattler R., Adamski J., Illig T. Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS Genet. 2011, 7:e1002215.
202. 2+ release mechanism of primate drug-induced coronary vasospasm. Am. J. Physiol. 1997, 272:H2645-H2654.
203. Moffat S.D., Hampson E., Hatzipantelis M. Navigation in a "virtual" maze: sex differences and correlation with psychometric measures of spatial ability in humans. Evol. Hum. Behav. 1998, 19:73-87.
204. Moffat S.D., Zonderman A.B., Metter E.J., Kawas C., Blackman M.R., Harman S.M., Resnick S.M. Free testosterone and risk for Alzheimer disease in older men. Neurology 2004, 62:188-193.
205. Moradpour F., Naghdi N., Fathollahi Y., Javan M., Choopani S., Gharaylou Z. Pre-pubertal castration improves spatial learning during mid-adolescence in rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 2013, 46:105-112.
206. Morali G., Letechipia-Vallejo G., Lopez-Loeza E., Montes P., Hernandez-Morales L., Cervantes M. Post-ischemic administration of progesterone in rats exerts neuroprotective effects on the hippocampus. Neurosci. Lett. 2005, 382:286-290.
207. Morse J.K., Scheff S.W., DeKosky S.T. Gonadal steroids influence axon sprouting in the hippocampal dentate gyrus: a sexually dimorphic response. Exp. Neurol. 1986, 94:649-658.
208. Mukai H., Kimoto T., Hojo Y., Kawato S., Murakami G., Higo S., Hatanaka Y., Ogiue-Ikeda M. Modulation of synaptic plasticity by brain estrogen in the hippocampus. Biochim. Biophys. Acta 1800, 2010:1030-1044.
209. Muller M., den Tonkelaar I., Thijssen J.H., Grobbee D.E., van der Schouw Y.T. Endogenous sex hormones in men aged 40-80 years. Eur. J. Endocrinol. 2003, 149:583-589.
210. Mulnard R.A., Cotman C.W., Kawas C., van Dyck C.H., Sano M., Doody R., Koss E., Pfeiffer E., Jin S., Gamst A., Grundman M., Thomas R., Thal L.J. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study. JAMA 2000, 283:1007-1015.
211. Munro C.A., Winicki J.M., Schretlen D.J., Gower E.W., Turano K.A., Munoz B., Keay L., Bandeen-Roche K., West S.K. Sex differences in cognition in healthy elderly individuals. Neuropsychol. Dev. Cogn. B Aging Neuropsychol. Cogn. 2012, 19:759-768.
212. Murre J.M., Janssen S.M., Rouw R., Meeter M. The rise and fall of immediate and delayed memory for verbal and visuospatial information from late childhood to late adulthood. Acta Psychol. (Amst.) 2013, 142:96-107.
213. Neri A.L., Ongaratto L.L., Yassuda M.S. Mini-Mental State Examination sentence writing among community-dwelling elderly adults in Brazil: text fluency and grammar complexity. Int. Psychogeriatr. 2012, 24:1732-1737.
214. Neufang S., Specht K., Hausmann M., Gunturkun O., Herpertz-Dahlmann B., Fink G.R., Konrad K. Sex differences and the impact of steroid hormones on the developing human brain. Cereb. Cortex 2009, 19:464-473.
215. Nihonmatsu-Kikuchi N., Hayashi Y., Yu X.J., Tatebayashi Y. Depression and Alzheimer's disease: novel postmortem brain studies reveal a possible common mechanism. J. Alzheimers Dis. 2013, 37:611-621.
216. Nilsen J., Brinton R.D. Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology 2002, 143:205-212.
217. Nilsen J., Brinton R.D. Impact of progestins on estradiol potentiation of the glutamate calcium response. NeuroReport 2002, 13:825-830.
218. Nilsen J., Brinton R.D. Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling. Proc. Natl. Acad. Sci. USA 2003, 100:10506-10511.
219. North American Menopause Society The 2012 hormone therapy position statement of the North American Menopause Society. Menopause 2012, 19:257-271.
220. O'Leary T.P., Savoie V., Brown R.E. Learning, memory and search strategies of inbred mouse strains with different visual abilities in the Barnes maze. Behav. Brain Res. 2011, 216:531-542.
221. Olgiati P., Politis A., Albani D., Rodilossi S., Polito L., Zisaki A., Piperi C., Liappas I., Stamouli E., Mailis A., Batelli S., Forloni G., Marsano A., Balestri M., Soldatos C.R., De Ronchi D., Kalofoutis A., Serretti A. Effects of SORL1 gene on Alzheimer's disease. Focus on gender, neuropsychiatric symptoms and pro-inflammatory cytokines. Curr. Alzheimer Res. 2013, 10:154-164.
222. Ooishi Y., Kawato S., Hojo Y., Hatanaka Y., Higo S., Murakami G., Komatsuzaki Y., Ogiue-Ikeda M., Kimoto T., Mukai H. Modulation of synaptic plasticity in the hippocampus by hippocampus-derived estrogen and androgen. J. Steroid Biochem. Mol. Biol. 2012, 131:37-51.
223. Paganini-Hill A. Estrogen replacement therapy and stroke. Prog. Cardiovasc. Dis. 1995, 38:223-242.
224. Paganini-Hill A., Henderson V.W. Estrogen deficiency and risk of Alzheimer's disease in women. Am. J. Epidemiol. 1994, 140:256-261.
225. Pan Y., Zhang H., Acharya A.B., Patrick P.H., Oliver D., Morley J.E. Effect of testosterone on functional recovery in a castrate male rat stroke model. Brain Res. 2005, 1043:195-204.
226. Panza F., Frisardi V., Capurso C., D'Introno A., Colacicco A.M., Imbimbo B.P., Santamato A., Vendemiale G., Seripa D., Pilotto A., Capurso A., Solfrizzi V. Late-life depression, mild cognitive impairment, and dementia: possible continuum?. Am. J. Geriatr. Psychiatry 2010, 18:98-116.
227. Papasozomenos S., Shanavas A. Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease. Proc. Natl. Acad. Sci. USA 2002, 99:1140-1145.
228. Park S.A. A common pathogenic mechanism linking type-2 diabetes and Alzheimer's disease: evidence from animal models. J. Clin. Neurol. 2011, 7:10-18.
229. Pauls F., Petermann F., Lepach A.C. Gender differences in episodic memory and visual working memory including the effects of age. Memory 2013, 21:857-874.
230. Penaloza C., Estevez B., Orlanski S., Sikorska M., Walker R., Smith C., Smith B., Lockshin R.A., Zakeri Z. Sex of the cell dictates its response: differential gene expression and sensitivity to cell death inducing stress in male and female cells. FASEB J. 2009, 23:1869-1879.
231. Perri R., Koch G., Carlesimo G.A., Serra L., Fadda L., Pasqualetti P., Pettenati C., Caltagirone C. Alzheimer's disease and frontal variant of frontotemporal dementia - a very brief battery for cognitive and behavioural distinction. J. Neurol. 2005, 252:1238-1244.
232. Persson J., Herlitz A., Engman J., Morell A., Sjolie D., Wikstrom J., Soderlund H. Remembering our origin: gender differences in spatial memory are reflected in gender differences in hippocampal lateralization. Behav. Brain Res. 2013, 256C:219-228.
233. Peters M. Sex differences and the factor of time in solving Vandenberg and Kuse mental rotation problems. Brain Cogn. 2005, 57:176-184.
234. Pettus E.H., Wright D.W., Stein D.G., Hoffman S.W. Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury. Brain Res. 2005, 1049:112-119.
235. Phillips S.M., Sherwin B.B. Effects of estrogen on memory function in surgically menopausal women. Psychoneuroendocrinology 1992, 17:485-495.
236. Phung T.K., Waltoft B.L., Laursen T.M., Settnes A., Kessing L.V., Mortensen P.B., Waldemar G. Hysterectomy, oophorectomy and risk of dementia: a nationwide historical cohort study. Dement. Geriatr. Cogn. Disord. 2010, 30:43-50.
237. Piccinelli M., Wilkinson G. Gender differences in depression. Critical review. Br. J. Psychiatry 2000, 177:486-492.
238. Pike C.J. Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease. J. Neurochem. 1999, 72:1552-1563.
239. Pike C.J. Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons. Brain Res. 2001, 919:160-165.
240. Pilz K.S., Konar Y., Vuong Q.C., Bennett P.J., Sekuler A.B. Age-related changes in matching novel objects across viewpoints. Vision. Res. 2011, 51:1958-1965.
241. Portin R., Saarijarvi S., Joukamaa M., Salokangas R.K. Education, gender and cognitive performance in a 62-year-old normal population: results from the Turva Project. Psychol. Med. 1995, 25:1295-1298.
242. Postma A., Jager G., Kessels R.P., Koppeschaar H.P., van Honk J. Sex differences for selective forms of spatial memory. Brain Cogn. 2004, 54:24-34.
243. Protas H.D., Chen K., Langbaum J.B., Fleisher A.S., Alexander G.E., Lee W., Bandy D., de Leon M.J., Mosconi L., Buckley S., Truran-Sacrey D., Schuff N., Weiner M.W., Caselli R.J., Reiman E.M. Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease. JAMA Neurol. 2013, 70:320-325.
244. Proust-Lima C., Amieva H., Letenneur L., Orgogozo J.M., Jacqmin-Gadda H., Dartigues J.F. Gender and education impact on brain aging: a general cognitive factor approach. Psychol. Aging 2008, 23:608-620.
245. Puts D.A., McDaniel M.A., Jordan C.L., Breedlove S.M. Spatial ability and prenatal androgens: meta-analyses of congenital adrenal hyperplasia and digit ratio (2D:4D) studies. Arch. Sex. Behav. 2008, 37:100-111.
246. Puts D.A., Cardenas R.A., Bailey D.H., Burriss R.P., Jordan C.L., Breedlove S.M. Salivary testosterone does not predict mental rotation performance in men or women. Horm. Behav. 2010, 58:282-289.
247. Qiu W.Q., Folstein M.F. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiol. Aging 2006, 27:190-198.
248. Raffaitin C., Feart C., Le Goff M., Amieva H., Helmer C., Akbaraly T.N., Tzourio C., Gin H., Barberger-Gateau P. Metabolic syndrome and cognitive decline in French elders: the Three-City Study. Neurology 2011, 76:518-525.
249. Ramsden M., Shin T.M., Pike C.J. Androgens modulate neuronal vulnerability to kainate lesion. Neuroscience 2003, 122:573-578.
250. Rapp S.R., Espeland M.A., Shumaker S.A., Henderson V.W., Brunner R.L., Manson J.E., Gass M.L., Stefanick M.L., Lane D.S., Hays J., Johnson K.C., Coker L.H., Dailey M., Bowen D. Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 2003, 289:2663-2672.
251. Read S., Pedersen N.L., Gatz M., Berg S., Vuoksimaa E., Malmberg B., Johansson B., McClearn G.E. Sex differences after all those years? Heritability of cognitive abilities in old age. J. Gerontol. B Psychol. Sci. Soc. Sci. 2006, 61:P137-P143.
252. Resnick S.M., Maki P.M. Effects of hormone replacement therapy on cognitive and brain aging. Ann. N. Y. Acad. Sci. 2001, 949:203-214.
253. Resnick S.M., Maki P.M., Golski S., Kraut M.A., Zonderman A.B. Effects of estrogen replacement therapy on PET cerebral blood flow and neuropsychological performance. Horm. Behav. 1998, 34:171-182.
254. Reynolds C.A., Zavala C., Gatz M., Vie L., Johansson B., Malmberg B., Ingelsson E., Prince J.A., Pedersen N.L. Sortilin receptor 1 predicts longitudinal cognitive change. Neurobiol. Aging 2013, 34(1710):e11-e18.
255. Richard E., Reitz C., Honig L.H., Schupf N., Tang M.X., Manly J.J., Mayeux R., Devanand D., Luchsinger J.A. Late-life depression, mild cognitive impairment, and dementia. JAMA Neurol. 2013, 70:374-382.
256. Roberts J.E., Bell M.A. Two- and three-dimensional mental rotation tasks lead to different parietal laterality for men and women. Int. J. Psychophysiol. 2003, 50:235-246.
257. Roberts, R.O., Knopman, D.S., Geda, Y.E., Cha, R.H., Pankratz, V.S., Baertlein, L., Boeve, B.F., Tangalos, E.G., Ivnik, R.J., Mielke, M.M., Petersen, R.C., 2013. Association of diabetes with amnestic and nonamnestic mild cognitive impairment. Alzheimers Dement.
258. Roberts R.O., Geda Y.E., Knopman D.S., Cha R.H., Pankratz V.S., Boeve B.F., Tangalos E.G., Ivnik R.J., Mielke M.M., Petersen R.C. Cardiac disease associated with increased risk of nonamnestic cognitive impairment: stronger effect on women. JAMA Neurol. 2013, 70:374-382.
259. Roberts A.L., Lyall K., Hart J.E., Laden F., Just A.C., Bobb J.F., Koenen K.C., Ascherio A., Weisskopf M.G. Perinatal air pollutant exposures and autism spectrum disorder in the children of nurses' health study II participants. Environ. Health Perspect. 2013, 121:978-984.
260. Rodriguez C.A., Chamizo V.D., Mackintosh N.J. Overshadowing and blocking between landmark learning and shape learning: the importance of sex differences. Learn. Behav. 2011, 39:324-335.
261. Rodriguez-Aranda C., Martinussen M. Age-related differences in performance of phonemic verbal fluency measured by Controlled Oral Word Association Task (COWAT): a meta-analytic study. Dev. Neuropsychol. 2006, 30:697-717.
262. Roof R.L., Hall E.D. Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone. J. Neurotrauma 2000, 17:367-388.
263. Roof R.L., Duvdevani R., Heyburn J.W., Stein D.G. Progesterone rapidly decreases brain edema: treatment delayed up to 24 hours is still effective. Exp. Neurol. 1996, 138:246-251.
264. Roof R.L., Hoffman S.W., Stein D.G. Progesterone protects against lipid peroxidation following traumatic brain injury in rats. Mol. Chem. Neuropathol. 1997, 31:1-11.
265. Rosano G.M., Webb C.M., Chierchia S., Morgani G.L., Gabraele M., Sarrel P.M., de Ziegler D., Collins P. Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women. J. Am. Coll. Cardiol. 2000, 36:2154-2159.
266. Rosario E.R., Chang L., Stanczyk F.Z., Pike C.J. Age-related testosterone depletion and the development of Alzheimer disease. JAMA 2004, 292:1431-1432.
267. Rosario E.R., Chang L., Beckett T.L., Carroll J.C., Paul Murphy M., Stanczyk F.Z., Pike C.J. Age-related changes in serum and brain levels of androgens in male Brown Norway rats. NeuroReport 2009, 20:1534-1537.
268. Rosario E.R., Chang L., Head E.H., Stanczyk F.Z., Pike C.J. Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease. Neurobiol. Aging 2011, 32:604-613.
269. Rossouw J.E., Anderson G.L., Prentice R.L., LaCroix A.Z., Kooperberg C., Stefanick M.L., Jackson R.D., Beresford S.A., Howard B.V., Johnson K.C., Kotchen J.M., Ockene J. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002, 288:321-333.
270. Rummel J., Epp J.R., Galea L.A. Estradiol does not influence strategy choice but place strategy choice is associated with increased cell proliferation in the hippocampus of female rats. Horm. Behav. 2010, 58:582-590.
271. Ryan J., Carriere I., Scali J., Ritchie K., Ancelin M.L. Life-time estrogen exposure and cognitive functioning in later life. Psychoneuroendocrinology 2009, 34:287-298.
272. Savage R.M., Gouvier W.D. Rey Auditory-Verbal Learning Test: the effects of age and gender, and norms for delayed recall and story recognition trials. Arch. Clin. Neuropsychol. 1992, 7:407-414.
273. Kaufman S.B Sex differences in mental rotation and spatial visualization ability: can they be accounted for by differences in working memory capacity?. Inteligence 2007, 35:211-223.
274. Schindler A.E., Campagnoli C., Druckmann R., Huber J., Pasqualini J.R., Schweppe K.W., Thijssen J.H. Classification and pharmacology of progestins. Maturitas 2003, 46(Suppl. 1):S7-S16.
275. Schneider L.S., Farlow M.R., Henderson V.W., Pogoda J.M. Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer's disease. Neurology 1996, 46:1580-1584.
276. Schneider J.S., Anderson D.W., Talsania K., Mettil W., Vadigepalli R. Effects of developmental lead exposure on the hippocampal transcriptome: influences of sex, developmental period, and lead exposure level. Toxicol. Sci. 2012, 129:108-125.
277. Schuck, N.W., Doeller, C.F., Schjeide, B.M., Schroder, J., Frensch, P.A., Bertram, L., Li, S.C., 2013. Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual navigation task. Hippocampus.
278. Schulz K.M., Molenda-Figueira H.A., Sisk C.L. Back to the future: the organizational-activational hypothesis adapted to puberty and adolescence. Horm. Behav. 2009, 55:597-604.
279. Schwendimann R.N., Alekseeva N. Gender issues in multiple sclerosis. Int. Rev. Neurobiol. 2007, 79:377-392.
280. Scott E., Zhang Q.G., Wang R., Vadlamudi R., Brann D. Estrogen neuroprotection and the critical period hypothesis. Front. Neuroendocrinol. 2012, 33:85-104.
281. Selkoe D.J., Yamazaki T., Citron M., Podlisny M.B., Koo E.H., Teplow D.B., Haass C. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Ann. N. Y. Acad. Sci. 1996, 777:57-64.
282. Seshadri S., Beiser A., Kelly-Hayes M., Kase C.S., Au R., Kannel W.B., Wolf P.A. The lifetime risk of stroke: estimates from the Framingham Study. Stroke 2006, 37:345-350.
283. Seurinck R., Vingerhoets G., de Lange F.P., Achten E. Does egocentric mental rotation elicit sex differences?. Neuroimage 2004, 23:1440-1449.
284. Sharps M.J., Welton A.L., Price J.L. Gender and task in the determination of spatial cognitive performance. Psychol. Women Quart. 1993, 17:71-83.
285. Sherwin B.B. Estrogen effects on cognition in menopausal women. Neurology 1997, 48:S21-S26.
286. Sherwin B.B. Estrogen and cognitive functioning in women. Proc. Soc. Exp. Biol. Med. 1998, 217:17-22.
287. Shumaker S.A., Legault C., Rapp S.R., Thal L., Wallace R.B., Ockene J.K., Hendrix S.L., Jones B.N., Assaf A.R., Jackson R.D., Kotchen J.M., Wassertheil-Smoller S., Wactawski-Wende J. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 2003, 289:2651-2662.
288. Shumaker S.A., Legault C., Kuller L., Rapp S.R., Thal L., Lane D.S., Fillit H., Stefanick M.L., Hendrix S.L., Lewis C.E., Masaki K., Coker L.H. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: women's Health Initiative Memory Study. JAMA 2004, 291:2947-2958.
289. Silverman I.I., Choi J., Mackewn A., Fisher M., Moro J., Olshansky E. Evolved mechanisms underlying wayfinding. further studies on the hunter-gatherer theory of spatial sex differences. Evol. Hum. Behav. 2000, 21:201-213.
290. Silverman I., Choi J., Peters M. The hunter-gatherer theory of sex differences in spatial abilities: data from 40 countries. Arch. Sex. Behav. 2007, 36:261-268.
291. Simpkins J.W., Rajakumar G., Zhang Y.Q., Simpkins C.E., Greenwald D., Yu C.J., Bodor N., Day A.L. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J. Neurosurg. 1997, 87:724-730.
292. Singh M., Setalo G., Guan X., Warren M., Toran-Allerand C.D. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J. Neurosci. 1999, 19:1179-1188.
293. Singh M., Setalo G., Guan X., Frail D.E., Toran-Allerand C.D. Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice. J. Neurosci. 2000, 20:1694-1700.
294. Sohrabji F., Selvamani A., Balden R. Revisiting the timing hypothesis: biomarkers that define the therapeutic window of estrogen for stroke. Horm. Behav. 2013, 63:222-230.
295. Spencer J.L., Waters E.M., Romeo R.D., Wood G.E., Milner T.A., McEwen B.S. Uncovering the mechanisms of estrogen effects on hippocampal function. Front. Neuroendocrinol. 2008, 29:219-237.
296. Spencer-Segal J.L., Tsuda M.C., Mattei L., Waters E.M., Romeo R.D., Milner T.A., McEwen B.S., Ogawa S. Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formation. Neuroscience 2012, 202:131-146.
297. Spritzer M.D., Fox E.C., Larsen G.D., Batson C.G., Wagner B.A., Maher J. Testosterone influences spatial strategy preferences among adult male rats. Horm. Behav. 2013, 63:800-812.
298. Stein D.G. The case for progesterone. Ann. N. Y. Acad. Sci. 2005, 1052:152-169.
299. Steiner M., Dunn E., Born L. Hormones and mood: from menarche to menopause and beyond. J. Affect. Disord. 2003, 74:67-83.
300. Sudo S., Wen T.C., Desaki J., Matsuda S., Tanaka J., Arai T., Maeda N., Sakanaka M. Beta-estradiol protects hippocampal CA1 neurons against transient forebrain ischemia in gerbil. Neurosci. Res. 1997, 29:345-354.
301. Sunderaraman P., Blumen H.M., DeMatteo D., Apa Z.L., Cosentino S. Task demand influences relationships among sex, clustering strategy, and recall: 16-word versus 9-word list learning tests. Cogn. Behav. Neurol. 2013, 26:78-84.
302. Swaab D.F., Chung W.C., Kruijver F.P., Hofman M.A., Ishunina T.A. Structural and functional sex differences in the human hypothalamus. Horm. Behav. 2001, 40:93-98.
303. Takayanagi, Y., Spira, A.P., McIntyre, R.S., Eaton, W.W., 2013. Sex hormone binding globulin and verbal memory in older men. Am. J. Geriatr. Psychiatry.
304. Tan R.S. Testosterone effect on brain metabolism in elderly patients with Alzheimer's disease: comparing two cases at different disease stages. Aging Clin. Exp. Res. 2013, 25:343-347.
305. Tan R.S., Pu S.J. A pilot study on the effects of testosterone in hypogonadal aging male patients with Alzheimer's disease. Aging Male: Off. J. Int. Soc. Study Aging Male 2003, 6:13-17.
306. Tang M.X., Jacobs D., Stern Y., Marder K., Schofield P., Gurland B., Andrews H., Mayeux R. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 1996, 348:429-432.
307. Thielscher, C., Thielscher, S., Kostev, K., 2013. The risk of developing depression when suffering from neurological diseases. Ger. Med. Sci. 11, Doc02.
308. Thomas A.J., Nockels R.P., Pan H.Q., Shaffrey C.I., Chopp M. Progesterone is neuroprotective after acute experimental spinal cord trauma in rats. Spine 1999, 24:2134-2138.
309. Tippett W.J., Lee J.H., Mraz R., Zakzanis K.K., Snyder P.J., Black S.E., Graham S.J. Convergent validity and sex differences in healthy elderly adults for performance on 3D virtual reality navigation learning and 2D hidden maze tasks. Cyberpsychol. Behav. 2009, 12:169-174.
310. Toung T.J., Traystman R.J., Hurn P.D. Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke 1998, 29:1666-1670.
311. Trahan D.E., Quintana J.W. Analysis of gender effects upon verbal and visual memory performance in adults. Arch. Clin. Neuropsychol. 1990, 5:325-334.
312. Tzuriel D., Egozi G. Gender differences in spatial ability of young children: the effects of training and processing strategies. Child Dev. 2010, 81:1417-1430.
313. van Elderen S.G., de Roos A., de Craen A.J., Westendorp R.G., Blauw G.J., Jukema J.W., Bollen E.L., Middelkoop H.A., van Buchem M.A., van der Grond J. Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up. Neurology 2010, 75:997-1002.
314. van Hooren S.A., Valentijn A.M., Bosma H., Ponds R.W., van Boxtel M.P., Jolles J. Cognitive functioning in healthy older adults aged 64-81: a cohort study into the effects of age, sex, and education. Neuropsychol. Dev. Cogn. B: Aging Neuropsychol. Cogn. 2007, 14:40-54.
315. Vandromme M., Melton S.M., Kerby J.D. Progesterone in traumatic brain injury: time to move on to phase III trials. Crit. Care 2008, 12:153.
316. Verdelho A., Madureira S., Moleiro C., Ferro J.M., Santos C.O., Erkinjuntti T., Pantoni L., Fazekas F., Visser M., Waldemar G., Wallin A., Hennerici M., Inzitari D. White matter changes and diabetes predict cognitive decline in the elderly: the LADIS study. Neurology 2010, 75:160-167.
317. Verdile G., Laws S.M., Henley D., Ames D., Bush A.I., Ellis K.A., Faux N.G., Gupta V.B., Li Q.X., Masters C.L., Pike K.E., Rowe C.C., Szoeke C., Taddei K., Villemagne V.L., Martins R.N., AIBL Research Group Associations between gonadotropins, testosterone and beta amyloid in men at risk of Alzheimer's disease. Mol. Psychiatry 2012.
318. Vest R.S., Pike C.J. Gender, sex steroid hormones, and Alzheimer's disease. Horm. Behav. 2013, 63:301-307.
319. Vestergren P., Ronnlund M., Nyberg L., Nilsson L.G. Multigroup Confirmatory Factor Analysis of the Cognitive Dysfunction Questionnaire: instrument refinement and measurement invariance across age and sex. Scand. J. Psychol. 2012, 53:390-400.
320. Vina J., Lloret A. Why women have more Alzheimer's disease than men: gender and mitochondrial toxicity of amyloid-beta peptide. J. Alzheimers Dis. 2010, 20(Suppl. 2):S527-S533.
321. Viscoli C.M., Brass L.M., Kernan W.N., Sarrel P.M., Suissa S., Horwitz R.I. A clinical trial of estrogen-replacement therapy after ischemic stroke. N. Engl. J. Med. 2001, 345:1243-1249.
322. Vuoksimaa E., Kaprio J., Eriksson C.J., Rose R.J. Pubertal testosterone predicts mental rotation performance of young adult males. Psychoneuroendocrinology 2012, 37:1791-1800.
323. Waber D.P. Neuropsychological aspects of Turner's syndrome. Dev. Med. Child Neurol. 1979, 21:58-70.
324. Wali B., Sayeed I., Stein D.G. Improved behavioral outcomes after progesterone administration in aged male rats with traumatic brain injury. Restor. Neurol. Neurosci. 2011, 29:61-71.
325. Weaver C.E., Park-Chung M., Gibbs T.T., Farb D.H. 17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors. Brain Res. 1997, 761:338-341.
326. Weniger G., Ruhleder M., Lange C., Irle E. Impaired egocentric memory and reduced somatosensory cortex size in temporal lobe epilepsy with hippocampal sclerosis. Behav. Brain Res. 2012, 227:116-124.
327. Wessel J., Topol E.J., Ji M., Meyer J., McCarthy J.J. Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction. Am. Heart J. 2004, 147:905-909.
328. Wharton W., Hirshman E., Merritt P., Doyle L., Paris S., Gleason C. Oral contraceptives and androgenicity: influences on visuospatial task performance in younger individuals. Exp. Clin. Psychopharmacol. 2008, 16:156-164.
329. Wiener J.M., de Condappa O., Harris M.A., Wolbers T. Maladaptive bias for extrahippocampal navigation strategies in aging humans. J. Neurosci. 2013, 33:6012-6017.
330. Williams C.L., Meck W.H. The organizational effects of gonadal steroids on sexually dimorphic spatial ability. Psychoneuroendocrinology 1991, 16:155-176.
331. Winneker R.C., Bitran D., Zhang Z. The preclinical biology of a new potent and selective progestin: trimegestone. Steroids 2003, 68:915-920.
332. Wright D.W., Kellermann A.L., Hertzberg V.S., Clark P.L., Frankel M., Goldstein F.C., Salomone J.P., Dent L.L., Harris O.A., Ander D.S., Lowery D.W., Patel M.M., Denson D.D., Gordon A.B., Wald M.M., Gupta S., Hoffman S.W., Stein D.G. ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann. Emerg. Med. 2007, 49:391-402. 402 e1-2.
333. Xiao G., Wei J., Yan W., Wang W., Lu Z. Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial. Crit. Care 2008, 12:R61.
334. Xu H., Gouras G.K., Greenfield J.P., Vincent B., Naslund J., Mazzarelli L., Fried G., Jovanovic J.N., Seeger M., Relkin N.R., Liao F., Checler F., Buxbaum J.D., Chait B.T., Thinakaran G., Sisodia S.S., Wang R., Greengard P., Gandy S. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat. Med. 1998, 4:447-451.
335. Xu H., Wang R., Zhang Y.W., Zhang X. Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer's disease. Ann. N. Y. Acad. Sci. 2006, 1089:324-342.
336. Yang S.H., Perez E., Cutright J., Liu R., He Z., Day A.L., Simpkins J.W. Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal model. J. Appl. Physiol. 1985, 92(2002):195-201.
337. Yao M., Nguyen T.V., Pike C.J. Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death. J. Neurosci. 2007, 27:1422-1433.
338. Ye B.S., Seo S.W., Lee Y., Kim S.Y., Choi S.H., Lee Y.M., Kim do H., Han H.J., Na D.L., Kim E.J. Neuropsychological performance and conversion to Alzheimer's disease in early- compared to late-onset amnestic mild cognitive impairment: CREDOS study. Dement. Geriatr. Cogn. Disord. 2012, 34:156-166.
339. Yonker J.E., Eriksson E., Nilsson L.G., Herlitz A. Sex differences in episodic memory: minimal influence of estradiol. Brain Cogn. 2003, 52:231-238.
340. Youngjohn J.R., Larrabee G.J., Crook T.H. First-Last Names and the Grocery List Selective Reminding Test: two computerized measures of everyday verbal learning. Arch. Clin. Neuropsychol. 1991, 6:287-300.
341. Yue X., Lu M., Lancaster T., Cao P., Honda S., Staufenbiel M., Harada N., Zhong Z., Shen Y., Li R. Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model. Proc. Natl. Acad. Sci. USA 2005, 102:19198-19203.
342. Zandi P.P., Carlson M.C., Plassman B.L., Welsh-Bohmer K.A., Mayer L.S., Steffens D.C., Breitner J.C. Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study. JAMA 2002, 288:2123-2129.
343. Zhang Y., Champagne N., Beitel L.K., Goodyer C.G., Trifiro M., LeBlanc A. Estrogen and androgen protection of human neurons against intracellular amyloid beta1-42 toxicity through heat shock protein 70. J. Neurosci. 2004, 24:5315-5321.
344. Zhang Q.G., Wang R., Khan M., Mahesh V., Brann D.W. Role of Dickkopf-1, an antagonist of the Wnt/beta-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphorylation. J. Neurosci. 2008, 28:8430-8441.
345. Zhang Q.G., Wang R.M., Scott E., Han D., Dong Y., Tu J.Y., Yang F., Reddy Sareddy G., Vadlamudi R.K., Brann D.W. Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause. Brain 2013, 136:1432-1445.
346. Zhao L., Yao J., Mao Z., Chen S., Wang Y., Brinton R.D. 17beta-Estradiol regulates insulin-degrading enzyme expression via an ERbeta/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention. Neurobiol. Aging 2011, 32:1949-1963.
347. Zhao L., Morgan T.E., Mao Z., Lin S., Cadenas E., Finch C.E., Pike C.J., Mack W.J., Brinton R.D. Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. PLoS ONE 2012, 7:e31267.
348. Zuloaga D.G., Puts D.A., Jordan C.L., Breedlove S.M. The role of androgen receptors in the masculinization of brain and behavior: what we've learned from the testicular feminization mutation. Horm. Behav. 2008, 53:613-626.