Long-Standing Balancing Selection in the THBS4 Gene: Influence on Sex-Specific Brain Expression and Gray Matter Volumes in Alzheimer Disease

Human Mutation

Volumn 34, Issue 5, 2013, Pages 743-753

  Cagliani, Rachele ^a   Guerini, Franca R ^b   Rubio Acero, Raquel ^c   Baglio, Francesca ^b   Forni, Diego ^a   Agliardi, Cristina ^b   Griffanti, Ludovica ^b   Fumagalli, Matteo ^a   Pozzoli, Uberto ^a   Riva, Stefania ^a   Calabrese, Elena ^b   Sikora, Martin ^d,g   Casals, Ferran ^d   Comi, Giacomo P ^e   Bresolin, Nereo ^a,e   Cáceres, Mario ^c,f   Clerici, Mario ^b,e   Sironi, Manuela ^a  

^a SCIENTIFIC INSTITUTE   (Italy)

^b IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d UNIVERSITAT POMPEU FABRA   (Spain)

^e UNIVERSITY OF MILAN   (Italy)

^f INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^g STANFORD UNIVERSITY   (United States)

Author keywords

Alzheimer disease; Balancing selection; Brain; THBS4; Transcriptional regulation

Indexed keywords

GLYCOPROTEIN; THOMBOSPONDIN 4; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN SIZE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; GRAY MATTER; HAPLOTYPE; HOMOZYGOTE; HUMAN; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEX;

ALZHEIMER DISEASE; ANIMALS; BASE SEQUENCE; BRAIN; FEMALE; GENETICS, POPULATION; HAPLOTYPES; HUMANS; MALE; SEQUENCE HOMOLOGY, NUCLEIC ACID; SEX FACTORS; THROMBOSPONDINS;

MACACA; PAN; PRIMATES;

EID: 84876298895     PISSN: 10597794     EISSN: 10981004     Source Type: Journal    
DOI: 10.1002/humu.22301     Document Type: Article

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