Pre-pubertal castration improves spatial learning during mid-adolescence in rats

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 46, Issue , 2013, Pages 105-112

  Moradpour, Farshad ^a   Naghdi, Nasser ^b   Fathollahi, Yaghoub ^a   Javan, Mohamad ^a   Choopani, Samira ^b   Gharaylou, Zeinab ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Adolescence; Gonads; Pre pubertal; Rat; Spatial memory; Testosterone

Indexed keywords

TESTOSTERONE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BODY WEIGHT; BRAIN FUNCTION; BRAIN REGION; CASTRATION; CONTROLLED STUDY; GROUPS BY AGE; HIPPOCAMPUS; HORMONAL REGULATION; HORMONE DETERMINATION; LATENT PERIOD; MALE; MAZE TEST; NONHUMAN; PREPUBERTY; RAT; SPATIAL LEARNING; SPATIAL MEMORY; STIMULUS RESPONSE; TASK PERFORMANCE;

ADOLESCENCE; D; DAYS; FEPSP; FIELD EXCITATORY POSTSYNAPTIC POTENTIAL; GONADS; HFS; HIGH FREQUENCY STIMULATION; LONG TERM POTENTIATION; LTP; MORRIS WATER MAZE; MWM; N-METHY D-ASPARTIC ACID; NMDA; POPULATION SPIKE; PRE-PUBERTAL; PS; RAT; SPATIAL MEMORY; TESTOSTERONE;

AGE FACTORS; ANIMALS; ESCAPE REACTION; MALE; MAZE LEARNING; ORCHIECTOMY; RATS; RATS, WISTAR; SEXUAL MATURATION; SPATIAL BEHAVIOR; TESTOSTERONE;

EID: 84881110239     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2013.07.005     Document Type: Article

References (34)

1. Akers K.G., Candelaria-Cook F.T., Hamilton D.A. Preweanling rats solve the Morris water task via directional navigation. Behav Neurosci 2007, 121:1426.
2. Akers K.G., Candelaria-Cook F.T., Rice J.P., Johnson T.E., Hamilton D.A. Delayed development of place navigation compared to directional responding in young rats. Behav Neurosci 2009, 123:267-275.
3. Akers K.G., Candelaria-Cook F.T., Rice J.P., Johnson T.E., Hamilton D.A. Cued platform training reveals early development of directional responding among preweanling rats in the Morris water task. Dev Psychobiol 2011, 53:1-12.
4. Bayer S.A. Development of the hippocampal region in the rat. II. Morphogenesis during embryonic and early postnatal life. J Comp Neurol 1980, 190:115-134.
5. Dutlow C.M., Rachman J., Jacobs T.W., Millar R.P. Prepubertal increases in gonadotropin-releasing hormone mRNA, gonadotropin-releasing hormone precursor, and subsequent maturation of precursor processing in male rats. J Clin Invest 1992, 90:2496-2501.
6. Feeser H.R., Raskin L.A. Effects of neonatal dopamine depletion on spatial ability during ontogeny. Behav Neurosci 1987, 101:812-818.
7. Foy M.R., Xu J., Xie X., Brinton R.D., Thompson R.F., Berger T.W. 17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation. J Neurophysiol 1999, 81:925-929.
8. Frankola K.A., Flora A.L., Torres A.K., Grissom E.M., Overstreet S., Dohanich G.P. Effects of early rearing conditions on cognitive performance in prepubescent male and female rats. Neurobiol Learn Mem 2010, 94:91-99.
9. Gladwin T.E., Figner B., Crone E.A., Wiers R.W. Addiction, adolescence, and the integration of control and motivation. Dev Cogn Neurosci 2011, 1:364-376.
10. Grissom E.M., Hawley W.R., Bromley-Dulfano S.S., Marino S.E., Stathopoulos N.G., Dohanich G.P. Learning strategy is influenced by trait anxiety and early rearing conditions in prepubertal male, but not prepubertal female rats. Neurobiol Learn Mem 2012, 98:174-181.
11. Grissom E.M., Hawley W.R., Hodges K.S., Fawcett Patel J.M., Dohanich G.P. Biological sex influences learning strategy preference and muscarinic receptor binding in specific brain regions of prepubertal rats. Hippocampus 2012, 163:1333-1338.
12. He J., Crews F. Neurogenesis decreases during brain maturation from adolescence to adulthood. Pharmacol Biochem Behav 2007, 86:327-333.
13. Isgor C., Sengelaub D.R. Prenatal gonadal steroids affect adult spatial behavior, CA1 and CA3 pyramidal cell morphology in rats. Horm Behav 1998, 34:183-198.
14. Isgor C., Sengelaub D.R. Effects of neonatal gonadal steroids on adult CA3 pyramidal neuron dendritic morphology and spatial memory in rats. J Neurobiol 2003, 55:179-190.
15. Ito K., Skinkle K.L., Hicks T.P. Age-dependent, steroid-specific effects of oestrogen on long-term potentiation in rat hippocampal slices. J Physiol 1999, 515(Pt 1):209-220.
16. Jonasson Z. Meta-analysis of sex differences in rodent models of learning and memory: a review of behavioral and biological data. Neurosci Biobehav Rev 2005, 28:811-825.
17. Kanit L., Taskiran D., Yilmaz Ö.A., Balkan B., Demirgören S., Furedy J., et al. Sexually dimorphic cognitive style in rats emerges after puberty. Brain Res Bull 2000, 52:243-248.
18. Koshibu K., Levitt P., Ahrens E. Sex-specific, postpuberty changes in mouse brain structures revealed by three-dimensional magnetic resonance microscopy. Neuroimage 2004, 22:1636-1645.
19. Lee V.W., de Kretser D.M., Hudson B., Wang C. Variations in serum FSH, LH and testosterone levels in male rats from birth to sexual maturity. J Reprod Fertil 1975, 42:121-126.
20. Leuner B., Gould E., Shors T. Is there a link between adult neurogenesis and learning?. Hippocampus Recollect 2006, 16:216-224.
21. Li M., Masugi-Tokita M., Takanami K., Yamada S., Kawata M. Testosterone has sublayer-specific effects on dendritic spine maturation mediated by BDNF and PSD-95 in pyramidal neurons in the hippocampus CA1 area 2012.
22. McCarthy M.M., Konkle A.T. When is a sex difference not a sex difference?. Front Neuroendocrinol 2005, 26:85-102.
23. Mitsushima D., Takase K., Takahashi T., Kimura F. Activational and organisational effects of gonadal steroids on sex-specific acetylcholine release in the dorsal hippocampus. J Neuroendocrinol 2009, 21:400-405.
24. Mohaddes G., Naghdi N., Khamnei S., Khatami S., Haeri A. Effect of spatial learning on hippocampal testosterone in intact and castrated male rats. Iran Biomed J 2009, 13:49-58.
25. Moradpour F., Fathollahi Y., Naghdi N., Hosseinmardi N., Javan M. Prepubertal castration causes the age-dependent changes in hippocampal long-term potentiation. Synapse 2013, 67:235-244.
26. Moradpour F., Naghdi N., Fathollahi Y. Anastrozole improved testosterone-induced impairment acquisition of spatial learning and memory in the hippocampal CA1 region in adult male rats. Behav Brain Res 2006, 175:223-232.
27. Pleil K.E., Williams C.L. The development and stability of estrogen-modulated spatial navigation strategies in female rats. Horm Behav 2010, 57:360-367.
28. Sakata K., Tokue A., Kawai N. Altered synaptic transmission in the hippocampus of the castrated male mouse is reversed by testosterone replacement. J Urol 2000, 163:1333-1338.
29. Sandstrom N.J., Kim J.H., Wasserman M.A. Testosterone modulates performance on a spatial working memory task in male rats. Horm Behav 2006, 50:18-26.
30. Schenk F. Development of place navigation in rats from weaning to puberty. Behav Neural Biol 1985, 43:69-85.
31. Schulz K.M., Molenda-Figueira H.A., Sisk C.L. Back to the future: the organizational-activational hypothesis adapted to puberty and adolescence. Horm Behav 2009, 55:597-604.
32. Sisk C.L., Foster D.L. The neural basis of puberty and adolescence. Nat Neurosci 2004, 7:1040-1047.
33. Sisk C.L., Zehr J.L. Pubertal hormones organize the adolescent brain and behavior. Front Neuroendocrinol 2005, 26:163-174.
34. Spritzer M.D., Gill M., Weinberg A., Galea L.A. Castration differentially affects spatial working and reference memory in male rats. Arch Sex Behav 2008, 37:19-29.