Estrogen stimulates degradation of β-amyloid peptide by up-regulating Neprilysin

Journal of Biological Chemistry

Volumn 285, Issue 2, 2010, Pages 935-942

  Liang, Kaiwei ^a   Yang, Liuqing ^a   Yin, Chen ^a   Xiao, Zhimin ^a   Zhang, Junjian ^a   Liu, Yumin ^a   Huang, Jian ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PEPTIDES; BRAIN TISSUE; DEGRADING ENZYMES; ESTROGEN RECEPTOR; ESTROGEN RESPONSE ELEMENTS; HUMAN DISORDERS; IN-VITRO; IN-VIVO; MODEL SYSTEM; MOLECULAR MECHANISM; NEPRILYSIN; NEUROBLASTOMAS; PHYSICAL INTERACTIONS; REPORTER-GENE EXPRESSION; RISK FACTORS; SHIFT-AND; SPECIFIC BINDING; UP-REGULATION;

BIOACTIVITY; GENE EXPRESSION; GLYCOPROTEINS; PEPTIDES;

DEGRADATION;

AMYLOID BETA PROTEIN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MEMBRANE METALLOENDOPEPTIDASE;

ALZHEIMER DISEASE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME REGULATION; ESTROGEN RESPONSIVE ELEMENT; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HORMONE ACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; MOLECULAR INTERACTION; NEUROBLASTOMA; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; REPORTER GENE; YEAST;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BRAIN; CELL LINE, TUMOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MODELS, BIOLOGICAL; NEPRILYSIN; POSTMENOPAUSE; RESPONSE ELEMENTS; RISK FACTORS; SACCHAROMYCES CEREVISIAE; UP-REGULATION;

EID: 74049100935     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.051664     Document Type: Article

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